B cells promote hepatic inflammation, biliary cyst formation, and salivary gland inflammation in the NOD.c3c4 model of autoimmune cholangitis.


:There are now several murine models of autoimmune cholangitis that have features both similar and distinct from human PBC. One such model, the NOD.c3c4 mouse, manifests portal cell infiltrates, anti-mitochondrial antibodies but also biliary cysts. The biliary cysts are not a component of PBC and not found in the other murine models. To address the immunopathology in these mice, we generated genetically B cell deficient Igμ(-/-) NOD.c3c4 mice and compared the immunopathology of these animals to control B cell sufficient NOD.c3c4 mice. B cell deficient mice demonstrated decreased number of non-B cells in the liver accompanied by reduced numbers of activated natural killer cells. The degree of granuloma formation and bile duct damage were comparable to NOD.c3c4 mice. In contrast, liver inflammation, biliary cyst formation and salivary gland inflammation was significantly attenuated in these B cell deficient mice. In conclusion, B cells play a critical role in promoting liver inflammation and also contribute to cyst formation as well as salivary gland pathology in autoimmune NOD.c3c4 mice, illustrating a critical role of B cells in modulating specific organ pathology and, in particular, in exacerbating both the biliary disease and the sialadenitis.


Cell Immunol


Cellular immunology


Moritoki Y,Tsuda M,Tsuneyama K,Zhang W,Yoshida K,Lian ZX,Yang GX,Ridgway WM,Wicker LS,Ansari AA,Gershwin ME




Has Abstract


2011-01-01 00:00:00














  • The expression of T-cell surface antigens CTLA-4, CD26, and CD28 is modulated by inhibition of dipeptidylpeptidase IV (DPP IV, CD26) activity in murine stress-induced abortions.

    abstract::Inhibition of DPP IV has been shown to abrogate the stress-related increase in murine abortions and a concomitant increase in gamma-interferon. The aim of the present study was to investigate a potential impact of the DPP IV inhibitor Isoleucine Cyanopyrrolidide on the expression of surface antigens involved in T-cell...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Rüter J,Hoffmann T,Heiser U,Demuth HU,Arck PC,Klapp BF,Hildebrandt M

    更新日期:2002-12-01 00:00:00

  • Role of lymphokines in regulation of macrophage differentiation.

    abstract::The regulatory mechanism of guinea pig lymphokines was investigated in regard to differentiation of myeloid cells to macrophages. The Ml-cell line, established from a myeloid leukemia of an SL-strain mouse, was induced to differentiate in vitro into mature macrophages possessing Fc receptors and the ability to phagocy...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Onozaki K,Akagawa KS,Haga S,Miura K,Hashimoto T,Tokunaga T

    更新日期:1983-02-15 00:00:00

  • A revertant TCR gamma delta + cell clone which has lost MHC nonrestricted cytotoxic activity but retains redirected killing upon stimulation of the CD3 receptor.

    abstract::A variant nonkiller (K-) T-cell clone derived from the MHC nonrestricted killer (K+) cell line TALL-103/2 (CD3/TCR gamma delta +) was studied to determine whether its lytic defects were at the tumor-binding or post-binding level. The two TALL-103/2 clones were found to display similar mRNA expression of TCR/CD3 comple...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Visonneau S,Cesano A,Santoli D

    更新日期:1995-10-15 00:00:00

  • Eomesodermin driven IL-10 production in effector CD8+ T cells promotes a memory phenotype.

    abstract::CD8+ T cell differentiation is controlled by the transcription factors T-bet and Eomesodermin, in concert with the cytokines IL-2, IL-10 and IL-12. Among these pathways, the mechanisms by which T-box proteins and IL-10 interact to promote a memory T cell fate remain poorly understood. Here, we show that Eomes and IL-1...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Reiser J,Sadashivaiah K,Furusawa A,Banerjee A,Singh N

    更新日期:2019-01-01 00:00:00

  • Soluble suppressor factors elaborated in experimental malignant ascites.

    abstract::Soluble suppressor factors in the sera of cancer patients inhibit lectin-stimulated lymphocyte proliferation. These factors, derived from human material, preclude easy corroboration by other investigators. To gain a general understanding of soluble suppressor factors and to avoid the necessary restrictions of human ex...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wile AG,Hensen D,Nahabedian M,Ibsen KH,Granger GA

    更新日期:1984-07-01 00:00:00

  • Bronchial epithelial cells produce IL-5: implications for local immune responses in the airways.

    abstract::IL-5 is a pleiotropic cytokine that promotes eosinophil differentiation and survival. While naïve bronchial epithelial cells (BEC) produce low levels of IL-5, the role of BEC-derived IL-5 in allergic airway inflammation is unknown. We now show that BEC, isolated from mice with OVA-induced allergic airway disease (AAD)...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Wu CA,Peluso JJ,Zhu L,Lingenheld EG,Walker ST,Puddington L

    更新日期:2010-01-01 00:00:00

  • Transdermal entry of yeast components elicits transient B cell-associated responses in skin-draining lymph nodes.

    abstract::Immune responses to non-pathogenic yeasts induced within the draining lymph node remain to be understood. In this study, we have investigated the changes in lymphocytes and their activity in skin-draining lymph nodes in response to transdermally injected zymosan (component of the yeast cell wall). Zymosan elicited the...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Rahman MA,Kanda Y,Ozawa M,Kawamura T,Takeuchi A,Katakai T

    更新日期:2020-09-01 00:00:00

  • Transcutaneous immunization with hydrophilic recombinant gp100 protein induces antigen-specific cellular immune response.

    abstract::The objective of this study was to evaluate the potential of transcutaneous immunization with tumor antigen to induce cell-mediated immunity. For this purpose, hydrophilic recombinant gp100 protein (HR-gp100) was topically applied on human intact skin in vitro, and used as a vaccine in a mouse model. We demonstrate th...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Eisenberg G,Machlenkin A,Frankenburg S,Mansura A,Pitcovski J,Yefenof E,Peretz T,Lotem M

    更新日期:2010-01-01 00:00:00

  • Heterogeneity of bone marrow lymphocytes: radioautographic detection of pre-B cells bearing cytoplasmic mu chains, and of B and T lymphocytes, and characterization of null lymphoid cells.

    abstract::A radioautographic immunolabeling technique has been developed to detect pre-B cells bearing cytoplasmic mu chains among populations of bone marrow lymphoid cells identified by conventional hematologic stains. 125I-Anti-mu antibody was applied either to fixed marrow smears, labeling total mu chains both in the cytopla...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Rahal MD,Osmond DG

    更新日期:1984-09-01 00:00:00

  • Association of serine protease with the rise of intracellular calcium in cytotoxic T lymphocytes.

    abstract::The precise role of the granular enzyme A (granzyme A), a serine protease, in the lytic process of cytotoxic T lymphocytes (CTL) is not clear. We have recently constructed a CTL line transfected with the antisense gene of granzyme A (a-GrA). These a-GrA CTL had lower GrA activity as well as decreased lytic activities,...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Koo GC,Luk Y,Talento A,Wu J,Sirotina A,Fischer PA,Blake JT,Nguyen MP,Parsons W,Poe M

    更新日期:1996-12-15 00:00:00

  • The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers.

    abstract::Within the lymphoid compartment, CD8 is expressed either as an alphaalpha homodimer or as an alphabeta heterodimer. Prior functional characterization of CD8alpha transfectants has demonstrated that CD8alphaalpha homodimers can reconstitute T cell responses in the absence of the CD8beta subunit. In order to now examine...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Witte T,Spoerl R,Chang HC

    更新日期:1999-02-01 00:00:00

  • Multi-modal image cytometry approach - From dynamic to whole organ imaging.

    abstract::Optical imaging is a valuable tool to visualise biological processes in the context of the tissue. Each imaging modality provides the biologist with different types of information - cell dynamics and migration over time can be tracked with time-lapse imaging (e.g. intra-vital imaging); an overview of whole tissues can...

    journal_title:Cellular immunology

    pub_type: 杂志文章,评审


    authors: Husna N,Gascoigne NRJ,Tey HL,Ng LG,Tan Y

    更新日期:2019-10-01 00:00:00

  • Mimotope vaccination for epitope-specific induction of anti-CD20 antibodies.

    abstract::CD20 is expressed strictly by B-cells and is ubiquitously expressed at high surface densities of malignant human B-cells. This suggests that CD20 may be a tumor target for immunotherapy of B-cell lymphomas. Rituximab, a chimeric monoclonal antibody directed against CD20, has been demonstrated to be an effective treatm...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Li M,Yan Z,Han W,Zhang Y

    更新日期:2006-02-01 00:00:00

  • Effects of D-allose on the endocytic activity of dendritic cells and the subsequent stimulation of T cells.

    abstract::We examined the effects of a rare sugar, D-allose, which is 6-carbon monosaccharide, on endocytosis and T cell stimulation by dendritic cells (DCs). The endocytosis of BCG-anti-BCG immune complexes by DCs markedly decreased in D-allose-containing medium. Co-culture with T cells (mixed leukocyte reaction, MLR) of DCs, ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Tanaka S,Sakamoto H

    更新日期:2011-01-01 00:00:00

  • Development and characterization of v-myc/v-raf-transformed murine fetal thymocyte cell lines.

    abstract::Transformed murine fetal thymocyte cell lines were derived by incubating fetal thymic organ cultures with a v-myc/v-raf-containing retroviral construct in order to model developmental stages within the early triple negative (CD3-CD4-CD8-) thymocyte population. The resulting 10 cell lines had a lymphoid morphology, wer...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Taubenberger JK,Reid AH,Izon D,Boehme SA

    更新日期:1996-07-10 00:00:00

  • Alternative splice variants of the human PD-1 gene.

    abstract::PD-1 is an immunoregulatory receptor expressed on the surface of activated T cells, B cells, and monocytes. We describe four alternatively spliced PD-1 mRNA transcripts (PD-1Deltaex2, PD-1Deltaex3, PD-1Deltaex2,3, and PD-1Deltaex2,3,4) in addition to the full length isoform. PD-1Deltaex2 and PD-1Deltaex3 are generated...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Nielsen C,Ohm-Laursen L,Barington T,Husby S,Lillevang ST

    更新日期:2005-06-01 00:00:00

  • Semaphorin 4A is dynamically regulated during thymocyte development in mice.

    abstract::Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Linder GE,Chuntova PD,McLelland BT,Añó L,Obodo UC,Crider NJ,Matthes DJ,García-Ojeda ME,Manilay JO,Chatterjea D

    更新日期:2013-02-01 00:00:00

  • Tissue macrophages as mediators of a healthy relationship with gut commensal microbiota.

    abstract::Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for the host. The gastrointestinal tract (GI) harbors th...

    journal_title:Cellular immunology

    pub_type: 杂志文章,评审


    authors: Nakagaki BN,Vieira AT,Rezende RM,David BA,Menezes GB

    更新日期:2018-08-01 00:00:00

  • Characterisation of monoclonal antibodies to the TNF and TNF receptor families.

    abstract::Tumour necrosis factor (TNF) family ligands and their corresponding receptors play important roles in the immune system and are involved in immune regulation such as lymphoid development, cell proliferation, differentiation, activation and death. Antibodies against these ligands and receptors together with Fc-fusion p...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Ch'en PF,Xu XG,Liu XS,Liu Y,Song CJ,Screaton GR,Jin BQ,Xu XN

    更新日期:2005-07-01 00:00:00

  • Interleukin-6 is used as a growth factor by virulent Mycobacterium avium: presence of specific receptors.

    abstract::In this paper, we examined the contribution of the lymphokine interleukin-6 (IL-6) to the growth of four virulent strains of Mycobacterium avium and the nature of the binding moieties on the mycobacteria. First, we showed that human or mouse recombinant interleukin-6 are potent growth factors for four strains of virul...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Denis M

    更新日期:1992-04-15 00:00:00

  • Cellular immune response evaluation of cutaneous leishmaniasis patients cells stimulated with Leishmania (Viannia) braziliensis antigenic fractions before and after clinical cure.

    abstract::American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Brelaz-de-Castro MC,de Almeida AF,de Oliveira AP,de Assis-Souza M,da Rocha LF,Pereira VR

    更新日期:2012-10-01 00:00:00

  • Murine T-cell clones specific for chicken erythrocyte alloantigens.

    abstract::We have established murine T-cell clones which respond to allotypic and species-specific determinants found on chicken erythrocytes (cRBC). Their relative antigen specificities were determined by assessing lymphokine production and proliferation in response to syngeneic spleen cells and cRBC obtained from chickens hom...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Giedlin MA,Longenecker BM,Mosmann TR

    更新日期:1986-02-01 00:00:00

  • Interferon-gamma receptor polymorphisms determine strain differences in accessibility of activated lymphocyte NK-triggering antigens to recognition by self-reactive NK cells.

    abstract::The "NK-triggering-antigen regulator" (Nktar) gene is a locus identified in the C57BL/6 genome which regulates the ability of unlabeled activated Con A blasts to compete for recognition of labeled syngeneic Con A blasts by BALB/c NK cells. Linkage analysis on Con A blasts from (BALB/c x CByB6F1) N2 backcross progeny f...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Chou SR,Brownell A,Ko MS,Kaplan J

    更新日期:2000-03-15 00:00:00

  • Galectins distinctively regulate central monocyte and macrophage function.

    abstract::Monocytes and macrophages link the innate and adaptive immune systems and protect the host from the outside world. In inflammatory disorders their activation leads to tissue damage. Galectins have emerged as central regulators of the immune system. However, if they regulate monocyte/macrophage physiology is still unkn...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Paclik D,Werner L,Guckelberger O,Wiedenmann B,Sturm A

    更新日期:2011-01-01 00:00:00

  • Monocytic myeloid-derived suppressor cells generated from rhesus macaque bone marrow enrich for regulatory T cells.

    abstract::Putative monocytic myeloid-derived suppressor cells (mMDSC; lineage-HLA-DR-/lo) were generated in 7-day cultures from normal rhesus macaque bone marrow (BM) cells in GM-CSF and IL-6. Three subsets were identified based on their differential expression of CD14, CD33, CD34 and CD11b. Following flow sorting, assessment o...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Zahorchak AF,Perez-Gutierrez A,Ezzelarab MB,Thomson AW

    更新日期:2018-07-01 00:00:00

  • The generation of oxygen radicals: a positive signal for lymphocyte activation.

    abstract::The induction of ornithine decarboxylase (ODC) activity in lymphocytes is associated with activation and the initiation of cellular proliferation. ODC is also an essential component in tumor promotion. Phorbol myristic acetate (PMA) is a mitogen for lymphocytes, but can also promote tumor formation. Tumor promotion is...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Fidelus RK

    更新日期:1988-04-15 00:00:00

  • A syngeneic splenic cell antigen induces a suppressor T cell in lymph nodes that controls cytotoxic T-cell and primary antibody responses.

    abstract::The nonspecific suppression of immunological responses that is generated within host popliteal lymph nodes upon exposure to syngeneic normal spleen cells has been examined. The suppression, which had previously been described as being capable of preventing initiation of cytotoxic T lymphocytes (CTLs) to hapten-altered...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Emara M,Battisto JR

    更新日期:1987-03-01 00:00:00

  • Fatal autoimmunity results from the conditional deletion of Snai2 and Snai3.

    abstract::Transcriptional regulation of gene expression is a key component of orchestrating proper immune cell development and function. One strategy for maintaining these transcriptional programs has been the evolution of transcription factor families with members possessing overlapping functions. Using the germ line deletion ...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Pioli PD,Chen X,Weis JJ,Weis JH

    更新日期:2015-05-01 00:00:00

  • IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation.

    abstract::The aim of our work was to study apoptosis as a possible mechanism of CD4+ lymphocyte depletion in AIDS patients and to test whether IL-12 could limit this phenomenon. As an in vitro model, we used a human IL-2-dependent Th1 clone from an uninfected individual. We found that CD4 cross-linking, obtained either by mouse...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Radrizzani M,Accornero P,Amidei A,Aiello A,Delia D,Kurrle R,Colombo MP

    更新日期:1995-03-01 00:00:00

  • Tissue distribution and appearance in ontogeny of alpha/beta T cell receptor (TCR2) in chicken.

    abstract::We have performed immunoperoxidase staining on cryostat tissue sections and immunofluorescence analysis on cell suspensions to identify cells expressing the alpha/beta T cell antigen receptor during ontogeny and adult life in chickens. We used the mouse monoclonal antibody, TCR2, which was previously shown to recogniz...

    journal_title:Cellular immunology

    pub_type: 杂志文章


    authors: Vainio O,Lassila O,Cihak J,Lösch U,Houssaint E

    更新日期:1990-01-01 00:00:00