Abstract:
:Participation of IE antigens (Ag) in immune response as the transplantation Ag was examined. IE- B10.A(4R)(4R; Kk, IAk, IE-, Db) mice could not reject skin graft from IE Ag alone-disparate B10.A(2R) (2R; Kk, IAk, IEk, Db) mice despite intravenous (iv) injection of 2R spleen cells (SC) before or after skin grafting, indicating that graft rejection could not be caused across IE Ag-barrier alone. Furthermore, 4R SC could not induce lethal graft-versus-host disease (GVHD) in supralethally (950 rad) irradiated 2R mice. On the other hand, infiltration of lymphoid cells was observed at the site of transplanted 2R skin in 4R mice. SC of 4R mice unprimed or primed with 2R skin or 2R SC showed the capability to proliferate in vitro in response to 2R Ag. In immunofluorescence analysis of lymph node cells (LNC) of 4R mice injected iv with 2R SC 7 days earlier, IE-reactive CD4+Vbeta 11+ T cells did not change in number, but slightly increased the expression of interleukin-2 receptor (IL-2R). In 2R mice irradiated with 670 rad and injected iv with 4R SC 7 days earlier, 4R-derived CD4+V beta 11+ T cells proliferated, changed to blastoid form, and showed a markedly increased expression of IL-2R. To further investigate the influence of IE alloantigens on transplantation immunity, IL-2 production and anti-class I CTL activity were assayed. The 4R SC capable of recognizing IEk and Dk Ag of B10.BR (Kk, IAk, IEk, Dk) generated levels of both IL-2 and CTL activities higher than those of 2R SC capable of recognizing Dk Ag alone. These results strongly suggest that IE alloantigens indirectly act as the transplantation Ag by the stimulation of IE-reactive CD4+ helper T cells resulting in the differentiation of class I-restricted CD8+ T cells.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Harada M,Tomita Y,Matsuzaki G,Miyazono M,Nomoto Kdoi
10.1016/0008-8749(92)90037-psubject
Has Abstractpub_date
1992-09-01 00:00:00pages
420-33issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(92)90037-Pjournal_volume
143pub_type
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pub_type: 杂志文章,评审
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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pub_type: 杂志文章
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更新日期:1994-04-01 00:00:00
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更新日期:1986-04-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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