Abstract:
:Ca(2+) and Sr(2+) entry pathways activated by pro-inflammatory agonists FMLP, LTB(4) and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10microM) increased Ca(2+) influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca(2+) because 2-APB did not augment Sr(2+) entry in agonist and thapsigargin stimulated neutrophils. This suggests that Ca(2+) and Sr(2+) entry can be used to discriminate between receptor and non-receptor (store)-operated Ca(2+) influx. Our data show for the first time that Pyr3 whilst partially inhibiting agonist induced Ca(2+) influx almost completely abolished Ca(2+) influx after thapsigargin stimulation.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Salmon MD,Ahluwalia Jdoi
10.1016/j.cellimm.2010.07.009subject
Has Abstractpub_date
2010-01-01 00:00:00pages
1-5issue
1eissn
0008-8749issn
1090-2163pii
S0008-8749(10)00197-8journal_volume
265pub_type
杂志文章abstract::The lymphokine IL-4 is a potent enhancer of anti-IgM-induced B cell proliferation. Although the mechanism of this enhancement is not known, a commonly held view suggests that IL-4 acts together with anti-IgM as a costimulating factor for the activation of a subpopulation of B cells. To evaluate this hypothesis we exam...
journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2005.01.003
更新日期:2004-11-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1998.1264
更新日期:1998-02-25 00:00:00
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journal_title:Cellular immunology
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doi:10.1016/j.cellimm.2009.06.001
更新日期:2009-01-01 00:00:00
abstract::Mycobacterium bovis BCG, a live attenuated tuberculosis vaccine offers protection against disseminated TB in children. BCG exhibits heterologous protective effects against unrelated infections and reduces infant mortality due to non-mycobacterial infections. Recent reports have suggested that BCG vaccination might hav...
journal_title:Cellular immunology
pub_type: 杂志文章,评审
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更新日期:2020-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2014.03.006
更新日期:2014-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2001-05-01 00:00:00
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journal_title:Cellular immunology
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90035-2
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1995.1073
更新日期:1995-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(89)90354-7
更新日期:1989-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2008-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2013.05.005
更新日期:2013-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1998-06-15 00:00:00
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journal_title:Cellular immunology
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journal_title:Cellular immunology
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pub_type: 杂志文章
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