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Differential regulation of CD40-mediated human B cell responses by antibodies directed against different CD40 epitopes.

Abstract：

:Ligation of CD40 using anti-CD40 or soluble CD40-ligand activates numerous intracellular kinases which transduce signals to the nucleus. The nature whereby these signaling events are coupled to distal functional events in B cells is poorly understood. In this study, using anti-CD40 monoclonal antibodies which recognize different epitopes on CD40, we compare the ability to activate the stress-activated protein kinases (SAPK) such as c-Jun NH(2) terminal kinase and p38 in human B cells with CD40 function. Activation of the SAPK pathway correlated with levels of activation of Rel/NF-kappaB transcription factors, but did not appear to be associated with rescue from anti-IgM induced apoptosis by suppressing caspase (CPP32) activity. Somewhat surprisingly, in the presence of IL-4, those antibodies to CD40 which failed to activate SAPK were most active in IgE production. IgE production was augmented in the presence of wortmannin. These studies suggest that rescue from apoptosis and IgE production mediated via CD40 may be independent of SAPK activation, induction of Rel/NF-kappaB, or suppression of CPP32 and that IgE production is, at least in part, regulated by signaling pathways that are dependent on phosphatidylinositol 3-kinase.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Sakata N,Hamelmann E,Siadak AW,Terada N,Gerwins P,Aruffo A,Johnson GL,Gelfand EW

doi

10.1006/cimm.2000.1645

subject

Has Abstract

pub_date

2000-05-01 00:00:00

pages

109-23

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(00)91645-9

journal_volume

201

pub_type

杂志文章

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