Requirement for surface aminopeptidase activities during development of CD8+ fetal thymocytes.

abstract：:Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of...

journal_title：Cellular immunology

authors： Linder GE,Chuntova PD,McLelland BT,Añó L,Obodo UC,Crider NJ,Matthes DJ,García-Ojeda ME,Manilay JO,Chatterjea D

更新日期：2013-02-01 00:00:00

abstract：:The primary function of the thymus is to develop immature T-cells into cells that further in the periphery will be able to carry out immune functions. The Literature has shown that thymus can be a target for many pathogens and severe structural alterations take place in this organ during infectious diseases. Here, we ...

journal_title：Cellular immunology

authors： Andrade CF,Gameiro J,Nagib PR,Carvalho BO,Talaisys RL,Costa FT,Verinaud L

更新日期：2008-05-01 00:00:00

abstract：:Coxsackievirus group B type 3 (CVB3) induces myocarditis in male Balb/c mice but produces little cardiac injury in females. Males develop cytolytic T lymphocytes (CTL) reactive to heart antigens which primarily cause the inflammation and cardiac injury observed in the disease. Infected female mice lack this CTL respon...

journal_title：Cellular immunology

authors： Job LP,Lyden DC,Huber SA

更新日期：1986-03-01 00:00:00

abstract：:Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB). Recognition of DNP/class I MHC (signal one) s...

journal_title：Cellular immunology

authors： Fairchild RL,Moorhead JW

更新日期：1991-03-01 00:00:00

abstract：:A mouse IgG1 monoclonal antibody ED12F8C10 (C10) binds a constant percentage of peripheral blood neutrophils in the same individual when studied over time, defining a distinct subset of neutrophils in all normal individuals studied to date. Bone marrow studies confirm that the heterogeneity is present to the same degr...

journal_title：Cellular immunology

authors： Brown CC,Malech HL,Jacobson RJ,Shrimpton CF,Beverly PC,Segal AW,Gallin JI

更新日期：1991-01-01 00:00:00

abstract：:Although most intraepithelial lymphocytes (IEL) in mouse small intestine bear surface markers classically associated with T lymphocytes, the T-cell nature of these cells remains controversial. In the present study IEL from normal mice, or from mice infected with the gut nematode Trichinella spiralis, were therefore te...

journal_title：Cellular immunology

authors： Dillon SB,Dalton BJ,MacDonald TT

更新日期：1986-12-01 00:00:00

abstract：:We report experiments attempting to optimize the proliferative response of human B cells to rabbit anti-immunoglobulin antibody (RAHIg)-linked beads (anti-Ig beads). By choosing polyacrylamide beads of small size (3 micron) and coupling anti-Ig to them at high concentrations, beads were obtained which were both B-cell...

journal_title：Cellular immunology

authors： Boyd AW,Freedman AS,Horowitz JC,Anderson KC,Fisher DC,Rosen KJ,Schlossman SF,Nadler LM

更新日期：1986-04-15 00:00:00

abstract：:As an atypical guanine nucleotide exchange factor (GEF), Dock5 has been extensively studied in cellular functions. However, the role of Dock5 on B-cell immunity still remain elusive. In this study, we generated a Dock5 knockout mouse model to study the effect of Dock5 deficiency on B cell development, differentiation ...

journal_title：Cellular immunology

authors： Chen A,Yang D,Xuan X,Miller H,Luo X,Yu J,Yang G,Wang H,Liu C

更新日期：2019-03-01 00:00:00

abstract：:The clinical outcome of Leishmania pathogenesis ranges from active skin lesions to fatal visceral dissemination and severely impaired T cell immunity. It is well established that a strong Th1 immune response is protective against cutaneous forms of the disease, however a mixed Th1/Th2 response is most commonly observe...

journal_title：Cellular immunology

authors： Banerjee A,Bhattacharya P,Joshi AB,Ismail N,Dey R,Nakhasi HL

更新日期：2016-11-01 00:00:00

abstract：:Murine bone marrow-derived cultured mast cells (BMMCs) are most widely used in in vitro experiments for evaluation of mast cell functions. The present study has shown that cell preparation procedure, i.e., cell collection by centrifugation and the subsequent adjustment and culture of cell density at the desired concen...

journal_title：Cellular immunology

authors： Murakami M,Ikeda T,Nishino Y,Funaba M

更新日期：2005-11-01 00:00:00

abstract：:Mice homozygous for either the generalized lymphoproliferative disease (gld) or the lymphoproliferation (lpr) nonallelic mutations develop similar syndromes combining systemic autoimmunity and lymphoproliferative disease. Though essentially recessive, the lpr and gld mutations may be expressed in the heterozygous stat...

journal_title：Cellular immunology

authors： Rosenblatt N,Hartmann KU,Loor F

更新日期：1994-07-01 00:00:00

abstract：:Various anti-Fc gamma RIII (CD16) monoclonal antibodies (mAbs) are shown here to have positive or negative modulatory effects on human NK cells. Thus, 3G8 mAb (IgG1) triggered a dose-dependent augmentation of NK activity in 67% (23/34) of individuals tested, who were designated as responders. All four IgG1 anti-CD16 m...

journal_title：Cellular immunology

authors： Galatiuc C,Gherman M,Metes D,Sulica A,DeLeo A,Whiteside TL,Herberman RB

更新日期：1995-07-01 00:00:00

abstract：:Activated macrophages are known to release a variety of immunoregulatory substances including the low-molecular-weight substances hydrogen peroxide and lactate. We report here that lactate but not hydrogen peroxide is capable of supporting a substantial production of T-cell growth factor (TCGF) in cultures of accessor...

journal_title：Cellular immunology

authors： Roth S,Dröge W

更新日期：1987-09-01 00:00:00

abstract：:Stimulated macrophages are known to inhibit the growth of certain tumor cells. Using mouse peritoneal exudates as a source of macrophages and the mastocytoma cell line P815 as the target, the inhibition was found to depend on direct contact between the macrophages and the growing cells. Cytostatic activities were dete...

journal_title：Cellular immunology

authors： Ritter K,Härtl R,Bandlow G,Thomssen R

更新日期：1986-02-01 00:00:00

abstract：:The morbidity and mortality of infectious diseases are significantly increased in aged humans. Hence, vaccination has been suggested as a means to reduce or prevent the impact of infections on old individuals. However, it has remained unresolved whether or not standard vaccine adjuvants such as aluminum hydroxide (Alu...

journal_title：Cellular immunology

authors： Ebhardt MB,Shive CL,Guardia R,Gapin L,Boehm BO,Forsthuber TG

更新日期：2002-01-01 00:00:00

abstract：:In order to track hematopoetic cells of all lineages unambiguously at all stages of development, we have developed C57BL/6 mice that express a transgene coding for green fluorescent protein (GFP) under control of the human ubiquitin C promoter. These mice, called UBI-GFP/BL6, express GFP in all tissues examined, with ...

journal_title：Cellular immunology

authors： Schaefer BC,Schaefer ML,Kappler JW,Marrack P,Kedl RM

更新日期：2001-12-15 00:00:00

abstract：:The CD2 (T11) molecule belongs to a family of cell-surface glycoproteins that function as adhesion molecules in the immune system. Human CD2 is found exclusively on cells of the T lineage: peripheral T lymphocytes, NK cells, and thymocytes. CD2 binds specifically to the surface glycoprotein LFA-3. CD2/LFA-3 adhesion i...

journal_title：Cellular immunology

authors： Rabin EM,Gordon K,Knoppers MH,Luther MA,Neidhardt EA,Flynn JF,Sardonini CA,Sampo TM,Concino MF,Recny MA

更新日期：1993-06-01 00:00:00

abstract：:Purine nucleoside phosphorylase (PNP) is a purine salvage pathway enzyme which we have found to be 8-10 times more active (per cell) in human peripheral blood null lymphocytes than in T lymphocytes. To test the hypothesis that null cells are, in part, pre-T lymphocytes we have defined an in vitro system for null cell ...

journal_title：Cellular immunology

authors： Cowan MJ,Fraga M,Ammann AJ

更新日期：1983-06-01 00:00:00

abstract：:Macrophages in varying states of activation differ in their ability to perform antibody-dependent cellular cytotoxicity (ADCC) and antibody-independent macrophage-mediated tumor cytotoxicity (MTC). To define further the activation requirements for macrophages to perform various cytolytic functions, we stimulated pepto...

journal_title：Cellular immunology

authors： Fan S,Fehr HG,Adams D

更新日期：1991-06-01 00:00:00

abstract：:The poor immunogenicity of many tumors can be partly explained by the inefficiency of the MHC class I peptide presentation pathway. MHC-I-based single-chain trimers (SCT) represent a new class of molecules with the potential to overcome this limitation. We here evaluated the ability of SCT presenting a melanoma antige...

journal_title：Cellular immunology

authors： Ordaz ML,Larmonier N,Lybarger L

更新日期：2010-01-01 00:00:00

abstract：:Functionally distinct subpopulations within the CD4+ subset of T lymphocytes have been described in man, rat, and mouse. In the rat different functions have been assigned to CD45R+ and CD45R- T helper cells. The CD45R+ in contrast to the CD45R- T helper cells have been reported to produce IL-2 and to proliferate well ...

journal_title：Cellular immunology

authors： Hedlund G,Dohlsten M,Ericsson PO,Sjögren HO

更新日期：1989-04-01 00:00:00

abstract：:The 4F2 antigenic complex is expressed on most human cell lines in culture, on monocytes and activated lymphocytes, but not on resting T and B lymphocytes. Monoclonal antibody (mAb) CB43 recognizes an epitope of the 4F2 heterodimer either located on the light chain or dependent on the conformation of the molecule. The...

journal_title：Cellular immunology

authors： Spagnoli GC,Ausiello C,Palma C,Bellone G,Ippoliti G,Letarte M,Malavasi F

更新日期：1991-08-01 00:00:00

abstract：:A single nucleotide A49G polymorphism (SNP) of CTLA-4 has been linked and associated with the autoimmune thyroid diseases (AITD) and thyroid autoantibody secretion. We have explored the functional mechanisms of CTLA-4 by means of recombinant human CTLA-4 expressed on transfected Jurkat T cells. Analysis of CTLA-4 tran...

journal_title：Cellular immunology

authors： Xu Y,Graves PN,Tomer Y,Davies TF

更新日期：2002-02-01 00:00:00

abstract：:T helper cells reactive to myelin basic protein are clearly implicated in the pathogenesis of murine EAE. We have developed a T cell line, BML-1 that (1) is reactive to the encephalitogenic amino terminal nonapeptide (1-9NAC) of MBP, (2) is I-Au restricted, and (3) induces relapsing EAE in B10.PL (H-2u) mice. Measurem...

journal_title：Cellular immunology

authors： Ando DG,Clayton J,Kono D,Urban JL,Sercarz EE

更新日期：1989-11-01 00:00:00

abstract：:Mice that received a sublethal, intraperitoneal dose of viable Listeria monocytogenes, virulent strain 10403, exhibited a systemic increase in natural killer (NK) activity. The kinetics of the response differed with respect to the various effector cell populations analyzed. Resident peritoneal cells and peripheral blo...

journal_title：Cellular immunology

authors： Kearns RJ,Leu RW

更新日期：1984-04-01 00:00:00

abstract：:Transduction with recombinant, replication-defective adenoviral (rAd) vectors encoding a transgene is an efficient method for gene transfer into human dendritic cells (DCs). Livin is a good candidate for cancer immunotherapy since it is overexpressed in most common human cancers, poorly expressed in most normal adult ...

journal_title：Cellular immunology

authors： Xie J,Guo X,Liu F,Luo J,Duan F,Tao X

更新日期：2015-09-01 00:00:00

abstract：:UM4D4 is a recently defined antigen that is expressed on approximately 25% of peripheral blood T cells, but on the majority of T cells in inflammatory synovial fluid. Anti-UM4D4 activates peripheral blood T cells in the presence of accessory cells and/or phorbol ester. UM4D4 has been assigned to a new antigen cluster ...

journal_title：Cellular immunology

authors： Fox DA,Davis W,Zeldes W,Kan L,Higgs J,Duby AD,Holoshitz J

更新日期：1990-07-01 00:00:00

abstract：:A spontaneously arising murine plasmacytoma, HPC-202, derived from a BALB/c.H-2b congenic mouse that lacks any detectable H-2 determinants on its cell surface is described. However, the expression of H-2 determinants is inducible by interferon-gamma. The H-2 negative cell surface phenotype permits the HPC-202 tumor to...

journal_title：Cellular immunology

authors： Daley MJ,Williams TJ,Giorgi J,Warner NL

更新日期：1990-04-15 00:00:00

abstract：:Although pulmonary inflammation is a serious, sometimes life-threatening, consequence of respiratory syncytial virus (RSV) infection, the mechanisms involved are not well understood. Since the process of inflammation is initiated by a complex series of events including the activation of specific adhesion molecules on ...

journal_title：Cellular immunology

authors： Chang CH,Huang Y,Anderson R

更新日期：2003-01-01 00:00:00

abstract：:Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...

journal_title：Cellular immunology

authors： Chrobak P,Gress RE

更新日期：2001-03-15 00:00:00