Natural killer (NK) activity in human responders and nonresponders to stimulation by anti-CD16 antibodies.

abstract：:Although most intraepithelial lymphocytes (IEL) in mouse small intestine bear surface markers classically associated with T lymphocytes, the T-cell nature of these cells remains controversial. In the present study IEL from normal mice, or from mice infected with the gut nematode Trichinella spiralis, were therefore te...

journal_title：Cellular immunology

authors： Dillon SB,Dalton BJ,MacDonald TT

更新日期：1986-12-01 00:00:00

abstract：:To investigate a role for T lymphocytes in primary demyelination of central nervous system (CNS) tissue, antigen-specific T cell lines sensitized to myelin-associated and myelin-unrelated antigens were developed from SJL mice and tested on myelinated organotypic cultures of syngeneic spinal cord. Demyelination was ass...

journal_title：Cellular immunology

authors： Lyman WD,Roth GA,Chiu FC,Brosnan CF,Bornstein MB,Raine CS

更新日期：1986-10-01 00:00:00

abstract：:The induction of ornithine decarboxylase (ODC) activity in lymphocytes is associated with activation and the initiation of cellular proliferation. ODC is also an essential component in tumor promotion. Phorbol myristic acetate (PMA) is a mitogen for lymphocytes, but can also promote tumor formation. Tumor promotion is...

journal_title：Cellular immunology

authors： Fidelus RK

更新日期：1988-04-15 00:00:00

abstract：:We investigated the role of HLA-DR molecules in T cell stimulation by staphylococcal enterotoxin A (SEA). Previous results with immobilized purified HLA-DR preincubated with peptide showed that peptide-specific T cell clones were able to bind to and proliferate in response to purified HLA-DR/peptide complexes in the a...

journal_title：Cellular immunology

authors： Rust CJ,Koning F,van Schooten WC

更新日期：1993-10-15 00:00:00

abstract：:Enriched human B lymphocytes cocultivated with mouse L cells produced human leukocyte interferon (IFN-alpha) and shortly thereafter transferred antiviral activity to the recipient cells (99% inhibition of expected virus yield). In contrast, cocultivation of enriched T-cell populations with mouse L cells resulted in no...

journal_title：Cellular immunology

authors： Weigent DA,Langford MP,Stanton GJ,Blalock JE

更新日期：1984-09-01 00:00:00

abstract：:Platelet-activating factor (PAF) has previously been shown to stimulate intracellular signal transductional events similar to the macrophage tumoricidal activators interferon-gamma (IFN-gamma) and lipopolysaccharide (LPS). Macrophages stimulated with IFN-gamma and LPS utilize various cytolytic mediators in order to ki...

journal_title：Cellular immunology

authors： Howard AD,Erickson KL

更新日期：1995-08-01 00:00:00

abstract：:Earlier work from this laboratory revealed an increase in the level of null (Thy-1-, IgM-) lymphocytes in the maternal lymphoid organs during the first pregnancy in the mouse that was more pronounced during allogeneic pregnancy than during syngeneic pregnancy. In view of the suggestive evidence for the bone marrow ori...

journal_title：Cellular immunology

authors： Chatterjee-Hasrouni S,Parhar R,Lala PK

更新日期：1984-04-01 00:00:00

abstract：:The kinetic and the H-2 requirements for the induction of nucleoside-specific suppression were examined in several strains of mice; specifically, whether adenosine (A)-coupled spleen cells given intravenously suppress the primary response to adenosine-KLH. The adenosine system was chosen because C57Bl/6 mice were orig...

journal_title：Cellular immunology

authors： Giroir BP,Raps EC,Cookson E,Borel Y

更新日期：1983-02-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) isolated from BALB/c mice bearing a B-cell leukemia (BCL1) showed a marked proliferative response upon two days culturing with poly(L-lysine) (PLL) of various molecular weights. An inverse relationship was noted between the molecular weight of the PLL and the dose required for optima...

journal_title：Cellular immunology

authors： Morecki S,Flechner Y,Slavin S

更新日期：1985-02-01 00:00:00

abstract：:An IgG1 monoclonal antibody, termed ACM-1, has been shown to react with rabbit T cells, but not Ig+ cells or macrophages. This antibody appears to recognize the same epitope as the previously described 9AE10 antibody and, together with 9AE10, has been used to obtain highly pure and fully functional T- and B-cell popul...

journal_title：Cellular immunology

authors： Chen Z,Metzger DW,Adler FL

更新日期：1984-05-01 00:00:00

abstract：:This study provides evidence that both rat and mouse thymic and splenic T cells express significant levels of MHC class II glycoproteins (MHCII) in vivo. Derivation of rat and mouse chimeras revealed that a major source of MHCII on thymic T cells was acquired from radioresistant host APC. Expression of MHC on thymic T...

journal_title：Cellular immunology

authors： Walker MR,Mannie MD

更新日期：2002-07-01 00:00:00

abstract：:Cells from the spleen, lymph nodes, and peritoneum of DBA/2 mice bearing a subcutaneous tumor mediate nonspecific suppression of an in vitro antibody response to sheep red blood cells (SRBC) when cocultured with a normal T-cell subset(s). The spleen cells from the tumor-bearing mouse required for the suppression bear ...

journal_title：Cellular immunology

authors： Ingenito GG,Calkins CE

更新日期：1983-07-01 00:00:00

abstract：:Numerous reports in the literature describe the effects of beta-adrenergic agonists and/or their second messenger cyclic AMP on in vitro and in vivo immune responses. The fact that the murine spleen receives rich adrenergic innervation and that the pharmacologic disruption of this innervation leads to altered immune r...

journal_title：Cellular immunology

authors： Fuchs BA,Campbell KS,Munson AE

更新日期：1988-12-01 00:00:00

abstract：AIMS:Non-enzymatic reaction of biomolecules leads to the formation of advanced glycation end products (AGEs). AGEs plays significant role in the pathophysiology of type 2 diabetes mellitus. Methylglyoxal (MG) is a highly reactive carbonyl compound which causes formation of early (ketoamines), intermediate (dicarbonyls)...

journal_title：Cellular immunology

authors： Khan MY,Alouffi S,Khan MS,Husain FM,Akhter F,Ahmad S

更新日期：2020-05-01 00:00:00

abstract：:The pim-1 gene encodes a serine/threonine protein kinase with expression restricted primarily to cells of hematopoietic lineage and is thought to play a role in the signal transduction events associated with lymphocyte activation. A rapid increase in pim-1 mRNA levels was found after stimulation of normal unseparated ...

journal_title：Cellular immunology

authors： Wingett D,Stone D,Davis WC,Magnuson NS

更新日期：1995-04-15 00:00:00

abstract：:The mechanisms of glucocorticoid-induced immunosuppression of human monocytes for the defense of Candida albicans were examined in this in vitro study. Dexamethasone at pharmacological concentrations (10(-7)-10(-5) M) dose-dependently attenuated growth inhibition of C. albicans by resident monocytes. In interferon-gam...

journal_title：Cellular immunology

authors： Heidenreich S,Kubis T,Schmidt M,Fegeler W

更新日期：1994-09-01 00:00:00

abstract：:We have examined signal transduction via membrane IgM (mIgM) in resting and cycling human B cells. Crosslinking mIgM on all of the cell types studied transduced a signal through the phosphatidylinositol pathway, producing inositol 1,4,5-trisphosphate and release of intracellular free calcium. These second messengers w...

journal_title：Cellular immunology

authors： Valentine MA,Bursten SL,Harris WE,Draves KE,Pollok BA,Ostrowski J,Bomsztyk K,Clark EA

更新日期：1992-05-01 00:00:00

abstract：:As fascinating a molecule as it can potentially get, nuclear factor-κB (NF-κB), a regulatory transcription factor, is as intriguing. NF-κB is a dimeric complex that controls the transcription of essential genes. NF-κB is involved in a variety of responses that play a pivotal role in regulating the immune response to i...

journal_title：Cellular immunology

authors： Haddad JJ,Abdel-Karim NE

更新日期：2011-01-01 00:00:00

abstract：:The mechanism of polyclonal B cell activation in autoimmune diseases was investigated by using an autoreactive B cell clone established by somatic hybridization with B cells derived from NZB X NZW (B/W) F1 mice. Briefly, splenic B cells from B/W F1 mice were fused with M12.4.1, a mutant of a B cell line, in the presen...

journal_title：Cellular immunology

authors： Iwasaki T,Hamano T,Hase K,Murata Y,Yamasaki T,Kakishita E

更新日期：1992-02-01 00:00:00

abstract：:The role of class II antigens for B-cell activation was analyzed using purified human B cells and anti-class II monoclonal antibodies. The stimulation of purified B cells with Staphylococcus aureus Cowan I induced proliferation and differentiation into immunoglobulin-producing cells in the presence of interleukin-1 an...

journal_title：Cellular immunology

authors： Tanaka Y,Shirakawa F,Ota T,Suzuki H,Eto S,Yamashita U

更新日期：1988-04-01 00:00:00

abstract：:Macrophage-mediated cytostasis was measured in a mouse syngeneic system where EL4 thymoma cells were found to be inhibited by C57B1/6 mouse macrophages. When tumor cells were pretreated with TPA, they became resistant to macrophage-mediated stasis. Nonelutriated as well as elutriated cells enriched in G1/early S and l...

journal_title：Cellular immunology

authors： Nycum LM,Fishman M

更新日期：1989-01-01 00:00:00

abstract：:The nonspecific suppression of immunological responses that is generated within host popliteal lymph nodes upon exposure to syngeneic normal spleen cells has been examined. The suppression, which had previously been described as being capable of preventing initiation of cytotoxic T lymphocytes (CTLs) to hapten-altered...

journal_title：Cellular immunology

authors： Emara M,Battisto JR

更新日期：1987-03-01 00:00:00

abstract：:The humoral response to encapsulated BSA appears to be a classical TD antigen response with a high ratio of IgG to IgM, whereas that to covalently-linked antigen is more complex, characterized by an enhanced synthesis of IgM, leading to an equal production of IgM and IgG. In a recent paper, we observed that surface-li...

journal_title：Cellular immunology

authors： Shahum E,Thérien HM

更新日期：1989-10-01 00:00:00

abstract：:Although TGF-β and IL-6 would turn CD8(+) T cells to differentiate into non-cytotoxic state, these treated cells were converted to cytolytic phenotypes after re-exposure to their antigenic epitope in vitro. Here, using spleen cells from TCR transgenic mice expressing TCRαβ genes of clone RT1 recognizing an epitope pep...

journal_title：Cellular immunology

authors： Takaku S,Nakagawa Y,Owaki A,Shimizu M,Takahashi M,Takahashi H

更新日期：2012-12-01 00:00:00

abstract：:Overexpression of TNF-alpha in the body is critically involved in many diseases. A strategy to construct TNF-alpha autovaccine by introducing a T cell helper epitope to the protein has been developed and may be an alternative because it is cheaper and highly efficient. However, the induction of high level anti-TNF-alp...

journal_title：Cellular immunology

authors： Wan Y,Xue X,Li M,Zhang X,Qin X,Zhang C,You Y,Wang W,Jiang C,Wu S,Liu Y,Zhu W,Ran Y,Zhang Z,Han W,Zhang Y

更新日期：2007-04-01 00:00:00

abstract：:Participation of IE antigens (Ag) in immune response as the transplantation Ag was examined. IE- B10.A(4R)(4R; Kk, IAk, IE-, Db) mice could not reject skin graft from IE Ag alone-disparate B10.A(2R) (2R; Kk, IAk, IEk, Db) mice despite intravenous (iv) injection of 2R spleen cells (SC) before or after skin grafting, in...

journal_title：Cellular immunology

authors： Harada M,Tomita Y,Matsuzaki G,Miyazono M,Nomoto K

更新日期：1992-09-01 00:00:00

abstract：:The antimicrobial peptide LL-37 is known to have a potent LPS-neutralizing activity in monocytes and macrophages. Recently, LL-37 in gingival crevicular fluids is suggested to be the major protective factor preventing infection of periodontogenic pathogens. In this study, we tried to address the effect of LL-37 on pro...

journal_title：Cellular immunology

authors： Into T,Inomata M,Shibata K,Murakami Y

更新日期：2010-01-01 00:00:00

abstract：:Murine histocompatibility antigens were solubilized from the spleens and lungs of C57BL/6 (H-2b) animals with hypertonic salt (3 M KC1). Aggregate-free soluble antigens were incubated with nonadherent lymph node cells from BALB/c (H-2d) mice for 18 hr prior to their use as responder cells in the mixed-lymphocyte react...

journal_title：Cellular immunology

authors： Long PM,Sommer CV,Kong YM

更新日期：1983-06-01 00:00:00

abstract：:Recombinant IL-4 inhibits IL-2-induced lymphokine-activated killer (LAK) cell development of PBMC. We evaluated the effect of various cytokines in reversing IL-4-mediated LAK inhibition. PBMC were cultured in IL-2 (10-1000 u/ml) with or without IL-4 (2-100 u/ml) and tested for cytotoxicity against the NK-sensitive K56...

journal_title：Cellular immunology

authors： Swisher SG,Economou JS,Holmes EC,Golub SH

更新日期：1990-07-01 00:00:00

abstract：:The objective of this study was to evaluate the potential of transcutaneous immunization with tumor antigen to induce cell-mediated immunity. For this purpose, hydrophilic recombinant gp100 protein (HR-gp100) was topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. We demonstrate th...

journal_title：Cellular immunology

authors： Eisenberg G,Machlenkin A,Frankenburg S,Mansura A,Pitcovski J,Yefenof E,Peretz T,Lotem M

更新日期：2010-01-01 00:00:00