当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Mutations in the alpha 1 domain of a class I gene define residues important for specific allorecognition.

Mutations in the alpha 1 domain of a class I gene define residues important for specific allorecognition.

Abstract：

:Our strategy to use saturation mutagenesis to produce an unbiased collection of major histocompatibility class I mutants has resulted in unpredicted mutant phenotypes. First, we have shown data supporting our earlier work of the Dp20(Y27N) mutant. Allorecognition is altered at the clonal level while no variation in lymphocytic choriomeningitis virus (LCMV)-restricted recognition is observed. The defect does not destroy the integrity of this class I protein on the basis of three observations: (i) LCMV self-restricted recognition is not impaired, (ii) beta 2 microglobulin still associates with Dp20(Y27N) at the cell surface, and (iii) this mutant can stimulate a primary MLR. Thus, we believe Dp20(Y27N) specifically affects allorecognition, perhaps by altering self peptide associations. The Dp14(A11V;E32Q) mutant appears to interact with T cell receptors (TCR) from a cloned cytotoxic T lymphocyte, but is altered in inducing a wild type signal into the responding cell. This is presumably due to decreased interaction at the cell surface between Dp14(A11V;E32Q) and wild type-specific TCR such that variations are detected in how a cell perceives extracellular signals. Analysis of additional mutants suggests that mutant Dp163(N66S) alters the binding site for monoclonal antibodies 7-16.10 and 135, while leaving unaltered the binding site for monoclonal antibodies 34-1.2 and 11-20.3. This maps the residue responsible for 7-16.10 and 135 binding to the region of Dp163(N66S).

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Murray R,Katoh K,Alexander J,Muller D,Pederson K,Frelinger JA

doi

10.1016/0008-8749(90)90020-r

subject

Has Abstract

pub_date

1990-06-01 00:00:00

pages

220-30

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(90)90020-R

journal_volume

128

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Activation of vascular endothelial cells by IL-1alpha released by epithelial cells infected with respiratory syncytial virus.

    abstract：:Although pulmonary inflammation is a serious, sometimes life-threatening, consequence of respiratory syncytial virus (RSV) infection, the mechanisms involved are not well understood. Since the process of inflammation is initiated by a complex series of events including the activation of specific adhesion molecules on ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/s0008-8749(03)00058-3

    authors： Chang CH,Huang Y,Anderson R

    更新日期：2003-01-01 00:00:00

  • Antigen-induced arthritis in rats is suppressed by the inducing antigen administered orally before, but not after immunization.

    abstract：:The effects of oral administration of methylated bovine serum albumin (mBSA) on antigen-induced arthritis (AIA) in rats that was induced by immunization with mBSA followed by the intraarticular injection of the same antigen were investigated. When mBSA was orally given to animals before immunization with the antigen, ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1995.1098

    authors： Yoshino S

    更新日期：1995-06-01 00:00:00

  • Effects of irradiation on development of Theiler's murine encephalomyelitis virus (TMEV)-induced demyelinating disease in genetically resistant mice.

    abstract：:Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a model for multiple sclerosis, is a chronic T cell-mediated disease. Development of clinical symptoms in susceptible mouse strains generally correlates with TMEV-specific delayed-type hypersensitivity (DTH) responses. These responses, ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1303

    authors： Pelka A,Olsberg C,Miller S,Waltenbaugh C,Creighton TM,dal Canto MC,Melvold R

    更新日期：1993-12-01 00:00:00

  • VSTM1-v2, a novel soluble glycoprotein, promotes the differentiation and activation of Th17 cells.

    abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2012.07.009

    authors： Guo X,Zhang Y,Wang P,Li T,Fu W,Mo X,Shi T,Zhang Z,Chen Y,Ma D,Han W

    更新日期：2012-07-01 00:00:00

  • Blocking the interleukin-1 receptor inhibits leukotriene B4 and prostaglandin E2 generation in human monocyte cultures.

    abstract：:Interleukin-1 is a potent stimulator of arachidonic acid (AA) metabolism and this activity could be attributed to the activation of the prostaglandin-forming enzyme cyclooxygenase or of the arachidonic-releasing enzyme phospholipase A2 or both. Prostaglandin E2 (PGE2), a cyclooxygenase product, and LTB4 (5-(S),12-(R)-...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90323-h

    authors： Conti P,Panara MR,Barbacane RC,Placido FC,Bongrazio M,Reale M,Dempsey RA,Fiore S

    更新日期：1992-11-01 00:00:00

  • VCAM-1 influences lymphocyte proliferation and cytokine production during mixed lymphocyte responses.

    abstract：:The allogeneic mixed lymphocyte reaction (MLR) is regarded as an effective model for examining the events which occur during an allospecific immune response. Numerous studies have delineated the role of adherence molecule interactions during the MLR response. In the present study we have identified VCAM-1 as having a ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1059

    authors： Lukacs NW,Strieter RM,Evanoff HL,Burdick MD,Kunkel SL

    更新日期：1994-03-01 00:00:00

  • In vivo mechanisms of acquired thymic tolerance.

    abstract：:Injection of antigen into the thymus of adult animals induces specific systemic tolerance, but the mechanisms of acquired thymic tolerance are not well understood. To investigate these mechanisms we used a model of intrathymic injection of ovalbumin (OVA) in BALB/c mice. We show an antigen-specific decrease in prolife...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1997.1165

    authors： Chen W,Issazadeh S,Sayegh MH,Khoury SJ

    更新日期：1997-08-01 00:00:00

  • Effects of vitamin D on macrophages and myeloid-derived suppressor cells (MDSCs) hyperinflammatory response in the lungs of COVID-19 patients.

    abstract：:Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 i...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2020.104259

    authors： Kloc M,Ghobrial RM,Lipińska-Opałka A,Wawrzyniak A,Zdanowski R,Kalicki B,Kubiak JZ

    更新日期：2021-02-01 00:00:00

  • Antibody-induced suppression and postsuppression stimulation of complement in vitro. III. Long-term C4 suppression is actively maintained by a soluble suppressor factor (FsC4).

    abstract：:Previous work in our laboratory established that individual complement components can be regulated in vivo by administration of specific antibody or immunocompetent cells to newborns and in vitro by administration of specific antibody to cultured peritoneal macrophages or splenic fragments. Antibody-induced suppressio...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90337-5

    authors： Goldman JN,O'Rourke KS,Goldman MB

    更新日期：1985-11-01 00:00:00

  • Effects of pertussis toxin (PT) on T-cell populations sensitized for delayed-type hypersensitivity in mice.

    abstract：:Effects of pertussis toxin (PT) on sensitized T-cell populations for delayed-type hypersensitivity (DTH) were examined in mice. DTH was induced by sensitizing mice with ovalbumin (OA) and elicited by injecting OA into the footpad. DTH could be conferred on naive recipient mice by injecting sensitized spleen cells eith...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90249-1

    authors： Tamura SI,Nakanishi Y,Kojima A,Otokawa M,Uchida N,Sato H,Sato Y

    更新日期：1984-05-01 00:00:00

  • The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers.

    abstract：:Within the lymphoid compartment, CD8 is expressed either as an alphaalpha homodimer or as an alphabeta heterodimer. Prior functional characterization of CD8alpha transfectants has demonstrated that CD8alphaalpha homodimers can reconstitute T cell responses in the absence of the CD8beta subunit. In order to now examine...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1998.1412

    authors： Witte T,Spoerl R,Chang HC

    更新日期：1999-02-01 00:00:00

  • IL-6 rescues the hyporesponsiveness of c-Rel deficient B cells independent of Bcl-xL, Mcl-1, and Bcl-2.

    abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/s0008-8749(02)00513-0

    authors： Tumang JR,Hsia CY,Tian W,Bromberg JF,Liou HC

    更新日期：2002-05-01 00:00:00

  • Role of bacterial components in macrophage activation by the LAC and MW2 strains of community-associated, methicillin-resistant Staphylococcus aureus.

    abstract：:We tested the contribution of four staphylococcal components - PSM-α, PSM-β, δ-toxin, and PVL - in triggering macrophage secretion of tumor necrosis factor (TNF) and interleukins 6 (IL-6) and 12 (IL-12) by two prominent, circulating strains of community-associated, methicillin-resistant Staphylococcus aureus (CA-MRSA)...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.03.009

    authors： Spentzas T,Kudumula R,Acuna C,Talati AJ,Ingram KC,Savorgnan F,Meals EA,English BK

    更新日期：2011-01-01 00:00:00

  • Cytotoxic effectors in human peripheral blood mononuclear cells induced by a mannoprotein complex of Candida albicans: a comparison with interleukin 2-activated killer cells.

    abstract：:In this study, the major histocompatibility complex-unrestricted cytotoxic effectors elicited in human peripheral blood mononuclear cells (PBMC) by a mannoprotein (MP) component from the cell wall of the human indigenous microorganism Candida albicans have been compared with those obtained by stimulation with interleu...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90033-6

    authors： Ausiello CM,Palma C,Spagnoli GC,Piazza A,Casciani CU,Cassone A

    更新日期：1989-07-01 00:00:00

  • Selective modulation of IFN-gamma mRNA stability by IL-12/NKSF.

    abstract：:We investigated the role of IL-12 in regulating IL-2 and IFN-gamma production in primary culture of human T cells. Addition of neutralizing antiserum against the 40-kDa subunit of IL-12 to PHA-stimulated PBMC markedly reduced both IFN-gamma protein production and mRNA accumulation and stability. Moreover, concurrent t...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1303

    authors： Nagy E,Buhlmann JE,Henics T,Waugh M,Rigby WF

    更新日期：1994-12-01 00:00:00

  • Effect of CD95 on inflammatory response in rheumatoid arthritis fibroblast-like synoviocytes.

    abstract：OBJECTIVE:Many CD95-expressing cells don't always undergo apoptosis after stimulation with CD95 ligation. The purpose of this paper is to investigate the role of expression of CD95 (Fas/Apo1) on inflammatory response in fibroblast-like synoviocytes (FLS) obtained from rheumatoid arthritis (RA) and to evaluate the role ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2014.07.004

    authors： Li X,Zhang Z,Peng A,He M,Xu J,Shen S,Zhuang J,Huang X

    更新日期：2014-08-01 00:00:00

  • Inhibition by anti-CD2 monoclonal antibodies of anti-CD3-induced T cell-dependent B cell activation.

    abstract：:Anti-CD3 mAb can activate T cells to help in B cell activation as detected by late events, such as maturation of B cells into Ig-secreting cells (IgSC), or by early events, such as B cell surface expression of the activation marker CD23. Two different anti-CD2 mAb each inhibited anti-CD3-induced T cell-dependent B cel...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90269-w

    authors： Stohl W,Crow MK

    更新日期：1990-10-15 00:00:00

  • Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis.

    abstract：:Phagocytosis of pathogens by macrophages is crucial for the successful resolution of inflammation induced by microbial infection. Taurine chloramine (TauCl), an endogenous anti-inflammatory and antioxidative substance, is produced by reaction between taurine and hypochlorous acid by myeloperoxidase activity in neutrop...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.02.003

    authors： Kim W,Kim SH,Jang JH,Kim C,Kim K,Suh YG,Joe Y,Chung HT,Cha YN,Surh YJ

    更新日期：2018-05-01 00:00:00

  • Accessory cell requirements for saponin adjuvant-induced class I MHC antigen-restricted cytotoxic T-lymphocytes.

    abstract：:The in vivo and in vitro accessory cell requirements of class I major histocompatability complex (MHC) antigen-restricted cytotoxic T-lymphocyte (CTL) responses were determined using cell-depletion experiments coupled with active immunizations using ovalbumin (OVA) as the immunogen and saponin adjuvant (QS-21). To par...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1086

    authors： Wu JY,Gardner BH,Kushner NN,Pozzi LA,Kensil CR,Cloutier PA,Coughlin RT,Newman MJ

    更新日期：1994-04-01 00:00:00

  • On the molecular basis of T-helper-cell function. IV. B-lymphocyte-promotor factors: on their mode of action, biochemical nature and possible relationship to molecules involved in specific T-helper-cell activity.

    abstract：:Some further aspects of B-lymphocyte-promotor factor (B-LPF) activity have been studied. This activity was present in the supernatants of certain helper-T-cell lines, and it induced polyclonal activation of Ig+ B cells into Ig-secreting cells. It was found that B-LPF induced polyclonal, terminal B-cell differentiation...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90067-x

    authors： Reininger L,Fueri J,Boned A,Prat M,Landolfo S,Rubin B

    更新日期：1985-04-15 00:00:00

  • Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice.

    abstract：:We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2004.04.001

    authors： Sun D,Krishnan A,Su J,Lawrence R,Zaman K,Fernandes G

    更新日期：2004-03-01 00:00:00

  • Function and behavior of surface immunoglobulin receptors in antigen-specific T cell-B cell interaction.

    abstract：:The expression and function of surface immunoglobulin (sIg) receptors was analyzed using antigen-specific monoclonal B cells and T cells. When B cells were incubated with antigen (hapten carrier), hapten-specific sIg receptor expression was greatly reduced. The specific antigen-presentation activity of the B cells was...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90291-2

    authors： Watanabe M,Watts TH,Gariepy J,Hozumi N

    更新日期：1988-03-01 00:00:00

  • Frequent inoculations with radiation attenuated sporozoite is essential for inducing sterile protection that correlates with a threshold level of Plasmodia liver-stage specific CD8+ T cells.

    abstract：:Whole sporozoite vaccine (WSV) is shown to induce sterile protection that targets Plasmodium liver-stage infection. There are many underlying issues associated with induction of effective sterile protracted protection. In this study, we have addressed how the alterations in successive vaccine regimen could possibly af...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2017.05.001

    authors： Patel H,Yadav N,Parmar R,Patel S,Singh AP,Shrivastava N,Dalai SK

    更新日期：2017-07-01 00:00:00

  • Impact of polyunsaturated fatty acids on cytoskeletal linkage of L-selectin.

    abstract：:Polyunsaturated fatty acid [omega-3 polyunsaturated fatty acids (omega-3PUFAs)] incorporation into cell membranes has been shown to have potent anti-inflammatory activity, though the mechanisms involved are only partially characterized. Here, we show that PUFA enrichment of T cell membranes decreased the overall expre...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2004.04.004

    authors： Leid JG,Jutila MA

    更新日期：2004-04-01 00:00:00

  • In vitro production of antigen-specific T cells from unprimed mice: role of dexamethasone and anti-IL-10 antibodies.

    abstract：:We describe here a culture system for studying the development, in vitro, of antigen-specific CD4 T cells from unprimed mice. T cells from young mice are initially exposed to antigen, such as pigeon cytochrome C or keyhole limpet hemocyanin, in the presence of adherent accessory cells and then allowed to proliferate i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1997.1134

    authors： Dozmorov I,Miller RA

    更新日期：1997-06-15 00:00:00

  • CD8+ T cells lyse autologous monocytes in the presence of anti-CD3 monoclonal antibody: association with interleukin-1 production.

    abstract：:Human peripheral blood T cells lysed autologous or allogeneic monocytes, but not polymorphonuclear cells (PMN) or lymphocytes, in the presence of anti-CD3 (OKT3 (IgG2a) or anti-Leu 4 (IgG1)) monoclonal antibody (mAb). Other mAbs such as OKT4 (IgG2b), OKT8 (IgG2a), OKT11 (IgG2a), and OKM1 (IgG2a) did not mediate lysis ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90320-6

    authors： Itoh K,Balch CM,Trial J,Platsoucas CD

    更新日期：1988-07-01 00:00:00

  • Inhibition of experimental autoimmune thyroiditis in mice by anti-I-A antibodies.

    abstract：:Experimental autoimmune thyroiditis is induced in mice by immunization with thyroglobulin emulsified in Freund's complete adjuvant. The disease is characterized both by thyroid infiltration with mononuclear cells and by circulating thyroglobulin antibodies. The magnitude of the thyroid infiltration and the titer of th...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90302-9

    authors： Vladutiu AO,Steinman L

    更新日期：1987-10-01 00:00:00

  • Inhibition of proinflammatory macrophage responses and lymphocyte proliferation in vitro by ethyl acetate leaf extract from Daphne gnidium.

    abstract：:Medicinal plants are considered immunomodulatory as they display various biological activities. There is no report addressing the anti-inflammatory effects of Daphne gnidium. In this study, we investigated the effects of D. gnidium ethyl acetate (EA) leaf extract on mice immune cell function in vitro. Production of pr...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2010.12.002

    authors： Harizi H,Chaabane F,Ghedira K,Chekir-Ghedira L

    更新日期：2011-01-01 00:00:00

  • TPA induction of EL4 resistance to macrophage-released TNF: role of ADP-ribosylation in tumoricidal activities of TNF and other factors.

    abstract：:Activated macrophages synthesize and release numerous tumoricidal soluble factors that can be divided into receptor- or nonreceptor-dependent agents. Tumor necrosis factor (TNF) would be an example of the former. In our experimental model the killing of EL4 thymoma cells by syngeneic activated macrophages involves, bu...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90116-9

    authors： Fishman M,Essani N,Costlow M

    更新日期：1990-04-15 00:00:00

  • Immature CD4- CD8+ murine thymocytes.

    abstract：:Mature thymocytes are usually defined and separated from other less mature thymocytes on the basis of their mutually exclusive expression of either CD4 or CD8. However, such murine "single positives" include a subpopulation of immature cells with properties resembling CD4- CD8- thymocytes or CD4+ CD8+ cortical blasts....

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90042-1

    authors： Shortman K,Wilson A,Egerton M,Pearse M,Scollay R

    更新日期：1988-05-01 00:00:00