FK506 and cyclosporin A each inhibit antigen-specific signaling in the T cell line 171 in the absence of a calcium signal.

abstract：:A majority (42/62) of TCR2+ interleukin 2-dependent human T lymphocyte clones was found concordantly to express not only the CD28 co-receptor structure at the cell surface but also its ligand B7. Interactions between CD28 and B7 can have important consequences for T cell activation, particularly in providing "signal 2...

journal_title：Cellular immunology

authors： Friccius H,Siegels-Hübenthal P,Rehbein A,Schlotz E,Pawelec G

更新日期：1993-10-15 00:00:00

abstract：:Numerous reports in the literature describe the effects of beta-adrenergic agonists and/or their second messenger cyclic AMP on in vitro and in vivo immune responses. The fact that the murine spleen receives rich adrenergic innervation and that the pharmacologic disruption of this innervation leads to altered immune r...

journal_title：Cellular immunology

authors： Fuchs BA,Campbell KS,Munson AE

更新日期：1988-12-01 00:00:00

abstract：:The role of class II antigens for B-cell activation was analyzed using purified human B cells and anti-class II monoclonal antibodies. The stimulation of purified B cells with Staphylococcus aureus Cowan I induced proliferation and differentiation into immunoglobulin-producing cells in the presence of interleukin-1 an...

journal_title：Cellular immunology

authors： Tanaka Y,Shirakawa F,Ota T,Suzuki H,Eto S,Yamashita U

更新日期：1988-04-01 00:00:00

abstract：:Two monoclonal antibodies specific for different rat T-cell subpopulations, the anti-helper-T-cell antibody, W3/25, and the OX8 suppressor cell antibody were used to investigate lectin-stimulated T-lymphocyte differentiation of F-344 rat bone marrow cells in culture. Cytofluorometric analysis of freshly isolated lymph...

journal_title：Cellular immunology

authors： Pfeifer RW,Stillman WS,Irons RD

更新日期：1983-12-01 00:00:00

abstract：:A thymic epithelial cell line (tsTNC-1) that maintains the ability to selectively bind and internalize immature alpha beta TCRloCD4+CD8+ thymocytes in vitro was used in the development of a monoclonal antibody that is specific to the cell surface of thymic nurse cells (TNCs) in the thymus. The rat monoclonal antibody ...

journal_title：Cellular immunology

authors： Pezzano M,King KD,Philp DD,Adeyemi A,Gardiner B,Yang J,Samms M,Boto W,Guyden JC

更新日期：1998-05-01 00:00:00

abstract：:We have previously used human Epstein Barr virus (EBV)-transformed B lymphoblastoid cell lines for the identification and purification of a novel cytokine, natural killer cell stimulatory factor (NKSF/IL-12), that has pleiotropic effects on human lymphocytes. B cell lines are also routinely employed as feeder cells fo...

journal_title：Cellular immunology

authors： Valiante NM,Rengaraju M,Trinchieri G

更新日期：1992-11-01 00:00:00

abstract：:We have recently established a new animal model for primary Sjögren's syndrome in NFS/sld mutant mice thymectomized 3 days after birth (3dTX) bearing an autosomal recessive gene with sublingual gland differentiation arrest. In this study, we analyze developing mechanisms of experimental autoimmune sialadenitis (EAS) i...

journal_title：Cellular immunology

authors： Hayashi Y,Haneji N,Hamano H,Yanagi K,Takahashi M,Ishimaru N

更新日期：1996-08-01 00:00:00

abstract：:Peripheral blood mononuclear cells (PBMCs) from cattle vaccinated with Bacillus Calmette-Guerin (BCG) were obtained and expanded in vitro by incubation with purified protein derivative. The ability of these cells to modulate the replication of virulent Mycobacterium bovis in autologous-infected macrophages was compare...

journal_title：Cellular immunology

authors： Denis M,Wedlock DN,Buddle BM

更新日期：2004-11-01 00:00:00

abstract：:The impact of BCR:CD21 co-engagement on B cell expression of molecules critical for T cell activation was investigated with receptor-specific mAbs conjugated to high MW dextran as stimulatory ligands. In the absence of IL-4, BCR:CD21 co-ligation augmented BCR-triggered CD86 only under conditions of very low BCR ligand...

journal_title：Cellular immunology

authors： Mongini PK,Tolani S,Fattah RJ,Inman JK

更新日期：2002-03-01 00:00:00

abstract：:Whole sporozoite vaccine (WSV) is shown to induce sterile protection that targets Plasmodium liver-stage infection. There are many underlying issues associated with induction of effective sterile protracted protection. In this study, we have addressed how the alterations in successive vaccine regimen could possibly af...

journal_title：Cellular immunology

authors： Patel H,Yadav N,Parmar R,Patel S,Singh AP,Shrivastava N,Dalai SK

更新日期：2017-07-01 00:00:00

abstract：:Chitin oligosaccharides (NA-COS) of two different molecular weight ranges (below 1 and 1-3 kDa) were examined for their capabilities against lipopolysaccharide-induced inflammatory responses in BV-2 murine microglia. It was found that NA-COS reduced the level of nitric oxide (NO) and prostaglandin E(2) (PGE(2)) produc...

journal_title：Cellular immunology

authors： Vo TS,Ngo DH,Ta QV,Wijesekara I,Kong CS,Kim SK

更新日期：2012-05-01 00:00:00

abstract：:Coxsackievirus group B type 3 (CVB3) induces myocarditis in male Balb/c mice but produces little cardiac injury in females. Males develop cytolytic T lymphocytes (CTL) reactive to heart antigens which primarily cause the inflammation and cardiac injury observed in the disease. Infected female mice lack this CTL respon...

journal_title：Cellular immunology

authors： Job LP,Lyden DC,Huber SA

更新日期：1986-03-01 00:00:00

abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

journal_title：Cellular immunology

authors： Nilsson N,Carlsten H

更新日期：1994-10-01 00:00:00

abstract：:Chronic relapsing experimental allergic encephalomyelitis (CR-EAE) can be adoptively transferred using myelin basic protein (BP)-specific helper T cell lines, and suppressor cells may be important in recovery from EAE. In order to generate suppressor cells, spleen cells obtained from BP-complete Freund's adjuvant (CFA...

journal_title：Cellular immunology

authors： Whitham RH,Vandenbark AA,Bourdette DN,Chou YK,Offner H

更新日期：1990-04-01 00:00:00

abstract：:IgA nephropathy (IgAN) is a tonsil-related disease. We previously showed that oligodeoxynucleotides with CpG (CpG-ODN) and B-cell activation factor (BAFF) are involved in hyperproduction of IgA from tonsillar mononuclear cells of patients with IgAN (IgAN-TMCs). In this study, we focused on a proliferation-inducing lig...

journal_title：Cellular immunology

authors： Takahara M,Nagato T,Nozaki Y,Kumai T,Katada A,Hayashi T,Harabuchi Y

更新日期：2019-07-01 00:00:00

abstract：:In this paper, we examined the contribution of the lymphokine interleukin-6 (IL-6) to the growth of four virulent strains of Mycobacterium avium and the nature of the binding moieties on the mycobacteria. First, we showed that human or mouse recombinant interleukin-6 are potent growth factors for four strains of virul...

journal_title：Cellular immunology

authors： Denis M

更新日期：1992-04-15 00:00:00

abstract：:In vitro incubations of CD4+ T cells with anti-CD4 monoclonal antibody (Mab) demonstrated saturation binding and inhibited both PPD-stimulated proliferation and delayed-type hypersensitivity (DTH) after passive transfer of these cells into naive rats. In comparison, in vivo administration of anti-CD4 Mab into rats, 2 ...

journal_title：Cellular immunology

authors： Morrison WJ,Kennedy NJ,Offner H,Vandenbark AA

更新日期：1995-06-01 00:00:00

abstract：AIMS:Non-enzymatic reaction of biomolecules leads to the formation of advanced glycation end products (AGEs). AGEs plays significant role in the pathophysiology of type 2 diabetes mellitus. Methylglyoxal (MG) is a highly reactive carbonyl compound which causes formation of early (ketoamines), intermediate (dicarbonyls)...

journal_title：Cellular immunology

authors： Khan MY,Alouffi S,Khan MS,Husain FM,Akhter F,Ahmad S

更新日期：2020-05-01 00:00:00

abstract：:In the search for its role in inflammatory joint diseases, soluble HLA-DR (sHLA-DR) was quantitated in 72 synovial fluids (SF) by a newly established immunoenzyme assay. Unlike other soluble receptors which accumulated only moderately (sCD25, sCD4) or negligibly (sHLA class I, sCD8) in the SF, SF sHLA-DR levels exceed...

journal_title：Cellular immunology

authors： Claus R,Bittorf T,Walzel H,Brock J,Uhde R,Meiske D,Schulz U,Hobusch D,Schumacher K,Witt M,Bartel F,Hausmann S

更新日期：2000-12-15 00:00:00

abstract：:Immunity to Schistosoma mansoni is regulated by an auto-anti-idiotypic network. The T cells in this network interact through soluble regulatory factors. These studies describe a soluble suppressor-inducer factor (TsiF) derived from TCR+ suppressor-inducer clone Q37. Q37 is the fusion product of CD4+ T cells derived fr...

journal_title：Cellular immunology

authors： Perrin PJ,Phillips SM

更新日期：1993-06-01 00:00:00

abstract：:Blockade of the immune cell checkpoint inhibitors programmed death 1 (PD-1) and programmed death-ligand 1 (PD-L1) has become a powerful tool in cancer treatment, which is effective across various solid cancer types and hematologic malignancies. Our previous studies showed that by reducing immune tolerance, clustered r...

journal_title：Cellular immunology

authors： Shao J,Xu Q,Su S,Meng F,Zou Z,Chen F,Du J,Qian X,Liu B

更新日期：2017-10-01 00:00:00

abstract：:During the gestational cycle the placental tissue does not express class II MHC antigens and whether this phenomenon is important to fetal survival has not yet been evoked. It has been reported that class II antigen expression precedes renal and cardiac graft rejection, which may also be the case in fetal abortion. In...

journal_title：Cellular immunology

authors： Athanassakis-Vassiliadis I,Galanopoulos VK,Grigoriou M,Papamatheakis J

更新日期：1990-07-01 00:00:00

abstract：:The susceptibility of murine embryonic cells to CTL lysis has been assessed. Zona-free blastocysts were not lysed during 6 hr incubation with CTL sensitized against the embryonic genotype and remained capable of implantation and normal development in vivo as well as outgrowth in vitro. Freshly dissociated cells from p...

journal_title：Cellular immunology

authors： Croy BA,Rossant J

更新日期：1987-02-01 00:00:00

abstract：:Some further aspects of B-lymphocyte-promotor factor (B-LPF) activity have been studied. This activity was present in the supernatants of certain helper-T-cell lines, and it induced polyclonal activation of Ig+ B cells into Ig-secreting cells. It was found that B-LPF induced polyclonal, terminal B-cell differentiation...

journal_title：Cellular immunology

authors： Reininger L,Fueri J,Boned A,Prat M,Landolfo S,Rubin B

更新日期：1985-04-15 00:00:00

abstract：:The activation of large granular lymphocytes (LGLs)/natural killer (NK) cells with interleukin-2 (IL-2) has been shown to increase the ability of these cells to lyse NK-resistant tumor target cells. Activated LGLs, termed LAK (lymphokine-activated killer) cells, have been demonstrated to be of therapeutic value in viv...

journal_title：Cellular immunology

authors： McCoy JP Jr,Hanley-Yanez K,Brumfield A,Herberman RB,Chambers WH

更新日期：1990-05-01 00:00:00

abstract：:Serum of an autoimmune MRL/Mp-lpr/lpr (MRL/l) mouse supported the proliferation of interleukin 3 (IL-3)-dependent cell line, FDC-P2. This IL-3-like activity initially appeared at 1 month of age and increased with age. Females showed higher titers than did males. MRL/Mp-+/+ mouse sera also exhibited such activity, thou...

journal_title：Cellular immunology

authors： Tasaka K,Sakihama T,Shirakura-Shibata Y,Matsuda S,Nakajima Y

更新日期：1989-07-01 00:00:00

abstract：:We previously reported that protein tyrosine phosphatase non-receptor type 3 (PTPN3), which is upregulated in activated lymphocytes, acts as an immune checkpoint. However, the mechanism by which PTPN3 expression is enhanced in activated lymphocytes is unknown. In this study, we analyzed the mechanism of PTPN3 expressi...

journal_title：Cellular immunology

authors： Nakayama K,Onishi H,Fujimura A,Imaizumi A,Kawamoto M,Oyama Y,Ichimiya S,Koga S,Fujimoto Y,Nakashima K,Nakamura M

更新日期：2020-12-01 00:00:00

abstract：:Hen egg white lysozyme (HEL)-specific T cell lines and clones were generated from B6 and BDF1 mice. A variety of clonotypes were found among clones generated at an early stage (1 month) whereas fewer clonotypes were detected after several weeks of culture. Furthermore, a bulk line switched from its initial fine peptid...

journal_title：Cellular immunology

authors： Manca F,Dessí V,Shastri N,Oki A,Kaplan M,Clarke J,Miller A,Sercarz EE

更新日期：1994-04-01 00:00:00

abstract：:The interaction between Newcastle disease virus (NDV) and the suppressor cell circuit which regulates the induction phase of contact sensitivity reaction to picryl chloride (Pcl) was investigated. NDV infection impairs the activity of the T suppressor afferent cells (Ts-aff) which inhibit DNA synthesis in the draining...

journal_title：Cellular immunology

authors： Dieli F,Colonna Romano G,Abrignani S,Colizzi V,Salerno A

更新日期：1985-08-01 00:00:00

abstract：:The lpr mutation in mice results in premature termination of transcription of the gene encoding the apoptosis-signaling receptor Fas. As a result, lpr mice develop severe lymphoproliferation and lupus-like autoantibodies. Growing evidence suggests that the lpr mutation is "leaky" and that low levels of Fas are express...

journal_title：Cellular immunology

authors： Weintraub JP,Godfrey V,Wolthusen PA,Cheek RL,Eisenberg RA,Cohen PL

更新日期：1998-05-25 00:00:00