Tissue distribution and appearance in ontogeny of alpha/beta T cell receptor (TCR2) in chicken.


:We have performed immunoperoxidase staining on cryostat tissue sections and immunofluorescence analysis on cell suspensions to identify cells expressing the alpha/beta T cell antigen receptor during ontogeny and adult life in chickens. We used the mouse monoclonal antibody, TCR2, which was previously shown to recognize the alpha/beta TCR in chickens. TCR2+ cells were observed in thymic cortex and medulla and in T-dependent areas of spleen, intestine, and cecal tonsils of young adult chickens. Some TCR2+ cells were found in the cortex of bursal follicles and in liver. The first TCR2+ cells appear in thymus on Day 13 of the embryonic life and it is only after hatching that TCR2+ cells begin to migrate to the periphery.


Cell Immunol


Cellular immunology


Vainio O,Lassila O,Cihak J,Lösch U,Houssaint E




Has Abstract


1990-01-01 00:00:00














  • Age-associated decline in IL-4 production by murine T lymphocytes in extended culture.

    abstract::Aging leads to an increase in the proportion of cells that have the surface phenotype (CD45RBlo, CD44hi) characteristic of memory T lymphocytes and also to a decline in both the production of IL-2 and the response to this lymphokine. Several groups have reported an increase, with age, in the secretion of IL-4 in short...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Li SP,Miller RA

    更新日期:1993-10-01 00:00:00

  • Interferon-gamma receptor polymorphisms determine strain differences in accessibility of activated lymphocyte NK-triggering antigens to recognition by self-reactive NK cells.

    abstract::The "NK-triggering-antigen regulator" (Nktar) gene is a locus identified in the C57BL/6 genome which regulates the ability of unlabeled activated Con A blasts to compete for recognition of labeled syngeneic Con A blasts by BALB/c NK cells. Linkage analysis on Con A blasts from (BALB/c x CByB6F1) N2 backcross progeny f...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Chou SR,Brownell A,Ko MS,Kaplan J

    更新日期:2000-03-15 00:00:00

  • Mouse embryonic cells become susceptible to CTL lysis after midgestation.

    abstract::The susceptibility of murine embryonic cells to CTL lysis has been assessed. Zona-free blastocysts were not lysed during 6 hr incubation with CTL sensitized against the embryonic genotype and remained capable of implantation and normal development in vivo as well as outgrowth in vitro. Freshly dissociated cells from p...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Croy BA,Rossant J

    更新日期:1987-02-01 00:00:00

  • Target-induced anergy of natural killer cytotoxic function is restricted to the NK-target conjugate subset.

    abstract::This study examined the characteristics of functional anergy of natural killer cells (NK) following their interaction with target cells. Purified NK cells were cocultured with K562 for 15 min or 4 hr to allow for binding of targets to NK cells. The resulting NK-target conjugates were then dissociated by EDTA, and the ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Jewett A,Bonavida B

    更新日期:1995-01-01 00:00:00

  • TNF-alpha and IFN-gamma reverse IL-4 inhibition of lymphokine-activated killer cell function.

    abstract::Recombinant IL-4 inhibits IL-2-induced lymphokine-activated killer (LAK) cell development of PBMC. We evaluated the effect of various cytokines in reversing IL-4-mediated LAK inhibition. PBMC were cultured in IL-2 (10-1000 u/ml) with or without IL-4 (2-100 u/ml) and tested for cytotoxicity against the NK-sensitive K56...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Swisher SG,Economou JS,Holmes EC,Golub SH

    更新日期:1990-07-01 00:00:00

  • Mechanisms underlying immunologic states during pregnancy: possible association of the sympathetic nervous system.

    abstract::NK and extrathymic T cells are abundant in the decidua of the pregnant uterus. To determine how this unique pattern is induced, overall populations of leukocytes were examined in the blood and other tissues in pregnant women. Time-kinetic studies showed that a basal change of leukocytes during pregnancy was granulocyt...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Minagawa M,Narita J,Tada T,Maruyama S,Shimizu T,Bannai M,Oya H,Hatakeyama K,Abo T

    更新日期:1999-08-25 00:00:00

  • Suppressive effects of soluble histocompatibility antigens on the in vitro generation of cytotoxic T cells to D-end alloantigens.

    abstract::Murine histocompatibility antigens were solubilized from the spleens and lungs of C57BL/6 (H-2b) animals with hypertonic salt (3 M KC1). Aggregate-free soluble antigens were incubated with nonadherent lymph node cells from BALB/c (H-2d) mice for 18 hr prior to their use as responder cells in the mixed-lymphocyte react...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Long PM,Sommer CV,Kong YM

    更新日期:1983-06-01 00:00:00

  • Regulation of cyclophosphamide-induced eosinophilia in contact sensitivity: functional roles of interleukin-5-producing CD4(+) lymphocytes.

    abstract::Blood and tissue eosinophilia is obtained when mice pretreated with cyclophosphamide (CY) and sensitized with picryl chloride are challenged on each ear lobe on day 13. To gain important insights into the cellular mechanisms involved in CY-induced eosinophilia in the contact-sensitivity reaction, we examined the cytok...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Sasaki G,Satoh T,Yokozeki H,Katayama I,Nishioka K

    更新日期:2000-08-01 00:00:00

  • Protective efficacy of a plasmid DNA vaccine against transgene-specific tumors by Th1 cellular immune responses after intradermal injection.

    abstract::With DNA vaccines, it is important to monitor the movement of transfectants and to overcome immune deviations. We used a pCMV-LacZ plasmid (expressing β-galactosidase) and a pcDNA-hNIS plasmid (expressing the human sodium/iodide symporter [hNIS] gene) as non-secreted visual-imaging markers. Transfectants carrying the ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Son HY,Apostolopoulos V,Chung JK,Kim CW,Park JU

    更新日期:2018-07-01 00:00:00

  • Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation.

    abstract::Chinese hamster ovary (CHO) cells are commonly used in the generation of transfectants for use in in vitro costimulation assays. However, we have noted that nontransfected CHO cells can themselves provide a low-level B7/CD28 independent costimulatory signal for CD3-mediated murine T cell activation and IL-2 production...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gaglia JL,Mattoo A,Greenfield EA,Freeman GJ,Kuchroo VK

    更新日期:2001-11-01 00:00:00

  • An evaluation of the maternal natural killer cell population during the course of murine pregnancy.

    abstract::Earlier work from this laboratory revealed an increase in the level of null (Thy-1-, IgM-) lymphocytes in the maternal lymphoid organs during the first pregnancy in the mouse that was more pronounced during allogeneic pregnancy than during syngeneic pregnancy. In view of the suggestive evidence for the bone marrow ori...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Chatterjee-Hasrouni S,Parhar R,Lala PK

    更新日期:1984-04-01 00:00:00

  • Interleukin-6 is used as a growth factor by virulent Mycobacterium avium: presence of specific receptors.

    abstract::In this paper, we examined the contribution of the lymphokine interleukin-6 (IL-6) to the growth of four virulent strains of Mycobacterium avium and the nature of the binding moieties on the mycobacteria. First, we showed that human or mouse recombinant interleukin-6 are potent growth factors for four strains of virul...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Denis M

    更新日期:1992-04-15 00:00:00

  • Long-term exposure to superantigen induces p27Kip1 and Bcl-2 expression in effector memory CD4+ T cells.

    abstract::The long-term exposure of mice to superantigen SEA using a mini-osmotic pump (SEA pump) induced a long-lasting expansion of Vbeta3+ CD4+ T cells with T helper (Th) 2 cell-type properties. Removal of the SEA pump 10 days after pump implantation did not significantly alter the level of Vbeta3+ CD4+ T cell expansion/main...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Koyanagi M,Fukada K,Uchiyama T,Yagi J,Arimura Y

    更新日期:2007-08-01 00:00:00

  • Interleukin-12 is expressed by infiltrating macrophages and synovial lining cells in rheumatoid arthritis and osteoarthritis.

    abstract::TH1 cytokines have recently been detected in rheumatoid arthritis (RA) and osteoarthritis (OA). For this reason we studied the TH-1-promoting cytokine IL-12 in synovial membranes from patients with RA and OA. IL-12 transcripts and protein were analyzed by reverse transcriptase-polymerase chain reaction (PCR) and immun...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Sakkas LI,Johanson NA,Scanzello CR,Platsoucas CD

    更新日期:1998-09-15 00:00:00

  • Clonal anergy is a potent mechanism of oral tolerance in the suppression of acute antigen-induced arthritis in rats by oral administration of the inducing antigen.

    abstract::The effects of oral administration of ovalbumin (OVA) on acute OVA-induced arthritis (OIA) in rats, which is mediated by Arthus reaction to the antigen in the joint space, were investigated. The oral administration of OVA before immunization with OVA significantly suppressed the development of acute OIA in a dose-depe...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Inada S,Yoshino S,Haque MA,Ogata Y,Kohashi O

    更新日期:1997-01-10 00:00:00

  • Interferon-gamma stimulates lipid metabolism in human monocytes.

    abstract::In nonactivated human monocytes, radiolabeled oleic, arachidonic, and palmitic acids are primarily incorporated into neutral lipids and phosphatidylcholine. Each of these fatty acids is also incorporated into phosphatidylethanolamine, phosphatidylserine, phosphatidylinositol, and sphingomyelin in characteristic propor...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Furlong ST,Mednis A,Remold HG

    更新日期:1992-08-01 00:00:00

  • Natural cytotoxic T cells (NCTC) that differ from natural killer (NK) and natural cytotoxic (NC) cells are present in Peyer's patches of mice.

    abstract::We have examined noninduced cytotoxicity of mouse gut associated and peripheral lymphoid tissues for a wide variety of syngeneic as well as allogeneic cell lines and lymphoblasts. Lymphoid cells from Peyer's patches were found to lyse these targets in a 3-hr chromium release assay whereas lymphoid cells from intestina...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Gautam SC,Beckman K,Battisto JR

    更新日期:1986-09-01 00:00:00

  • Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure.

    abstract::American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Brelaz-de-Castro MC,de Almeida AF,de Oliveira AP,de Assis-Souza M,da Rocha LF,Pereira VR

    更新日期:2012-10-01 00:00:00

  • The appearance of eosinophil-directed chemotactic inhibitory factor in the serum of complete Freund's adjuvant-treated guinea pigs.

    abstract::When guinea pigs were treated by complete Freund's adjuvant (CFA), eosinophil-directed chemotactic inhibitory factor (ECIF) appeared in the serum of the treated animals. The inhibition of the response of eosinophils by ECIF was selective for the T cell-derived chemotactic factor, which has been isolated from DNP-ascar...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Hirashima M,Tashiro K,Hayashi H

    更新日期:1984-11-01 00:00:00

  • GF109203X, a specific PKC inhibitor, abrogates anti-CD3 antibody-induced upregulation of CD4+ T cell adhesion to B cells.

    abstract::Antigen-independent adhesion of CD4+ T lymphocytes to Epstein-Barr virus transformed B cells is mainly mediated by LFA-1 (CD11a/CD18) and CD2 molecules. Low-affinity binding of resting T cells can be transiently upregulated by cross-linking of CD3-TCR (T cell receptor) complexes. This inside-out signaling influences i...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Hauss P,Mazerolles F,Hivroz C,Lecomte O,Barbat C,Fischer A

    更新日期:1993-09-01 00:00:00

  • Down-regulation of interleukin-2 receptor gene activation and protein expression by dideoxynucleoside analogs.

    abstract::The in vitro effect of single or combined doses of zidovudine (AZT) and dideoxycytidine (ddC) on the production and utilization of interleukin-2 (IL-2) by normal human peripheral blood mononuclear cells (PBMC) was evaluated by measuring IL-2 concentrations in supernatants from PHA-stimulated PBMC cultures. Drugs were ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Viora M,Camponeschi B

    更新日期:1995-07-01 00:00:00

  • Noradrenaline through β-adrenoceptor contributes to sexual dimorphism in primary CD4+ T-cell response in DA rat EAE model?

    abstract::Males exhibit stronger sympathetic nervous system (SNS) activity, but weaker primary CD4+ T-cell (auto)immune responses. To test the role of catecholamines, major end-point SNS mediators, in this dimorphism, influence of propranolol (β-adrenoceptor blocker) on mitogen/neuroantigen-stimulated CD4+ T cells from female a...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Vujnović I,Pilipović I,Jasnić N,Petrović R,Blagojević V,Arsenović-Ranin N,Stojić-Vukanić Z,Djordjević J,Leposavić G

    更新日期:2019-02-01 00:00:00

  • Construction of hybridomas from nude mice with phenotypes of precursors of regulatory T cells. I. A model for study of development of T-cell function in immune systems.

    abstract::Functional helper and suppressor hybridomas were constructed from fractionated Type II NFR/nude mouse splenocytes which resemble precursors of T cells. After carrier priming with rabbit erythrocytes (RE), splenocytes from Type II NFR/nude mice were fractionated on nylon wool columns. Cells from two distinct fractions ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Webb GC,Misfeldt ML,Hanna EE

    更新日期:1984-12-01 00:00:00

  • Ultraviolet-induced suppressor T cells and factor(s) in murine contact photosensitivity. III. Mode of action of T-cell-suppressor factor(s) and interaction with cytokines.

    abstract::The mode of action of T-cell-suppressor factor (TsF) induced by ultraviolet B (UVB) preirradiation in terms of interaction with several cytokines was studied. Suppression of murine contact photosensitivity (CPS) to 3,3',4',5-tetrachlorosalicylanilide (TCSA) by preirradiation of the sensitizing site to low doses of UVB...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Satoh T,Tokura Y,Satoh Y,Takigawa M

    更新日期:1990-11-01 00:00:00

  • Ca2+/calmodulin and protein kinase C regulation of serotonin transport in human K562 lymphocytes.

    abstract::This study was conducted on human K562 lymphocytes to investigate the mechanisms implicated in the regulation of the serotonin transport process. The uptake of serotonin in these cells was saturable (Km, 3.37 microM; Vmax, 2.03 nmol/10(6) cells) and Na+ dependent; isoosmotic replacement of Na+ with choline chloride in...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Khan NA,Meyneil JP,Deschaux P

    更新日期:1996-09-15 00:00:00

  • Selective modulation of IFN-gamma mRNA stability by IL-12/NKSF.

    abstract::We investigated the role of IL-12 in regulating IL-2 and IFN-gamma production in primary culture of human T cells. Addition of neutralizing antiserum against the 40-kDa subunit of IL-12 to PHA-stimulated PBMC markedly reduced both IFN-gamma protein production and mRNA accumulation and stability. Moreover, concurrent t...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nagy E,Buhlmann JE,Henics T,Waugh M,Rigby WF

    更新日期:1994-12-01 00:00:00

  • Both exogenous commensal and endogenous self antigens stimulate T cell proliferation under lymphopenic conditions.

    abstract::Within lymphopenic recipients, naïve T cells undergo proliferation that is induced by homeostatic mechanisms. Earlier studies have demonstrated that commensal antigens play a key role in inducing the proliferation. However, a relative contribution of endogenous self antigens in this process has not been formally inves...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Do JS,Foucras G,Kamada N,Schenk AF,Shaw M,Nuñez G,Paul WE,Min B

    更新日期:2012-01-01 00:00:00

  • E3 ubiquitin ligase: A potential regulator in fibrosis and systemic sclerosis.

    abstract::Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis in the skin and internal organs. The pathogenesis of SSc is not completely understood until now. Recently, many studies have focused on the role of E3 ubiquitin ligases in organ fibrosis. However, the possible regulatory mechanisms of E3 ubiqu...

    journal_title:Cellular immunology

    pub_type: 杂志文章,评审


    authors: Huang XL,Zhang L,Duan Y,Wang YJ,Zhao JH,Wang J

    更新日期:2016-08-01 00:00:00

  • Chemotactic subpopulation of macrophage cell line cells (M1 cells) discerned by three macrophage chemotactic factors from delayed hypersensitivity reaction sites.

    abstract::The functional specificity of three types of macrophage chemotactic factors ( MCFs ), -a, -b, and -c, from purified protein derivative of tuberculin (PPD)-induced delayed hypersensitivity reaction (DHR) skin sites on guinea pigs, was analyzed using macrophage cell line cells, M1, established from myeloid leukemia cell...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Honda M,Masuda T,Yoshimura T,Hayashi H

    更新日期:1984-06-01 00:00:00

  • Involvement of CD45 in MHC class II-allospecific cytotoxicity.

    abstract::Twenty-seven different CD45 monoclonal antibodies (mAb) were assessed for their ability to block cytotoxicity of alloreactive CD4+ MHC class II-specific or CD8+ class I-specific human T cell clones (n = 3 and 5, respectively). Twelve of 27 blocked the former but only 1/27 the latter, although all 27 significantly inhi...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Pawelec G,Bühring HJ,Müller C

    更新日期:1990-05-01 00:00:00