Kinetics of activation antigen expression by in vitro-stimulated human T lymphocytes.

abstract：:The activation of large granular lymphocytes (LGLs)/natural killer (NK) cells with interleukin-2 (IL-2) has been shown to increase the ability of these cells to lyse NK-resistant tumor target cells. Activated LGLs, termed LAK (lymphokine-activated killer) cells, have been demonstrated to be of therapeutic value in viv...

journal_title：Cellular immunology

authors： McCoy JP Jr,Hanley-Yanez K,Brumfield A,Herberman RB,Chambers WH

更新日期：1990-05-01 00:00:00

abstract：:Respiratory immunization is an attractive way to generate systemic and mucosal protective memory responses that are required for preventing mucosally transmitted infections. However, the molecular and cellular mechanisms for controlling memory T cell responses remain incompletely understood. In this study, we investig...

journal_title：Cellular immunology

authors： Acosta-Ramirez E,Tram C,Kampen RM,Tillman MR,Schwendener RA,Xing Z,Halperin SA,Wang J

更新日期：2016-12-01 00:00:00

abstract：:Mammals and microorganisms have evolved a complex and tightly controlled mutual relationship. This interaction grants protection and energy source for the microorganisms, and on the other hand, provides several immunologic, metabolic and physiological advantages for the host. The gastrointestinal tract (GI) harbors th...

journal_title：Cellular immunology

authors： Nakagaki BN,Vieira AT,Rezende RM,David BA,Menezes GB

更新日期：2018-08-01 00:00:00

abstract：:The effect of low-dose irradiation on the immune system was investigated in mice. When a 0.2 Gy dose of X-ray irradiation was administered every other day for a total of four times, the number of lymphocytes yielded by the liver, spleen and thymus decreased at the initial stage (around day 10). At this stage, NK cells...

journal_title：Cellular immunology

authors： Ren H,Shen J,Tomiyama-Miyaji C,Watanabe M,Kainuma E,Inoue M,Kuwano Y,Abo T

更新日期：2006-11-01 00:00:00

abstract：:Aging diminishes the amount of phosphotyrosine in the CD3zeta chains of resting and activated mouse CD4 T cells by about threefold and might therefore be expected to a corresponding decline in Zap-70 association with CD3zeta and in Zap-70 kinase function in CD3zeta complexes. We show here that aging leads, unexpectedl...

journal_title：Cellular immunology

authors： Garcia GG,Miller RA

更新日期：1998-12-15 00:00:00

abstract：:Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of...

journal_title：Cellular immunology

authors： Linder GE,Chuntova PD,McLelland BT,Añó L,Obodo UC,Crider NJ,Matthes DJ,García-Ojeda ME,Manilay JO,Chatterjea D

更新日期：2013-02-01 00:00:00

abstract：:The experiments in this manuscript confirm and extend our previous finding that IL4 has minimal enhancing activity on B cell activation stimulated by anti-Ig-dextran conjugates. The absence of significant IL4-mediated enhancement is seen also under conditions which are limiting for optimal B cell proliferation. Thus, ...

journal_title：Cellular immunology

authors： Lindsberg ML,Brunswick M,Keegan A,Mond JJ

更新日期：1990-10-15 00:00:00

abstract：:The myelin-associated stress protein alphaB-crystallin triggers strong proliferative responses and IFN-gamma production by human T cells and it is considered a candidate autoantigen in multiple sclerosis. In this study we examined the capacity of alphaB-crystallin or peptides derived thereof to induce experimental aut...

journal_title：Cellular immunology

authors： van Stipdonk MJ,Willems AA,Verbeek R,Boog CJ,van Noort JM

更新日期：2000-09-15 00:00:00

abstract：:7 anterior gradient homolog 2 (AGR2)-inhibited different molecular mutual positive correlation network was constructed in lung adenocarcinoma compared with human normal adjacent tissues by 17 overlapping molecules of 358 GRNInfer and 19 Pearson (AGR2 CC⩽-0.25). Based on GO, KEGG, GenMAPP, BioCarta and disease database...

journal_title：Cellular immunology

authors： Huang J,Wang L,Jiang M,Chen Q,Jiang Z,Feng H

更新日期：2014-07-01 00:00:00

abstract：:Interleukin-4 (IL-4) acts directly on purified human peripheral blood B cells cultured in the presence of Epstein-Barr virus (EBV) to induce IgE secretion and to enhance the secretion of IgG and IgM. Interferon-gamma (IFN-gamma) inhibits IgE secretion in this system, without affecting the secretion of the other Ig iso...

journal_title：Cellular immunology

authors： Thyphronitis G,Banchereau J,Heusser C,Tsokos GC,Levine AD,Finkelman FD

更新日期：1991-04-01 00:00:00

abstract：:Hen egg white lysozyme (HEL)-specific T cell lines and clones were generated from B6 and BDF1 mice. A variety of clonotypes were found among clones generated at an early stage (1 month) whereas fewer clonotypes were detected after several weeks of culture. Furthermore, a bulk line switched from its initial fine peptid...

journal_title：Cellular immunology

authors： Manca F,Dessí V,Shastri N,Oki A,Kaplan M,Clarke J,Miller A,Sercarz EE

更新日期：1994-04-01 00:00:00

abstract：:In vitro ultraviolet-B (UVB) irradiation of murine and rodent bone marrow cells prevents GVHD without compromising engraftment while inducing tolerance to donor-type allografts. In anticipation of clinical trials of UVB-modified bone marrow grafts, we studied the in vitro effects of UVB irradiation (50-300 J/m2) on hu...

journal_title：Cellular immunology

authors： Yaron I,Zakheim AR,Oluwole SF,Hardy MA

更新日期：1995-10-15 00:00:00

abstract：:The functional specificity of three types of macrophage chemotactic factors ( MCFs ), -a, -b, and -c, from purified protein derivative of tuberculin (PPD)-induced delayed hypersensitivity reaction (DHR) skin sites on guinea pigs, was analyzed using macrophage cell line cells, M1, established from myeloid leukemia cell...

journal_title：Cellular immunology

authors： Honda M,Masuda T,Yoshimura T,Hayashi H

更新日期：1984-06-01 00:00:00

abstract：:The knowledge of mechanisms of regulation of IL-10 production by B cells remains still very limited. We show here that highly purified mouse B cells stimulated with LPS produce significant levels of IL-10, but Bregs in our model do not express detectable level of either Foxp3 or GATA-3. Nevertheless, IL-10 production ...

journal_title：Cellular immunology

authors： Bohacova P,Kossl J,Hajkova M,Hermankova B,Javorkova E,Zajicova A,Krulova M,Holan V

更新日期：2020-01-01 00:00:00

abstract：:Mice carrying a rearranged TCR Vbeta 8.2 transgene express the Vbeta protein on the vast majority of peripheral T-cells. The bone marrow and peripheral blood, as well as other lymphoid organs of both untreated animals and animals depleted of T-cells by neonatal thymectomy and/or injection from birth of monoclonal anti...

journal_title：Cellular immunology

authors： Lincoln GC,Sheng B,Odebralski J,Lucchetta R,Smith RT

更新日期：1997-10-10 00:00:00

abstract：:Bispecific antibodies have been successfully introduced into clinical application. γδ T cells are of special interest for tumor immunotherapy, due to their recognition of pyrophosphates that are overproduced by many tumor cells resulting in HLA-nonrestricted tumor cell killing. Here we describe in detail a [(Her2)2 × ...

journal_title：Cellular immunology

authors： Oberg HH,Kellner C,Gonnermann D,Peipp M,Peters C,Sebens S,Kabelitz D,Wesch D

更新日期：2015-07-01 00:00:00

abstract：:The ability of calcium ionophore and phorbol ester to stimulate entry into S phase was assessed during short-term cultures of murine B cells extensively depleted of T cells. Neither ionomycin alone nor PMA alone stimulated DNA synthesis. However, the combination of ionomycin plus PMA acted in synergy to induce initiat...

journal_title：Cellular immunology

authors： Rothstein TL,Baeker TR,Miller RA,Kolber DL

更新日期：1986-10-15 00:00:00

abstract：:Patients with head and neck cancer often have decreased local or regional immunocompetence. Lymphocytes obtained from tumor-involved or -uninvolved lymph nodes (LNL) of these patients showed low or undetectable levels of antitumor cytotoxicity and low proliferative responses in vitro to interleukin 2 (IL2) or mitogens...

journal_title：Cellular immunology

authors： Letessier EM,Sacchi M,Johnson JT,Herberman RB,Whiteside TL

更新日期：1990-10-15 00:00:00

abstract：:Facilitating cells (FC) are bone marrow-derived cells that facilitate allogeneic hematopoietic stem cell (SC) engraftment and induce transplantation tolerance without causing graft vs. host disease. Although there is evidence for FC directing the development of FoxP3+CD4+CD25+ regulatory T cells, the specific FC subse...

journal_title：Cellular immunology

authors： Taylor KN,Laszkowska M,Cohick E,Colson YL

更新日期：2008-01-01 00:00:00

abstract：:Activation of lck-fyn kinases during T cell receptor signaling leads to Vav phosphorylation, activation of downstream targets including Rac1, and a transient decline in ezrin and moesin phosphorylation. We have shown that age increases Rac1 activity and lowers ezrin and moesin phosphorylation in resting mouse CD4 cell...

journal_title：Cellular immunology

authors： Garcia GG,Miller RA

更新日期：2009-01-01 00:00:00

abstract：:Cells from the draining lymph nodes of DBA/2 mice bearing syngeneic intradermal P-815 tumors represent an excellent responding cell population for secondary stimulation in vitro, despite the virtual absence of response by spleen cells of the same animals. Cytotoxicity is a result of stimulation with intact mitomycin-t...

journal_title：Cellular immunology

authors： Bertschmann M,Lüscher EF

更新日期：1983-05-01 00:00:00

abstract：:Osteopontin (OPN) expression in tumors is associated with more aggressive tumor growth; however, several studies have suggested that OPN as a host protein can regulate tumor growth as well. OPN is produced by macrophages and T cells, and reportedly modifies macrophage function. Here, we have investigated the effect of...

journal_title：Cellular immunology

authors： Bourassa B,Monaghan S,Rittling SR

更新日期：2004-01-01 00:00:00

abstract：:The MCA 102 sarcoma has been defined by a variety of immunologic studies as a tumor lacking intrinsic immunogenicity. Nevertheless, we have recently demonstrated the feasibility of generating therapeutically effective lymphocytes for adoptive immunotherapy of this tumor. Procedures to achieve this required in vivo pri...

journal_title：Cellular immunology

authors： Sakai K,Chang AE,Shu S

更新日期：1990-08-01 00:00:00

abstract：:Human melanoma tumor cells were genetically modified in vitro by transferring the interleukin-2 (IL-2) gene via a retroviral vector into established or fresh tumor cells. In addition, human melanoma cells were transduced in vivo by the direct injection of the IL-2/retroviral vector into melanoma xenografts in nude mic...

journal_title：Cellular immunology

authors： Abdel-Wahab Z,Li WP,Osanto S,Darrow TL,Hessling J,Vervaert CE,Burrascano M,Barber J,Seigler HF

更新日期：1994-11-01 00:00:00

abstract：:Recently, it has been reported that IL-4 production by murine Th2 cell lines is insensitive to inhibition by E-type prostaglandins. In the present study, IL-4 production in vitro by freshly isolated concanavalin A (Con A)-stimulated murine spleen cells was readily suppressed by PGE2 with an I50 of 2 nM. Comparable sup...

journal_title：Cellular immunology

authors： Parker CW,Huber MG,Godt SM

更新日期：1995-02-01 00:00:00

abstract：:We examined the effects of a rare sugar, D-allose, which is 6-carbon monosaccharide, on endocytosis and T cell stimulation by dendritic cells (DCs). The endocytosis of BCG-anti-BCG immune complexes by DCs markedly decreased in D-allose-containing medium. Co-culture with T cells (mixed leukocyte reaction, MLR) of DCs, ...

journal_title：Cellular immunology

authors： Tanaka S,Sakamoto H

更新日期：2011-01-01 00:00:00

abstract：:Cultures of gradient-purified human peripheral blood mononuclear cells (PBMC) have been employed to examine the effects of three bacteria-derived human leukocyte interferon subtypes on certain aspects of in vitro immune responses. The addition of highly purified IFN-alpha 1, -alpha 2, -alpha 2/alpha 1 to PMBC cultures...

journal_title：Cellular immunology

authors： Shalaby MR,Weck PK

更新日期：1983-12-01 00:00:00

abstract：:Anti-TNF-α therapies have been applied in RA treatment, but the regulatory effect of the drug on immune system is not clear. In this study, we included 33 active RA patients and divided them into two groups. One group received anti-TNF-α mAb+methotrexate for 24 weeks, the other group got placebo+methotrexate for the f...

journal_title：Cellular immunology

authors： Huang Z,Yang B,Shi Y,Cai B,Li Y,Feng W,Fu Y,Luo L,Wang L

更新日期：2012-09-01 00:00:00

abstract：:Engraftment of stem cell-enriched donor marrow implanted in the thymus of a foreign host might facilitate acceptance of donor-specific organ or tissue grafts. To test this hypothesis, allogeneic and xenogeneic CD34+ marrow cells from unrelated adult male baboons and humans were injected intrathymically in eight infant...

journal_title：Cellular immunology

authors： Allen MD,Weyhrich J,Gaur L,Akimoto H,Hall J,Dalesandro J,Sai S,Thomas R,Nelson KA,Andrews RG

更新日期：1997-11-01 00:00:00

abstract：:Inherited deficiency of the enzyme adenosine deaminase (ADA) has been found in a significant proportion of patients with severe combined immunodeficiency disease and inherited defect generally characterized by a deficiency of both B and T cells. Two questions are central to understanding the pathophysiology of this di...

journal_title：Cellular immunology

authors： Barton RW

更新日期：1985-10-15 00:00:00