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Study on B-memory generation by Tnp-Ficoll: induction but not expression is observed among various inbred mouse strains.

Abstract：

:The primary and secondary responses to Tnp-Ficoll, a class 2 thymus-independent antigen, were assessed in various inbred strains of mice. The eventual implication of H-2 or IgH linked genes was searched for. Contrasting with our previous reports using Tnp-LPS, a class 1 thymus-independent antigen, no homologous memory-type response to Tnp-Ficoll and consequently no genetic control was observed. However Tnp-specific B-memory lymphocytes were induced in most strains since a heterologous challenge with Tnp-LPS evoked a typical memory type response characterized by an increased number of antibody-secreting cells and/or significant amount of anti-Tnp antibodies of the IgG isotype. The lack of memory revelation by Tnp-Ficoll is discussed in terms of a possible humoral or cellular regulation and of B-memory cell generation and maturation.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Le Moal MA,Colle JH,Truffa-Bachi P

doi

10.1016/0008-8749(84)90135-7

subject

Has Abstract

pub_date

1984-08-01 00:00:00

pages

110-7

issue

1

eissn

0008-8749

issn

1090-2163

pii

0008-8749(84)90135-7

journal_volume

87

pub_type

杂志文章

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