A alpha and A beta class II I-A determinants of antigen-specific T-helper factor and its antigen-nonbinding chain.

abstract：:Arriving at an understanding of the role of suppressor T-cells (regulatory T-cells, CD4(+)CD25+) depends on whether their functional repertoire is somatically selected to be anti-Self or anti-Nonself. Immunologists are ambivalent; often publications espousing opposite views share an author. Here the arguments are deta...

journal_title：Cellular immunology

authors： Cohn M

更新日期：2004-02-01 00:00:00

abstract：:Idiotypic immunoglobulin, which can be considered to bear tumour-associated antigens in the context of B-cell lymphoma, has been obtained from the splenic A31 tumour, purified, and used to immunise syngeneic mice. On subsequent exposure to a lethal challenge of lymphoma cells, the mice showed no overt tumour developme...

journal_title：Cellular immunology

authors： Dyke RJ,McBride H,George AJ,Hamblin TJ,Stevenson FK

更新日期：1991-01-01 00:00:00

abstract：:A monoclonal anti-actin antibody, 2C9, was used to study the distribution of an actin-like cell-surface antigen (hereafter termed actin) on a lymphoblastoid cell line LA350 and on human peripheral blood lymphocytes. It was determined that 8-40% of LA350 cells and 3-15% of peripheral blood lymphocytes from healthy dono...

journal_title：Cellular immunology

authors： Bach MA,Lewis DE,McClure JE,Parikh N,Rosenblatt HM,Shearer WT

更新日期：1986-04-01 00:00:00

abstract：:Nontypeable Haemophilus influenzae (NTHi) is the etiological agent most frequently associated with bacterial exacerbations of chronic obstructive pulmonary disease (COPD). The present work shows that NTHi strains induced in primary normal human bronchial epithelial cells (NHBE) a cytokine/chemokine response in which C...

journal_title：Cellular immunology

authors： Teng F,Slavik V,Duffy KE,San Mateo L,Goldschmidt R

更新日期：2010-01-01 00:00:00

abstract：:The pathogenic antibody response to acetylcholine receptor (AChR) in experimental autoimmune myasthenia gravis (EAMG) is T cell dependent. Therefore, it should be possible to design specific immunotherapeutic approaches to treat EAMG (and human MG) by interfering with AChR-specific helper T cells. Productive T cell ac...

journal_title：Cellular immunology

authors： McIntosh KR,Linsley PS,Drachman DB

更新日期：1995-11-01 00:00:00

abstract：BACKGROUND:Piper nigrum L. (Piperaceae) is commonly used as a spice and traditional medicine in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the protective role of P. nigrum on epithelial function of uppe...

journal_title：Cellular immunology

authors： Bui TT,Fan Y,Piao CH,Nguyen TV,Shin DU,Jung SY,Hyeon E,Song CH,Lee SY,Shin HS,Chai OH

更新日期：2020-05-01 00:00:00

abstract：:We have examined noninduced cytotoxicity of mouse gut associated and peripheral lymphoid tissues for a wide variety of syngeneic as well as allogeneic cell lines and lymphoblasts. Lymphoid cells from Peyer's patches were found to lyse these targets in a 3-hr chromium release assay whereas lymphoid cells from intestina...

journal_title：Cellular immunology

authors： Gautam SC,Beckman K,Battisto JR

更新日期：1986-09-01 00:00:00

abstract：:Microglia are important immunoregulatory cells within the central nervous system (CNS). Viral infection of primary microglia and splenic macrophage clones revealed that both exhibited a heterogeneous, but relatively low, sensitivity to cytolysis mediated by CD8(+) cytotoxic T lymphocytes (CTL). The majority of clones ...

journal_title：Cellular immunology

authors： Bergmann CC,Yao Q,Stohlman SA

更新日期：1999-11-25 00:00:00

abstract：:Purine nucleoside phosphorylase (PNP) is a purine salvage pathway enzyme which we have found to be 8-10 times more active (per cell) in human peripheral blood null lymphocytes than in T lymphocytes. To test the hypothesis that null cells are, in part, pre-T lymphocytes we have defined an in vitro system for null cell ...

journal_title：Cellular immunology

authors： Cowan MJ,Fraga M,Ammann AJ

更新日期：1983-06-01 00:00:00

abstract：:The effects of oral administration of methylated bovine serum albumin (mBSA) on antigen-induced arthritis (AIA) in rats that was induced by immunization with mBSA followed by the intraarticular injection of the same antigen were investigated. When mBSA was orally given to animals before immunization with the antigen, ...

journal_title：Cellular immunology

authors： Yoshino S

更新日期：1995-06-01 00:00:00

abstract：:In this report, we present experimental evidence that antigen-presenting cell lines take up peptide antigens in a manner consistent with fluid-phase endocytosis. Using the fluid phase endocytic marker inulin and a mathematical model for fluid phase uptake, we have found a basal uptake rate constant of approximately 0....

journal_title：Cellular immunology

authors： Selby DM,Singer DF,Anderson RW,Coligan JE,Linderman JJ,Nairn R

更新日期：1995-06-01 00:00:00

abstract：:Macrophage-mediated cytostasis was measured in a mouse syngeneic system where EL4 thymoma cells were found to be inhibited by C57B1/6 mouse macrophages. When tumor cells were pretreated with TPA, they became resistant to macrophage-mediated stasis. Nonelutriated as well as elutriated cells enriched in G1/early S and l...

journal_title：Cellular immunology

authors： Nycum LM,Fishman M

更新日期：1989-01-01 00:00:00

abstract：:Putative monocytic myeloid-derived suppressor cells (mMDSC; lineage-HLA-DR-/lo) were generated in 7-day cultures from normal rhesus macaque bone marrow (BM) cells in GM-CSF and IL-6. Three subsets were identified based on their differential expression of CD14, CD33, CD34 and CD11b. Following flow sorting, assessment o...

journal_title：Cellular immunology

authors： Zahorchak AF,Perez-Gutierrez A,Ezzelarab MB,Thomson AW

更新日期：2018-07-01 00:00:00

abstract：:We investigated the cellular induction mechanism of antigen-nonspecific CD8+ T suppressor cells which suppressed delayed-type hypersensitivity to sheep red blood cells, by treating BALB/c mice with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, and 12-O-tetradecanoylphorbol 13-acetate (TPA), a tumor promote...

journal_title：Cellular immunology

authors： Negoro T,Iinuma F,Watanabe M

更新日期：1996-02-01 00:00:00

abstract：:Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for the host. The gastrointestinal tract (GI) harbors th...

journal_title：Cellular immunology

authors： Nakagaki BN,Vieira AT,Rezende RM,David BA,Menezes GB

更新日期：2018-08-01 00:00:00

abstract：:Pentraxin 3 (PTX3) is a prototype protein of long pentraxin. PTX3 is produced by various cells, such as monocytes/macrophages (Mphis) in response to lipopolysaccharide (LPS) and proinflammatory signals. We performed immunoblotting, immunohistochemical staining, reverse transcriptase-polymerase chain reaction (RT-PCR),...

journal_title：Cellular immunology

authors： Imamura M,Kawasaki T,Savchenko AS,Ohashi R,Jiang S,Miyamoto K,Ito Y,Iwanari H,Sagara M,Tanaka T,Hamakubo T,Kodama T,Uchiyama M,Naito M

更新日期：2007-08-01 00:00:00

abstract：:The lymphokine IL-4 is a potent enhancer of anti-IgM-induced B cell proliferation. Although the mechanism of this enhancement is not known, a commonly held view suggests that IL-4 acts together with anti-IgM as a costimulating factor for the activation of a subpopulation of B cells. To evaluate this hypothesis we exam...

journal_title：Cellular immunology

authors： Hodgkin PD,Go NF,Cupp JE,Howard M

更新日期：1991-04-15 00:00:00

abstract：:Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are major proinflammatory cytokines inducing the synthesis and release of many inflammatory mediators. They are involved in immune regulation, autoimmune diseases, and inflammation. Acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, is a pimaradiene d...

journal_title：Cellular immunology

authors： Kang HS,Kim YH,Lee CS,Lee JJ,Choi I,Pyun KH

更新日期：1996-06-15 00:00:00

abstract：:Patients with head and neck cancer often have decreased local or regional immunocompetence. Lymphocytes obtained from tumor-involved or -uninvolved lymph nodes (LNL) of these patients showed low or undetectable levels of antitumor cytotoxicity and low proliferative responses in vitro to interleukin 2 (IL2) or mitogens...

journal_title：Cellular immunology

authors： Letessier EM,Sacchi M,Johnson JT,Herberman RB,Whiteside TL

更新日期：1990-10-15 00:00:00

abstract：:Spleen cells from normal, nonautoimmune mice (C3H/HeN) spontaneously produce hemolytic plaques against autologous bromelain-treated red blood cells (BrMRBC). The number of anti-BrMRBC plaques detectable can be increased by including either a 3 M KCl extracted antigen from BrMRBCs or the hapten phosphorylcholine chlori...

journal_title：Cellular immunology

authors： Wieties KM,Moticka EJ

更新日期：1986-03-01 00:00:00

abstract：:The antifungal activity of nonactivated resident murine peritoneal macrophages for Cryptococcus neoformans was studied. Macrophages from five of six mouse strains tested had significant (40 to 80%) fungistatic activity, depending on the inoculum size, in a 24-hr coculture system. Macrophages from two outbred (SW and I...

journal_title：Cellular immunology

authors： Brummer E,Stevens DA

更新日期：1994-08-01 00:00:00

abstract：:In vivo adoptive transfer of T-cell-mediated immunity to the facultative intracellular bacterium Listeria monocytogenes is restricted, not only by the H-2 haplotype of the mice, but also by incompatibilities at non-H-2 loci. Thus, transfer between H-2 identical strains of mice with different background genes was repro...

journal_title：Cellular immunology

authors： Cheers C,McKenzie IF

更新日期：1983-03-01 00:00:00

abstract：:Macrophages generated with macrophage-colony stimulating factor (M-CSF) are defective in antigen presenting cell (APC) function, although they do express major histocompatibility (MHC) class II molecules, numerous accessory molecules, and intercellular adhesion molecules. In the present study, we show evidence that th...

journal_title：Cellular immunology

authors： Lee JK,Kim JK,Lee YR,Kim HS,Im SA,Kim K,Lee CK

更新日期：2005-03-01 00:00:00

abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

journal_title：Cellular immunology

authors： Nilsson N,Carlsten H

更新日期：1994-10-01 00:00:00

abstract：:The alloreactive feature of CD4+ cytotoxic T-cell clone that could specifically lyse the cells bearing DPB1*0202 sequence was described. The clone was generated from a mixed culture of peripheral blood lymphocytes derived from siblings who were HLA-A, B, C, DR, and DQ identical by serological typing and whose DNA sequ...

journal_title：Cellular immunology

authors： Nishimura M,Mitsunaga S,Akaza T,Mitomi Y,Tadokoro K,Juji T

更新日期：1994-01-01 00:00:00

abstract：:In previous studies, the murine SaI (A/J derived, KkDd) sarcoma was transfected with the allogeneic MHC class I H-2Kb gene, and expressed high levels of H-2Kb antigen. Contrary to expectations, the tumor cells expressing the alloantigen (SKB3.1M tumor cells) were not rejected by autologous A/J mice. Because these resu...

journal_title：Cellular immunology

authors： Cole GA,Ostrand-Rosenberg S

更新日期：1991-05-01 00:00:00

abstract：:Twenty-nine intravenous drug abusers (ivda), with asymptomatic HIV infection at entry, were sequentially studied at 4- to 6-month intervals for variable follow-up periods (mean, 19.6 months). Two of them progressed to AIDS and another one fell into the IV-C2 stage of the CDC classification at the end of the study. CD8...

journal_title：Cellular immunology

authors： Echaniz P,Arrizabalaga J,Iribarren JA,Cuadrado E

更新日期：1993-08-01 00:00:00

abstract：:Heterotrimeric G-proteins control diverse biological processes by conveying signals from seven-transmembrane receptors to intracellular effectors. Although their signaling roles were originally ascribed to their GTP-bound alpha-subunits, more recent evidence points to the equally active roles played by their betagamma...

journal_title：Cellular immunology

authors： Dubeykovskiy A,McWhinney C,Robishaw JD

更新日期：2006-04-01 00:00:00

abstract：:Two signals are required for the in vitro activation of Lyt2+ T suppressor cells (Ts) from mice tolerized with 2,4-dinitrobenzene sulfonate (DNBS) to produce soluble suppressor factors (SSF) which suppress the transfer of contact sensitivity to dinitrofluorobenzene (DNFB). Recognition of DNP/class I MHC (signal one) s...

journal_title：Cellular immunology

authors： Fairchild RL,Moorhead JW

更新日期：1991-03-01 00:00:00

abstract：:The proliferative responses of human peripheral blood mononuclear cells (PBL) and thymocytes to OKT3 monoclonal antibody have been investigated. The PBL response to OKT3 was maximal after 72 hr while that of thymocytes was inappreciable at all times measured. Unlike phytohemagglutinin, OKT3 was unable to elicit the mi...

journal_title：Cellular immunology

authors： Musiani P,Maggiano N,Aiello FB,Lauriola L,Ranelletti FO,Piantelli M

更新日期：1984-04-01 00:00:00