The CD8beta ectodomain contributes to the augmented coreceptor function of CD8alphabeta heterodimers relative to CD8alphaalpha homodimers.

abstract：:Short-term culture of murine lymphocytes in interleukin 2 (IL-2), in the absence of any priming antigen, has been shown to result in the differentiation of an activated killer cell population capable of potent cytotoxic activity against tumor cells. The progenitor and lineage of these lymphokine activated killer cells...

journal_title：Cellular immunology

authors： Owen-Schaub LB,Abraham SR,Hemstreet GP 3rd

更新日期：1986-12-01 00:00:00

abstract：:Medicinal plants are considered immunomodulatory as they display various biological activities. There is no report addressing the anti-inflammatory effects of Daphne gnidium. In this study, we investigated the effects of D. gnidium ethyl acetate (EA) leaf extract on mice immune cell function in vitro. Production of pr...

journal_title：Cellular immunology

authors： Harizi H,Chaabane F,Ghedira K,Chekir-Ghedira L

更新日期：2011-01-01 00:00:00

abstract：:Plasmacytoid dendritic cells (PDCs) from human umbilical cord blood (UCB) produce lower amounts of IFN-α upon TLR stimulation compared with adult counterparts. This difference may play a role in the low graft-versus-host disease rate after UCB transplantation and in the impaired immune response of the neonate to patho...

journal_title：Cellular immunology

authors： Charrier E,Cordeiro P,Cordeau M,Dardari R,Michaud A,Harnois M,Merindol N,Herblot S,Duval M

更新日期：2012-03-01 00:00:00

abstract：:In the search for its role in inflammatory joint diseases, soluble HLA-DR (sHLA-DR) was quantitated in 72 synovial fluids (SF) by a newly established immunoenzyme assay. Unlike other soluble receptors which accumulated only moderately (sCD25, sCD4) or negligibly (sHLA class I, sCD8) in the SF, SF sHLA-DR levels exceed...

journal_title：Cellular immunology

authors： Claus R,Bittorf T,Walzel H,Brock J,Uhde R,Meiske D,Schulz U,Hobusch D,Schumacher K,Witt M,Bartel F,Hausmann S

更新日期：2000-12-15 00:00:00

abstract：:Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, played an important role in immune-mediated diseases. The promoter region of MIF, which had functional polymorphisms, controlled MIF expression. MIF polymorphism was associated with many inflammatory diseases. But the association of MIF polymor...

journal_title：Cellular immunology

authors： Zhang K,Pan X,Shu X,Cao H,Chen L,Zou Y,Deng H,Li G,Xu Q

更新日期：2013-04-01 00:00:00

abstract：:Latex microspheres-based artificial antigen-presenting cell constructs (aAPCs) are proved to be valuable tools to expand T cells ex vivo for adoptive cell therapy, but little is known about their potential for active immunization. In this report, HLA-A2/peptide tetramers were generated and co-coated with anti-mouse CD...

journal_title：Cellular immunology

authors： Shen C,Zhang J,Xia L,Meng F,Xie W

更新日期：2007-05-01 00:00:00

abstract：:Patients with head and neck cancer often have decreased local or regional immunocompetence. Lymphocytes obtained from tumor-involved or -uninvolved lymph nodes (LNL) of these patients showed low or undetectable levels of antitumor cytotoxicity and low proliferative responses in vitro to interleukin 2 (IL2) or mitogens...

journal_title：Cellular immunology

authors： Letessier EM,Sacchi M,Johnson JT,Herberman RB,Whiteside TL

更新日期：1990-10-15 00:00:00

abstract：:Interleukin (IL)-4 has been shown to be secreted simultaneously with IL-2 and interferon (IFN)-gamma by the majority of CD4+ human T cell clones isolated and cultured using IL-2 as a growth factor. Moreover, IL-4 was found to be as efficient as IL-2 to promote the outgrowth of human T cell clones. In this study we hav...

journal_title：Cellular immunology

authors： Paliard X,de Vries JE,Spits H

更新日期：1991-07-01 00:00:00

abstract：:We have characterized the activation of the interleukin 1 (IL-1)-responsive T-cell lymphoma LBRM33-1A5-47 to interleukin 2 (IL-2) production by phytohemagglutinin (PHA) and IL-1. The signal provided by soluble IL-1 could be replaced by fixed P388D1 cells and the signal provided by PHA by a monoclonal antibody directed...

journal_title：Cellular immunology

authors： Zlotnik A,Daine B,Smith CA

更新日期：1985-09-01 00:00:00

abstract：:Blockade of the immune cell checkpoint inhibitors programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) has become a powerful tool in cancer treatment, which is effective across various solid cancer types and hematologic malignancies. Our previous studies showed that by reducing immune tolerance, clustered r...

journal_title：Cellular immunology

authors： Shao J,Xu Q,Su S,Meng F,Zou Z,Chen F,Du J,Qian X,Liu B

更新日期：2017-10-01 00:00:00

abstract：:Poxviruses are a large, complex group of highly successful pathogens that cause disease in humans and other animals. They encode several proteins postulated to be involved in the evasion of host immunity and therefore serve as excellent models for understanding virus-host interaction during the early stages of viral i...

journal_title：Cellular immunology

authors： Miller CG,Justus DE,Jayaraman S,Kotwal GJ

更新日期：1995-05-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a model for multiple sclerosis, is a chronic T cell-mediated disease. Development of clinical symptoms in susceptible mouse strains generally correlates with TMEV-specific delayed-type hypersensitivity (DTH) responses. These responses, ...

journal_title：Cellular immunology

authors： Pelka A,Olsberg C,Miller S,Waltenbaugh C,Creighton TM,dal Canto MC,Melvold R

更新日期：1993-12-01 00:00:00

abstract：:Some further aspects of B-lymphocyte-promotor factor (B-LPF) activity have been studied. This activity was present in the supernatants of certain helper-T-cell lines, and it induced polyclonal activation of Ig+ B cells into Ig-secreting cells. It was found that B-LPF induced polyclonal, terminal B-cell differentiation...

journal_title：Cellular immunology

authors： Reininger L,Fueri J,Boned A,Prat M,Landolfo S,Rubin B

更新日期：1985-04-15 00:00:00

abstract：:Ferric ammonium citrate (FAC) is nonmitogenic for human peripheral blood mononuclear cells (PBM) but has a potent mitogenic activity in the presence of IL-2. FAC in the presence of IL-2 increases the number of human peripheral blood mononuclear cells (PBM) expressing receptors for IL-2 and transferrin. FAC also marked...

journal_title：Cellular immunology

authors： Novogrodsky A,Suthanthiran M,Stenzel KH

更新日期：1991-04-01 00:00:00

abstract：:This report describes a model for investigating the role of the thymus in regulating natural killer (NK) cell activity in vivo. Evidence is presented that the thymus can regulate NK cells, and that at least some NK cells can develop without thymic help. Marrow from thymectomized rats depleted of circulating T cells by...

journal_title：Cellular immunology

authors： Flexman JP,Holt PG,Mayrhofer G,Latham BI,Shellam GR

更新日期：1985-02-01 00:00:00

abstract：:The proliferative responses of human peripheral blood mononuclear cells (PBL) and thymocytes to OKT3 monoclonal antibody have been investigated. The PBL response to OKT3 was maximal after 72 hr while that of thymocytes was inappreciable at all times measured. Unlike phytohemagglutinin, OKT3 was unable to elicit the mi...

journal_title：Cellular immunology

authors： Musiani P,Maggiano N,Aiello FB,Lauriola L,Ranelletti FO,Piantelli M

更新日期：1984-04-01 00:00:00

abstract：:Human mononuclear cells stimulated with soluble IgG aggregates generated chemiluminescence, a response attributable to monocytes. Some requirements of this reaction were examined by preincubation of the cells with a variety of inhibitors. The protease antagonists TPCK and TLCK, the phospholipase inhibitors quinacrine ...

journal_title：Cellular immunology

authors： Rush DN,Keown PA

更新日期：1984-08-01 00:00:00

abstract：:Due to their immunomodulatory properties, adipose tissue (AT) and Wharton's Jelly (WJ) constitute valuable alternatives to BM as sources of MSCs for managing graft-versus-host disease. To ensure the efficiency of AT- and WJ-MSCs implies the characterization of their immunomodulatory functions in comparison to those of...

journal_title：Cellular immunology

authors： Najar M,Raicevic G,Boufker HI,Fayyad Kazan H,De Bruyn C,Meuleman N,Bron D,Toungouz M,Lagneaux L

更新日期：2010-01-01 00:00:00

abstract：:Murine C57BL/6 thymocytes were cultivated together with syngeneic thymus-derived macrophages (TDM phi) for up to 96 hr to determine whether TDM phi participate in thymocyte maturation. The expression level of H-2b and Thy-1.2 antigens served as thymocyte differentiation surface markers as analyzed by flow cytometry. I...

journal_title：Cellular immunology

authors： Zeira M,Gallily R,Stein I,Giloh H

更新日期：1991-05-01 00:00:00

abstract：:Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strate...

journal_title：Cellular immunology

authors： Alves AC,Ramaldes GA,Oliveira MC,Cardoso VN,Mota-Santos TA,Faria AM,Gontijo CM

更新日期：2008-01-01 00:00:00

abstract：:A variant nonkiller (K-) T-cell clone derived from the MHC nonrestricted killer (K+) cell line TALL-103/2 (CD3/TCR gamma delta +) was studied to determine whether its lytic defects were at the tumor-binding or post-binding level. The two TALL-103/2 clones were found to display similar mRNA expression of TCR/CD3 comple...

journal_title：Cellular immunology

authors： Visonneau S,Cesano A,Santoli D

更新日期：1995-10-15 00:00:00

abstract：:Recently we reported on a novel H2E transgenic, IA-negative model of experimental autoimmune thyroiditis (EAT) that excludes reactivity to self in its susceptibility pattern to heterologous thyroglobulin (Tg). In conventional, susceptible mouse strains, EAT is inducible with both homologous and heterologous Tg; e.g., ...

journal_title：Cellular immunology

authors： Yan Y,Panos JC,McCormick DJ,Wan Q,Giraldo AA,Brusic V,David CS,Kong YC

更新日期：2001-08-25 00:00:00

abstract：:NK and extrathymic T cells are abundant in the decidua of the pregnant uterus. To determine how this unique pattern is induced, overall populations of leukocytes were examined in the blood and other tissues in pregnant women. Time-kinetic studies showed that a basal change of leukocytes during pregnancy was granulocyt...

journal_title：Cellular immunology

authors： Minagawa M,Narita J,Tada T,Maruyama S,Shimizu T,Bannai M,Oya H,Hatakeyama K,Abo T

更新日期：1999-08-25 00:00:00

abstract：:In this study, we demonstrate that HIV-1 Tat protein is able to induce IL-10 and TNF-alpha in human macrophages. We show that N-terminal Tat 1-45 fragment initiates the PKC pathway by acting at the membrane. Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha pr...

journal_title：Cellular immunology

authors： Leghmari K,Contreras X,Moureau C,Bahraoui E

更新日期：2008-01-01 00:00:00

abstract：:Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of the IL-2/retroviral vector into melanoma xenografts in nude mic...

journal_title：Cellular immunology

authors： Abdel-Wahab Z,Li WP,Osanto S,Darrow TL,Hessling J,Vervaert CE,Burrascano M,Barber J,Seigler HF

更新日期：1994-11-01 00:00:00

abstract：:To understand the role of cAMP during macrophage activation, we investigated the effects of various cAMP analogues in the induction of nitric oxide (NO) synthesis in murine peritoneal macrophages. Intracellular cAMP modulators such as N6,O2'-dibutyryl cyclic AMP (DB-cAMP), 8-bromo-cAMP, or 8-chloro-cAMP had no effect ...

journal_title：Cellular immunology

authors： Park YC,Park SJ,Jun CD,Kim GE,Park KI,Kim HD,Park RK,Chung HT

更新日期：1997-07-10 00:00:00

abstract：:The utility of multiple antigenic peptides (MAPs) for the induction of antibody and cellular immune responses in animal models has been demonstrated for a variety of peptide epitopes involved in human disease. However, little is known about immune responses to MAPs constructed with antigenic tumor epitopes, nor has pe...

journal_title：Cellular immunology

authors： Schott ME,Wells DT,Schlom J,Abrams SI

更新日期：1996-12-15 00:00:00

abstract：:To determine the contribution of B cells to brain myelin injury in Semliki Forest Virus (SFV) encephalomyelitis, normal C57BL/6 (B6) and B-cell-deficient (C57BL/6-tm1Cgn) B6 mice were infected with SFV. The peak of clinical disease, i.e., the time at which the greatest proportions of mice had moderate to severe clinic...

journal_title：Cellular immunology

authors： Smith-Norowitz TA,Sobel RA,Mokhtarian F

更新日期：2000-02-25 00:00:00

abstract：:The immediate effects and mechanisms of desensitization of contact sensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) were investigated. Mice were sensitized with DNFB, desensitized with antigen 2 weeks later, and challenged 1 day after desensitization. Significant inhibition (approximately 50%) of contact sensitivity ...

journal_title：Cellular immunology

authors： Mekori YA,Claman HN

更新日期：1984-11-01 00:00:00

abstract：:The functional specificity of three types of macrophage chemotactic factors ( MCFs ), -a, -b, and -c, from purified protein derivative of tuberculin (PPD)-induced delayed hypersensitivity reaction (DHR) skin sites on guinea pigs, was analyzed using macrophage cell line cells, M1, established from myeloid leukemia cell...

journal_title：Cellular immunology

authors： Honda M,Masuda T,Yoshimura T,Hayashi H

更新日期：1984-06-01 00:00:00