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Atorvastatin decreases Toll-like receptor 4 expression and downstream signaling in human monocytic leukemia cells.

Abstract：

PURPOSE:We aim to evaluate the effects of atorvastatin on the expression of Toll-like receptor (TLR4) protein and mRNA, and to explore their effects on TLR4-dependent downstream signaling in human monocytic leukemia (THP-1) cells. METHODS:TLR4 protein and mRNA expression, levels of NF-κB protein, and expression of TNF-α, IL-6, and IL-1β in lipopolysaccharide-induced THP-1 cells after incubation with different concentrations of atorvastatin (0.1, 1, 10, 20μM) were quantified via flow-cytometry, quantitative RT-PCR, western blotting, and ELSIA kits. RESULTS:Atorvastatin incubation resulted in significant decreases in the levels of TLR4 protein and mRNA, NF-κB expression, and levels of TNF-α, IL-6, and IL-1β in LPS-induced THP-1 cells (P<0.01). However, compared with the untreated control, the expression of these were significantly increased (P<0.01). CONCLUSIONS:Atorvastatin could inhibit the TLR4 expression and TLR4-dependent downstream signaling in THP-1 cells. These observations imply that the interactions with innate immunity may serve as one of the pleiotropic mechanisms of atorvastatin.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Yang SS,Li R,Qu X,Fang W,Quan Z

doi

10.1016/j.cellimm.2012.09.008

subject

Has Abstract

pub_date

2012-09-01 00:00:00

pages

96-102

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(12)00172-4

journal_volume

279

pub_type

杂志文章

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