Abstract:
:The kinetics and quality of the alloimmune reaction were studied in CBA (H-2k) mice treated for passive enhancement of tumor allografts (Sa 1 indigenous of A/J (H-2a or H-2k/d) mice). Serum samples of treated animals were tested for their biological properties relevant to different antibody isotypes in vitro (hemagglutination, complement-dependent cytotoxicity, and anaphylaxis, i.e., mast cell degranulation involving all main Ig isotypes; IgM, IgG2, and IgG1, IgE, respectively) as well as in vivo (allograft enhancement). Spleen cells from these treated animals were examined for their capacity to interfere with the rejection of tumor allografts by adoptive transfers into syngeneic recipients. In vitro, 51Cr release cytolysis assays were performed in order to test their cytolytic and regulatory activities in comparison to rejecting control animals. It has been shown that: grafted mice, pretreated for passive enhancement, kept their grafts longer and synthetized anaphylactic antibodies (mainly IgG1) earlier and at higher titers than normal serum controls, which rejected the same Sa 1 allografts. Mice with enhanced tumors synthetized cytotoxic antibodies (mainly IgG2) later than rejecting controls. Serum samples from treated and control animals, harvested 10 days (early sera) and 30 days (late sera) after grafting, were injected with a "normal dose" (0.2 ml) and a "high" dose (0.4 ml) to new CBA recipients grafted with Sa 1. Early immune sera were only enhancing at high doses when derived from animals previously treated for enhancement (at the low dose both immune sera were enhancing). Late sera, presenting both complement-fixing, cytotoxic (predominantly IgG2), and IgG1 anaphylactic alloantibodies in the two groups, induced enhancement in all cases, but more strongly when derived from the group treated for Sa 1 enhancement. Adoptive transfer of spleen cells from animals treated for passive enhancement were able either to inhibit the accelerated rejection (Day 10) or to promote enhancement of Sa 1 allogeneic cells (Day 30) while similar cells taken (Day 10 and Day 30) from control graft-rejecting mice transferred accelerated rejection. Among the transferred T-cell sub-populations, the suppressive effect was mediated by Lyt 2 T cells. In vitro, these spleen cells showed a weaker cytolytic activity than those of allograft-rejecting mice. Moreover, they were able to regulate the cytolytic activity of cytotoxic effector cells from specifically immunized CBA mice.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Duc HT,Kinsky RG,Monnot P,Voisin GAdoi
10.1016/0008-8749(85)90306-5subject
Has Abstractpub_date
1985-10-01 00:00:00pages
180-94issue
1eissn
0008-8749issn
1090-2163pii
0008-8749(85)90306-5journal_volume
95pub_type
杂志文章abstract::Psoriasis is a common dermatosis mediated by T cells. This study investigated the correlation of Th22 cells and Tc22 cells with psoriasis. A total of 30 psoriasis patients and 11 age- and sex-matched healthy controls were recruited for this study. The proportions of circulating Th22 and Tc22 cells, expression of aryl ...
journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90050-2
更新日期:1990-07-01 00:00:00
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journal_title:Cellular immunology
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更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1990-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2009.02.007
更新日期:2009-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1984-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90177-1
更新日期:1984-10-15 00:00:00
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pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2015-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.cellimm.2007.03.008
更新日期:2007-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1993-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2012-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1011
更新日期:1993-01-01 00:00:00
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journal_title:Cellular immunology
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