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In vivo localization of cloned IL-2-dependent T cells.

Abstract：

:The quantitative organ distribution and tissue microenvironment positioning of radioisotopically labeled cloned T cells were characterized. Intravenous (iv) injection of 51chromium (51Cr)-labeled, long-term cultured cloned T-helper cells and cells from several cloned cytolytic T-lymphocyte lines (CTLL) resulted in poor localization of these cells in recipient lymphoid tissues, similar to results reported for activated lymphoblastoid cells. Simultaneous administration of interleukin 2 (IL-2) with labeled cells resulted in enhanced recovery from recipient spleen. By the intraperitoneal (ip) injection route, overall percentage recovery of injected radioactivity was lower than by the iv route, but significant localization to lymph nodes occurred. Examination of autoradiographs of tissue sections from recipients of [3H]adenosine-labeled cells showed most label associated with intact, isolated cells in the liver, lungs, spleen, and small intestine. By 24 hr after iv injection, labeled cells in spleen sections were distributed to both nonlymphoid and T- and B-lymphoid areas. These findings suggest that poor localization of these cells to recipient lymphoid tissue is due both to intrinsic characteristics of cultured lymphocytes and to the possible reduced viability of IL-2-dependent cells in vivo.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Carroll AM,Palladino MA,Oettgen H,De Sousa M

doi

10.1016/0008-8749(83)90349-0

subject

Has Abstract

pub_date

1983-02-15 00:00:00

pages

69-80

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(83)90349-0

journal_volume

76

pub_type

杂志文章

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