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Exposure to chemokines during maturation modulates antigen presenting cell function of mature macrophages.

Abstract：

:Macrophages generated with macrophage-colony stimulating factor (M-CSF) are defective in antigen presenting cell (APC) function, although they do express major histocompatibility (MHC) class II molecules, numerous accessory molecules, and intercellular adhesion molecules. In the present study, we show evidence that the acquisition of APC function is influenced significantly by microenvironmental condition of development. Macrophages generated from bone marrow progenitor cells with M-CSF and interleukin (IL)-6 were defective in APC function as determined by their ability to induce anti-CD3 monoclonal antibody (mAb)-primed T cell proliferation. Macrophages generated in the presence of some of the CC chemokines such as leukotactin-1, macrophage inflammatory protein (MIP)-1alpha, and RANTES together with M-CSF and IL-6, however, induced proliferation of anti-CD3 mAb-primed T cells. Maximum level of APC function was obtained when developing macrophages were exposed with the chemokines at the late stage of maturation. Enhanced APC function of the macrophages appeared to be correlated with the expression of co-stimulatory molecules and the ability to produce cytokines. These results suggest that the acquisition of APC function of mature macrophage is modulated significantly by the microenvironmental condition during development.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Lee JK,Kim JK,Lee YR,Kim HS,Im SA,Kim K,Lee CK

doi

10.1016/j.cellimm.2005.04.017

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

1-8

issue

1

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(05)00067-5

journal_volume

234

pub_type

杂志文章

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