New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19?

abstract：:The internalization of surface immunoglobulin (Ig) by B lymphocytes is the first step in the antigen-presenting function performed by these cells. Mature B cells coexpress on their surface IgM and IgD. At this time, there is controversy over whether these two isotypes serve different functions in the antigen-presentin...

journal_title：Cellular immunology

authors： Guarini L,Weber DA,Pernis B

更新日期：1989-10-15 00:00:00

abstract：:Hybrid human-murine major histocompatibility antigens have been constructed and expressed on the surface of both human RD and murine L cell lines after DNA mediated gene transfer. These antigens linked the polymorphic domains (alpha 1 and alpha 2) of H-2Kb and the carboxy-terminal domains (alpha 3, transmembrane, and ...

journal_title：Cellular immunology

authors： Maziarz RT,Burakoff SJ,Reiss CS

更新日期：1986-04-15 00:00:00

abstract：:The "NK-triggering-antigen regulator" (Nktar) gene is a locus identified in the C57BL/6 genome which regulates the ability of unlabeled activated Con A blasts to compete for recognition of labeled syngeneic Con A blasts by BALB/c NK cells. Linkage analysis on Con A blasts from (BALB/c x CByB6F1) N2 backcross progeny f...

journal_title：Cellular immunology

authors： Chou SR,Brownell A,Ko MS,Kaplan J

更新日期：2000-03-15 00:00:00

abstract：:We investigated whether sn-1,2-dioctanoylglycerol (diC8) activates highly purified human T cells. diC8's signaling activity was also compared with that of 12-O-tetradecanoylphorbol-13-acetate (TPA). diC8 and ionomycin were synergistic in promoting T-cell proliferation. The proliferative response was dependent upon an ...

journal_title：Cellular immunology

authors： Subramaniam A,Sehajpal P,Murthi VK,Stenzel KH,Suthanthiran M

更新日期：1988-10-15 00:00:00

abstract：:Gene products coded for within the HLA complex play an important role in the control of immune responses. Class I antigens, coded for by the HLA-A, B, and C loci, are expressed by virtually all mononuclear blood cells. Class II antigens, coded for by the DR, DQ, and DP loci, have a more limited tissue distribution. Th...

journal_title：Cellular immunology

authors： Zier KS

更新日期：1986-07-01 00:00:00

abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...

journal_title：Cellular immunology

authors： Tumang JR,Hsia CY,Tian W,Bromberg JF,Liou HC

更新日期：2002-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the i...

journal_title：Cellular immunology

authors： Zhou M,Chen J,Zhou L,Chen W,Ding G,Cao L

更新日期：2014-11-01 00:00:00

abstract：:Recognition of lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) activates two district proinflammatory signaling pathway and initiates LPS internalization. To investigate roles of LPS internalization, a traditionally regarded metabolic pathway for LPS, in regulation of these two pathways, three internalization ...

journal_title：Cellular immunology

authors： Wang Y,Yang Y,Liu X,Wang N,Cao H,Lu Y,Zhou H,Zheng J

更新日期：2012-01-01 00:00:00

abstract：:Osteopontin (OPN) expression in tumors is associated with more aggressive tumor growth; however, several studies have suggested that OPN as a host protein can regulate tumor growth as well. OPN is produced by macrophages and T cells, and reportedly modifies macrophage function. Here, we have investigated the effect of...

journal_title：Cellular immunology

authors： Bourassa B,Monaghan S,Rittling SR

更新日期：2004-01-01 00:00:00

abstract：:CCR5 is a chemokine receptor expressed by T cells and macrophages, which also functions as the principal coreceptor for macrophage (M)-tropic HIV-1 strains to enter the host cells. In this study, we aim to better understand the ligand-binding profiles of CCR5 and the chemokine-receptor usage on leukocyte cells. We fou...

journal_title：Cellular immunology

authors： Ruffing N,Sullivan N,Sharmeen L,Sodroski J,Wu L

更新日期：1998-11-01 00:00:00

abstract：:Dendritic cell (DC)-based immunotherapy has promising for treatment of non-small cell lung cancer (NSCLC). Melanoma-associated antigen 3 (MAGE-A3) is a tumor-specific antigen and expressed in approximately 35-40% of NSCLC tissues. Calreticulin (CALR) is a protein chaperone and can enhance DC maturation and antigen pre...

journal_title：Cellular immunology

authors： Liu X,Li J,Liu Y,Ding J,Tong Z,Liu Y,Zhou Y,Liu Y

更新日期：2016-02-01 00:00:00

abstract：:The frequency of obesity is enormously growing worldwide. Obesity results when energy intake exceeds, energy expenditure. Excess adiposity is a major risk factor in the progress of various metabolic disorders accounting insulin resistance, hypertension, Type 2 diabetes, nonalcoholic fatty liver disease, polycystic ova...

journal_title：Cellular immunology

authors： Asghar A,Sheikh N

更新日期：2017-05-01 00:00:00

abstract：:The mechanism underlying the apparent differences in the capacity of murine and human class I MHC molecules to function as signal transducing structures in T cells was examined. Cross-linking murine class I MHC molecules on splenic T cells did not stimulate an increase in intracellular calcium ([Ca2+]i) and failed to ...

journal_title：Cellular immunology

authors： Gur H,Wacholtz MC,Lie WR,Lipsky PE,Geppert TD

更新日期：1992-10-15 00:00:00

abstract：:A spontaneously arising murine plasmacytoma, HPC-202, derived from a BALB/c.H-2b congenic mouse that lacks any detectable H-2 determinants on its cell surface is described. However, the expression of H-2 determinants is inducible by interferon-gamma. The H-2 negative cell surface phenotype permits the HPC-202 tumor to...

journal_title：Cellular immunology

authors： Daley MJ,Williams TJ,Giorgi J,Warner NL

更新日期：1990-04-15 00:00:00

abstract：:Tumor-associated chemokines, including CC chemokine ligand 2/monocyte chemoattractant protein-1 (CCL2), are thought to play many roles in cancer progression. Here we demonstrate the novel finding that during growth of the D1-7,12-dimethylbenzanthracene-3 mammary tumor in BALB/c mice, there is a dramatic up-regulation ...

journal_title：Cellular immunology

authors： Owen JL,Lopez DM,Grosso JF,Guthrie KM,Herbert LM,Torroella-Kouri M,Iragavarapu-Charyulu V

更新日期：2005-06-01 00:00:00

abstract：:Murine graft versus host (GVH) disease takes two forms depending on the parental/F1 strain combination employed. In an accompanying paper (Singh et al., Clin. Immunol. 151, 1993) many of the clinical features of these two forms of GVH disease are described. In addition to these clinical characteristics, acute lethal G...

journal_title：Cellular immunology

authors： Mann RA,Singh AB,Singh M,Jetzt AE

更新日期：1993-10-01 00:00:00

abstract：AIMS:Evaluate the participation of IL-17 pathway in T1D pathogenesis. T helper 17 cells are potent, highly inflammatory cells that produce interleukin 17A (IL-17A), considered a mediator of various immune disorders. However, their role in Type 1 diabetes (T1D) pathogenesis in humans is not totally elucidated. METHODS:...

journal_title：Cellular immunology

authors： Fores JP,Crisostomo LG,Orii NM,Santos AS,Fukui RT,Matioli SR,de Moraes Vasconcelos D,Silva MERD

更新日期：2018-02-01 00:00:00

abstract：:PICOT (PKC-interacting cousin of thioredoxin) consists of one thioredoxin homology domain in the N-terminal and two tandem PICOT homology domains in the C-terminal. PICOT specifically interacts with protein kinase C theta (PKC-theta) via its thioredoxin homology domain and acts as an important modulator of T cell rece...

journal_title：Cellular immunology

authors： Kato N,Motohashi S,Okada T,Ozawa T,Mashima K

更新日期：2008-01-01 00:00:00

abstract：:Spleen cells from neonatal mice belonging to strains with the I-J-b or I-J-k genotype, were treated with anti-I-Jb or anti-I-Jk antibody and complement. This reduces their suppressor cell activity as demonstrated by a decrease in the ability to suppress the mixed-lymphocyte reactivity of adult spleen cells. Injection ...

journal_title：Cellular immunology

authors： Argyris BF,Waltenbaugh C

更新日期：1983-09-01 00:00:00

abstract：:The effects of oral administration of ovalbumin (OVA) on acute OVA-induced arthritis (OIA) in rats, which is mediated by Arthus reaction to the antigen in the joint space, were investigated. The oral administration of OVA before immunization with OVA significantly suppressed the development of acute OIA in a dose-depe...

journal_title：Cellular immunology

authors： Inada S,Yoshino S,Haque MA,Ogata Y,Kohashi O

更新日期：1997-01-10 00:00:00

abstract：:A B lymphoblastoid cell line can provide a comitogenic, accessory signal for mitogen-treated T cells. In a study evaluating the antigenic determinant of such cells that mediate this effect, a monoclonal antibody (I57) was raised against the Daudi cell line. This antibody was found to interact with a 30-kDa protein on ...

journal_title：Cellular immunology

authors： Hardy B,Dotan D,Novogrodsky A

更新日期：1989-01-01 00:00:00

abstract：:When guinea pigs were treated by complete Freund's adjuvant (CFA), eosinophil-directed chemotactic inhibitory factor (ECIF) appeared in the serum of the treated animals. The inhibition of the response of eosinophils by ECIF was selective for the T cell-derived chemotactic factor, which has been isolated from DNP-ascar...

journal_title：Cellular immunology

authors： Hirashima M,Tashiro K,Hayashi H

更新日期：1984-11-01 00:00:00

abstract：:To determine the relative contributions of DC subsets in the development of protective immunity to Listeria monocytogenes we examined the relationship between maturation, bacterial burden, and T cell priming capacity of four well characterized subsets of splenic DC following infection with Lm. CD8α(+), CD4(+), and CD8...

journal_title：Cellular immunology

authors： Mitchell LM,Brzoza-Lewis KL,Henry CJ,Grayson JM,Westcott MM,Hiltbold EM

更新日期：2011-01-01 00:00:00

abstract：:During the gestational cycle the placental tissue does not express class II MHC antigens and whether this phenomenon is important to fetal survival has not yet been evoked. It has been reported that class II antigen expression precedes renal and cardiac graft rejection, which may also be the case in fetal abortion. In...

journal_title：Cellular immunology

authors： Athanassakis-Vassiliadis I,Galanopoulos VK,Grigoriou M,Papamatheakis J

更新日期：1990-07-01 00:00:00

abstract：:Mice from strains showing either phenotypical expression of Bcg gene (C57BL/6, BALB/c, DBA/1, and (C57BL/6 X DBA/2)/F1, CBA, A/J, DBA/2) were infected intravenously with 10(7) Mycobacterium lepraemurium (MLM). The number of acid-fast bacilli (AFB) within the spleens, the ability of spleen cells to produce in vitro int...

journal_title：Cellular immunology

authors： Hoffenbach A,Lagrange PH,Bach MA

更新日期：1985-03-01 00:00:00

abstract：:Class I antigens are necessary for the recognition of tumor cells by cytotoxic T lymphocytes (CTL). The line 1 lung carcinoma is a spontaneous murine tumor deficient in class I antigen expression. Consistent with this, line 1 cells are highly metastatic in vivo. We investigated whether increasing class I antigen expre...

journal_title：Cellular immunology

authors： Cerosaletti KM,Blieden TM,Harwell LW,Welsh KM,Frelinger JG,Lord EM

更新日期：1990-05-01 00:00:00

abstract：:This report compares the ability of cyclosporin A and FK-506 to inhibit human T cell activation triggered via cell surface molecules that utilize different intracellular processes. We stimulated highly purified peripheral blood T lymphocytes with mitogens (Con A and PHA), ionomycin + PMA, or monoclonal antibodies spec...

journal_title：Cellular immunology

authors： Lin CS,Boltz RC,Siekierka JJ,Sigal NH

更新日期：1991-04-01 00:00:00

abstract：:Staphylococcus enterotoxins bind class II MHC molecules on antigen-presenting cells (APC) and stimulate T cells expressing appropriate V beta gene products. Although the role of non-TcR-associated costimulatory receptors during antigen-specific T cell stimulation has been clearly established, the involvement of costim...

journal_title：Cellular immunology

authors： Muraille E,De Smedt T,Thielemans K,Urbain J,Moser M,Leo O

更新日期：1995-05-01 00:00:00

abstract：:In vivo treatment with anti-IA antibodies has been shown to induce a haplotype-specific inhibition of EAE when the disease was following passive transfer of MBP-sensitized T cells. In order to determine the mechanism by which anti-IA antibody prevents passively transferred EAE, the homing of radiolabeled cells to the ...

journal_title：Cellular immunology

authors： Sriram S,Carroll L

更新日期：1991-06-01 00:00:00

abstract：:Permanent graft acceptance was induced with cyclosporine A in a low responder rat strain combination PVG (RT1(c)) to DA (RT1(av1)) of cardiac transplants. Challenge (alloimmunization) with donor and third-party WF (RT1(u)) cells was performed and followed by the analysis of alloreactive cytotoxicity. The cytotoxic T l...

journal_title：Cellular immunology

authors： Petersson E,Qi Z,Hedlund G,Ekberg H

更新日期：1998-10-10 00:00:00