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A thymic nurse cell-specific monoclonal antibody.

Abstract：

:A thymic epithelial cell line (tsTNC-1) that maintains the ability to selectively bind and internalize immature alpha beta TCRloCD4+CD8+ thymocytes in vitro was used in the development of a monoclonal antibody that is specific to the cell surface of thymic nurse cells (TNCs) in the thymus. The rat monoclonal antibody ph91 showed specificity to cells of the subcapsular region of the thymic cortex. Upon mechanical dispersion of the thymus in vitro, ph91 recognized cells displaying the multicellular morphology unique to TNCs. Ph91 staining was not detected on fresh thymocytes, stromal cells of the inner thymic cortex, thymic medullary cells, B cells or fibroblasts. Ph91 recognized a 43-kDa protein on the surface of TNCs. Exposure of tsTNC-1 cells to ph91 in tissue culture significantly reduced the percentage of binding of the alpha beta TCRloCD4+CD8+ thymocyte subset previously shown to target TNCs. In organ culture, ph91 reduced the viability of developing thymocytes by 70%. The largest reduction was found in the alpha beta TCR+CD4+CD8+ thymocyte subset. These results represent the first report of a TNC-specific monoclonal antibody. Further, the antigen to which ph91 binds may play a role in the process of thymocyte binding and their subsequent internalization which is unique to TNCs and important to the T cell developmental process.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Pezzano M,King KD,Philp DD,Adeyemi A,Gardiner B,Yang J,Samms M,Boto W,Guyden JC

doi

10.1006/cimm.1998.1279

subject

Has Abstract

pub_date

1998-05-01 00:00:00

pages

123-33

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(98)91279-5

journal_volume

185

pub_type

杂志文章

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