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Relationship between MIF-173 G/C polymorphism and susceptibility to chronic hepatitis B and HBV-induced liver cirrhosis.

Abstract：

:Macrophage migration inhibitory factor (MIF), a pro-inflammatory cytokine, played an important role in immune-mediated diseases. The promoter region of MIF, which had functional polymorphisms, controlled MIF expression. MIF polymorphism was associated with many inflammatory diseases. But the association of MIF polymorphism with chronic hepatitis B (CHB) or HBV-induced liver cirrhosis (HC) had not yet been reported. In present study, polymorphism of MIF-173 was genotyped in 95 CHB patients, 73 HC patients and 90 healthy controls in southern China. The frequency of MIF-173 C/C genotype in patients with CHB or HC was statistically significantly higher than that in healthy controls, respectively. Moreover, difference in the distribution of MIF-173 C allele between CHB patients and healthy controls was statistically significant. However, there was no statistical relationship between MIF-173 genotype and clinical features in patients with CHB or HC. Our results suggest that MIF-173 C/C polymorphism might be associated with increased risk of CHB or HC in Chinese southern population.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Zhang K,Pan X,Shu X,Cao H,Chen L,Zou Y,Deng H,Li G,Xu Q

doi

10.1016/j.cellimm.2013.04.013

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

113-6

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(13)00064-6

journal_volume

282

pub_type

杂志文章

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