Effects of D-allose on the endocytic activity of dendritic cells and the subsequent stimulation of T cells.

Abstract:

:We examined the effects of a rare sugar, D-allose, which is 6-carbon monosaccharide, on endocytosis and T cell stimulation by dendritic cells (DCs). The endocytosis of BCG-anti-BCG immune complexes by DCs markedly decreased in D-allose-containing medium. Co-culture with T cells (mixed leukocyte reaction, MLR) of DCs, which had been exposed to BCG in D-allose-supplemented medium, induced apoptosis of CD4(+) T cells in a manner dependent on D-allose concentration. After the MLR, DCs cultured in the medium with D-allose expressed less CD40 and more Fas ligands than those cultured without D-allose. It was suggested that the functions of DCs, internalization, processing and the subsequent antigen presentation to T cells, are down-regulated via the action of d-allose.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Tanaka S,Sakamoto H

doi

10.1016/j.cellimm.2011.06.015

subject

Has Abstract

pub_date

2011-01-01 00:00:00

pages

141-6

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(11)00153-5

journal_volume

271

pub_type

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