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Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response.

Abstract：

:The objective of this study was to evaluate the potential of transcutaneous immunization with tumor antigen to induce cell-mediated immunity. For this purpose, hydrophilic recombinant gp100 protein (HR-gp100) was topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. We demonstrate that HR-gp100 permeates into human skin, and is processed and presented by human dendritic cells. In a mouse model, an HR-gp100-based vaccine triggered antigen-specific T cell responses, as shown by proliferation assays, ELISA and intracellular staining for IFN-γ. Transcutaneous antigen delivery may provide a safe, simple and effective method to elicit cell-mediated immunity.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Eisenberg G,Machlenkin A,Frankenburg S,Mansura A,Pitcovski J,Yefenof E,Peretz T,Lotem M

doi

10.1016/j.cellimm.2010.09.003

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

98-103

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(10)00236-4

journal_volume

266

pub_type

杂志文章

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