Effect of CD95 on inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.

abstract：:Activin A is a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily and acts as an anti-inflammatory cytokine produced by microglia and macrophages. In this study, we investigated the regulatory effect and possible mechanism of activin A on activation of lipopolysaccharide (LPS)-induced...

journal_title：Cellular immunology

authors： Zhou J,Tai G,Liu H,Ge J,Feng Y,Chen F,Yu F,Liu Z

更新日期：2009-01-01 00:00:00

abstract：:Mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (MER) in incomplete Freund's adjuvant produced high titers of circulating antibodies against MER, as assessed by the enzyme-linked immunosorbent assay (ELISA) method. Spleen cells derived from these animals failed to respond to...

journal_title：Cellular immunology

authors： Halperin D,Reuben C,Ben-Efraim S,Grover N,Weiss DW

更新日期：1985-05-01 00:00:00

abstract：:Antigen-specific signal transduction leading to IL2 induction and secretion in the T cell line 171 is augmented by association of p56lck with CD4. Although no change in cytoplasmic calcium level ([Ca2+]i) was detectable during antigen-specific signal transduction of 171-CD4+ cells, IL2 induction was inhibited by FK506...

journal_title：Cellular immunology

authors： Metcalfe S,Alexander D,Turner J

更新日期：1994-10-01 00:00:00

abstract：:The biochemical events leading to enhanced membrane expression of HLA-DR and CR3 by human peripheral blood monocytes (MO) following exposure to bacterial lipopolysaccharide (LPS) were examined. In a previous study we demonstrated that an increase in intracellular calcium was necessary, but not sufficient, for MO to in...

journal_title：Cellular immunology

authors： McLeish KR,Wellhausen SR,Dean WL

更新日期：1987-08-01 00:00:00

abstract：:The role of lymphostromal complexes in T-cell differentiation is far from elucidated, mainly because a clear association of a particular stromal cell type with a distinct thymocyte subset has never been identified. Using an in vitro system, detecting the adherence of thymocytes to a thymic medullary epithelial cell li...

journal_title：Cellular immunology

authors： Hugo P,Potworowski EF

更新日期：1990-03-01 00:00:00

abstract：:Mitogenic stimulation of sublines of the human histiocytic lymphoma, U937, results in the production of an inhibitor of lymphocyte proliferation (IDS-U937). The relationship of IDS-U937 to alpha- and gamma-interferon was examined by several techniques: (1) the antiviral activity of the IDS preparations was determined,...

journal_title：Cellular immunology

authors： Wilkins JA,Warrington RJ

更新日期：1984-07-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis in the skin and internal organs. The pathogenesis of SSc is not completely understood until now. Recently, many studies have focused on the role of E3 ubiquitin ligases in organ fibrosis. However, the possible regulatory mechanisms of E3 ubiqu...

journal_title：Cellular immunology

authors： Huang XL,Zhang L,Duan Y,Wang YJ,Zhao JH,Wang J

更新日期：2016-08-01 00:00:00

abstract：:This report describes a model for investigating the role of the thymus in regulating natural killer (NK) cell activity in vivo. Evidence is presented that the thymus can regulate NK cells, and that at least some NK cells can develop without thymic help. Marrow from thymectomized rats depleted of circulating T cells by...

journal_title：Cellular immunology

authors： Flexman JP,Holt PG,Mayrhofer G,Latham BI,Shellam GR

更新日期：1985-02-01 00:00:00

abstract：:Tumor necrosis factor (TNF) is a 17-kDa protein produced by endotoxin-stimulated macrophages. We have demonstrated that recombinant human TNF activates human macrophages to kill intracellular bacteria of the Mycobacterium avium complex (MAC) in a dose-related manner. TNF also primed macrophages to produce superoxide a...

journal_title：Cellular immunology

authors： Bermudez LE,Young LS

更新日期：1992-10-15 00:00:00

abstract：:Murine Leydig (TM3) and Sertoli (TM4) cell lines were studied as nonprofessional antigen-presenting cells using the antigen model of human choriogonadotropin (hCG alpha/beta) and specific T-cell hybridomas. Both cell lines were treated with IFN-gamma to induce I-A(d) and I-E(d) molecules expression. Only the TM3 cell ...

journal_title：Cellular immunology

authors： Housseau F,Rouas-Freiss N,Roy M,Bidart JM,Guillet JG,Bellet D

更新日期：1997-04-10 00:00:00

abstract：:Although most intraepithelial lymphocytes (IEL) in mouse small intestine bear surface markers classically associated with T lymphocytes, the T-cell nature of these cells remains controversial. In the present study IEL from normal mice, or from mice infected with the gut nematode Trichinella spiralis, were therefore te...

journal_title：Cellular immunology

authors： Dillon SB,Dalton BJ,MacDonald TT

更新日期：1986-12-01 00:00:00

abstract：:In nonactivated human monocytes, radiolabeled oleic, arachidonic, and palmitic acids are primarily incorporated into neutral lipids and phosphatidylcholine. Each of these fatty acids is also incorporated into phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and sphingomyelin in characteristic propor...

journal_title：Cellular immunology

authors： Furlong ST,Mednis A,Remold HG

更新日期：1992-08-01 00:00:00

abstract：:The humoral response to encapsulated BSA appears to be a classical TD antigen response with a high ratio of IgG to IgM, whereas that to covalently-linked antigen is more complex, characterized by an enhanced synthesis of IgM, leading to an equal production of IgM and IgG. In a recent paper, we observed that surface-li...

journal_title：Cellular immunology

authors： Shahum E,Thérien HM

更新日期：1989-10-01 00:00:00

abstract：:Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of the IL-2/retroviral vector into melanoma xenografts in nude mic...

journal_title：Cellular immunology

authors： Abdel-Wahab Z,Li WP,Osanto S,Darrow TL,Hessling J,Vervaert CE,Burrascano M,Barber J,Seigler HF

更新日期：1994-11-01 00:00:00

abstract：:The oral administration of myelin basic protein (MBP) to Lewis rats prior to an encephalitogenic challenge resulted in total inhibition or a significant delay in the onset of experimental autoimmune encephalomyelitis (EAE). In vitro lymphocyte proliferative responses to MBP were significantly decreased in MBP-fed rats...

journal_title：Cellular immunology

authors： Bitar DM,Whitacre CC

更新日期：1988-04-01 00:00:00

abstract：:Sequential immunization with a carrier molecule and a new epitope (hapten) conjugated to the carrier (carrier/hapten-carrier immunization) induces specific suppression for IgG antibody production to the new epitope (hapten) on the carrier. Once induced, this "epitope-specific" suppression persists and specifically sup...

journal_title：Cellular immunology

authors： Tagawa M,Tokuhisa T,Ono K,Taniguchi M,Herzenberg LA,Herzenberg LA

更新日期：1984-07-01 00:00:00

abstract：:Activated macrophages synthesize and release numerous tumoricidal soluble factors that can be divided into receptor- or nonreceptor-dependent agents. Tumor necrosis factor (TNF) would be an example of the former. In our experimental model the killing of EL4 thymoma cells by syngeneic activated macrophages involves, bu...

journal_title：Cellular immunology

authors： Fishman M,Essani N,Costlow M

更新日期：1990-04-15 00:00:00

abstract：:Attempts have been made to induce cytolytic T cells to kill target cells that do not express the appropriate target molecules by crosslinking the T cells and the target cells in various ways. One successful strategy has been to use heteroconjugates or bispecific monoclonal antibodies reacting with T cell molecules wit...

journal_title：Cellular immunology

authors： Hedlund G,Dohlsten M,Lando PA,Kalland T

更新日期：1990-09-01 00:00:00

abstract：:Staphylococcal enterotoxin B (SEB) is a potent polyclonal activator of both human and murine T cells. We previously reported data which show that SEB-induced T cells suppress antibody secretion by various mouse plasmacytoma cell lines. This suppression of antibody secretion was found to be both idiotype and isotype no...

journal_title：Cellular immunology

authors： Newcomb JR,Lin YS,Rogers TJ

更新日期：1990-09-01 00:00:00

abstract：:We showed previously that the expressions of various src family protein tyrosine kinases (PTKs) were induced independently during the monocytic differentiation of HL-60 cells. The role of PTKs was further assessed in the present study by investigating the effects of PTK inhibitors on the differentiation. It was demons...

journal_title：Cellular immunology

authors： Katagiri K,Katagiri T,Kajiyama K,Uehara Y,Yamamoto T,Yoshida T

更新日期：1992-04-01 00:00:00

abstract：:Previous results have shown that in addition to their ability to kill tumor cell lines, peripheral blood leukocytes (PBL) expanded in interleukin 2 (IL-2) can also destroy normal PBL targets. Cold target competition results show that PBL and tumor cells can be destroyed by the same population of IL-2-expanded leukocyt...

journal_title：Cellular immunology

authors： Chen BP,Malkovsky M,Hank JA,Sondel PM

更新日期：1987-12-01 00:00:00

abstract：:In this study we investigated whether T cells expressing high or low levels of CD62L were differentially susceptible to the T cell chemokine lymphotactin. We found that lymphotactin induced preferential migration of antigen-specific (CD62L(lo)) T cells over the nonspecific (CD62L(hi)) T cells in vitro and in vivo. The...

journal_title：Cellular immunology

authors： Kurt RA,Bauck M,Harma S,McCulloch K,Baher A,Urba WJ

更新日期：2001-05-01 00:00:00

abstract：:When lymphoid cells from rats recovered from experimental autoimmune encephalomyelitis (EAE) were incubated in vitro for 1 hr with myelin basic protein (BP), then washed and transferred along with anti-BP immune serum to naive recipients, those recipients immediately developed a solid, long-lasting resistance to activ...

journal_title：Cellular immunology

authors： Hugh AR,Simmons RD,Willenborg DO

更新日期：1989-10-01 00:00:00

abstract：:Experimental autoimmune thyroiditis is induced in mice by immunization with thyroglobulin emulsified in Freund's complete adjuvant. The disease is characterized both by thyroid infiltration with mononuclear cells and by circulating thyroglobulin antibodies. The magnitude of the thyroid infiltration and the titer of th...

journal_title：Cellular immunology

authors： Vladutiu AO,Steinman L

更新日期：1987-10-01 00:00:00

abstract：:It has been reported that the three-dimensional structure of thymic epithelial cells (TECs) is responsible for thymic positive selection but that this ability disappears when TECs are cultured in monolayer. These results have supported the hypothesis that certain TEC-specific molecules are extinguished during monolaye...

journal_title：Cellular immunology

authors： Sato T,Sato C,Suzuki D,Yoshida Y,Nunomura S,Matsumura T,Hozumi K,Habu S

更新日期：2001-07-10 00:00:00

abstract：:Natural suppressor (NS) cells, which nonspecifically suppress immune responses, are present in the spleen following exposure to radiation, chronic graft-versus-host disease, or cancer and in normal bone marrow. A model system is described which allows the study of cytokines activating and inhibiting NS cells, cytokine...

journal_title：Cellular immunology

authors： Moore SC,Theus SA,Barnett JB,Soderberg LS

更新日期：1992-05-01 00:00:00

abstract：:Like the thymus, the bursa of Fabricius is a site of massive lymphopoiesis accompanied by cell death in vivo. In the present study we have, therefore, examined whether chicken bursa and thymus cells exhibit apoptosis. Bursa and thymus cells from SC chickens, 4-10 weeks of age, were incubated for 8-24 hr with various r...

journal_title：Cellular immunology

authors： Asakawa J,Tsiagbe VK,Thorbecke GJ

更新日期：1993-03-01 00:00:00

abstract：:Endogenous retroviral superantigens such as vSAG-7 are highly stimulatory for T cells through interaction with the T cell receptor on the basis of V beta usage. Priming of adult MMTV 7-negative mice with vSAG-7-expressing cells has been shown to result in peripheral V beta 6/CD4+ T cell activation followed by toleranc...

journal_title：Cellular immunology

authors： Modlin CS,Todd GT,Cohen TD,Fairchild RL

更新日期：1995-09-01 00:00:00

abstract：:Positive selection of T lymphocytes expressing self. MHC-restricted T cell receptors is mediated by MHC molecules expressed on thymic stroma. Among the more controversial aspects of this process is the relative role of MHC molecules on epithelial versus bone marrow-derived stromal elements (BM-APC). For CD4+ T cells, ...

journal_title：Cellular immunology

authors： Fort MM,Pardoll DM

更新日期：1996-07-10 00:00:00

abstract：:American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...

journal_title：Cellular immunology

authors： Brelaz-de-Castro MC,de Almeida AF,de Oliveira AP,de Assis-Souza M,da Rocha LF,Pereira VR

更新日期：2012-10-01 00:00:00