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Extrathymic development of self-reactive gamma(delta) T cells in athymic BALB/c nu/nu mice.

Abstract：

:In the present report, we demonstrated that extrathymic gamma(delta) T cells proliferated in the mixed culture of lymph node cells of BALB/c nu/nu mice and irradiated syngeneic spleen cells (syngeneic MLR). Reverse transcription-polymerase chain reaction (RT-PCR) analyses revealed that V(delta)5 and V(delta)6 were dominantly expressed by the gamma(delta) T cells from the syngeneic MLR. Furthermore, the syngeneic MLR may expand V(delta)5+ T cells with BALB invariant delta (BID) sequence which is specifically detected in BALB background mice because V(delta)5 RT-PCR products from syngeneic MLR were digested with an AluI restriction enzyme which cut the D(delta)2-J(delta)1 junction of the BID sequence but not those of most non-BID V(delta)5 sequences. Interestingly, anti-mycobacterial and mammalian heat shock protein (Hsp) 60 mAb ML30 suppressed the generation of V(delta)5 with an AluI site in syngeneic MLR. These results suggest that extrathymically derived V(delta)5+ and V(delta)6+ gamma(delta) T cells recognize BALB/c self antigens and that the Hsp60 or an Hsp60-related molecule may be involved in the anti-self response of V(delta)5+ BID+ gamma(delta) T cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Matsuzaki G,Kenai H,Fujise S,Kobayashi N,Kishihara K,Nomoto K

doi

10.1006/cimm.1996.0250

subject

Has Abstract

pub_date

1996-10-10 00:00:00

pages

49-54

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(96)90250-6

journal_volume

173

pub_type

杂志文章

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