当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Activation of macrophages for ADCC in vitro: effects of IL-4, TNF, interferons-alpha/beta, interferon-gamma, and GM-CSF.

Activation of macrophages for ADCC in vitro: effects of IL-4, TNF, interferons-alpha/beta, interferon-gamma, and GM-CSF.

Abstract：

:Macrophages in varying states of activation differ in their ability to perform antibody-dependent cellular cytotoxicity (ADCC) and antibody-independent macrophage-mediated tumor cytotoxicity (MTC). To define further the activation requirements for macrophages to perform various cytolytic functions, we stimulated peptone-elicited peritoneal macrophages, which are only poorly cytolytic, with one of a panel of cytokines and then quantified three distinct cytolytic capacities. The peptone-elicited macrophages, after stimulation with IFN-alpha/beta, IL-4, or TNF, had increased ability to perform both the rapid and slow variants of ADCC but not to perform MTC. Stimulation with high doses of IFN-gamma, however, increased the macrophages' ability to perform all three cytolytic functions. GM-CSF had no effects on any cytolytic capacity. The effects of IL-4, TNF, IFN-gamma, and IFN-alpha/beta on the macrophages' capacity for both forms of ADCC were dose-dependent. IFN-gamma and IFN-alpha/beta increased the macrophages' capacity for both variants of ADCC within 4 hr of treatment, whereas IL-4 and TNF did so only after prolonged treatment. These results suggest that three forms of macrophage cytolytic capacity can be enhanced by cytokine treatment but that the requirements for enhancing each of the three forms of macrophage cytolytic capacity differ.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Fan S,Fehr HG,Adams D

doi

10.1016/0008-8749(91)90255-a

subject

Has Abstract

pub_date

1991-06-01 00:00:00

pages

78-87

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(91)90255-A

journal_volume

135

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Natural cytotoxic T cells (NCTC) that differ from natural killer (NK) and natural cytotoxic (NC) cells are present in Peyer's patches of mice.

    abstract：:We have examined noninduced cytotoxicity of mouse gut associated and peripheral lymphoid tissues for a wide variety of syngeneic as well as allogeneic cell lines and lymphoblasts. Lymphoid cells from Peyer's patches were found to lyse these targets in a 3-hr chromium release assay whereas lymphoid cells from intestina...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90158-9

    authors： Gautam SC,Beckman K,Battisto JR

    更新日期：1986-09-01 00:00:00

  • Interleukin-12 (IL-12) augments cytolytic activity of natural killer cells toward Mycobacterium tuberculosis-infected human monocytes.

    abstract：:We tested the impact of interleukin-12 (IL-12) and of cytotoxic leukocytes (particularly natural killer (NK) cells) from normal and HIV-1-infected subjects on lysis of human monocytes infected with Mycobacterium tuberculosis. Nylon wool nonadherent cells stimulated with interleukin-2 (IL-2) or with IL-12 developed sig...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1196

    authors： Denis M

    更新日期：1994-07-01 00:00:00

  • Norepinephrine and serotonin content of the murine spleen: its relationship to lymphocyte beta-adrenergic receptor density and the humoral immune response in vivo and in vitro.

    abstract：:Numerous reports in the literature describe the effects of beta-adrenergic agonists and/or their second messenger cyclic AMP on in vitro and in vivo immune responses. The fact that the murine spleen receives rich adrenergic innervation and that the pharmacologic disruption of this innervation leads to altered immune r...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90123-2

    authors： Fuchs BA,Campbell KS,Munson AE

    更新日期：1988-12-01 00:00:00

  • Mechanisms of increased immunogenicity for DNA-based vaccines adsorbed onto cationic microparticles.

    abstract：:Investigation into the mechanism of action of vaccine adjuvants provides opportunities to define basic immune principles underlying the induction of strong immune responses and insights useful for the rational development of subunit vaccines. A novel HIV vaccine composed of plasmid DNA-encoding p55 gag formulated with...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2003.09.003

    authors： Denis-Mize KS,Dupuis M,Singh M,Woo C,Ugozzoli M,O'Hagan DT,Donnelly JJ 3rd,Ott G,McDonald DM

    更新日期：2003-09-01 00:00:00

  • Viral-restricted cytolytic T lymphocyte recognition of hybrid human-murine class I histocompatibility antigens.

    abstract：:Hybrid human-murine major histocompatibility antigens have been constructed and expressed on the surface of both human RD and murine L cell lines after DNA mediated gene transfer. These antigens linked the polymorphic domains (alpha 1 and alpha 2) of H-2Kb and the carboxy-terminal domains (alpha 3, transmembrane, and ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90235-2

    authors： Maziarz RT,Burakoff SJ,Reiss CS

    更新日期：1986-04-15 00:00:00

  • Regulation of helper T cell clone proliferation via the CD2 molecule.

    abstract：:We have investigated the requirements for CD2-induced proliferation of a CD4+, CD8-, CD3+, CD2+ antigen-specific, class II-restricted proliferating cloned cell line. A combination pair of two monoclonal antibodies (MoAb) recognizing, respectively, TII1 and D66 epitopes on the CD2 molecule was used as a stimulus. The r...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90304-2

    authors： Sterkers G,Huet S,Moachon L,Hu J,Boumsell L,Bernard A

    更新日期：1987-10-01 00:00:00

  • Role of macrophages as modulators but not as stimulators in primary mixed leukocyte reaction.

    abstract：:The role of macrophages (M phi) and that of splenic dendritic cells (DC) in the allogeneic mixed leukocyte reaction (MLR) in the mouse have been investigated. In contrast with the high stimulatory capacity of DC, we obtained no evidence in favor of the competence of M phi, whether Ia + or Ia-, as an autonomous stimula...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90169-2

    authors： Naito K,Komatsubara S,Kawai J,Mori K,Muramatsu S

    更新日期：1984-10-15 00:00:00

  • Induction of apoptosis in activated T cell blasts by suppressive macrophages: a possible immunotherapeutic approach for treatment of autoimmune disease.

    abstract：:Large suppressive macrophages (LSM) were induced by restimulating spleen cells from rats with experimental autoimmune myasthenia gravis (EAMG) in vitro, with the autoantigen acetylcholine receptor (AChR) in the presence of cyclosporine A. LSM, purified from these cultures, are extremely potent suppressors of AChR-stim...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1445

    authors： McIntosh KR,Drachman DB

    更新日期：1999-04-10 00:00:00

  • Interleukin-10 production by B cells is regulated by cytokines, but independently of GATA-3 or FoxP3 expression.

    abstract：:The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2019.103987

    authors： Bohacova P,Kossl J,Hajkova M,Hermankova B,Javorkova E,Zajicova A,Krulova M,Holan V

    更新日期：2020-01-01 00:00:00

  • Suppression of experimental autoimmune encephalomyelitis by the oral administration of myelin basic protein.

    abstract：:The oral administration of myelin basic protein (MBP) to Lewis rats prior to an encephalitogenic challenge resulted in total inhibition or a significant delay in the onset of experimental autoimmune encephalomyelitis (EAE). In vitro lymphocyte proliferative responses to MBP were significantly decreased in MBP-fed rats...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90305-x

    authors： Bitar DM,Whitacre CC

    更新日期：1988-04-01 00:00:00

  • Different time course patterns of local expression of delayed-type hypersensitivity to sheep red blood cells in mice.

    abstract：:The delayed-type hypersensitivity (DTH) reaction, a peripheral expression of cell-mediated immunity is still a crucial in vivo immunological test. Nevertheless, the biological significance of its time course remains unclear. Thus, an exhaustive study of DTH was undertaken in mice immunized with increasing doses of she...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90287-y

    authors： Hurtrel B,Maire MA,Hurtrel M,Lagrange PH

    更新日期：1992-07-01 00:00:00

  • Tumor necrosis factor alpha stimulates mycobactericidal/mycobacteriostatic activity in human macrophages by a protein kinase C-independent pathway.

    abstract：:Tumor necrosis factor (TNF) is a 17-kDa protein produced by endotoxin-stimulated macrophages. We have demonstrated that recombinant human TNF activates human macrophages to kill intracellular bacteria of the Mycobacterium avium complex (MAC) in a dose-related manner. TNF also primed macrophages to produce superoxide a...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90243-i

    authors： Bermudez LE,Young LS

    更新日期：1992-10-15 00:00:00

  • Aminopeptidase N/CD13 is directly linked to signal transduction pathways in monocytes.

    abstract：:In the present study, we characterized in monocytes the rise in [Ca(2+)](i) evoked by monoclonal antibodies (mAbs) to aminopeptidase N (APN)/CD13, showing a two-phase calcium increase with a small-belled [Ca(2+)](i) rise due to the release of calcium from intracellular stores and a more sustained plateau due to the in...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.2000.1629

    authors： Santos AN,Langner J,Herrmann M,Riemann D

    更新日期：2000-04-10 00:00:00

  • Activation of donor-specific CTL in a tolerant recipient of cardiac allograft.

    abstract：:Permanent graft acceptance was induced with cyclosporine A in a low responder rat strain combination PVG (RT1(c)) to DA (RT1(av1)) of cardiac transplants. Challenge (alloimmunization) with donor and third-party WF (RT1(u)) cells was performed and followed by the analysis of alloreactive cytotoxicity. The cytotoxic T l...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1353

    authors： Petersson E,Qi Z,Hedlund G,Ekberg H

    更新日期：1998-10-10 00:00:00

  • CD45 isoforms associated with distinct functions of CD4 cells derived from unusual healthy donors lacking CD45RA- T lymphocytes.

    abstract：:We now report two healthy individuals whose T lymphocytes were over 95% positive for CD45RA antigen expression. However, these donors normally expressed both the CD29 high (CD29+) and CD45RO high (CD45RO+) antigens on approximately 40 and 50% of their CD4 cells, respectively. Despite the strong CD45RA expression on th...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90089-t

    authors： Matsuyama T,Yamada A,Rothstein DM,Anderson KC,Schlossman SF,Morimoto C

    更新日期：1991-10-15 00:00:00

  • Generation of HSP60-specific regulatory T cell and effect on atherosclerosis.

    abstract：:Although CD4(+)CD25(+) regulatory T cells are pivotal in the suppression of autoimmunity, little is known about the effect of antigen-specific regulatory T cells on the formation of atheromatous plaques. Here, we describe the induction of heat-shock protein 60 (HSP60)-specific CD4(+)CD25(high) T cells by rapamycin (RP...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2007.01.002

    authors： Yang K,Li D,Luo M,Hu Y

    更新日期：2006-10-01 00:00:00

  • Suppressor cell regulation of encephalitogenic T cell lines: generation of suppressor macrophages with cyclosporin A and myelin basic protein.

    abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) can be adoptively transferred using myelin basic protein (BP)-specific helper T cell lines, and suppressor cells may be important in recovery from EAE. In order to generate suppressor cells, spleen cells obtained from BP-complete Freund's adjuvant (CFA...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90322-i

    authors： Whitham RH,Vandenbark AA,Bourdette DN,Chou YK,Offner H

    更新日期：1990-04-01 00:00:00

  • The role of B cells in the establishment of T cell response in mice infected with an intracellular bacteria, Listeria monocytogenes.

    abstract：:To clarify the role of B cells in the establishment of T cell response against intracellular bacteria, B-cell-deficient (muMT-/-) mice were infected with an intracellular bacteria, Listeria monocytogenes, and T cell response against the bacteria was analyzed. On day 6 of primary Listeria infection, spleen T cells of t...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1503

    authors： Matsuzaki G,Vordermeier HM,Hashimoto A,Nomoto K,Ivanyi J

    更新日期：1999-06-15 00:00:00

  • Changes in purine nucleoside phosphorylase activity during thymosin-induced human null cell differentiation.

    abstract：:Purine nucleoside phosphorylase (PNP) is a purine salvage pathway enzyme which we have found to be 8-10 times more active (per cell) in human peripheral blood null lymphocytes than in T lymphocytes. To test the hypothesis that null cells are, in part, pre-T lymphocytes we have defined an in vitro system for null cell ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90288-5

    authors： Cowan MJ,Fraga M,Ammann AJ

    更新日期：1983-06-01 00:00:00

  • Comparative proteome analysis of splenic lymphocytes in long-term high-fat diet and dietary supplement with lipoic acid mice.

    abstract：:The objective of this investigation was to explore possible molecular changes for role of a high-fat diet (HFD)-induced oxidative stress in splenic lymphocytes, and whether a dietary lipoic acid (LA) supplement could attenuate these changes. Male C57BL/6 mice were fed one of three diets 10 weeks and outcome measures c...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.06.002

    authors： Cui J,Xiao Y,Shi Y,Le G,Miao X

    更新日期：2010-01-01 00:00:00

  • Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3.

    abstract：:Transcriptional regulation of gene expression is a key component of orchestrating proper immune cell development and function. One strategy for maintaining these transcriptional programs has been the evolution of transcription factor families with members possessing overlapping functions. Using the germ line deletion ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2015.02.009

    authors： Pioli PD,Chen X,Weis JJ,Weis JH

    更新日期：2015-05-01 00:00:00

  • Characterization of IL-2-induced murine cells which exhibit ADCC activity.

    abstract：:The incubation of murine splenocytes in recombinant interleukin 2 (IL-2) gives rise to both lymphokine-activated killer (LAK) cells capable of lysing fresh tumor cells and cells capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of anti-H2 allosera. A similarity between these two IL-2...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90180-3

    authors： Eisenthal A,Shiloni E,Rosenberg SA

    更新日期：1988-09-01 00:00:00

  • The role of PIM kinases in human and mouse CD4+ T cell activation and inflammatory bowel disease.

    abstract：:PIM kinases are a family of three serine/threonine kinases expressed following T cell activation. Using potent selective small molecule antagonists of PIM-1/3 kinases, we demonstrate a potential role for these enzymes in naïve and effector CD4+ T cell activation. PIM-1/3 inhibition prevented CD4+ T cell proliferation ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.10.011

    authors： Jackson LJ,Pheneger JA,Pheneger TJ,Davis G,Wright AD,Robinson JE,Allen S,Munson MC,Carter LL

    更新日期：2012-01-01 00:00:00

  • Bacteria-derived human leukocyte interferons alter in vitro humoral and cellular immune responses.

    abstract：:Cultures of gradient-purified human peripheral blood mononuclear cells (PBMC) have been employed to examine the effects of three bacteria-derived human leukocyte interferon subtypes on certain aspects of in vitro immune responses. The addition of highly purified IFN-alpha 1, -alpha 2, -alpha 2/alpha 1 to PMBC cultures...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(83)90161-2

    authors： Shalaby MR,Weck PK

    更新日期：1983-12-01 00:00:00

  • Induction of T-lymphocyte adhesion by histidine-proline-rich glycoprotein and concanavalin A.

    abstract：:Histidine-proline-rich glycoprotein (HPRG) is a plasma protein which binds to a specific receptor on T-lymphocytes and represses T-cell activation and proliferation. In the presence of Concanavalin A (Con A), HPRG causes human T-lymphoblastic MOLT-3 cells and a fraction of normal human peripheral blood lymphocytes to ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1311

    authors： Lamb-Wharton RJ,Morgan WT

    更新日期：1993-12-01 00:00:00

  • Post-transcriptional down-regulation of Toll-like receptor signaling pathway in umbilical cord blood plasmacytoid dendritic cells.

    abstract：:Plasmacytoid dendritic cells (PDCs) from human umbilical cord blood (UCB) produce lower amounts of IFN-α upon TLR stimulation compared with adult counterparts. This difference may play a role in the low graft-versus-host disease rate after UCB transplantation and in the impaired immune response of the neonate to patho...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2012.04.010

    authors： Charrier E,Cordeiro P,Cordeau M,Dardari R,Michaud A,Harnois M,Merindol N,Herblot S,Duval M

    更新日期：2012-03-01 00:00:00

  • L3T4+ T-cell-independent reactivity of Lyt2+ T cells in vivo.

    abstract：:The aim of this study was to analyze in vivo the L3T4+ T-cell-subset-independent reactivity of Lyt2+ T cells toward transplantation alloantigens. To this end, we depleted normal mice of L3T4+ T cells by injection of monoclonal antibodies to the L3T4 antigen. This procedure not only led phenotypically to a disappearanc...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90059-7

    authors： Heeg K,Steeg C,Wagner H

    更新日期：1988-01-01 00:00:00

  • Deletion of the C6orf120 gene with unknown function ameliorates autoimmune hepatitis induced by concanavalin A.

    abstract：:The present study was conducted to characterize the C6orf120 gene, by using C6orf120 gene-deleted rats (C6orf120-/-), to determine its role in the development and severity of autoimmune hepatitis induced by concanavalin A (Con A), as well as the underlying mechanisms. We found that following Con A injection, C6orf120-...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.04.017

    authors： Zhang MK,Ma HM,Zhang J,Song XC,Ye XH,Li YF,Zhang YF,He LL,Wei HS,Li X

    更新日期：2018-09-01 00:00:00

  • Age-associated B cells (ABC) inhibit B lymphopoiesis and alter antibody repertoires in old age.

    abstract：:With old age (∼2y old), mice show substantial differences in B cell composition within the lymphoid tissues. In particular, a novel subset of IgM+ CD21/35lo/- CD23- mature B cells, the age-associated B cells or ABC, increases numerically and proportionately. This occurs at the expense of other B cell subsets, includin...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2017.04.008

    authors： Riley RL,Khomtchouk K,Blomberg BB

    更新日期：2017-11-01 00:00:00

  • The repertoire diversity and magnitude of antibody responses to bacterial antigens in aged mice: I. Age-associated changes in antibody responses differ according to the mouse strain.

    abstract：:Aging influences the host immune responses in various ways. In aging mice we have studied the antibody responses to two unrelated bacterial antigens. Streptococcus pneumoniae R36a vaccine (Pn) and TNP coupled to Brucella abortus (TNP-BA). Aged animals (20-24 months old) of the C57BL/6 strain had markedly reduced numbe...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90180-j

    authors： Nicoletti C,Cerny J

    更新日期：1991-03-01 00:00:00