Shear stress affects migration behavior of polymorphonuclear cells arrested on endothelium.

abstract：:Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of the IL-2/retroviral vector into melanoma xenografts in nude mic...

journal_title：Cellular immunology

authors： Abdel-Wahab Z,Li WP,Osanto S,Darrow TL,Hessling J,Vervaert CE,Burrascano M,Barber J,Seigler HF

更新日期：1994-11-01 00:00:00

abstract：:The inflammatory mechanisms that lead to the clinical symptoms that are grouped under the term inflammatory bowel disease have not been fully characterized. Although a specific mechanism has not been identified, inflammatory bowel disease is believed to be related to an inability by the immune system to shut active in...

journal_title：Cellular immunology

authors： Hashash JG,Hartman DJ

更新日期：2019-09-01 00:00:00

abstract：:Extracellular adenine nucleotides are inhibitors of the human natural killer cell line NK3.3 natural cytotoxicity activity. Natural cytotoxicity was inhibited approximately 26% by 1 mM ATP and 21% by 1 mM ADP. 5'-Adenylyl imidodiphosphate, a nonhydrolyzable ATP analog, inhibited natural cytotoxicity by 41% at a concen...

journal_title：Cellular immunology

authors： Dombrowski KE,Cone JC,Bjorndahl JM,Phillips CA

更新日期：1995-02-01 00:00:00

abstract：:Effects of pertussis toxin (PT) on sensitized T-cell populations for delayed-type hypersensitivity (DTH) were examined in mice. DTH was induced by sensitizing mice with ovalbumin (OA) and elicited by injecting OA into the footpad. DTH could be conferred on naive recipient mice by injecting sensitized spleen cells eith...

journal_title：Cellular immunology

authors： Tamura SI,Nakanishi Y,Kojima A,Otokawa M,Uchida N,Sato H,Sato Y

更新日期：1984-05-01 00:00:00

abstract：:The mode of action of T-cell-suppressor factor (TsF) induced by ultraviolet B (UVB) preirradiation in terms of interaction with several cytokines was studied. Suppression of murine contact photosensitivity (CPS) to 3,3',4',5-tetrachlorosalicylanilide (TCSA) by preirradiation of the sensitizing site to low doses of UVB...

journal_title：Cellular immunology

authors： Satoh T,Tokura Y,Satoh Y,Takigawa M

更新日期：1990-11-01 00:00:00

abstract：:This study examines cytotoxic mechanisms used by channel catfish peripheral blood-derived effector cells. Transmission electron microscopy (TEM), coupled with [(3)H]thymidine DNA fragmentation (JAM) and terminal deoxynucleotidyl nick-end labeling (TUNEL) assays, provided the first evidence that catfish peripheral bloo...

journal_title：Cellular immunology

authors： Hogan RJ,Taylor WR,Cuchens MA,Naftel JP,Clem LW,Miller NW,Chinchar VG

更新日期：1999-08-01 00:00:00

abstract：:Tumour necrosis factor (TNF) family ligands and their corresponding receptors play important roles in the immune system and are involved in immune regulation such as lymphoid development, cell proliferation, differentiation, activation and death. Antibodies against these ligands and receptors together with Fc-fusion p...

journal_title：Cellular immunology

authors： Ch'en PF,Xu XG,Liu XS,Liu Y,Song CJ,Screaton GR,Jin BQ,Xu XN

更新日期：2005-07-01 00:00:00

abstract：:The molecular mechanism responsible for the age-dependent decline of natural killer (NK) cell response was examined. The responses of NK cells to poly(I:C), Con A, and LPS were compared between the young and the aged animals. We observed that both basal and induced NK cell activity declined with age. To further determ...

journal_title：Cellular immunology

authors： Hsueh CM,Chen SF,Ghanta VK,Hiramoto RN

更新日期：1996-11-01 00:00:00

abstract：:Investigation into the mechanism of action of vaccine adjuvants provides opportunities to define basic immune principles underlying the induction of strong immune responses and insights useful for the rational development of subunit vaccines. A novel HIV vaccine composed of plasmid DNA-encoding p55 gag formulated with...

journal_title：Cellular immunology

authors： Denis-Mize KS,Dupuis M,Singh M,Woo C,Ugozzoli M,O'Hagan DT,Donnelly JJ 3rd,Ott G,McDonald DM

更新日期：2003-09-01 00:00:00

abstract：:The pim-1 gene encodes a serine/threonine protein kinase with expression restricted primarily to cells of hematopoietic lineage and is thought to play a role in the signal transduction events associated with lymphocyte activation. A rapid increase in pim-1 mRNA levels was found after stimulation of normal unseparated ...

journal_title：Cellular immunology

authors： Wingett D,Stone D,Davis WC,Magnuson NS

更新日期：1995-04-15 00:00:00

abstract：:Autoimmune regulator (Aire) is a transcriptional activator that regulates the ectopic expression of many tissue-restricted antigens in medullary thymic epithelial cells, and that has an important role in the negative selection of autoreactive T cells. However, the roles of Aire expression in peripheral lymphoid tissue...

journal_title：Cellular immunology

authors： Zhu W,Yang W,He Z,Liao X,Wu J,Sun J,Yang Y,Li Y

更新日期：2011-01-01 00:00:00

abstract：:AK-5 is a spontaneously regressing rat histiocytoma and the tumor regression is mediated by CD8+ NK cells. We have investigated the functional status of effector cells mediating complete remission of the tumor. The effector-target interaction takes place with the help of antibody to AK-5 and the mechanism of lysis inv...

journal_title：Cellular immunology

authors： Bright JJ,Hegde SP,Begum Z,Khar A

更新日期：1994-03-01 00:00:00

abstract：:Although it is well known that the CD3/T-cell receptor (TCR) complex modulates from the surface of T cells upon exposure to monoclonal antibodies (mAb) directed against it, the fate of bound mAb has not been yet elucidated. We therefore perform direct binding experiments of 125I-labeled mAb against CD3 or TCR to inves...

journal_title：Cellular immunology

authors： Schaffar L,Dallanegra A,Breittmayer JP,Carrel S,Fehlmann M

更新日期：1988-10-01 00:00:00

abstract：:In this study, we demonstrate that HIV-1 Tat protein is able to induce IL-10 and TNF-alpha in human macrophages. We show that N-terminal Tat 1-45 fragment initiates the PKC pathway by acting at the membrane. Inhibition of PKC pathway, by chemical inhibitors or after PMA treatment, abolishes both IL-10 and TNF-alpha pr...

journal_title：Cellular immunology

authors： Leghmari K,Contreras X,Moureau C,Bahraoui E

更新日期：2008-01-01 00:00:00

abstract：:The ontogeny of T cells which express major histocompatibility complex (MHC)-unrestricted T cell antigen-binding molecules (TABM) on the cell membrane was investigated. We used a rabbit anti-mouse TABM antiserum to investigate the expression of TABM by subsets of adult thymocytes, peripheral T cells, and thymocytes du...

journal_title：Cellular immunology

authors： Rellahan BL,Cone RE

更新日期：1990-10-01 00:00:00

abstract：:Recombinant IL-4 inhibits IL-2-induced lymphokine-activated killer (LAK) cell development of PBMC. We evaluated the effect of various cytokines in reversing IL-4-mediated LAK inhibition. PBMC were cultured in IL-2 (10-1000 u/ml) with or without IL-4 (2-100 u/ml) and tested for cytotoxicity against the NK-sensitive K56...

journal_title：Cellular immunology

authors： Swisher SG,Economou JS,Holmes EC,Golub SH

更新日期：1990-07-01 00:00:00

abstract：:Recently we have shown that the generation of IFN-gamma-producing cells (IFN-gamma pc) were severely suppressed in cultures of Con A-stimulated splenocytes obtained from HgCl2-exposed BN but not Lewis rats. Since BN rats develop a TH2-biased polyclonal autoimmune syndrome upon exposure to HgCl2, whereas Lewis rats exh...

journal_title：Cellular immunology

authors： van der Meide PH,de Labie MC,Botman CA,Aten J,Weening JJ

更新日期：1995-04-01 00:00:00

abstract：:Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation in murine allergic a...

journal_title：Cellular immunology

authors： Shilling RA,Clay BS,Tesciuba AG,Berry EL,Lu T,Moore TV,Bandukwala HS,Tong J,Weinstock JV,Flavell RA,Horan T,Yoshinaga SK,Welcher AA,Cannon JL,Sperling AI

更新日期：2009-01-01 00:00:00

abstract：:Anti-TNF-α therapies have been applied in RA treatment, but the regulatory effect of the drug on immune system is not clear. In this study, we included 33 active RA patients and divided them into two groups. One group received anti-TNF-α mAb+methotrexate for 24 weeks, the other group got placebo+methotrexate for the f...

journal_title：Cellular immunology

authors： Huang Z,Yang B,Shi Y,Cai B,Li Y,Feng W,Fu Y,Luo L,Wang L

更新日期：2012-09-01 00:00:00

abstract：:Macrophages are highly plastic immune cells with temporally distinct transcriptome changes upon lipopolysaccride (LPS) activation. However, to what extent transcriptome reprogramming is mediated via spatial chromatin looping is not well studied. We generated high resolution chromatin interaction maps for LPS-stimulate...

journal_title：Cellular immunology

authors： Pradhananga S,Spalinskas R,Poujade FA,Eriksson P,Sahlén P

更新日期：2020-09-01 00:00:00

abstract：:Class II major histocompatibility antigens (Ia) play a major role in regulating T-B cell interactions; therefore, regulation of the amount of Ia on B cells may be an important point of control in the immune response. Mitogens in human and murine systems have been reported to increase Ia expression on B cells, and in t...

journal_title：Cellular immunology

authors： Leitenberg D,Feldbush TL

更新日期：1988-02-01 00:00:00

abstract：:We report experiments attempting to optimize the proliferative response of human B cells to rabbit anti-immunoglobulin antibody (RAHIg)-linked beads (anti-Ig beads). By choosing polyacrylamide beads of small size (3 micron) and coupling anti-Ig to them at high concentrations, beads were obtained which were both B-cell...

journal_title：Cellular immunology

authors： Boyd AW,Freedman AS,Horowitz JC,Anderson KC,Fisher DC,Rosen KJ,Schlossman SF,Nadler LM

更新日期：1986-04-15 00:00:00

abstract：:Many studies have shown that tumor necrosis factor (TNF) is a potent soluble mediator of immunoregulation and inflammation. Neuropeptide substance P (SP) has been known to exert significant influence on production of certain inflammatory cytokine by immune cells. Immunopathogenic mechanism underlying the effect of neu...

journal_title：Cellular immunology

authors： Nair MP,Schwartz SA

更新日期：1995-12-01 00:00:00

abstract：:We previously demonstrated that injection of a high dose (4 X 10(9] of sheep erythrocytes (SRBC) into C57BL/6 mice results in the generation of splenic B cells (plastic nonadherent, Thy-1- and Ig+) which, when transferred to normal syngeneic recipients, subsequently induce antigen-specific suppressor T cells to suppre...

journal_title：Cellular immunology

authors： Shimamura T,Habu S,Hashimoto K,Sasaki S

更新日期：1984-01-01 00:00:00

abstract：:The induction of ornithine decarboxylase (ODC) activity in lymphocytes is associated with activation and the initiation of cellular proliferation. ODC is also an essential component in tumor promotion. Phorbol myristic acetate (PMA) is a mitogen for lymphocytes, but can also promote tumor formation. Tumor promotion is...

journal_title：Cellular immunology

authors： Fidelus RK

更新日期：1988-04-15 00:00:00

abstract：:Medicinal plants are considered immunomodulatory as they display various biological activities. There is no report addressing the anti-inflammatory effects of Daphne gnidium. In this study, we investigated the effects of D. gnidium ethyl acetate (EA) leaf extract on mice immune cell function in vitro. Production of pr...

journal_title：Cellular immunology

authors： Harizi H,Chaabane F,Ghedira K,Chekir-Ghedira L

更新日期：2011-01-01 00:00:00

abstract：:TNF-alpha plays an important role in the development of secondary lymphoid tissues. Earlier studies showed that fibroblastic reticular cells express TNF-alpha receptor, suggesting that TNF-alpha may affect the development of FRCs. To test this, we analyzed the development and function of FRCs in wild-type or TNF-alpha...

journal_title：Cellular immunology

authors： Zhao L,Chen J,Liu L,Gao J,Guo B,Zhu B

更新日期：2015-02-01 00:00:00

abstract：:In the present report, we demonstrated that extrathymic gamma(delta) T cells proliferated in the mixed culture of lymph node cells of BALB/c nu/nu mice and irradiated syngeneic spleen cells (syngeneic MLR). Reverse transcription-polymerase chain reaction (RT-PCR) analyses revealed that V(delta)5 and V(delta)6 were dom...

journal_title：Cellular immunology

authors： Matsuzaki G,Kenai H,Fujise S,Kobayashi N,Kishihara K,Nomoto K

更新日期：1996-10-10 00:00:00

abstract：:The effects of oral administration of methylated bovine serum albumin (mBSA) on antigen-induced arthritis (AIA) in rats that was induced by immunization with mBSA followed by the intraarticular injection of the same antigen were investigated. When mBSA was orally given to animals before immunization with the antigen, ...

journal_title：Cellular immunology

authors： Yoshino S

更新日期：1995-06-01 00:00:00

abstract：:In this study a panel of monoclonal antibodies was used to investigate the kinetics of the appearance of activation-linked surface determinants as well as cytoplasmic and nuclear determinants in human T cells following lectin stimulation. Well known activation markers, such as Ia/DR, transferrin receptor, IL-2 recepto...

journal_title：Cellular immunology

authors： Holter W,Majdic O,Liszka K,Stockinger H,Knapp W

更新日期：1985-02-01 00:00:00