当前位置： SCI文献检索 > CELLULAR IMMUNOLOGY期刊下所有文献 > Cellular induction mechanism of CD8+ suppressor T cells by DMBA and TPA: formation of CD4+ suppressor-inducer T cells.

Cellular induction mechanism of CD8+ suppressor T cells by DMBA and TPA: formation of CD4+ suppressor-inducer T cells.

Abstract：

:We investigated the cellular induction mechanism of antigen-nonspecific CD8+ T suppressor cells which suppressed delayed-type hypersensitivity to sheep red blood cells, by treating BALB/c mice with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, and 12-O-tetradecanoylphorbol 13-acetate (TPA), a tumor promoter. Macrophages were activated by painting with 400 nmol of DMBA on mice. And the macrophages plus TPA induced CD4+ T suppressor inducer cells in the mice spleens. These cells were efficient at inducing CD8+ T suppressor-effector cells. When 8 nmol of TPA was painted daily on mice for 3 days following the treatment with 400 nmol of DMBA, or when spleen cells from mice pretreated with 400 nmol of DMBA were cultured in 32 nmol/5 ml of TPA for 3 days, inducer cells were formed in the spleen. Both T suppressor-inducer cells and macrophages from mice treated with DMBA were shown to act with the formation of soluble factors, which may be different from IL-10.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Negoro T,Iinuma F,Watanabe M

doi

10.1006/cimm.1996.0029

subject

Has Abstract

pub_date

1996-02-01 00:00:00

pages

216-23

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(96)90029-5

journal_volume

167

pub_type

杂志文章

相关文献

CELLULAR IMMUNOLOGY文献大全
  • Tissue distribution and appearance in ontogeny of alpha/beta T cell receptor (TCR2) in chicken.

    abstract：:We have performed immunoperoxidase staining on cryostat tissue sections and immunofluorescence analysis on cell suspensions to identify cells expressing the alpha/beta T cell antigen receptor during ontogeny and adult life in chickens. We used the mouse monoclonal antibody, TCR2, which was previously shown to recogniz...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(90)90079-7

    authors： Vainio O,Lassila O,Cihak J,Lösch U,Houssaint E

    更新日期：1990-01-01 00:00:00

  • TLR3 agonist enhances CC chemokine ligand 20 production in IL-1β-stimulated human gingival fibroblasts.

    abstract：:Viruses are related to the etiology of periodontitis. However, the role of viruses on Th17 cells infiltration in periodontitis lesions is unknown. Therefore, we examined the effects of TLR3 ligand on CCL20, which is related to Th17 cells migration, production in human gingival fibroblasts (HGFs). Polyinosinic-polycyti...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2013.05.005

    authors： Hosokawa Y,Hosokawa I,Shindo S,Ozaki K,Matsuo T

    更新日期：2013-05-01 00:00:00

  • Clonotypic heterogeneity of Lewis rat T cells specific for the encephalitogenic 68-86 region of myelin basic protein.

    abstract：:Experimental autoimmune encephalomyelitis was induced in a Lewis rat by sensitization with synthetic peptide GP68-86, representing the 68-86 sequence of guinea pig myelin basic protein (GPMBP). To delineate T cell determinants of GP68-86, lymph node cells from this rat were activated in culture with GP68-86 and were f...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90099-3

    authors： Mannie MD,Paterson PY,U'Prichard DC,Thomas DW

    更新日期：1989-09-01 00:00:00

  • Anti-Fas antibody induces different types of cell death in the human histiocytic cell line, U937, and the human B cell line, B104: the role of single-strand DNA breaks and poly (ADP-ribosyl)ation in cell death.

    abstract：:We investigated the anti-Fas antibody-induced cell death in two different types of human cell lines, U937 and B104. IFN-gamma increased the surface expression of Fas antigen and susceptibility to anti-Fas Ab-induced cell death of B104 and U937 cells. Anti-Fas Ab-induced death of U937 and B104 cells required neither a ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1994.1016

    authors： Sumimoto S,Ishigami T,Horiguchi Y,Yonehara S,Kanazashi S,Heike T,Katamura K,Mayumi M

    更新日期：1994-01-01 00:00:00

  • Analysis of the K+ current in human CD4+ T lymphocytes in hypercholesterolemic state.

    abstract：:Atherosclerosis involves immune mechanisms: T lymphocytes are found in atherosclerotic plaques, suggesting their activation during atherogenesis. The predominant voltage-gated potassium channel of T cells, Kv1.3 is a key regulator of the Ca(2+)-dependent activation pathway. In the present experiments we studied the pr...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2013.01.004

    authors： Somodi S,Balajthy A,Szilágyi O,Pethő Z,Harangi M,Paragh G,Panyi G,Hajdu P

    更新日期：2013-01-01 00:00:00

  • Tissue macrophages as mediators of a healthy relationship with gut commensal microbiota.

    abstract：:Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for the host. The gastrointestinal tract (GI) harbors th...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2018.01.017

    authors： Nakagaki BN,Vieira AT,Rezende RM,David BA,Menezes GB

    更新日期：2018-08-01 00:00:00

  • Testosterone treatment of aged male mice improves some but not all aspects of age-associated increases in influenza severity.

    abstract：:The severity of influenza increases with age, with worse disease in aged males than females. Testosterone concentrations decline with age in males, which may impact influenza pathogenesis. Aged male mice were treated with testosterone or placebo and outcomes during influenza A virus (IAV) infection were compared with ...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2019.103988

    authors： Vom Steeg LG,Attreed SE,Zirkin B,Klein SL

    更新日期：2019-11-01 00:00:00

  • Antagonistic effect of Candida albicans and IFNγ on E-cadherin expression and production by human primary gingival epithelial cells.

    abstract：:Caused mainly by Candida albicans, oropharyngeal candidiasis is the most common oral complication associated with HIV disease worldwide. Host defenses against C. albicans essentially fall into two categories: specific immune mechanisms and local oral mucosal epithelial cell defenses. Since oral mucosa is the first lin...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2012.11.008

    authors： Rouabhia M,Semlali A,Audoy J,Chmielewski W

    更新日期：2012-11-01 00:00:00

  • Artificial antigen-presenting cells are superior to dendritic cells at inducing antigen-specific cytotoxic T lymphocytes.

    abstract：:Adoptive immunotherapy is a promising cancer treatment that entails infusion of immune cells manipulated to have antitumor specificity, in vitro. Antigen-specific cytotoxic T lymphocytes are the main executors of transformed cells during cancer immunotherapy. To induce antigen-specific cytotoxic T lymphocytes, we deve...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2018.10.002

    authors： Shao J,Xu Q,Su S,Wei J,Meng F,Chen F,Zhao Y,Du J,Zou Z,Qian X,Liu B

    更新日期：2018-12-01 00:00:00

  • Anti-allergic drug olopatadine suppresses murine contact hypersensitivity and downmodulates antigen-presenting ability of epidermal Langerhans cells.

    abstract：:Olopatadine hydrochloride is an H1-receptor-blocker but has other anti-allergic pharmacological potencies. We investigated whether olopatadine inhibits murine contact hypersensitivity, focussing on its modulatory action on epidermal Langerhans cells serving as antigen-presenting cells. While BALB/c mice were sensitize...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2003.08.002

    authors： Tokura Y,Kobayashi M,Ito T,Takahashi H,Matsubara A,Takigawa M

    更新日期：2003-07-01 00:00:00

  • Specific immune responses but not basal functions of B and T cells are impaired in aged mice.

    abstract：:Senescence is characterized by several alterations in the immune system. Such modifications can be found in lymphoid organs as well as in the cellular components of the immune system. Several reports have suggested that immune dysfunction can affect both T and B cells, but T cells have been shown to be more susceptibl...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2009.01.010

    authors： Speziali E,Santiago AF,Fernandes RM,Vaz NM,Menezes JS,Faria AM

    更新日期：2009-01-01 00:00:00

  • B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis.

    abstract：:There are now several murine models of autoimmune cholangitis that have features both similar and distinct from human PBC. One such model, the NOD.c3c4 mouse, manifests portal cell infiltrates, anti-mitochondrial antibodies but also biliary cysts. The biliary cysts are not a component of PBC and not found in the other...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2011.01.005

    authors： Moritoki Y,Tsuda M,Tsuneyama K,Zhang W,Yoshida K,Lian ZX,Yang GX,Ridgway WM,Wicker LS,Ansari AA,Gershwin ME

    更新日期：2011-01-01 00:00:00

  • Cytokine regulation of bone marrow natural suppressor cell activity in the suppression of lymphocyte function.

    abstract：:Natural suppressor (NS) cells, which nonspecifically suppress immune responses, are present in the spleen following exposure to radiation, chronic graft-versus-host disease, or cancer and in normal bone marrow. A model system is described which allows the study of cytokines activating and inhibiting NS cells, cytokine...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90158-l

    authors： Moore SC,Theus SA,Barnett JB,Soderberg LS

    更新日期：1992-05-01 00:00:00

  • Induction of FoxP3+CD4+CD25+ regulatory T cells by a bone marrow population distinct from plasmacytoid-DC.

    abstract：:Facilitating cells (FC) are bone marrow-derived cells that facilitate allogeneic hematopoietic stem cell (SC) engraftment and induce transplantation tolerance without causing graft vs. host disease. Although there is evidence for FC directing the development of FoxP3+CD4+CD25+ regulatory T cells, the specific FC subse...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.03.003

    authors： Taylor KN,Laszkowska M,Cohick E,Colson YL

    更新日期：2008-01-01 00:00:00

  • Accessory cell function in a Con A response: role of Ia and interleukin 1.

    abstract：:Accessory cell (A-cell) function in a Con A response was analyzed. Irradiated P388D1 cells efficiently induced a proliferative response to Con A of T cells purified from spleen cells, whereas paraformaldehyde-fixed P388D1 cells failed to serve as A cells. Although IL-1 containing culture supernatant (SN) of a macropha...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90169-9

    authors： Kohno K,Kakiuchi T,Takeuchi M,Taira S,Nariuchi H

    更新日期：1987-05-01 00:00:00

  • Ability of tolerized Th1 and Th2 clones to stimulate B cell activation and cell cycle progression.

    abstract：:Tolerant and nontolerant murine Th1 and Th2 clones, specific for human gamma-globulin (HGG), were compared for their ability to promote cell cycle entry and progression by B cells in vitro. When stimulated with HGG, nontolerant Th1 and Th2 clones induced similar increases in B cell membrane MHC class II levels--a phen...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(92)90264-p

    authors： Gilbert KM,Rothermel AL,Ernst DN,Hobbs MV,Weigle WO

    更新日期：1992-06-01 00:00:00

  • Mouse embryonic cells become susceptible to CTL lysis after midgestation.

    abstract：:The susceptibility of murine embryonic cells to CTL lysis has been assessed. Zona-free blastocysts were not lysed during 6 hr incubation with CTL sensitized against the embryonic genotype and remained capable of implantation and normal development in vivo as well as outgrowth in vitro. Freshly dissociated cells from p...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90037-2

    authors： Croy BA,Rossant J

    更新日期：1987-02-01 00:00:00

  • Th17 pathway in recent-onset autoimmune diabetes.

    abstract：AIMS:Evaluate the participation of IL-17 pathway in T1D pathogenesis. T helper 17 cells are potent, highly inflammatory cells that produce interleukin 17A (IL-17A), considered a mediator of various immune disorders. However, their role in Type 1 diabetes (T1D) pathogenesis in humans is not totally elucidated. METHODS:...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2017.11.005

    authors： Fores JP,Crisostomo LG,Orii NM,Santos AS,Fukui RT,Matioli SR,de Moraes Vasconcelos D,Silva MERD

    更新日期：2018-02-01 00:00:00

  • Characterization of a monoclonal antibody reactive with rabbit T lymphocytes and neutrophils.

    abstract：:An IgG1 monoclonal antibody, termed ACM-1, has been shown to react with rabbit T cells, but not Ig+ cells or macrophages. This antibody appears to recognize the same epitope as the previously described 9AE10 antibody and, together with 9AE10, has been used to obtain highly pure and fully functional T- and B-cell popul...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(84)90244-2

    authors： Chen Z,Metzger DW,Adler FL

    更新日期：1984-05-01 00:00:00

  • Expression of chemokine receptors on natural killer cells in HIV-infected individuals.

    abstract：:Chemokine receptors CCR5 and CXCR4 are of major importance in the pathogenesis of HIV-1 infection because they are co-receptors for human immunodeficiency virus (HIV) entry. We examined the frequency of CD3-CD56+CCR5+ and CD3-CD56+CXCR4+ in HIV-infected long-term slow progressors (SPs), HIV typical progressors (TPs) w...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2008.01.010

    authors： Jiang Y,Zhang Z,Diao Y,Jin X,Shi W,Geng W,Dai D,Zhang M,Han X,Liu J,Wang Y,Shang H

    更新日期：2008-01-01 00:00:00

  • Divergent effects of cyclosporine A on interferon- and mitogen-induced Ly-6A antigen suggest autocrine regulation of Ly-6A expression in activated T cells.

    abstract：:The murine Ly-6A cell surface antigen is normally present on a minor subset of mature T cells. This marker has been shown to become highly expressed on mitogen-activated T cells. We found that expression of Ly-6A is also markedly increased in resting T cells by incubation with IFN-alpha/beta or IFN-gamma. Here, we com...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(87)90083-9

    authors： Dumont FJ

    更新日期：1987-04-01 00:00:00

  • Induction of tumor antigen-specific cytotoxic T cell responses in naïve mice by latex microspheres-based artificial antigen-presenting cell constructs.

    abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/j.cellimm.2007.07.002

    authors： Shen C,Zhang J,Xia L,Meng F,Xie W

    更新日期：2007-05-01 00:00:00

  • New disease old vaccine: Is recombinant BCG vaccine an answer for COVID-19?

    abstract：:Mycobacterium bovis BCG, a live attenuated tuberculosis vaccine offers protection against disseminated TB in children. BCG exhibits heterologous protective effects against unrelated infections and reduces infant mortality due to non-mycobacterial infections. Recent reports have suggested that BCG vaccination might hav...

    journal_title：Cellular immunology

    pub_type： 杂志文章,评审

    doi：10.1016/j.cellimm.2020.104187

    authors： Gupta PK

    更新日期：2020-10-01 00:00:00

  • Immobilized staphylococcal enterotoxin A is sufficient to induce T cell proliferation.

    abstract：:We investigated the role of HLA-DR molecules in T cell stimulation by staphylococcal enterotoxin A (SEA). Previous results with immobilized purified HLA-DR preincubated with peptide showed that peptide-specific T cell clones were able to bind to and proliferate in response to purified HLA-DR/peptide complexes in the a...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1993.1255

    authors： Rust CJ,Koning F,van Schooten WC

    更新日期：1993-10-15 00:00:00

  • Soluble factors in tolerance and contact sensitivity to DNFB in mice. X. IL-2 is the activation signal mediating release of synthesized suppressor factor.

    abstract：:Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB). Recognition of DNP/class I MHC (signal one) s...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90187-g

    authors： Fairchild RL,Moorhead JW

    更新日期：1991-03-01 00:00:00

  • Evolution of alloantibodies and suppressor cells in allografted mice treated for passive enhancement.

    abstract：:The kinetics and quality of the alloimmune reaction were studied in CBA (H-2k) mice treated for passive enhancement of tumor allografts (Sa 1 indigenous of A/J (H-2a or H-2k/d) mice). Serum samples of treated animals were tested for their biological properties relevant to different antibody isotypes in vitro (hemagglu...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(85)90306-5

    authors： Duc HT,Kinsky RG,Monnot P,Voisin GA

    更新日期：1985-10-01 00:00:00

  • Comparison of lymphokine secretion and responsiveness of human T cell clones isolated in IL-4 and in IL-2.

    abstract：:Interleukin (IL)-4 has been shown to be secreted simultaneously with IL-2 and interferon (IFN)-gamma by the majority of CD4+ human T cell clones isolated and cultured using IL-2 as a growth factor. Moreover, IL-4 was found to be as efficient as IL-2 to promote the outgrowth of human T cell clones. In this study we hav...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(91)90283-h

    authors： Paliard X,de Vries JE,Spits H

    更新日期：1991-07-01 00:00:00

  • Cytotoxic properties of CD4(+) T-cell clones which lyse HLA class II negative autologous non-small-cell lung cancer cells.

    abstract：:In this report, a subset of CD4(+) cells which kills autologous HLA class I positive and HLA class II negative non-small-cell lung cancer (NSCLC) cells is described. Killing was performed both by direct cytolytic mechanisms and by apoptosis. The peculiar characteristic of these effectors was their capability of lysing...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1006/cimm.1999.1547

    authors： Semino C,Ferlazzo G,Ratto GB,Melioli G

    更新日期：1999-09-15 00:00:00

  • Properties of anti-Lyb-2-mediated B-cell activation and the relationship between Lyb-2 molecules and receptors for B-cell stimulatory factor-1 on murine B lymphocytes.

    abstract：:The murine B-cell differentiation antigen Lyb-2 has been shown to be involved in B-lymphocyte activation and has been postulated by some to be related to a receptor for B-cell stimulatory factor I (BSF-1) (H. Yakura et al., J. Immunol. 137, 1475, 1986). Here we have demonstrated that monoclonal antibody (mAB) to Lyb-2...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(88)90302-4

    authors： Subbarao B,Morris J,Baluyut AR

    更新日期：1988-04-01 00:00:00

  • Interferon-gamma-treated K562 target cells distinguish functional NK cells from lymphokine-activated killer (LAK) cells.

    abstract：:In vitro incubation of the erythroleukemic cell line K562 with interferon-gamma (IFN-gamma) renders these cells relatively resistant to natural killer (NK) cell lysis. However, such treatment does not alter their sensitivity to LAK cell lysis. Thus, the lytic susceptibility of interferon-gamma-treated K562 (I-K562) ce...

    journal_title：Cellular immunology

    pub_type： 杂志文章

    doi：10.1016/0008-8749(89)90376-6

    authors： Powell J,Stone J,Chan WC,Yang ZD,Leatherbury A,Sell KW,Wiktor-Jedrzejczak W,Ahmed-Ansari A

    更新日期：1989-02-01 00:00:00