Abstract:
:Mitogenic stimulation of sublines of the human histiocytic lymphoma, U937, results in the production of an inhibitor of lymphocyte proliferation (IDS-U937). The relationship of IDS-U937 to alpha- and gamma-interferon was examined by several techniques: (1) the antiviral activity of the IDS preparations was determined, (2) the effects of antibodies to interferon on IDS activities, and (3) the comparison of the antiproliferative activities of gamma-IFN and IDS. The relationship of IDS to other macrophage derived inhibitors is also discussed with respect to target cell specificities and modes of action.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Wilkins JA,Warrington RJdoi
10.1016/0008-8749(84)90390-3subject
Has Abstractpub_date
1984-07-01 00:00:00pages
354-61issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(84)90390-3journal_volume
86pub_type
杂志文章abstract::Dendritic cell (DC)-based immunotherapy has promising for treatment of non-small cell lung cancer (NSCLC). Melanoma-associated antigen 3 (MAGE-A3) is a tumor-specific antigen and expressed in approximately 35-40% of NSCLC tissues. Calreticulin (CALR) is a protein chaperone and can enhance DC maturation and antigen pre...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2015.12.003
更新日期:2016-02-01 00:00:00
abstract::In Jurkat cells, the three Ca(2+)-ATPase blockers, thapsigargin, cyclopiazonic acid, and di-tert-butylhydroquinone (DtBuHQ) induced both a release of Ca2+ from intracellular stores and a Ca2+ influx. In contrast to CD3 mAb, the Ca(2+)-ATPase inhibitors did not induce the formation of inositol trisphosphate from the hy...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1152
更新日期:1993-07-01 00:00:00
abstract::As fascinating a molecule as it can potentially get, nuclear factor-κB (NF-κB), a regulatory transcription factor, is as intriguing. NF-κB is a dimeric complex that controls the transcription of essential genes. NF-κB is involved in a variety of responses that play a pivotal role in regulating the immune response to i...
journal_title:Cellular immunology
pub_type: 杂志文章,评审
doi:10.1016/j.cellimm.2011.06.021
更新日期:2011-01-01 00:00:00
abstract::The adoptive transfer of tumor-reactive T lymphocytes has recently been demonstrated to be an effective means for mediating the regression of experimental intracranial fibrosarcomas. In this study, mice bearing syngeneic intracranial GL261 gliomas were cured by the combination of sublethal whole body irradiation follo...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1997.1140
更新日期:1997-06-15 00:00:00
abstract::Tumor necrosis factor (TNF) is a 17-kDa protein produced by endotoxin-stimulated macrophages. We have demonstrated that recombinant human TNF activates human macrophages to kill intracellular bacteria of the Mycobacterium avium complex (MAC) in a dose-related manner. TNF also primed macrophages to produce superoxide a...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(92)90243-i
更新日期:1992-10-15 00:00:00
abstract::Essential thrombocythemia (ET), polycythemia vera (PV) and myelofibrosis share the same acquired genetic lesion, JAK2V617F. It is believed that cytokines participate in the activation of JAK2V617F. In this study, we analyzed the plasma levels of interleukin (IL)-23, IL-10 and IL-22 in patients with PV and ET. In the s...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2012.07.003
更新日期:2012-07-01 00:00:00
abstract::Using fetal thymic organ culture (FTOC), we describe the effects of IL-1 on T cell differentiation, particularly within the CD4-CD8- subset. While treatment of FTOC with IL-1 led to a modest reduction in total thymocyte yield, it induced an increase in the percentage of CD4-CD8- cells that express IL-2R early in cultu...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(92)90240-p
更新日期:1992-10-01 00:00:00
abstract::Upregulation of immunoglobulin D-specific receptors (IgD-R) on CD4+ T cells may facilitate their interaction with specific carbohydrate moieties uniquely associated with membrane IgD on B cells. Previous studies have shown that upregulation of IgD-R facilitates cognate T-B cell interactions by mediating bidirectional ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.2000.1747
更新日期:2001-02-01 00:00:00
abstract::Because of the massive cytokine response elicited by superantigen exposure, it has been suggested that superantigens may act as adjuvants to boost conventional antigen responses. However, most previous studies have shown that in vivo exposure to superantigen suppressed subsequent T cell responses. Here we analyzed the...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.1077
更新日期:1997-03-15 00:00:00
abstract::Mice from strains showing either phenotypical expression of Bcg gene (C57BL/6, BALB/c, DBA/1, and (C57BL/6 X DBA/2)/F1, CBA, A/J, DBA/2) were infected intravenously with 10(7) Mycobacterium lepraemurium (MLM). The number of acid-fast bacilli (AFB) within the spleens, the ability of spleen cells to produce in vitro int...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90026-7
更新日期:1985-03-01 00:00:00
abstract::Mutations in the X-linked inhibitor of apoptosis (XIAP) have recently been identified in patients with the rare genetic disease, X-linked lymphoproliferative syndrome (XLP), which was previously thought to be solely attributable to mutations in a distinct gene, SAP. To further understand the roles of these two factors...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2009.05.017
更新日期:2009-01-01 00:00:00
abstract::Germ-free (GF) mice have increased bone mass that is normalized by colonization with gut microbiota (GM) from conventionally raised (CONV-R) mice. To determine if innate immune signaling pathways mediated the effect of the GM, we studied the skeleton of GF and CONV-R mice with targeted inactivation of MYD88, NOD1 or N...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2017.05.003
更新日期:2017-07-01 00:00:00
abstract::Although it is known that IGF-1 increases T lymphocyte proliferation, the regulation of its receptor expression during the process has not been defined. Consequently the regulation of IGF-1R expression by IGF-1 and the activation events in human blood T lymphocytes and the Jurkat T cell line were now investigated. IGF...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1997.1237
更新日期:1998-02-01 00:00:00
abstract::Within the lymphoid compartment, CD8 is expressed either as an alphaalpha homodimer or as an alphabeta heterodimer. Prior functional characterization of CD8alpha transfectants has demonstrated that CD8alphaalpha homodimers can reconstitute T cell responses in the absence of the CD8beta subunit. In order to now examine...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1412
更新日期:1999-02-01 00:00:00
abstract::Tumors harbor a population of cancer stem cells (CSCs) which can drive tumor progression and therapeutical resistance. Nature killer (NK) cells are best known for their ability to directly recognize and kill malignant cells. However, the susceptibility of cancer stem cells to NK cells is not fully understood. Here we ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2015.11.009
更新日期:2016-02-01 00:00:00
abstract::Seeking common abnormalities in mice genetically predisposed to lupus-like autoimmune disease, we investigated (1) the ontogeny of Ia antigens (I-A/I-E) on the surfaces of resident peritoneal macrophages (rpM phi) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of M phi-stimulating fac...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90133-3
更新日期:1984-08-01 00:00:00
abstract::Double immunofluorescence studies for terminal deoxynucleotidyl transferase (TdT) and leucocyte surface membrane antigens have been used to characterize the small subpopulation of TdT-positive cells in human peripheral blood. The predominant antigens demonstrated were those coded for by the major histocompatibility co...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90223-0
更新日期:1985-02-01 00:00:00
abstract::Tumour necrosis factor (TNF) family ligands and their corresponding receptors play important roles in the immune system and are involved in immune regulation such as lymphoid development, cell proliferation, differentiation, activation and death. Antibodies against these ligands and receptors together with Fc-fusion p...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2005.08.010
更新日期:2005-07-01 00:00:00
abstract::We have previously reported that antibody secretion by B.22 hybridoma cells can be suppressed in an MHC-restricted manner, by idiotype-specific T cells. It was shown that T cells of both helper and suppressor phenotypes are involved, and that the suppression is mediated by soluble factors. In the present paper, we hav...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90288-8
更新日期:1989-10-15 00:00:00
abstract::The role of macrophages (M phi) and that of splenic dendritic cells (DC) in the allogeneic mixed leukocyte reaction (MLR) in the mouse have been investigated. In contrast with the high stimulatory capacity of DC, we obtained no evidence in favor of the competence of M phi, whether Ia + or Ia-, as an autonomous stimula...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90169-2
更新日期:1984-10-15 00:00:00
abstract::To clarify the role of B cells in the establishment of T cell response against intracellular bacteria, B-cell-deficient (muMT-/-) mice were infected with an intracellular bacteria, Listeria monocytogenes, and T cell response against the bacteria was analyzed. On day 6 of primary Listeria infection, spleen T cells of t...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1999.1503
更新日期:1999-06-15 00:00:00
abstract::In this study, skin-infiltrating cells were prepared from guinea pig delayed-type hypersensitivity reaction sites, and their phenotypic properties and cytokine production were examined. Our cell preparations contained around 45% nonspecific esterase-positive cells and a few skin-derived cells. Skin-infiltrating cells ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1139
更新日期:1995-08-01 00:00:00
abstract::Two monoclonal antibodies specific for different rat T-cell subpopulations, the anti-helper-T-cell antibody, W3/25, and the OX8 suppressor cell antibody were used to investigate lectin-stimulated T-lymphocyte differentiation of F-344 rat bone marrow cells in culture. Cytofluorometric analysis of freshly isolated lymph...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(83)90160-0
更新日期:1983-12-01 00:00:00
abstract::T-Cell subsets identified by polyclonal and monoclonal antibodies to dipeptidyl peptidase IV (DP IV) were investigated. Analysis in a cytofluorograf revealed 63 +/- 7% positive scatter-gated T lymphocytes. DP IV-positive cells were found to be T11+, 74-81% OKT4+, and 12-19% OKT8+. DP IV-negative cells were T11+ and co...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(85)90400-9
更新日期:1985-06-01 00:00:00
abstract::Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a beta-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth. Histopathological analysis showed that the tumor masses of control mice (Ehr) presented giant tumor cells and many mitotic figures whereas the tumor ti...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2009.01.002
更新日期:2009-01-01 00:00:00
abstract::G proteins are membrane-bound molecules involved in coupling of surface receptors with signal transduction effector systems in multiple cell types including T lymphocytes. Given that mature T cells which lack antigen receptors (CDl-Ti) are refractory to stimulation through CD2 or other accessory molecules, T cell rece...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(90)90050-2
更新日期:1990-07-01 00:00:00
abstract::Recently, we reported that the CD5 protein can bind to the B cell antigen CD72. So far, no functional evidence has been given for this interaction. We used soluble native CD5 and two anti-CD72 monoclonal antibodies, JT3 and WL225, produced and characterized in our laboratory in order to investigate the role of CD5 in ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.0218
更新日期:1996-08-25 00:00:00
abstract::Although pulmonary inflammation is a serious, sometimes life-threatening, consequence of respiratory syncytial virus (RSV) infection, the mechanisms involved are not well understood. Since the process of inflammation is initiated by a complex series of events including the activation of specific adhesion molecules on ...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/s0008-8749(03)00058-3
更新日期:2003-01-01 00:00:00
abstract::Apolipoprotein E (apoE), a lipid transport protein important in cholesterol homeostasis, inhibits the proliferation of interleukin-dependent lymphocytes. Growth factor-responsive cells are blocked in the G1A phase of the cell cycle. Suppression by apoE is independent of growth factor, as evidenced by the fact that int...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(95)80004-3
更新日期:1995-01-01 00:00:00
abstract::This study examines cytotoxic mechanisms used by channel catfish peripheral blood-derived effector cells. Transmission electron microscopy (TEM), coupled with [(3)H]thymidine DNA fragmentation (JAM) and terminal deoxynucleotidyl nick-end labeling (TUNEL) assays, provided the first evidence that catfish peripheral bloo...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1999.1523
更新日期:1999-08-01 00:00:00