NFκB and TGFβ contribute to the expression of PTPN3 in activated human lymphocytes.

abstract：:Tiazofurin treatment of K562 leukemia cells in vitro depletes the metabolites of the guanylate biosynthetic pathway, inducing erythroid differentiation, that, in turn, alters the phenotypic profile. As a consequence, K562 cells possibly modify their interaction with immune cells. Here we describe the binding and killi...

journal_title：Cellular immunology

authors： Zamai L,Zauli G,Bavelloni A,Marmiroli S,Cataldi A,Weber G,Vitale M

更新日期：1995-08-01 00:00:00

abstract：:Although ligation of the T-cell antigen receptor (TCR) is central to the responsiveness and antigen specificity of T-cells, it is insufficient to elicit a response. To determine whether the need for costimulation reflects inadequate strength of signal transduction through the TCR or an absolute block of signaling in t...

journal_title：Cellular immunology

authors： Adler B,Ashkar S,Cantor H,Weber GF

更新日期：2001-05-25 00:00:00

abstract：:Oral administration of protein antigens, such as ovalbumin, may result in induction of either tolerance or immunization. To avoid oral tolerance, there are new strategies to protect the antigens from degradation within the gastrointestinal tract and to allow them to reach inductive immunological sites. One such strate...

journal_title：Cellular immunology

authors： Alves AC,Ramaldes GA,Oliveira MC,Cardoso VN,Mota-Santos TA,Faria AM,Gontijo CM

更新日期：2008-01-01 00:00:00

abstract：:Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation in murine allergic a...

journal_title：Cellular immunology

authors： Shilling RA,Clay BS,Tesciuba AG,Berry EL,Lu T,Moore TV,Bandukwala HS,Tong J,Weinstock JV,Flavell RA,Horan T,Yoshinaga SK,Welcher AA,Cannon JL,Sperling AI

更新日期：2009-01-01 00:00:00

abstract：:Although it is well established that the processes of cellular proliferation and apoptosis are linked, the role of cell cycle regulators in T cell responses in vivo is not well understood. In recent years, tumor suppressor molecule p19(ARF) has emerged as a key cell cycle regulator important in cellular apoptosis agai...

journal_title：Cellular immunology

authors： Gao X,Svaren J,Suresh M

更新日期：2002-10-01 00:00:00

abstract：:The internalization of surface immunoglobulin (Ig) by B lymphocytes is the first step in the antigen-presenting function performed by these cells. Mature B cells coexpress on their surface IgM and IgD. At this time, there is controversy over whether these two isotypes serve different functions in the antigen-presentin...

journal_title：Cellular immunology

authors： Guarini L,Weber DA,Pernis B

更新日期：1989-10-15 00:00:00

abstract：:Possible causes were examined for the inability of heat-inactivated lymphocytes to induce proliferative responses in mixed-lymphocyte cultures (MLC). Cells heated at 45 degrees C for 60 min lost greater than 90% of their capacity to stimulate in primary (1 degree) or secondary (2 degrees) MLC. This was not due to acce...

journal_title：Cellular immunology

authors： Boyer CM,Kostyu DD,Brissette CS,Amos DB

更新日期：1986-09-01 00:00:00

abstract：:To characterize the binding properties of the Fc receptors on human macrophages, the binding of radiolabeled human IgG1 to peritoneal macrophages was assessed. Cells were obtained at the time of diagnostic laparoscopy from women undergoing evaluation of infertility. Macrophages bound on the average more IgG1 monomer t...

journal_title：Cellular immunology

authors： Kurlander RJ,Haney AF,Gartrell J

更新日期：1984-07-01 00:00:00

abstract：:Within the lymphoid compartment, CD8 is expressed either as an alphaalpha homodimer or as an alphabeta heterodimer. Prior functional characterization of CD8alpha transfectants has demonstrated that CD8alphaalpha homodimers can reconstitute T cell responses in the absence of the CD8beta subunit. In order to now examine...

journal_title：Cellular immunology

authors： Witte T,Spoerl R,Chang HC

更新日期：1999-02-01 00:00:00

abstract：:American cutaneous leishmaniasis (ACL) is a disease where susceptibility or resistance is dependent on T cell response. This is characterized by an increased in CD4⁺ T cells, capable of inducing opposite disease profiles, and CD8⁺ T cells, that are related to immuno protection. We characterized T lymphocytes from pati...

journal_title：Cellular immunology

authors： Brelaz-de-Castro MC,de Almeida AF,de Oliveira AP,de Assis-Souza M,da Rocha LF,Pereira VR

更新日期：2012-10-01 00:00:00

abstract：:Our group has shown in a randomized clinical trial that psychological intervention to reduce stress in patients with stages II and III breast cancer led to enhanced immune function, fewer recurrences and improved overall survival. We hypothesized that patients with high levels of stress would have alterations in myelo...

journal_title：Cellular immunology

authors： Mundy-Bosse BL,Thornton LM,Yang HC,Andersen BL,Carson WE

更新日期：2011-01-01 00:00:00

abstract：:The utility of multiple antigenic peptides (MAPs) for the induction of antibody and cellular immune responses in animal models has been demonstrated for a variety of peptide epitopes involved in human disease. However, little is known about immune responses to MAPs constructed with antigenic tumor epitopes, nor has pe...

journal_title：Cellular immunology

authors： Schott ME,Wells DT,Schlom J,Abrams SI

更新日期：1996-12-15 00:00:00

abstract：:Multiple previous studies have demonstrated significant alterations of immunologic parameters associated with mouse hepatitis virus (MHV) infection, but effects of the virus on mucosal lymphoid cells have not been examined. Coincident with a natural outbreak of MHV at our institution, we noted alterations in immunoglo...

journal_title：Cellular immunology

authors： Casebolt DB,Spalding DM,Schoeb TR,Lindsey JR

更新日期：1987-10-01 00:00:00

abstract：:The expression of HLA Class II antigens by resting and phytohemagglutinin (PHA)-activated T cells and their functional properties in autologous mixed-lymphocyte reactions (MLR) were investigated in patients with chronic active hepatitis, with alcoholic cirrhosis, and with primary biliary cirrhosis. In all groups of pa...

journal_title：Cellular immunology

authors： Scudeletti M,Indiveri F,Pierri I,Picciotto A,Ferrone S

更新日期：1986-10-01 00:00:00

abstract：:Following interaction of the random polymer (Glu60,Phe40)n (GPhe) with antigen-presenting accessory cells (APC), unusual costimulatory activities were noted in several murine T cell systems. When GPhe, in contrast with other random copolymers (GT,GL), was added during "inhibition" and T cell "repertoire" studies as a ...

journal_title：Cellular immunology

authors： Liu DC,Grun JL,Maurer PH

更新日期：1990-08-01 00:00:00

abstract：:Spontaneously cytotoxic cells possessing specificity and having a complex pattern of reactivity directed at least partly against self-determinants develop by the age of 10 weeks in the autoimmune mouse strain MRL/Mp-lpr/lpr (MRL-lpr) and by the age of 6 months in C57BL/6-lprl/lpr. Similar effector cells do not develop...

journal_title：Cellular immunology

authors： Muraoka S,Miller RG

更新日期：1988-04-15 00:00:00

abstract：:TE44, an H-2b-restricted, self-reactive T-cell line, did not produce autocrine-acting growth factors, neither after antigenic nor after mitogenic activation; they remained for their proliferation completely dependent on exogenously added IL-2. Administration of IL-4, which poorly promotes growth by itself, resulted in...

journal_title：Cellular immunology

authors： Vandenabeele P,Grooten J,Fiers W

更新日期：1990-10-01 00:00:00

abstract：:We report experiments attempting to optimize the proliferative response of human B cells to rabbit anti-immunoglobulin antibody (RAHIg)-linked beads (anti-Ig beads). By choosing polyacrylamide beads of small size (3 micron) and coupling anti-Ig to them at high concentrations, beads were obtained which were both B-cell...

journal_title：Cellular immunology

authors： Boyd AW,Freedman AS,Horowitz JC,Anderson KC,Fisher DC,Rosen KJ,Schlossman SF,Nadler LM

更新日期：1986-04-15 00:00:00

abstract：:We examined the effects of a rare sugar, D-allose, which is 6-carbon monosaccharide, on endocytosis and T cell stimulation by dendritic cells (DCs). The endocytosis of BCG-anti-BCG immune complexes by DCs markedly decreased in D-allose-containing medium. Co-culture with T cells (mixed leukocyte reaction, MLR) of DCs, ...

journal_title：Cellular immunology

authors： Tanaka S,Sakamoto H

更新日期：2011-01-01 00:00:00

abstract：:Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB). Recognition of DNP/class I MHC (signal one) s...

journal_title：Cellular immunology

authors： Fairchild RL,Moorhead JW

更新日期：1991-03-01 00:00:00

abstract：:A variety of thymus hormone preparations, as well as drugs known to perturb cell differentiation, were tested for their ability to induce nonfunctional cortical thymocytes to become functional precursor cells. Murine cortical thymocytes, defined as the high peanut agglutinin (PNA) binding or as the low H-2K, major [86...

journal_title：Cellular immunology

authors： Andrews P,Shortman K,Scollay R,Potworowski EF,Kruisbeek AM,Goldstein G,Trainin N,Bach JF

更新日期：1985-04-01 00:00:00

abstract：:Imiquimod, a toll-like receptor 7 (TLR7) agonist, is an active pharmaceutical ingredient (API) established for the topical treatment of several dermal cancerous and precancerous skin lesions. Within this work, the immunostimulatory effect of imiquimod is further exploited in a transcutaneous immunization (TCI) approac...

journal_title：Cellular immunology

authors： Gogoll K,Stein P,Lee KD,Arnold P,Peters T,Schild H,Radsak M,Langguth P

更新日期：2016-10-01 00:00:00

abstract：:The effects of oral administration of methylated bovine serum albumin (mBSA) on antigen-induced arthritis (AIA) in rats that was induced by immunization with mBSA followed by the intraarticular injection of the same antigen were investigated. When mBSA was orally given to animals before immunization with the antigen, ...

journal_title：Cellular immunology

authors： Yoshino S

更新日期：1995-06-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DP IV, CD26), known as an activation marker of T lymphocytes, is a proline-specific protease thought to be involved in the regulation of the immune response. The physiological role of dipeptidyl peptidase IV in the immune system and the molecular events of lymphocyte activation mediated by thi...

journal_title：Cellular immunology

authors： Kähne T,Kröning H,Thiel U,Ulmer AJ,Flad HD,Ansorge S

更新日期：1996-05-25 00:00:00

abstract：:Human peripheral blood T cells lysed autologous or allogeneic monocytes, but not polymorphonuclear cells (PMN) or lymphocytes, in the presence of anti-CD3 (OKT3 (IgG2a) or anti-Leu 4 (IgG1)) monoclonal antibody (mAb). Other mAbs such as OKT4 (IgG2b), OKT8 (IgG2a), OKT11 (IgG2a), and OKM1 (IgG2a) did not mediate lysis ...

journal_title：Cellular immunology

authors： Itoh K,Balch CM,Trial J,Platsoucas CD

更新日期：1988-07-01 00:00:00

abstract：:Toll-like receptor (TLR) 2/1 signalling is linked to autophagy through transcriptional actions of the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-vitamin D receptor (VDR) complex. Population-specific effects have been reported for TLR2/1-VDR signalling. We hypothesized that population effects extend to autophagy and are in...

journal_title：Cellular immunology

authors： Abhimanyu,Meyer V,Jones BR,Bornman L

更新日期：2020-06-01 00:00:00

abstract：:In vivo treatment with anti-IA antibodies has been shown to induce a haplotype-specific inhibition of EAE when the disease was following passive transfer of MBP-sensitized T cells. In order to determine the mechanism by which anti-IA antibody prevents passively transferred EAE, the homing of radiolabeled cells to the ...

journal_title：Cellular immunology

authors： Sriram S,Carroll L

更新日期：1991-06-01 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) play a major role in modulating immune response, but only a few reports focused on MDSCs in the liver of sepsis states. Here, we investigated the changes in MDSCs in liver of the cecal ligation and puncture (CLP) mice. The results of flow cytometry showed that MDSCs accumulate ...

journal_title：Cellular immunology

authors： Ren D,Bi Q,Li L,Gao Y,Liang Y,Li Y,Liu J,Peng L,Xiao J

更新日期：2012-09-01 00:00:00

abstract：:Acting through CD14 and TLR4/MD-2, lipopolysaccharide (LPS) triggers strong pro-inflammatory activation of macrophages, which, if not appropriately controlled, may lead to lethal septic shock. Therefore, numerous mechanisms of negative regulation of responses to LPS exist, but whether they include down-regulation of L...

journal_title：Cellular immunology

authors： Józefowski S,Śróttek M

更新日期：2017-02-01 00:00:00

abstract：:Bcl-2 proto-oncogene is expressed in normal lymphoid tissues and its role has been suggested to involve the selection of B and T cells. Here we report three-color flow cytometric studies on the expression of bcl-2 protein in the thymus and periphery. Bcl-2 was expressed in the majority of T and B cells and down-regula...

journal_title：Cellular immunology

authors： Fujii Y,Okumura M,Takeuchi Y,Inada K,Nakahara K,Matsuda H,Tsujimoto Y

更新日期：1994-05-01 00:00:00