当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Th17 pathway in recent-onset autoimmune diabetes.

Th17 pathway in recent-onset autoimmune diabetes.

Abstract：

AIMS:Evaluate the participation of IL-17 pathway in T1D pathogenesis. T helper 17 cells are potent, highly inflammatory cells that produce interleukin 17A (IL-17A), considered a mediator of various immune disorders. However, their role in Type 1 diabetes (T1D) pathogenesis in humans is not totally elucidated. METHODS:The expression of IL-17 Receptor A (IL-17RA) in peripheral T lymphocytes and IL-17A serum levels in recent-onset patients with T1D were compared with healthy controls. IL-17A gene variants were evaluated in a greater cohort. RESULTS:Patients with recent-onset T1D (less than 6 months of diagnosis) exhibited lower expression of IL-17RA in CD3+ T (% of cells = 31.3% × 43.6%; p = .041) and CD4+ T cells (11.1% × 25.2%; p = .0019) and lower number of IL-17RA in CD4+ T cells (MFI = 1.16 × 4.56; p = .03) than controls. IL-17RA expression in CD8+ T cells and IL-17A serum levels were similar in both groups. The coding regions and boundary intron sequences of IL17A were sequenced. Seventeen allelic variants, including three novel variants in exon 3 (3'UTR n) were identified, but no one was associated with T1D susceptibility, as well as the resulting haplotypes and diplotypes. The expression of IL-17RA was not correlated with metabolic variables (glucose and HbA1c levels) or pancreatic autoantibodies titers. CONCLUSIONS:The lower expression of IL-17RA in CD3+ and CD4+ T cells suggests a reduced effect of IL-17A in immune response of recent-onset T1D patients, at least at peripheral tissues. IL-17A allelic variants were not related with T1D susceptibility.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Fores JP,Crisostomo LG,Orii NM,Santos AS,Fukui RT,Matioli SR,de Moraes Vasconcelos D,Silva MERD

doi

10.1016/j.cellimm.2017.11.005

subject

Has Abstract

pub_date

2018-02-01 00:00:00

pages

8-13

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(17)30212-5

journal_volume

324

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Vibrio vulnificus-induced death of Jurkat T-cells requires activation of p38 mitogen-activated protein kinase by NADPH oxidase-derived reactive oxygen species.

    abstract：:Vibrio vulnificus, a pathogenic bacterium causing primary septicemia, exhibited cytotoxicity towards Jurkat cells of T-lymphocytes through intracellular reactive oxygen species (ROS) production. Pretreatment of Jurkat T-cells with diphenyleneiodonium chloride (DPI) abolished V. vulnificus-induced ROS generation and ba...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.05.003

    authors： Kim WH,Goo SY,Shin MH,Chun SJ,Lee H,Lee KH,Park SJ

    更新日期：2008-05-01 00:00:00

  • Essential role for Cmtm7 in cell-surface phenotype, BCR signaling, survival and Igμ repertoire of splenic B-1a cells.

    abstract：:B-1a cells represent a distinct B cell population with unique phenotype, self-renewing capacity and restricted Igμ repertoire. They primarily locate in body cavity and also exist in spleen. The different subpopulations of B-1a cells are heavily affected by local environment. Our previous studies revealed that MARVEL-d...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2020.104100

    authors： Liu Z,Liu Y,Li T,Wang P,Mo X,Lv P,Ma D,Han W

    更新日期：2020-06-01 00:00:00

  • Accelerated progression of Hodgkin's-like lymphomas in golli deficient SJL mice.

    abstract：:Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2016.01.006

    authors： Ouyang S,Han G,Wu X,Jiang Z,Feng JM

    更新日期：2016-04-01 00:00:00

  • Changes in the host natural killer cell population in mice during tumor development. 2. The mechanism of suppression of NK activity.

    abstract：:Our earlier studies revealed that a rapid and progressive loss of splenic NK activity in mice during the development of a number of transplanted tumors as well as of spontaneous tumors was due to an inactivation of natural killer (NK) lineage cells rather than to their disappearance. The mechanism of this inactivation...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90133-9

    authors： Parhar RS,Lala PK

    更新日期：1985-07-01 00:00:00

  • Bacteria-derived human leukocyte interferons alter in vitro humoral and cellular immune responses.

    abstract：:Cultures of gradient-purified human peripheral blood mononuclear cells (PBMC) have been employed to examine the effects of three bacteria-derived human leukocyte interferon subtypes on certain aspects of in vitro immune responses. The addition of highly purified IFN-alpha 1, -alpha 2, -alpha 2/alpha 1 to PMBC cultures...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90161-2

    authors： Shalaby MR,Weck PK

    更新日期：1983-12-01 00:00:00

  • Interleukin-3 and Flt3-ligand induce adhesion of Baf3/Flt3 precursor B-lymphoid cells to fibronectin via activation of VLA-4 and VLA-5.

    abstract：:Adhesion of hematopoietic cells to extracellular matrix components is important for blood cell development. However, little is known regarding the potential influence of IL-3 on this process for precursor B cells and Flt3-ligand has not yet been implicated in induction of adhesion of any blood cell types to extracellu...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1318

    authors： Shibayama H,Anzai N,Ritchie A,Zhang S,Mantel C,Broxmeyer HE

    更新日期：1998-07-10 00:00:00

  • Induction of apoptosis in activated T cell blasts by suppressive macrophages: a possible immunotherapeutic approach for treatment of autoimmune disease.

    abstract：:Large suppressive macrophages (LSM) were induced by restimulating spleen cells from rats with experimental autoimmune myasthenia gravis (EAMG) in vitro, with the autoantigen acetylcholine receptor (AChR) in the presence of cyclosporine A. LSM, purified from these cultures, are extremely potent suppressors of AChR-stim...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1445

    authors： McIntosh KR,Drachman DB

    更新日期：1999-04-10 00:00:00

  • A CD8+ T cell clone specific for antigen also recognizes peptidomimics present in anti-idiotypic antibody: implications for T cell memory.

    abstract：:The relay hypothesis [R. Nayak, S. Mitra-Kaushik, M.S. Shaila, Perpetuation of immunological memory: a relay hypothesis, Immunology 102 (2001) 387-395] was earlier proposed to explain perpetuation of immunological memory without requiring long lived memory cells or persisting antigen. This hypothesis envisaged cycles ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2007.05.001

    authors： Vani J,Nayak R,Shaila MS

    更新日期：2007-03-01 00:00:00

  • Microglia exhibit clonal variability in eliciting cytotoxic T lymphocyte responses independent of class I expression.

    abstract：:Microglia are important immunoregulatory cells within the central nervous system (CNS). Viral infection of primary microglia and splenic macrophage clones revealed that both exhibited a heterogeneous, but relatively low, sensitivity to cytolysis mediated by CD8(+) cytotoxic T lymphocytes (CTL). The majority of clones ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1581

    authors： Bergmann CC,Yao Q,Stohlman SA

    更新日期：1999-11-25 00:00:00

  • Induction of hyporesponsiveness in human lymphocytes-T despite their expression of both the co-receptor CD28 and its ligand B7.

    abstract：:A majority (42/62) of TCR2+ interleukin 2-dependent human T lymphocyte clones was found concordantly to express not only the CD28 co-receptor structure at the cell surface but also its ligand B7. Interactions between CD28 and B7 can have important consequences for T cell activation, particularly in providing "signal 2...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1238

    authors： Friccius H,Siegels-Hübenthal P,Rehbein A,Schlotz E,Pawelec G

    更新日期：1993-10-15 00:00:00

  • A cycle involving HMGB1, IFN-γ and dendritic cells plays a putative role in anti-tumor immunity.

    abstract：:An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.08.011

    authors： Gao Q,Li F,Wang S,Shen Z,Cheng S,Ping Y,Qin G,Chen X,Yang L,Cao L,Liu S,Zhang B,Wang L,Sun Y,Zhang Y

    更新日期：2019-09-01 00:00:00

  • Altered immune response patterns in murine syngeneic pregnancy: presence of natural null suppressor cells in maternal spleen identifiable by monoclonal antibodies.

    abstract：:Expression of certain autologous lymphocyte-activating antigenic determinants on the developing embryo is known to provide a stimulus for maternal anti-fetal autoproliferative responses. If left unregulated these responses could exert negative influences on the reproductive process by converting to autoaggressive form...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90173-1

    authors： Hoskin DW,Gronvik KO,Hooper DC,Reilly BD,Murgita RA

    更新日期：1989-04-15 00:00:00

  • Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.

    abstract：:Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally inves...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.11.002

    authors： Do JS,Foucras G,Kamada N,Schenk AF,Shaw M,Nuñez G,Paul WE,Min B

    更新日期：2012-01-01 00:00:00

  • CCR5 expression on monocytes and T cells: modulation by transmigration across the blood-brain barrier in vitro.

    abstract：:Observational studies in multiple sclerosis (MS) demonstrated altered expression of chemokine receptors (CkRs) on comparable populations of mononuclear cells (e.g. CD4(+)/CD45RO(+) T-cells) in brain sections compared with blood. These findings raised questions about the regulation of CkRs on trafficking cells. Regulat...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2006.12.001

    authors： Ubogu EE,Callahan MK,Tucky BH,Ransohoff RM

    更新日期：2006-09-01 00:00:00

  • Characterization of natural killer cells induced in the peritoneal exudates of mice infected with Listeria monocytogenes: a study of their tumor target specificity and their expression of murine differentiation antigens and human NK-associated antigens.

    abstract：:That M1/70, a monoclonal anti-murine macrophage antibody, recognizes murine natural killer cells (NK) and that there is an increase in NK following intraperitoneal infection with live Listeria monocytogenes (LM) was previously reported. Here, LM-induced NK cells were further characterized with respect to tumor target ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90206-5

    authors： Holmberg LA,Ault KA

    更新日期：1984-11-01 00:00:00

  • Heterogeneity of bone marrow lymphocytes: radioautographic detection of pre-B cells bearing cytoplasmic mu chains, and of B and T lymphocytes, and characterization of null lymphoid cells.

    abstract：:A radioautographic immunolabeling technique has been developed to detect pre-B cells bearing cytoplasmic mu chains among populations of bone marrow lymphoid cells identified by conventional hematologic stains. 125I-Anti-mu antibody was applied either to fixed marrow smears, labeling total mu chains both in the cytopla...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90007-8

    authors： Rahal MD,Osmond DG

    更新日期：1984-09-01 00:00:00

  • Regulation of immune responses by E3 ubiquitin ligase Cbl-b.

    abstract：:Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, has been identified as a critical regulator of adaptive immune responses. Cbl-b is essential for establishing the threshold for T cell activation and regulating peripheral T cell tolerance through various mechanisms. Intriguingly, recent studies indicate...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2018.11.002

    authors： Tang R,Langdon WY,Zhang J

    更新日期：2019-06-01 00:00:00

  • The role of antigen-presenting cells in the regulation of delayed-type hypersensitivity. II. Epidermal Langerhans' cells and peritoneal exudate macrophages.

    abstract：:A new mechanism for regulation of delayed-type hypersensitivity (DTH) was investigated. The subcutaneous injection without adjuvant of syngeneic epidermal Langerhans' cells (LC) pulsed with keyhole limpet hemocyanin (KLH) into BALB/c mice gave rise to DTH upon challenge of the ear with the same antigen. When such cell...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1279

    authors： Morikawa Y,Furotani M,Matsuura N,Kakudo K

    更新日期：1993-11-01 00:00:00

  • Purine nucleoside metabolizing enzyme activities in mouse thymocytes at different stages of differentiation and maturation.

    abstract：:The activities of the enzymes involved in purine nucleoside metabolism, adenosine deaminase (ADA), adenosine kinase (AK), purine nucleoside phosphorylase (PNP) and deoxycytidine kinase (deoxyCRK), were determined in mouse thymocytes at various stages of differentiation and maturation, and compared with those in other ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90168-5

    authors： Kizaki H,Habu S,Ohsaka F,Sakurada T

    更新日期：1983-12-01 00:00:00

  • Allele-specific down-regulation of MHC class I antigens in Burkitt lymphoma lines.

    abstract：:We have reported that Burkitt lymphomas (BL) that arise in HLA-A11 positive individuals are resistant to lysis by HLA-A11-specific and HLA-A11-restricted CTLs(10,11). Here we show that this phenomenon can be explained by a selective loss of the HLA-A11 polypeptide. The HLA-A11 negative phenotype is due to a regulatory...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90207-4

    authors： Masucci MG,Stam NJ,Torsteinsdottir S,Neefjes JJ,Klein G,Ploegh HL

    更新日期：1989-05-01 00:00:00

  • Adoptive transfer of resistance to murine retrovirus-induced immune suppression.

    abstract：:Infection of certain strains of mice, such as C57BL/6 and C57BL/10 [B10], with LP-BM5 murine leukemia virus (MuLV) rapidly causes a profound and lethal immune suppression. The H2d congenic strain of B10, B10.D2, is resistant to disease, but B10 x B10.D2 F1 mice are susceptible, indicating that disease sensitivity is d...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0086

    authors： Gilmore GL

    更新日期：1996-04-10 00:00:00

  • Characterization of functional GTP binding proteins in Jurkat T cell mutants lacking either CD3-Ti or CD2 surface receptors.

    abstract：:G proteins are membrane-bound molecules involved in coupling of surface receptors with signal transduction effector systems in multiple cell types including T lymphocytes. Given that mature T cells which lack antigen receptors (CDl-Ti) are refractory to stimulation through CD2 or other accessory molecules, T cell rece...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90050-2

    authors： Moingeon P,Jin YJ,Stebbins CC,Lopez PA,Alcover A,Reinherz EL

    更新日期：1990-07-01 00:00:00

  • Evaluation of macrophage plasticity in brown and white adipose tissue.

    abstract：:There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate to a more mature phenotype after adoptive transfer to the peritoneal cavity (PEC-C2D). Since...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.06.012

    authors： Ortega MT,Xie L,Mora S,Chapes SK

    更新日期：2011-01-01 00:00:00

  • T cell receptor germline gene segments and HLA haplotypes control the length of the CDR3 of human T cell receptor beta chains.

    abstract：:The third complementarity determining region (CDR3) is the most variable part of alpha beta T cell receptors (TCR) and represents the putative antigen contacting site. To identify parameters determining the structural diversity of the CDR3 region, the CDR3 length distributions of 66 BV-J combinations in peripheral CD4...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0071

    authors： Kayser C,Waase I,Weyand CM,Goronzy JJ

    更新日期：1996-03-15 00:00:00

  • Isolation of lysozyme-specific T cell clones that discriminate between native and denatured antigen.

    abstract：:Hen egg white lysozyme (HEL)-specific T cell lines and clones were generated from B6 and BDF1 mice. A variety of clonotypes were found among clones generated at an early stage (1 month) whereas fewer clonotypes were detected after several weeks of culture. Furthermore, a bulk line switched from its initial fine peptid...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1088

    authors： Manca F,Dessí V,Shastri N,Oki A,Kaplan M,Clarke J,Miller A,Sercarz EE

    更新日期：1994-04-01 00:00:00

  • Distinct responses of splenic dendritic cell subsets to infection with Listeria monocytogenes: maturation phenotype, level of infection, and T cell priming capacity ex vivo.

    abstract：:To determine the relative contributions of DC subsets in the development of protective immunity to Listeria monocytogenes we examined the relationship between maturation, bacterial burden, and T cell priming capacity of four well characterized subsets of splenic DC following infection with Lm. CD8α(+), CD4(+), and CD8...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.03.001

    authors： Mitchell LM,Brzoza-Lewis KL,Henry CJ,Grayson JM,Westcott MM,Hiltbold EM

    更新日期：2011-01-01 00:00:00

  • Can bone marrow-derived thymic stromal cells mediate the positive selection of class I-restricted T cells?

    abstract：:Positive selection of T lymphocytes expressing self. MHC-restricted T cell receptors is mediated by MHC molecules expressed on thymic stroma. Among the more controversial aspects of this process is the relative role of MHC molecules on epithelial versus bone marrow-derived stromal elements (BM-APC). For CD4+ T cells, ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0175

    authors： Fort MM,Pardoll DM

    更新日期：1996-07-10 00:00:00

  • Estrogen induces suppression of natural killer cell cytotoxicity and augmentation of polyclonal B cell activation.

    abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1262

    authors： Nilsson N,Carlsten H

    更新日期：1994-10-01 00:00:00

  • NK and LAK activities from human marrow progenitors. I. The effects of interleukin-2 and interleukin-1.

    abstract：:We have investigated the role of interleukin-2 (IL2) as a differentiation factor for human marrow-derived NK cell progenitors and have assessed the effects of interleukin-1 (IL1) on this activity. The effects of these cytokines on early NK cell precursors was determined by testing marrow which had been depleted of mat...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90313-g

    authors： Keever CA,Pekle K,Gazzola MV,Collins NH,Gillio A

    更新日期：1990-03-01 00:00:00

  • Enhancement of antigen-induced interleukin 4 and IgE production by specific IgG1 in murine lymphocytes.

    abstract：:Conalbumin (CA)-specific type 2 helper T cell (Th2) clone, D10G4.1 (D10) produces IL4 when stimulated with varying doses of TNP-CA in the presence of mitomycin C-treated C3H spleen cells or purified B cells as antigen-presenting cells (APC). The production of IL4 was assessed by bioassay and by expression of IL4 mRNA....

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90333-k

    authors： Ohmori H,Hase N,Hikida M,Takai T,Endo N

    更新日期：1992-12-01 00:00:00