Nonrestricted cytotoxicity mediated by interleukin 2-expanded leukocytes is inhibited by anti-LFA-1 monoclonal antibodies (MoAb) but potentiated by anti-CD3 MoAb.

abstract：:Tegumentary leishmaniasis (TL) constitutes a major public health problem with significant morbidity worldwide. Synthetic peptide-based vaccines are attractive candidates to protect against leishmaniasis, since T cell-specific epitopes can be delivery to antigen-presenting cells, leading to the generation of a Th1 cell...

journal_title：Cellular immunology

authors： Martins VT,Lage DP,Duarte MC,Carvalho AM,Costa LE,Mendes TA,Vale DL,Menezes-Souza D,Roatt BM,Tavares CA,Soto M,Coelho EA

更新日期：2017-03-01 00:00:00

abstract：:Many studies have shown that tumor necrosis factor (TNF) is a potent soluble mediator of immunoregulation and inflammation. Neuropeptide substance P (SP) has been known to exert significant influence on production of certain inflammatory cytokine by immune cells. Immunopathogenic mechanism underlying the effect of neu...

journal_title：Cellular immunology

authors： Nair MP,Schwartz SA

更新日期：1995-12-01 00:00:00

abstract：:Al adjuvants are used in vaccines to increase the immune response. NTPDase and AChE play a pivotal role and act in the regulation of the immune system. The effect of Al exposure in vitro and in vivo on NTPDase and AChE activities in the lymphocytes of rats was determined. In vitro, ATP hydrolysis was decreased by 20.4...

journal_title：Cellular immunology

authors： Kaizer RR,Gutierres JM,Schmatz R,Spanevello RM,Morsch VM,Schetinger MR,Rocha JB

更新日期：2010-01-01 00:00:00

abstract：:The regulatory mechanism of guinea pig lymphokines was investigated in regard to differentiation of myeloid cells to macrophages. The Ml-cell line, established from a myeloid leukemia of an SL-strain mouse, was induced to differentiate in vitro into mature macrophages possessing Fc receptors and the ability to phagocy...

journal_title：Cellular immunology

authors： Onozaki K,Akagawa KS,Haga S,Miura K,Hashimoto T,Tokunaga T

更新日期：1983-02-15 00:00:00

abstract：:The adoptive transfer of tumor-reactive T lymphocytes has recently been demonstrated to be an effective means for mediating the regression of experimental intracranial fibrosarcomas. In this study, mice bearing syngeneic intracranial GL261 gliomas were cured by the combination of sublethal whole body irradiation follo...

journal_title：Cellular immunology

authors： Plautz GE,Touhalisky JE,Shu S

更新日期：1997-06-15 00:00:00

abstract：:There are now several murine models of autoimmune cholangitis that have features both similar and distinct from human PBC. One such model, the NOD.c3c4 mouse, manifests portal cell infiltrates, anti-mitochondrial antibodies but also biliary cysts. The biliary cysts are not a component of PBC and not found in the other...

journal_title：Cellular immunology

authors： Moritoki Y,Tsuda M,Tsuneyama K,Zhang W,Yoshida K,Lian ZX,Yang GX,Ridgway WM,Wicker LS,Ansari AA,Gershwin ME

更新日期：2011-01-01 00:00:00

abstract：:Endogenous retroviral superantigens such as vSAG-7 are highly stimulatory for T cells through interaction with the T cell receptor on the basis of V beta usage. Priming of adult MMTV 7-negative mice with vSAG-7-expressing cells has been shown to result in peripheral V beta 6/CD4+ T cell activation followed by toleranc...

journal_title：Cellular immunology

authors： Modlin CS,Todd GT,Cohen TD,Fairchild RL

更新日期：1995-09-01 00:00:00

abstract：:Activated natural killer T (NKT) cells produce a broad range of cytokines, including IL-4 and IFN-gamma, that determine immunomodulatory functions in various animal models. In this report, we show that a well-known proinflammatory cytokine, IL-17 is also produced by a distinct population of NKT cells upon TCR stimulat...

journal_title：Cellular immunology

authors： Lee KA,Kang MH,Lee YS,Kim YJ,Kim DH,Ko HJ,Kang CY

更新日期：2008-01-01 00:00:00

abstract：AIMS:Evaluate the participation of IL-17 pathway in T1D pathogenesis. T helper 17 cells are potent, highly inflammatory cells that produce interleukin 17A (IL-17A), considered a mediator of various immune disorders. However, their role in Type 1 diabetes (T1D) pathogenesis in humans is not totally elucidated. METHODS:...

journal_title：Cellular immunology

authors： Fores JP,Crisostomo LG,Orii NM,Santos AS,Fukui RT,Matioli SR,de Moraes Vasconcelos D,Silva MERD

更新日期：2018-02-01 00:00:00

abstract：:We investigated the cellular induction mechanism of antigen-nonspecific CD8+ T suppressor cells which suppressed delayed-type hypersensitivity to sheep red blood cells, by treating BALB/c mice with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, and 12-O-tetradecanoylphorbol 13-acetate (TPA), a tumor promote...

journal_title：Cellular immunology

authors： Negoro T,Iinuma F,Watanabe M

更新日期：1996-02-01 00:00:00

abstract：:Numerous reports in the literature describe the effects of beta-adrenergic agonists and/or their second messenger cyclic AMP on in vitro and in vivo immune responses. The fact that the murine spleen receives rich adrenergic innervation and that the pharmacologic disruption of this innervation leads to altered immune r...

journal_title：Cellular immunology

authors： Fuchs BA,Campbell KS,Munson AE

更新日期：1988-12-01 00:00:00

abstract：:The incubation of murine splenocytes in recombinant interleukin 2 (IL-2) gives rise to both lymphokine-activated killer (LAK) cells capable of lysing fresh tumor cells and cells capable of mediating antibody-dependent cellular cytotoxicity (ADCC) in the presence of anti-H2 allosera. A similarity between these two IL-2...

journal_title：Cellular immunology

authors： Eisenthal A,Shiloni E,Rosenberg SA

更新日期：1988-09-01 00:00:00

abstract：:In view of the critical role played by bacillus Calmette-Guérin (BCG) in the development and functional activation of protective T cells against tuberculosis, it has become important to understand the mechanisms by which cytokines regulate BCG-mediated immune responses. There is evidence that cytokine-mediated suppres...

journal_title：Cellular immunology

authors： Méndez-Samperio P,Hernández-Garay M,García-Martínez E

更新日期：2000-06-15 00:00:00

abstract：:Vitamin D regulates homeostasis, anti-microbial response, and inflammation. The vitamin D receptors are expressed in the macrophages and other immune cells, regulating the transcription of many different genes, including those coding the anti-microbial peptides. One of the most severe complications of the SARS-CoV-2 i...

journal_title：Cellular immunology

authors： Kloc M,Ghobrial RM,Lipińska-Opałka A,Wawrzyniak A,Zdanowski R,Kalicki B,Kubiak JZ

更新日期：2021-02-01 00:00:00

abstract：:Enriched human B lymphocytes cocultivated with mouse L cells produced human leukocyte interferon (IFN-alpha) and shortly thereafter transferred antiviral activity to the recipient cells (99% inhibition of expected virus yield). In contrast, cocultivation of enriched T-cell populations with mouse L cells resulted in no...

journal_title：Cellular immunology

authors： Weigent DA,Langford MP,Stanton GJ,Blalock JE

更新日期：1984-09-01 00:00:00

abstract：:Here, we established CD4(+)αβTh1 clones specific for rat vascular smooth muscle antigen (VSMAg) that induced vasculitis lesions in the lungs of MRL/Mp-Fas(+/+) mice following adoptive transfer. Six different T cell clones, MV1b1 (Vβ1), MV1b4 (Vβ4), MV1b8.3 (Vβ8.3), MV1b61 (Vβ6), MV1b62 (Vβ6), and MV1b63 (Vβ6), were is...

journal_title：Cellular immunology

authors： Fujita Y,Fujii T,Shimizu H,Sato T,Nakamura T,Iwao H,Nakajima A,Miki M,Sakai T,Kawanami T,Tanaka M,Masaki Y,Fukushima T,Okazaki T,Umehara H,Mimori T

更新日期：2016-05-01 00:00:00

abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

journal_title：Cellular immunology

authors： Shen C,Zhang J,Xia L,Meng F,Xie W

更新日期：2007-05-01 00:00:00

abstract：:MicroRNAs (miRNAs) are aberrant in many human tumors which can be transferred to immune cells by tumor-derived exosomes. Dendritic cells (DCs) play an important role in activation of immune response. However, the effect of tumor-derived exosomes on toll-like receptor (TLR) in DCs remains unclear. We investigated the i...

journal_title：Cellular immunology

authors： Zhou M,Chen J,Zhou L,Chen W,Ding G,Cao L

更新日期：2014-11-01 00:00:00

abstract：:Peripheral blood large granular lymphocytes (LGL) expressing Leu 11 (CD16) antigen with potent natural killer cytotoxicity inhibited soluble antigen-induced T-cell production of interleukin 2 (IL-2). Depletion of Leu 11-reactive cells from T-cells doubled IL-2 activity (P less than 0.05). Leu 11-enriched cells did not...

journal_title：Cellular immunology

authors： Toossi Z,Paris MR,Purvis SF,Ellner JJ

更新日期：1989-02-01 00:00:00

abstract：:The activities of the enzymes involved in purine nucleoside metabolism, adenosine deaminase (ADA), adenosine kinase (AK), purine nucleoside phosphorylase (PNP) and deoxycytidine kinase (deoxyCRK), were determined in mouse thymocytes at various stages of differentiation and maturation, and compared with those in other ...

journal_title：Cellular immunology

authors： Kizaki H,Habu S,Ohsaka F,Sakurada T

更新日期：1983-12-01 00:00:00

abstract：:The alloreactive feature of CD4+ cytotoxic T-cell clone that could specifically lyse the cells bearing DPB1*0202 sequence was described. The clone was generated from a mixed culture of peripheral blood lymphocytes derived from siblings who were HLA-A, B, C, DR, and DQ identical by serological typing and whose DNA sequ...

journal_title：Cellular immunology

authors： Nishimura M,Mitsunaga S,Akaza T,Mitomi Y,Tadokoro K,Juji T

更新日期：1994-01-01 00:00:00

abstract：:This study was designed to investigate the regulatory role of soluble interleukin-6 receptor (sIL-6R) and interleukin-6 (IL-6) fusion protein (Hyper-IL-6) in the differentiation of human myeloid and erythroid progenitors by a serum-free liquid suspension culture system, using the human cord blood-derived CD34(+)CD38(-...

journal_title：Cellular immunology

authors： Yu Z,Liu W,Liu D,Fan L

更新日期：2006-05-01 00:00:00

abstract：:Agents that extract or sequester membrane cholesterol stimulate IkappaB degradation and lead to NF-kappaB activation in a subset of B cells. Although the extraction of cholesterol by methyl-beta-cyclodextrin is the most potent stimulus of NF-kappaB, other agents that sequester cholesterol have similar effects. B cells...

journal_title：Cellular immunology

authors： Flemming JA,Perkins KH,Luus L,Ferguson AR,Corley RB

更新日期：2004-05-01 00:00:00

abstract：:Interleukin-4 (IL-4) acts directly on purified human peripheral blood B cells cultured in the presence of Epstein-Barr virus (EBV) to induce IgE secretion and to enhance the secretion of IgG and IgM. Interferon-gamma (IFN-gamma) inhibits IgE secretion in this system, without affecting the secretion of the other Ig iso...

journal_title：Cellular immunology

authors： Thyphronitis G,Banchereau J,Heusser C,Tsokos GC,Levine AD,Finkelman FD

更新日期：1991-04-01 00:00:00

abstract：:We investigated the regulation of IL6 biological activity, de novo synthesis, and mRNA levels in adult vascular endothelial cells (EC) by bacterial endotoxin or inflammatory cytokines. Cells incubated without stimulus released scant IL6 activity. IFN gamma, IL2, or PDGF did not augment IL6 release from EC. LPS, lipid ...

journal_title：Cellular immunology

authors： Loppnow H,Libby P

更新日期：1989-09-01 00:00:00

abstract：:Twenty-seven different CD45 monoclonal antibodies (mAb) were assessed for their ability to block cytotoxicity of alloreactive CD4+ MHC class II-specific or CD8+ class I-specific human T cell clones (n = 3 and 5, respectively). Twelve of 27 blocked the former but only 1/27 the latter, although all 27 significantly inhi...

journal_title：Cellular immunology

authors： Pawelec G,Bühring HJ,Müller C

更新日期：1990-05-01 00:00:00

abstract：:Recognition of lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) activates two district proinflammatory signaling pathway and initiates LPS internalization. To investigate roles of LPS internalization, a traditionally regarded metabolic pathway for LPS, in regulation of these two pathways, three internalization ...

journal_title：Cellular immunology

authors： Wang Y,Yang Y,Liu X,Wang N,Cao H,Lu Y,Zhou H,Zheng J

更新日期：2012-01-01 00:00:00

abstract：:In vitro ultraviolet-B (UVB) irradiation of murine and rodent bone marrow cells prevents GVHD without compromising engraftment while inducing tolerance to donor-type allografts. In anticipation of clinical trials of UVB-modified bone marrow grafts, we studied the in vitro effects of UVB irradiation (50-300 J/m2) on hu...

journal_title：Cellular immunology

authors： Yaron I,Zakheim AR,Oluwole SF,Hardy MA

更新日期：1995-10-15 00:00:00

abstract：:Treatment of human blood mononuclear cells with nanomolar concentrations of phorbol 12,13-dibutyrate (P(Bu)2) induced their aggregation. The phenomenon was seen within a few minutes and reached its maximum manifestation after 20 min. At this time, 20-30% of unfractionated and nylon wool-passed mononuclear leukocytes w...

journal_title：Cellular immunology

authors： Patarroyo M,Biberfeld P,Klein E,Klein G

更新日期：1983-01-01 00:00:00

abstract：:Within the lymphoid compartment, CD8 is expressed either as an alphaalpha homodimer or as an alphabeta heterodimer. Prior functional characterization of CD8alpha transfectants has demonstrated that CD8alphaalpha homodimers can reconstitute T cell responses in the absence of the CD8beta subunit. In order to now examine...

journal_title：Cellular immunology

authors： Witte T,Spoerl R,Chang HC

更新日期：1999-02-01 00:00:00