Abstract:
:Burn injury induces immune dysfunction and alters numerous physiological parameters. While clinical studies indicate that burn injury size profoundly impacts patient immune status, only limited experimental studies have systematically addressed its impact on immune functional parameters. In the present study, mice were subjected to burn injuries of varying sizes and splenic immune cells (splenocytes and macrophages) were isolated 7 days thereafter. Burn injury suppressed splenic T-cell proliferation in an injury size-dependent manner that correlated with the release of the immunosuppressive mediators PGE(2) and nitric oxide. In addition, a shift towards an immunosuppressive Th-2 cytokine profile and a hyperactive macrophage phenotype (increased release of inflammatory mediators) was observed post-injury, however, this effect was in part independent of burn size. Thus, unlike patient survival data, burn injury-induced changes in immune function do not necessarily correlate with the size of the injury.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Alexander M,Chaudry IH,Schwacha MGdoi
10.1016/s0008-8749(03)00024-8subject
Has Abstractpub_date
2002-11-01 00:00:00pages
63-9issue
1eissn
0008-8749issn
1090-2163pii
S0008874903000248journal_volume
220pub_type
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journal_title:Cellular immunology
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