当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Transfer of endogenous retroviral superantigen from donor to recipient B cells following priming to induce peripheral T cell tolerance.

Transfer of endogenous retroviral superantigen from donor to recipient B cells following priming to induce peripheral T cell tolerance.

Abstract：

:Endogenous retroviral superantigens such as vSAG-7 are highly stimulatory for T cells through interaction with the T cell receptor on the basis of V beta usage. Priming of adult MMTV 7-negative mice with vSAG-7-expressing cells has been shown to result in peripheral V beta 6/CD4+ T cell activation followed by tolerance to further interaction with the superantigen. The goal of the current study was to examine the cells presenting vSAG-7 during this initial burst of in vivo T cell activation. Priming of MMTV 7-negative BALB/c (H-2d) mice with DBA/2 (H-2d, MMTV 7+) spleen cells resulted in a 5- to 12-fold increase in the number of B cells in the lymph nodes. These B cells expressed increased levels of I-A and I-E class II MHC determinants. Use of MMTV 7-negative CB.17 (H-2d, Ighb) mice as recipients of DBA/2 (Igha) cells indicated that the increased number of B cells was of host, rather than donor, origin. The number of donor-derived (IgM/B220+) B cells observed during the course of vSAG-7-reactive V beta 6/CD4+ T cell activation was very low. Proliferation of unprimed T cells from MMTV 7-negative mice was induced during coculture with B cells from the lymph nodes of vSAG-7-primed recipients and was blocked by anti-class II MHC antibodies, as well as by an anti-vSAG-7 antibody. Highly purified host B cells from vSAG-7-primed recipients specifically stimulated the blastogenesis of V beta 6/CD4+ T cells in vitro. Collectively, the results indicate that following priming to induce peripheral tolerance, vSAG-7 is transferred from donor cells to class II MHC determinants on recipient B cells and is presented to the T cell repertoire by the autologous B cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Modlin CS,Todd GT,Cohen TD,Fairchild RL

doi

10.1006/cimm.1995.1164

subject

Has Abstract

pub_date

1995-09-01 00:00:00

pages

217-26

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(85)71164-1

journal_volume

164

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Functional role of self IA molecules in polyclonal B cell activation using an autoreactive B cell clone derived from (NZB X NZW) F1 mice.

    abstract：:The mechanism of polyclonal B cell activation in autoimmune diseases was investigated by using an autoreactive B cell clone established by somatic hybridization with B cells derived from NZB X NZW (B/W) F1 mice. Briefly, splenic B cells from B/W F1 mice were fused with M12.4.1, a mutant of a B cell line, in the presen...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90080-9

    authors： Iwasaki T,Hamano T,Hase K,Murata Y,Yamasaki T,Kakishita E

    更新日期：1992-02-01 00:00:00

  • Antibody-induced suppression and postsuppression stimulation of complement in vitro. III. Long-term C4 suppression is actively maintained by a soluble suppressor factor (FsC4).

    abstract：:Previous work in our laboratory established that individual complement components can be regulated in vivo by administration of specific antibody or immunocompetent cells to newborns and in vitro by administration of specific antibody to cultured peritoneal macrophages or splenic fragments. Antibody-induced suppressio...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90337-5

    authors： Goldman JN,O'Rourke KS,Goldman MB

    更新日期：1985-11-01 00:00:00

  • Anti-TNF-α therapy improves Treg and suppresses Teff in patients with rheumatoid arthritis.

    abstract：:Anti-TNF-α therapies have been applied in RA treatment, but the regulatory effect of the drug on immune system is not clear. In this study, we included 33 active RA patients and divided them into two groups. One group received anti-TNF-α mAb+methotrexate for 24 weeks, the other group got placebo+methotrexate for the f...

    journal_title：Cellular immunology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.cellimm.2012.09.001

    authors： Huang Z,Yang B,Shi Y,Cai B,Li Y,Feng W,Fu Y,Luo L,Wang L

    更新日期：2012-09-01 00:00:00

  • A comparison of the effects of human rIL-2 and autologous TCGF on Xenopus laevis splenocytes in vitro.

    abstract：:Prior studies have shown that intraperitoneal (ip) injection of 25 IU of human rIL-2 can effectively modulate in vivo immune reactivity to thymus-dependent and thymus-independent type 2 immunogens in Xenopus laevis, the South African clawed toad, but is less successful at affecting toad cells in vitro. Here we compare...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1224

    authors： Ruben LN,Rak JC,Johnson RO,Shiigi S,Clothier RH

    更新日期：1994-08-01 00:00:00

  • CD69-induced monocyte apoptosis involves multiple nonredundant signaling pathways.

    abstract：:Simultaneous stimulation of human monocytes/macrophages or THP1 cells with LPS and an antibody specific for the activation marker CD69 induces apoptosis. Here we demonstrate the involvement of multiple independent signals that are necessary for apoptosis induction. Thus, inhibitors of phospholipase A2 and lipoxygenase...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1996.0232

    authors： Ramírez R,Carracedo J,Castedo M,Zamzami N,Kroemer G

    更新日期：1996-09-15 00:00:00

  • The role of suppressor factors in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes. II. Activity of suppressor cell culture sonicates.

    abstract：:The purpose of this study was to determine whether multiple types of suppressor factors play a role in the regulation of immune responses by ultraviolet radiation-induced suppressor T lymphocytes (UV Ts). The UV Ts were induced by applying contact allergens to the ventral, unirradiated skin of mice exposed 5 days earl...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90007-5

    authors： Yee GK,Ullrich SE,Kripke ML

    更新日期：1989-06-01 00:00:00

  • T lymphocytes and neutrophil granulocytes differ in regulatory signaling and migratory dynamics with regard to spontaneous locomotion and chemotaxis.

    abstract：:Chemotactic migration of T lymphocytes and neutrophil granulocytes within a three-dimensional collagen matrix is distinct from spontaneous, matrix-induced migration concerning dynamic parameters and regulatory intracellular signaling. Both spontaneous T lymphocyte locomotion and stromal-cell-derived factor-1 (SDF-1)-i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1605

    authors： Entschladen F,Gunzer M,Scheuffele CM,Niggemann B,Zänker KS

    更新日期：2000-02-01 00:00:00

  • Regulation of human natural killer cell migration and proliferation by the exodus subfamily of CC chemokines.

    abstract：:Natural killer (NK) cells play an important role in innate and adaptive immune responses to obligate intracellular pathogens. Nevertheless, the regulation of NK cell trafficking and migration to inflammatory sites is poorly understood. Exodus-1/MIP-3alpha/LARC, Exodus-2/6Ckine/SLC, and Exodus-3/MIP-3beta/ELC/CKbeta-11...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1601

    authors： Robertson MJ,Williams BT,Christopherson K 2nd,Brahmi Z,Hromas R

    更新日期：2000-01-10 00:00:00

  • CD8+CD38+ and CD8+DR+ peripheral blood lymphoid subsets of HIV-infected intravenous drug abusers correlate with CD4+ cell counts and proliferation to mitogens.

    abstract：:Twenty-nine intravenous drug abusers (ivda), with asymptomatic HIV infection at entry, were sequentially studied at 4- to 6-month intervals for variable follow-up periods (mean, 19.6 months). Two of them progressed to AIDS and another one fell into the IV-C2 stage of the CDC classification at the end of the study. CD8...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1179

    authors： Echaniz P,Arrizabalaga J,Iribarren JA,Cuadrado E

    更新日期：1993-08-01 00:00:00

  • Microglia exhibit clonal variability in eliciting cytotoxic T lymphocyte responses independent of class I expression.

    abstract：:Microglia are important immunoregulatory cells within the central nervous system (CNS). Viral infection of primary microglia and splenic macrophage clones revealed that both exhibited a heterogeneous, but relatively low, sensitivity to cytolysis mediated by CD8(+) cytotoxic T lymphocytes (CTL). The majority of clones ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1581

    authors： Bergmann CC,Yao Q,Stohlman SA

    更新日期：1999-11-25 00:00:00

  • Haplotype-specific inhibition of homing of radiolabeled lymphocytes in experimental allergic encephalomyelitis following treatment with anti-IA antibodies.

    abstract：:In vivo treatment with anti-IA antibodies has been shown to induce a haplotype-specific inhibition of EAE when the disease was following passive transfer of MBP-sensitized T cells. In order to determine the mechanism by which anti-IA antibody prevents passively transferred EAE, the homing of radiolabeled cells to the ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90267-f

    authors： Sriram S,Carroll L

    更新日期：1991-06-01 00:00:00

  • On the molecular basis of T-helper-cell function. IV. B-lymphocyte-promotor factors: on their mode of action, biochemical nature and possible relationship to molecules involved in specific T-helper-cell activity.

    abstract：:Some further aspects of B-lymphocyte-promotor factor (B-LPF) activity have been studied. This activity was present in the supernatants of certain helper-T-cell lines, and it induced polyclonal activation of Ig+ B cells into Ig-secreting cells. It was found that B-LPF induced polyclonal, terminal B-cell differentiation...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90067-x

    authors： Reininger L,Fueri J,Boned A,Prat M,Landolfo S,Rubin B

    更新日期：1985-04-15 00:00:00

  • Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2.

    abstract：:Interleukin (IL)-4 has been shown to be secreted simultaneously with IL-2 and interferon (IFN)-gamma by the majority of CD4+ human T cell clones isolated and cultured using IL-2 as a growth factor. Moreover, IL-4 was found to be as efficient as IL-2 to promote the outgrowth of human T cell clones. In this study we hav...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90283-h

    authors： Paliard X,de Vries JE,Spits H

    更新日期：1991-07-01 00:00:00

  • B cells and antibodies in the pathogenesis of myelin injury in Semliki Forest Virus encephalomyelitis.

    abstract：:To determine the contribution of B cells to brain myelin injury in Semliki Forest Virus (SFV) encephalomyelitis, normal C57BL/6 (B6) and B-cell-deficient (C57BL/6-tm1Cgn) B6 mice were infected with SFV. The peak of clinical disease, i.e., the time at which the greatest proportions of mice had moderate to severe clinic...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.2000.1613

    authors： Smith-Norowitz TA,Sobel RA,Mokhtarian F

    更新日期：2000-02-25 00:00:00

  • Solid nanoemulsion as antigen and immunopotentiator carrier for transcutaneous immunization.

    abstract：:Imiquimod, a toll-like receptor 7 (TLR7) agonist, is an active pharmaceutical ingredient (API) established for the topical treatment of several dermal cancerous and precancerous skin lesions. Within this work, the immunostimulatory effect of imiquimod is further exploited in a transcutaneous immunization (TCI) approac...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2016.06.001

    authors： Gogoll K,Stein P,Lee KD,Arnold P,Peters T,Schild H,Radsak M,Langguth P

    更新日期：2016-10-01 00:00:00

  • GF109203X, a specific PKC inhibitor, abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells.

    abstract：:Antigen-independent adhesion of CD4+ T lymphocytes to Epstein-Barr virus transformed B cells is mainly mediated by LFA-1 (CD11a/CD18) and CD2 molecules. Low-affinity binding of resting T cells can be transiently upregulated by cross-linking of CD3-TCR (T cell receptor) complexes. This inside-out signaling influences i...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1211

    authors： Hauss P,Mazerolles F,Hivroz C,Lecomte O,Barbat C,Fischer A

    更新日期：1993-09-01 00:00:00

  • Evaluation of metabolic and immunological changes in streptozotocin-nicotinamide induced diabetic rats.

    abstract：:Type 2 diabetes is a chronic disease with growing public health concern globally. Finding remedies to assist this health issue requires recruiting appropriate animal model for experimental studies. This study was designated to evaluate metabolic and immunologic changes in streptozotocin-nicotinamide induced diabetic r...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2014.04.004

    authors： Mojani MS,Sarmadi VH,Vellasamy S,Sandrasaigaran P,Rahmat A,Peng LS,Ramasamy R

    更新日期：2014-05-01 00:00:00

  • Maternal HEL immunization has no lasting effects on the immune response of offspring to immunization with hen egg-white lysozyme.

    abstract：:The effect of prior maternal immunization on the murine offspring response to subsequent immunization with hen egg-white lysozyme was examined. Adult female A/J mice were immunized with 100 micrograms HEL-CFA intraperitoneally 10-27 weeks before conception. The offspring of these experimental female mice were then imm...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1123

    authors： Jelonek MT,Brust JL,Song CH,Calandra GB,Miller A,Sercarz EE,Keller MA

    更新日期：1993-05-01 00:00:00

  • Analysis of expression of lymphocyte homing-related adhesion molecules in ALY mice deficient in lymph nodes and Peyer's patches.

    abstract：:The aly, alymphoplasia, is an autosomal recessive mutation in mice of an unknown etiology, which induces total aplasia of lymph nodes and Peyer's patches. We hypothesized that the lack of lymphoid tissue may be due to abnormalities of lymphocyte traffic into these tissues. Therefore, we analyzed the expression of vari...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1997.1177

    authors： Koike R,Watanabe T,Satoh H,Hee CS,Kitada K,Kuramoto T,Serikawa T,Miyawaki S,Miyasaka M

    更新日期：1997-08-25 00:00:00

  • Antigenic phenotype of TdT-positive cells in human peripheral blood.

    abstract：:Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility co...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90223-0

    authors： Bradstock KF,Kerr A,Bollum FJ

    更新日期：1985-02-01 00:00:00

  • Stimulation of murine B cells by the combination of calcium ionophore plus phorbol ester.

    abstract：:The ability of calcium ionophore and phorbol ester to stimulate entry into S phase was assessed during short-term cultures of murine B cells extensively depleted of T cells. Neither ionomycin alone nor PMA alone stimulated DNA synthesis. However, the combination of ionomycin plus PMA acted in synergy to induce initiat...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(86)90430-2

    authors： Rothstein TL,Baeker TR,Miller RA,Kolber DL

    更新日期：1986-10-15 00:00:00

  • Activin A down-regulates the phagocytosis of lipopolysaccharide-activated mouse peritoneal macrophages in vitro and in vivo.

    abstract：:Activin A is a multifunctional factor of the transforming growth factor-beta (TGF-beta) superfamily and acts as an anti-inflammatory cytokine produced by microglia and macrophages. In this study, we investigated the regulatory effect and possible mechanism of activin A on activation of lipopolysaccharide (LPS)-induced...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.11.001

    authors： Zhou J,Tai G,Liu H,Ge J,Feng Y,Chen F,Yu F,Liu Z

    更新日期：2009-01-01 00:00:00

  • Interferon-gamma receptor polymorphisms determine strain differences in accessibility of activated lymphocyte NK-triggering antigens to recognition by self-reactive NK cells.

    abstract：:The "NK-triggering-antigen regulator" (Nktar) gene is a locus identified in the C57BL/6 genome which regulates the ability of unlabeled activated Con A blasts to compete for recognition of labeled syngeneic Con A blasts by BALB/c NK cells. Linkage analysis on Con A blasts from (BALB/c x CByB6F1) N2 backcross progeny f...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1624

    authors： Chou SR,Brownell A,Ko MS,Kaplan J

    更新日期：2000-03-15 00:00:00

  • Calreticulin acts as an adjuvant to promote dendritic cell maturation and enhances antigen-specific cytotoxic T lymphocyte responses against non-small cell lung cancer cells.

    abstract：:Dendritic cell (DC)-based immunotherapy has promising for treatment of non-small cell lung cancer (NSCLC). Melanoma-associated antigen 3 (MAGE-A3) is a tumor-specific antigen and expressed in approximately 35-40% of NSCLC tissues. Calreticulin (CALR) is a protein chaperone and can enhance DC maturation and antigen pre...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2015.12.003

    authors： Liu X,Li J,Liu Y,Ding J,Tong Z,Liu Y,Zhou Y,Liu Y

    更新日期：2016-02-01 00:00:00

  • Evidence for protein tyrosine kinase involvement in CD6-induced T cell proliferation.

    abstract：:Several studies have demonstrated that addition of soluble anti-CD6 mAbs to 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated naive T cells can induce cell proliferation. We showed in the present study that cell proliferation in TPA-treated T cell cultures can be enhanced several fold when the anti-CD6 mAbs are eithe...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1995.0006

    authors： Osorio LM,Ordonez C,Garcia CA,Jondal M,Chow SC

    更新日期：1995-11-01 00:00:00

  • Human thymus-independent antibody response in vitro: III. Precursor frequencies and fine specificity of human B cells stimulated by TNP-Ba in the presence and absence of Con A.

    abstract：:Previously, we reported that human B lymphocytes can be stimulated by trinitrophenylated Brucella abortus (TNP-Ba) in vitro to generate T-independent (TI) hapten specific plaque-forming cells (PFC). Furthermore we showed that addition of Con A on Day 3 of culture enhanced the anti-TNP response. In this report the char...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90245-4

    authors： Golding B,Rittenberg MB

    更新日期：1984-05-01 00:00:00

  • Characterisation of monoclonal antibodies to the TNF and TNF receptor families.

    abstract：:Tumour necrosis factor (TNF) family ligands and their corresponding receptors play important roles in the immune system and are involved in immune regulation such as lymphoid development, cell proliferation, differentiation, activation and death. Antibodies against these ligands and receptors together with Fc-fusion p...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2005.08.010

    authors： Ch'en PF,Xu XG,Liu XS,Liu Y,Song CJ,Screaton GR,Jin BQ,Xu XN

    更新日期：2005-07-01 00:00:00

  • Serological and biological cross-reactivity of class II antigens between mice and humans in antigen-specific T-cell proliferative responses.

    abstract：:Many studies have already been reported with regard to the serological cross-reactivities between the polymorphic determinants of murine Ia antigens and human HLA-DR antigens. In this paper, we examined the biological cross-reactivity of the polymorphism of Class II antigens in the xenogeneic antigen-presenting cell (...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90033-9

    authors： Yamamoto M,Yano A

    更新日期：1984-09-01 00:00:00

  • Sequential analysis of experimental autoimmune thyroiditis induced by neonatal thymectomy in the Buffalo strain rat.

    abstract：:We have studied the evolution of thyroiditis induced by neonatal thymectomy in Buffalo strain rats, with particular emphasis on the thyroid lymphocytic infiltrate. The earliest change was increased endothelial Ia expression, and infiltration of the thyroid at 5 weeks by ED1- and ED2-positive macrophages and B and T ce...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90260-2

    authors： Cohen SB,Dijkstra CD,Weetman AP

    更新日期：1988-06-01 00:00:00

  • A recombinant fusion protein displaying murine and human MHC class I- and II-specific epitopes protects against Leishmania amazonensis infection.

    abstract：:Tegumentary leishmaniasis (TL) constitutes a major public health problem with significant morbidity worldwide. Synthetic peptide-based vaccines are attractive candidates to protect against leishmaniasis, since T cell-specific epitopes can be delivery to antigen-presenting cells, leading to the generation of a Th1 cell...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2016.12.008

    authors： Martins VT,Lage DP,Duarte MC,Carvalho AM,Costa LE,Mendes TA,Vale DL,Menezes-Souza D,Roatt BM,Tavares CA,Soto M,Coelho EA

    更新日期：2017-03-01 00:00:00