Tissue distribution and appearance in ontogeny of alpha/beta T cell receptor (TCR2) in chicken.

Abstract:

:We have performed immunoperoxidase staining on cryostat tissue sections and immunofluorescence analysis on cell suspensions to identify cells expressing the alpha/beta T cell antigen receptor during ontogeny and adult life in chickens. We used the mouse monoclonal antibody, TCR2, which was previously shown to recognize the alpha/beta TCR in chickens. TCR2+ cells were observed in thymic cortex and medulla and in T-dependent areas of spleen, intestine, and cecal tonsils of young adult chickens. Some TCR2+ cells were found in the cortex of bursal follicles and in liver. The first TCR2+ cells appear in thymus on Day 13 of the embryonic life and it is only after hatching that TCR2+ cells begin to migrate to the periphery.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Vainio O,Lassila O,Cihak J,Lösch U,Houssaint E

doi

10.1016/0008-8749(90)90079-7

subject

Has Abstract

pub_date

1990-01-01 00:00:00

pages

254-60

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(90)90079-7

journal_volume

125

pub_type

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