Tissue distribution and appearance in ontogeny of alpha/beta T cell receptor (TCR2) in chicken.


:We have performed immunoperoxidase staining on cryostat tissue sections and immunofluorescence analysis on cell suspensions to identify cells expressing the alpha/beta T cell antigen receptor during ontogeny and adult life in chickens. We used the mouse monoclonal antibody, TCR2, which was previously shown to recognize the alpha/beta TCR in chickens. TCR2+ cells were observed in thymic cortex and medulla and in T-dependent areas of spleen, intestine, and cecal tonsils of young adult chickens. Some TCR2+ cells were found in the cortex of bursal follicles and in liver. The first TCR2+ cells appear in thymus on Day 13 of the embryonic life and it is only after hatching that TCR2+ cells begin to migrate to the periphery.


Cell Immunol


Cellular immunology


Vainio O,Lassila O,Cihak J,Lösch U,Houssaint E




Has Abstract


1990-01-01 00:00:00














  • Androgens alter B cell development in normal male mice.

    abstract::Castration of normal male mice leads to splenic enlargement and expansion of the B cell population. Since the spleen does not express receptors for androgens, these changes are most likely mediated by effects of androgens on other target organs. Two potential sites of androgen-mediated effects on B cells are evaluated...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Viselli SM,Reese KR,Fan J,Kovacs WJ,Olsen NJ

    更新日期:1997-12-15 00:00:00

  • In vitro production of antigen-specific T cells from unprimed mice: role of dexamethasone and anti-IL-10 antibodies.

    abstract::We describe here a culture system for studying the development, in vitro, of antigen-specific CD4 T cells from unprimed mice. T cells from young mice are initially exposed to antigen, such as pigeon cytochrome C or keyhole limpet hemocyanin, in the presence of adherent accessory cells and then allowed to proliferate i...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Dozmorov I,Miller RA

    更新日期:1997-06-15 00:00:00

  • Alloreactive feature of HLA-DP-specific cytotoxic T-cell clone.

    abstract::The alloreactive feature of CD4+ cytotoxic T-cell clone that could specifically lyse the cells bearing DPB1*0202 sequence was described. The clone was generated from a mixed culture of peripheral blood lymphocytes derived from siblings who were HLA-A, B, C, DR, and DQ identical by serological typing and whose DNA sequ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nishimura M,Mitsunaga S,Akaza T,Mitomi Y,Tadokoro K,Juji T

    更新日期:1994-01-01 00:00:00

  • Overexpression of programmed death-1 ligand-1 on NIT cells lead to negative regulation of allogeneic lymphocyte activation.

    abstract::PD-L1 have been identified as the ligand for PD-1, and shown to play a role in the regulation of immune responses. In the present study, we investigated whether overexpressing PD-L1 on islet beta cells could induce negative regulation in primary and primed allogeneic lymphocyte response. pPD-L1-EGFP or pEGFPn1 were tr...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wen X,Xu G,Liu J,Zhu H,Dai H,Li L,Hong Y,Yang J,Dai W,Ping L,Shen G

    更新日期:2010-01-01 00:00:00

  • B cell differentiation factor-induced B cell maturation: regulation via reduction in cAMP.

    abstract::We have previously described a novel human B cell differentiation factor (BCDF), 446-BCDF, that is distinct biochemically and functionally from other cytokines. Since signal transduction pathways involved in human B cell differentiation have been incompletely studied and are poorly understood, we assessed the effects ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Huang R,Cioffi J,Berg K,London R,Cidon M,Maayani S,Mayer L

    更新日期:1995-04-15 00:00:00

  • Experimental autoimmune encephalomyelitis in intercellular adhesion molecule-1-deficient mice.

    abstract::Intercellular adhesion molecule (ICAM)-1, or CD54, is a member of the immunoglobulin superfamily that binds to lymphocyte function-associated antigen-1 and macrophage-1 antigen. ICAM-1:LFA-1/Mac-1 interaction may be involved in both activation and extravasation of leukocytes. To determine the roles of ICAM-1 in the de...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Samoilova EB,Horton JL,Chen Y

    更新日期:1998-11-25 00:00:00

  • Inhibition of clathrin/dynamin-dependent internalization interferes with LPS-mediated TRAM-TRIF-dependent signaling pathway.

    abstract::Recognition of lipopolysaccharide (LPS) by Toll-like receptor 4 (TLR4) activates two district proinflammatory signaling pathway and initiates LPS internalization. To investigate roles of LPS internalization, a traditionally regarded metabolic pathway for LPS, in regulation of these two pathways, three internalization ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wang Y,Yang Y,Liu X,Wang N,Cao H,Lu Y,Zhou H,Zheng J

    更新日期:2012-01-01 00:00:00

  • Specific immune responses but not basal functions of B and T cells are impaired in aged mice.

    abstract::Senescence is characterized by several alterations in the immune system. Such modifications can be found in lymphoid organs as well as in the cellular components of the immune system. Several reports have suggested that immune dysfunction can affect both T and B cells, but T cells have been shown to be more susceptibl...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Speziali E,Santiago AF,Fernandes RM,Vaz NM,Menezes JS,Faria AM

    更新日期:2009-01-01 00:00:00

  • Correlations of programmed death 1 expression and serum IL-6 level with exhaustion of cytomegalovirus-specific T cells after allogeneic hematopoietic stem cell transplantation.

    abstract::The effect of programmed death 1 (PD-1) on cytomegalovirus (CMV)-specific T cells has not been thoroughly examined. We evaluated the involvement of exhausted CMV-specific T cells in persistent CMV infection after allogeneic hematopoietic stem cell transplantation (HSCT). CMV-specific CD8+ T cells obtained from an HLA-...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kato T,Nishida T,Ito Y,Murase M,Murata M,Naoe T

    更新日期:2014-03-01 00:00:00

  • Proliferative activity of autoimmune MRL mouse serum IgG to interleukin 3-dependent cell line through autocrine mechanism.

    abstract::Serum of an autoimmune MRL/Mp-lpr/lpr (MRL/l) mouse supported the proliferation of interleukin 3 (IL-3)-dependent cell line, FDC-P2. This IL-3-like activity initially appeared at 1 month of age and increased with age. Females showed higher titers than did males. MRL/Mp-+/+ mouse sera also exhibited such activity, thou...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Tasaka K,Sakihama T,Shirakura-Shibata Y,Matsuda S,Nakajima Y

    更新日期:1989-07-01 00:00:00

  • Effects of the methanol extraction residue (MER) tubercle bacillus fraction on the production of antibodies in vitro. III. Consequence of prior sensitization to MER.

    abstract::Mice repeatedly immunized with the methanol extraction residue fraction of tubercle bacilli (MER) in incomplete Freund's adjuvant produced high titers of circulating antibodies against MER, as assessed by the enzyme-linked immunosorbent assay (ELISA) method. Spleen cells derived from these animals failed to respond to...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Halperin D,Reuben C,Ben-Efraim S,Grover N,Weiss DW

    更新日期:1985-05-01 00:00:00

  • Ca2+/calmodulin and protein kinase C regulation of serotonin transport in human K562 lymphocytes.

    abstract::This study was conducted on human K562 lymphocytes to investigate the mechanisms implicated in the regulation of the serotonin transport process. The uptake of serotonin in these cells was saturable (Km, 3.37 microM; Vmax, 2.03 nmol/10(6) cells) and Na+ dependent; isoosmotic replacement of Na+ with choline chloride in...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Khan NA,Meyneil JP,Deschaux P

    更新日期:1996-09-15 00:00:00

  • Constitutive expression of ligand for natural killer cell NKp44 receptor (NKp44L) by normal human articular chondrocytes.

    abstract::Normal chondrocytes display susceptibility to lysis by natural killer (NK) cells and this phenomenon may play a role in some inflammatory cartilage disorders. The mechanisms of chondrocyte recognition and killing by NK cells remain unclear. Using flow cytometry and immunohistochemical staining we found that normal hum...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Białoszewska A,Baychelier F,Niderla-Bielińska J,Czop A,Debré P,Vieillard V,Kieda C,Malejczyk J

    更新日期:2013-09-01 00:00:00

  • Maternal HEL immunization has no lasting effects on the immune response of offspring to immunization with hen egg-white lysozyme.

    abstract::The effect of prior maternal immunization on the murine offspring response to subsequent immunization with hen egg-white lysozyme was examined. Adult female A/J mice were immunized with 100 micrograms HEL-CFA intraperitoneally 10-27 weeks before conception. The offspring of these experimental female mice were then imm...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Jelonek MT,Brust JL,Song CH,Calandra GB,Miller A,Sercarz EE,Keller MA

    更新日期:1993-05-01 00:00:00

  • Endogenous activation of apoptosis in bursal lymphocytes: inhibition by phorbol esters and protein synthesis inhibitors.

    abstract::The bursa of Fabricius represents the primary immune organ where immature B cells undergo maturational changes in avian species. Isolation of bursal lymphocytes for analysis in cell culture results in the rapid endogenous activation of apoptosis. After 2 h of incubation, over 45% of the lymphocytes were shown to be un...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Compton MM,Waldrip HM

    更新日期:1998-03-15 00:00:00

  • Severe and prolonged inflammatory response to localized cowpox virus infection in footpads of C5-deficient mice: investigation of the role of host complement in poxvirus pathogenesis.

    abstract::Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Miller CG,Justus DE,Jayaraman S,Kotwal GJ

    更新日期:1995-05-01 00:00:00

  • Accessory cell requirements for saponin adjuvant-induced class I MHC antigen-restricted cytotoxic T-lymphocytes.

    abstract::The in vivo and in vitro accessory cell requirements of class I major histocompatability complex (MHC) antigen-restricted cytotoxic T-lymphocyte (CTL) responses were determined using cell-depletion experiments coupled with active immunizations using ovalbumin (OVA) as the immunogen and saponin adjuvant (QS-21). To par...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wu JY,Gardner BH,Kushner NN,Pozzi LA,Kensil CR,Cloutier PA,Coughlin RT,Newman MJ

    更新日期:1994-04-01 00:00:00

  • Role of heme oxygenase-1 in potentiation of phagocytic activity of macrophages by taurine chloramine: Implications for the resolution of zymosan A-induced murine peritonitis.

    abstract::Phagocytosis of pathogens by macrophages is crucial for the successful resolution of inflammation induced by microbial infection. Taurine chloramine (TauCl), an endogenous anti-inflammatory and antioxidative substance, is produced by reaction between taurine and hypochlorous acid by myeloperoxidase activity in neutrop...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Kim W,Kim SH,Jang JH,Kim C,Kim K,Suh YG,Joe Y,Chung HT,Cha YN,Surh YJ

    更新日期:2018-05-01 00:00:00

  • Clonotypic heterogeneity of Lewis rat T cells specific for the encephalitogenic 68-86 region of myelin basic protein.

    abstract::Experimental autoimmune encephalomyelitis was induced in a Lewis rat by sensitization with synthetic peptide GP68-86, representing the 68-86 sequence of guinea pig myelin basic protein (GPMBP). To delineate T cell determinants of GP68-86, lymph node cells from this rat were activated in culture with GP68-86 and were f...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Mannie MD,Paterson PY,U'Prichard DC,Thomas DW

    更新日期:1989-09-01 00:00:00

  • Gain-of-function mutations in CARD11 promote enhanced aggregation and idiosyncratic signalosome assembly.

    abstract::BENTA (B cell Expansion with NF-κB and T cell Anergy) is a novel lymphoproliferative disorder caused by germline, gain-of-function (GOF) mutations in the lymphocyte-restricted scaffolding protein CARD11. Similar somatic CARD11 mutations are found in lymphoid malignancies such as diffuse large B cell lymphoma (DLBCL). ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Stinson JR,Dorjbal B,McDaniel DP,David L,Wu H,Snow AL

    更新日期:2020-07-01 00:00:00

  • Leukocyte reactivity as an objective means of quantifying mental loading during ergonomic evaluation.

    abstract::Psychological stress evokes rapid changes to the cardiovascular and neuroendocrine systems, responses that can become habituated following repeated exposure. This study, comprising of two phases, suggests that the immune system follows a similar trend. Phase 1: 15 healthy subjects (aged between 26 and 56years) provide...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Shelton-Rayner GK,Macdonald DW,Chandler S,Robertson D,Mian R

    更新日期:2010-01-01 00:00:00

  • Comparative analysis of the heterogeneity of mononuclear cells present in adult and cord blood by simultaneous examination of multiple phenotypic characteristics.

    abstract::In an attempt to better relate specific membrane characteristics of human adult and cord blood lymphocytes to specific functional activities, the phenotypic differences that exist in these two populations have been examined. Cord blood cells have considerably more spontaneous suppressor cell activity than adult cells....

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Johnson C,Dwyer JM

    更新日期:1983-10-01 00:00:00

  • Impaired rearrangement of IgH V to DJ segments in bone marrow Pro-B cells from old mice.

    abstract::There are fewer bone marrow Pre-B cells in old compared to young mice. We have demonstrated both decreased rearrangement of the V to DJ IgH gene segments and low levels of VH germline transcripts in Pro-B cells, the precursors of Pre-B cells, from old compared to young mice. However, there was no difference in the lev...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Szabo P,Shen S,Telford W,Weksler ME

    更新日期:2003-03-01 00:00:00

  • Burn injury suppresses human dermal dendritic cell and Langerhans cell function.

    abstract::Human skin contains epidermal Langerhans cells (LCs) and dermal dendritic cells (DCs) that are key players in induction of adaptive immunity upon infection. After major burn injury, suppressed adaptive immunity has been observed in patients. Here we demonstrate that burn injury affects adaptive immunity by altering bo...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: van den Berg LM,de Jong MA,Witte Ld,Ulrich MM,Geijtenbeek TB

    更新日期:2011-01-01 00:00:00

  • Ia- and IgG-Fc receptor-positive accessory cell sustains peripheral T lymphocyte but not thymocyte mitogenesis induced by OKT3 monoclonal antibody.

    abstract::The proliferative responses of human peripheral blood mononuclear cells (PBL) and thymocytes to OKT3 monoclonal antibody have been investigated. The PBL response to OKT3 was maximal after 72 hr while that of thymocytes was inappreciable at all times measured. Unlike phytohemagglutinin, OKT3 was unable to elicit the mi...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Musiani P,Maggiano N,Aiello FB,Lauriola L,Ranelletti FO,Piantelli M

    更新日期:1984-04-01 00:00:00

  • Veto activity of activated bone marrow does not require perforin and Fas ligand.

    abstract::Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Chrobak P,Gress RE

    更新日期:2001-03-15 00:00:00

  • Generation of HSP60-specific regulatory T cell and effect on atherosclerosis.

    abstract::Although CD4(+)CD25(+) regulatory T cells are pivotal in the suppression of autoimmunity, little is known about the effect of antigen-specific regulatory T cells on the formation of atheromatous plaques. Here, we describe the induction of heat-shock protein 60 (HSP60)-specific CD4(+)CD25(high) T cells by rapamycin (RP...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Yang K,Li D,Luo M,Hu Y

    更新日期:2006-10-01 00:00:00

  • Antitumor effects and immunoregulation mechanisms of IL-23 gene in mouse mammary cancer mediated by retrovirus.

    abstract:BACKGROUND:Interleukin (IL)-23, composed of p19 and p40 subunits, has diverse functions in regulating immune systems, enhancing cell-mediated immunity. In the present study, we investigated whether forced expression of the p19-linked p40 gene in murine mammary cancer cells (MA891) produced antitumor effects in vivo. Tu...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Liu L,Shan B,Feng Y

    更新日期:2009-01-01 00:00:00

  • The effects of temperature and oleic acid on murine memory and virgin T cell activation: interleukin-2 secretion and interleukin-2 receptor expression.

    abstract::Previous studies established that low in vitro temperatures (27 degrees C, termed nonpermissive) suppressed murine primary thymus-dependent (TD), but not primary thymus-independent (TI) or secondary TD, antibody responses. Suppression was rescued by the addition of oleic acid (18:1), recombinant interleukin (rIL)-2 an...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wooten RM,Clem LW,Bly JE

    更新日期:1993-11-01 00:00:00

  • Evidence for a defective accumulation of protective T cells in old mice infected with Mycobacterium tuberculosis.

    abstract::Mice infected with virulent Mycobacterium tuberculosis exhibit an age-related increase in susceptibility to disease. The basis of this susceptibility has previously been shown to reflect an inability of the aged host to generate protective CD4 T cells during the early course of the infection. The results of the presen...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Orme IM,Griffin JP,Roberts AD,Ernst DN

    更新日期:1993-03-01 00:00:00