Abstract:
:Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) derived from 129S6SvEv Tac mouse embryonic stem cells (mESCs) prevented the development of EAE. In this study, we expand our previous studies to show that transplantation of MOG expressing mESC-TEPs derived from C57BL/6 mice also prevents EAE development. Furthermore, by using a MOG-specific T cell receptor (TCR) transgenic mouse model, we demonstrate that both central and peripheral tolerances are involved in the prevention of EAE induced by MOG expressing mESC-TEPs. Our results suggest that transplantation of human ESC-TEPs expressing MOG may provide an effective approach for the induction of MOG-specific immune tolerance, thereby the prevention and treatment of MS.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Su M,Lin Y,Cui C,Tian X,Lu X,He Z,Lai Ldoi
10.1016/j.cellimm.2017.10.007subject
Has Abstractpub_date
2017-12-01 00:00:00pages
84-91eissn
0008-8749issn
1090-2163pii
S0008-8749(17)30172-7journal_volume
322pub_type
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