Abstract:
:Spleen cells from neonatal mice belonging to strains with the I-J-b or I-J-k genotype, were treated with anti-I-Jb or anti-I-Jk antibody and complement. This reduces their suppressor cell activity as demonstrated by a decrease in the ability to suppress the mixed-lymphocyte reactivity of adult spleen cells. Injection of anti-I-J antibody into neonatal mice also reduces splenic suppressor cell activity prematurely. The removal of suppressor cells from neonatal spleen does not result in an immediate increase in mixed-lymphocyte reactivity (cell-mediated immunity) but does hasten the development of mixed-lymphocyte reactivity in the young mice. The results are discussed in light of the hypothesis that suppressor cells inhibit the function of immunocompetent cells in the neonatal mouse and control the development of immunocompetence.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Argyris BF,Waltenbaugh Cdoi
10.1016/0008-8749(83)90115-6subject
Has Abstractpub_date
1983-09-01 00:00:00pages
267-78issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(83)90115-6journal_volume
80pub_type
杂志文章abstract::Normal chondrocytes display susceptibility to lysis by natural killer (NK) cells and this phenomenon may play a role in some inflammatory cartilage disorders. The mechanisms of chondrocyte recognition and killing by NK cells remain unclear. Using flow cytometry and immunohistochemical staining we found that normal hum...
journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90313-g
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/s0008-8749(03)00058-3
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1985-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(91)90048-g
更新日期:1991-02-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(92)90080-9
更新日期:1992-02-01 00:00:00
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journal_title:Cellular immunology
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更新日期:1986-04-01 00:00:00
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journal_title:Cellular immunology
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更新日期:1990-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2014.02.005
更新日期:2014-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(91)90394-q
更新日期:1991-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章,评审
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更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
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更新日期:2003-06-01 00:00:00
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1994-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1994.1016
更新日期:1994-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2009-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1998-06-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1983-02-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2020-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1995-01-01 00:00:00