Abstract：
:When lymphoid cells from rats recovered from experimental autoimmune encephalomyelitis (EAE) were incubated in vitro for 1 hr with myelin basic protein (BP), then washed and transferred along with anti-BP immune serum to naive recipients, those recipients immediately developed a solid, long-lasting resistance to active induction of EAE. To obtain this high level of suppression, both steps of BP-incubation of cells and transfer of immune serum were found to be essential, i.e., direct transfer of nonincubated cells plus immune serum had no comparable suppressive effect, nor had transfer of BP-incubated cells with nonimmune serum. Specificity of the suppressive effect was indicated by the finding that cells from BP-sensitized donors, incubated with BP, protected against BP-CFA-induced disease but not against disease induced with whole spinal cord homogenate (SCH-CFA). As expected, cells from SCH-CFA-sensitized donors incubated with SCH protected recipients against disease induced with either SCH-CFA or BP-CFA. The suppression appears to act early in the afferent stage of the immune response, since inoculation with incubated cells as little as 24 hr after active challenge was ineffective. There was no suppression of passively induced disease.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Hugh AR,Simmons RD,Willenborg DOdoi
10.1016/0008-8749(89)90272-4subject
Has Abstractpub_date
1989-10-01 00:00:00pages
108-17issue
1eissn
0008-8749issn
1090-2163pii
0008-8749(89)90272-4journal_volume
123pub_type
杂志文章abstract：:Idiotope-specific immunoenhancement or suppression was induced in C57BL/6 mice by the injection of physiological amounts (100 ng-10 micrograms) of monoclonal anti-idiotope antibody. As previously described, nanogram doses enhanced idiotope expression while a 10-micrograms dose of anti-idiotope antibody induced the act...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90275-3
更新日期：1986-03-01 00:00:00
abstract：:To investigate the process of tolerance induction we have developed an in vivo model using TCR beta-chain transgenic mice tolerized with the superantigen staphylococcal enterotoxin B. We have previously demonstrated that tolerized peripheral T cells were anergic when stimulated in vitro with immunogenic peptides, supe...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1177
更新日期：1994-07-01 00:00:00
abstract：:The ontogeny of T cells which express major histocompatibility complex (MHC)-unrestricted T cell antigen-binding molecules (TABM) on the cell membrane was investigated. We used a rabbit anti-mouse TABM antiserum to investigate the expression of TABM by subsets of adult thymocytes, peripheral T cells, and thymocytes du...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90171-m
更新日期：1990-10-01 00:00:00
abstract：:This study was conducted on human K562 lymphocytes to investigate the mechanisms implicated in the regulation of the serotonin transport process. The uptake of serotonin in these cells was saturable (Km, 3.37 microM; Vmax, 2.03 nmol/10(6) cells) and Na+ dependent; isoosmotic replacement of Na+ with choline chloride in...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0242
更新日期：1996-09-15 00:00:00
abstract：:This study addresses the nature of the pathogenic effector T cell in experimental autoimmune uveoretinitis and the effect of different cytokines on these cells in vitro. Lymph node cells of B10.RIII mice immunized with the uveitogenic peptide 161-180 of interphotoreceptor retinoid binding protein were cultured with th...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1997.1121
更新日期：1997-05-25 00:00:00
abstract：:Non-obese diabetic (NOD) mice develop spontaneous T-cell responses against pancreatic beta-cells, leading to islet cell destruction and diabetes. Despite high genetic similarity, non-obese resistant (NOR) mice do not develop diabetes. We show here that spleen cells of both NOD and NOR mice respond to the islet cell an...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2005.05.003
更新日期：2005-05-01 00:00:00
abstract：:We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1142
更新日期：1994-05-01 00:00:00
abstract：:We describe here a culture system for studying the development, in vitro, of antigen-specific CD4 T cells from unprimed mice. T cells from young mice are initially exposed to antigen, such as pigeon cytochrome C or keyhole limpet hemocyanin, in the presence of adherent accessory cells and then allowed to proliferate i...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1997.1134
更新日期：1997-06-15 00:00:00
abstract：:Adenomatous polyposis coli (APC) functions are involved in the heterotypic interactions occurring between intestinal epithelial cells (IECs) and intra-epithelial lymphocytes (IELs). These interactions may be of interest in cancer prevention, since recent data provide evidence for lymphocyte mediated immunosurveillance...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(03)00149-7
更新日期：2003-05-01 00:00:00
abstract：:Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 i...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2020.104259
更新日期：2021-02-01 00:00:00
abstract：:Our strategy to use saturation mutagenesis to produce an unbiased collection of major histocompatibility class I mutants has resulted in unpredicted mutant phenotypes. First, we have shown data supporting our earlier work of the Dp20(Y27N) mutant. Allorecognition is altered at the clonal level while no variation in ly...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90020-r
更新日期：1990-06-01 00:00:00
abstract：:The utility of multiple antigenic peptides (MAPs) for the induction of antibody and cellular immune responses in animal models has been demonstrated for a variety of peptide epitopes involved in human disease. However, little is known about immune responses to MAPs constructed with antigenic tumor epitopes, nor has pe...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0310
更新日期：1996-12-15 00:00:00
abstract：:Recombinant IL-4 inhibits IL-2-induced lymphokine-activated killer (LAK) cell development of PBMC. We evaluated the effect of various cytokines in reversing IL-4-mediated LAK inhibition. PBMC were cultured in IL-2 (10-1000 u/ml) with or without IL-4 (2-100 u/ml) and tested for cytotoxicity against the NK-sensitive K56...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90040-x
更新日期：1990-07-01 00:00:00
abstract：:Basic Immunology has had only two significant public priority disputes. The first began in the late 1650s and concerned the recognition of the peripheral network of vessels which collects lymph throughout the body. The publication of this major anatomical discovery prompted a priority feud discussed in a previous pape...
journal_title：Cellular immunology
pub_type： 历史文章,杂志文章
doi：10.1016/j.cellimm.2007.02.015
更新日期：2007-01-01 00:00:00
abstract：:The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2019.103987
更新日期：2020-01-01 00:00:00
abstract：:In this study the influence of a non-mitogenic anti-CD3 antibody on accessory cell-dependent antigen and mitogen-induced T-lymphocyte proliferation has been investigated. The antibody was found to completely inhibit PHA, Con A, PWM, and tetanus toxoid stimulation, with no effect on the proliferation induced by the cal...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90014-6
更新日期：1986-06-01 00:00:00
abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2007.07.002
更新日期：2007-05-01 00:00:00
abstract：:BST2 is a type II transmembrane protein that had been initially identified as a surface molecule expressed on terminally differentiated B cells. Here, we characterize the expression of BST2 in human endothelial cells, HUVECs. IFN-γ, among various inflammatory stimuli, dramatically upregulates BST2 expression in HUVECs...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2010.10.011
更新日期：2011-01-01 00:00:00
abstract：:The murine B-cell differentiation antigen Lyb-2 has been shown to be involved in B-lymphocyte activation and has been postulated by some to be related to a receptor for B-cell stimulatory factor I (BSF-1) (H. Yakura et al., J. Immunol. 137, 1475, 1986). Here we have demonstrated that monoclonal antibody (mAB) to Lyb-2...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90302-4
更新日期：1988-04-01 00:00:00
abstract：:CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-1...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2018.11.008
更新日期：2019-01-01 00:00:00
abstract：:Aging leads to an increase in the proportion of cells that have the surface phenotype (CD45RBlo, CD44hi) characteristic of memory T lymphocytes and also to a decline in both the production of IL-2 and the response to this lymphokine. Several groups have reported an increase, with age, in the secretion of IL-4 in short...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1993.1230
更新日期：1993-10-01 00:00:00
abstract：:Eicosanoids are important mediators of inflammation, but also play a role in regulation of lymphocyte function. In this study we have examined the function of both prostaglandins (PGs) and leukotrienes in regulating the release of a set of cytokines produced by T cells from mice primed with the contact-sensitising age...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1993.1157
更新日期：1993-07-01 00:00:00
abstract：:The mechanisms of glucocorticoid-induced immunosuppression of human monocytes for the defense of Candida albicans were examined in this in vitro study. Dexamethasone at pharmacological concentrations (10(-7)-10(-5) M) dose-dependently attenuated growth inhibition of C. albicans by resident monocytes. In interferon-gam...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1230
更新日期：1994-09-01 00:00:00
abstract：:Facilitating cells (FC) are bone marrow-derived cells that facilitate allogeneic hematopoietic stem cell (SC) engraftment and induce transplantation tolerance without causing graft vs. host disease. Although there is evidence for FC directing the development of FoxP3+CD4+CD25+ regulatory T cells, the specific FC subse...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2008.03.003
更新日期：2008-01-01 00:00:00
abstract：:The role of surface aminopeptidases (APs), enzymes that cleave amino-terminal residues from polypeptide chains, in the development of fetal thymocytes was studied using a murine fetal thymic organ culture (FTOC) model. FTOC AP activity was demonstrable for various amino acid-p-nitroanilide substrates, and specific inh...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1997.1099
更新日期：1997-04-10 00:00:00
abstract：:Blood and tissue eosinophilia is obtained when mice pretreated with cyclophosphamide (CY) and sensitized with picryl chloride are challenged on each ear lobe on day 13. To gain important insights into the cellular mechanisms involved in CY-induced eosinophilia in the contact-sensitivity reaction, we examined the cytok...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2000.1677
更新日期：2000-08-01 00:00:00
abstract：:Spleen cells from normal, nonautoimmune mice (C3H/HeN) spontaneously produce hemolytic plaques against autologous bromelain-treated red blood cells (BrMRBC). The number of anti-BrMRBC plaques detectable can be increased by including either a 3 M KCl extracted antigen from BrMRBCs or the hapten phosphorylcholine chlori...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(86)90268-6
更新日期：1986-03-01 00:00:00
abstract：:The lineage of lymphokine-activated killer (LAK) cells is poorly understood. To examine the relationship between LAK and natural killer (NK) cells we utilized two congenitally immunodeficient mice, namely severe combined immunodeficient (scid) and athymic (nude) mice that lack T cells but have normal NK cells. LAK act...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90190-1
更新日期：1989-04-15 00:00:00
abstract：:In this paper, we examined the contribution of the lymphokine interleukin-6 (IL-6) to the growth of four virulent strains of Mycobacterium avium and the nature of the binding moieties on the mycobacteria. First, we showed that human or mouse recombinant interleukin-6 are potent growth factors for four strains of virul...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(92)90137-e
更新日期：1992-04-15 00:00:00
abstract：:It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cel...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(87)90270-x
更新日期：1987-06-01 00:00:00
