Abstract：
:T-Cell hybridomas were constructed by fusing BW5147, an AKR lymphoma, with concanavalin A-stimulated murine splenic lymphocytes. The hybrids which were formed were studied for their ability to produce a lymphokine which inhibits tumor cell migration (TMIF) as well as macrophage migration (MIF) using in vitro assays. Clones were identified which affected tumor cell motility without exerting similar effects on murine macrophages, although the opposite effect was not observed. Although noncoordinate production of these factors cannot be unequivocally established, these results demonstrate that clones can be constructed that preferentially secrete TMIF. In these experiments, we also tested the supernatants for another lymphokine effect on tumor cells; namely, the ability to inhibit tumor cell binding to endothelial monolayers. A number of clones were identified that lacked TMIF activity, but could inhibit the tumor cell-endothelial interaction, suggesting the possibility that these effects may be due to separate mediators.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Cohen MC,Lazarus Mdoi
10.1016/0008-8749(85)90158-3subject
Has Abstractpub_date
1985-07-01 00:00:00pages
541-8issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(85)90158-3journal_volume
93pub_type
杂志文章abstract：:Receptors for the Fc domain of IgG mediate target recognition, signal transduction, and effector functions including antibody-dependent cytolysis, phagocytosis, and phagolysosome formation. To better understand FcR-mediated functions and to identify potential therapeutic strategies, we employed cell-penetrating ("Troj...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.12.002
更新日期：2010-01-01 00:00:00
abstract：:Complete T cell activation requires not only a first signal via TCR/CD3 engagement but also a costimulatory signal through accessory receptors such as CD2, CD28, or integrins. Focal adhesion kinase, pp125(FAK) (FAK), was previously shown to be localized in focal adhesions in fibroblasts and to be involved in integrin-...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1999.1472
更新日期：1999-05-01 00:00:00
abstract：:Experimental autoimmune encephalomyelitis (EAE) is an animal model for multiple sclerosis (MS), and is induced by immunization with disease-causative self-antigens such as myelin oligodendrocyte glycoprotein (MOG). We have previously reported that transplantation of MOG expressing thymic epithelial progenitors (TEPs) ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2017.10.007
更新日期：2017-12-01 00:00:00
abstract：:Inhibition of DPP IV has been shown to abrogate the stress-related increase in murine abortions and a concomitant increase in gamma-interferon. The aim of the present study was to investigate a potential impact of the DPP IV inhibitor Isoleucine Cyanopyrrolidide on the expression of surface antigens involved in T-cell...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/s0008-8749(03)00028-5
更新日期：2002-12-01 00:00:00
abstract：:The administration of low-density lipoproteins from chicken egg yolk (EyLDL) to mice induced T-dependent antibodies against bromelain-treated mouse erythrocytes (BrMRBC). The anti-BrMRBC antibodies produced antigen specifically by EyLDL appear to be identical to the antibodies produced polyclonally by lipopolysacchari...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(88)90195-5
更新日期：1988-09-01 00:00:00
abstract：:Subcutaneous Ehrlich tumor-bearing mice were treated with in situ inoculation of a beta-glucan-rich extract of Agaricus brasiliensis (ATF), which reduced tumor growth. Histopathological analysis showed that the tumor masses of control mice (Ehr) presented giant tumor cells and many mitotic figures whereas the tumor ti...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.01.002
更新日期：2009-01-01 00:00:00
abstract：:Human peripheral blood cells enriched for B lymphocytes were stimulated to focal proliferation in semisolid cultures with lymphocyte-conditioned media, Protein A (Prot A), lipopolysaccharide (LPS) and 2-mercaptoethanol (2-ME). After 6-8 days of incubation, two morphologically distinct colony types were observed. Type ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90059-5
更新日期：1984-10-01 00:00:00
abstract：:The in vivo and in vitro accessory cell requirements of class I major histocompatability complex (MHC) antigen-restricted cytotoxic T-lymphocyte (CTL) responses were determined using cell-depletion experiments coupled with active immunizations using ovalbumin (OVA) as the immunogen and saponin adjuvant (QS-21). To par...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1086
更新日期：1994-04-01 00:00:00
abstract：:Upregulation of immunoglobulin D-specific receptors (IgD-R) on CD4+ T cells may facilitate their interaction with specific carbohydrate moieties uniquely associated with membrane IgD on B cells. Previous studies have shown that upregulation of IgD-R facilitates cognate T-B cell interactions by mediating bidirectional ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2000.1747
更新日期：2001-02-01 00:00:00
abstract：:In mammals, macrophages (MF) are present in virtually all tissues where they serve many different functions linked primarily to the maintenance of homeostasis, innate defense against pathogens, tissue repair and metabolism. Although some of these functions appear common to all tissues, others are specific to the homin...
journal_title：Cellular immunology
pub_type： 杂志文章,评审
doi：10.1016/j.cellimm.2018.01.012
更新日期：2018-08-01 00:00:00
abstract：:Accumulating evidence indicates that inflammatory signals required for maximizing effector T cell generation have opposing effects on the development of memory T cell precursors. Toll-like receptor (TLR)2, and TLR9 significantly contribute to the inflammatory milieu and therefore in this study we examined whether the ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2015.12.009
更新日期：2016-04-01 00:00:00
abstract：:Twenty-nine intravenous drug abusers (ivda), with asymptomatic HIV infection at entry, were sequentially studied at 4- to 6-month intervals for variable follow-up periods (mean, 19.6 months). Two of them progressed to AIDS and another one fell into the IV-C2 stage of the CDC classification at the end of the study. CD8...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1993.1179
更新日期：1993-08-01 00:00:00
abstract：:Acting through CD14 and TLR4/MD-2, lipopolysaccharide (LPS) triggers strong pro-inflammatory activation of macrophages, which, if not appropriately controlled, may lead to lethal septic shock. Therefore, numerous mechanisms of negative regulation of responses to LPS exist, but whether they include down-regulation of L...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2016.11.008
更新日期：2017-02-01 00:00:00
abstract：:In this study, the major histocompatibility complex-unrestricted cytotoxic effectors elicited in human peripheral blood mononuclear cells (PBMC) by a mannoprotein (MP) component from the cell wall of the human indigenous microorganism Candida albicans have been compared with those obtained by stimulation with interleu...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90033-6
更新日期：1989-07-01 00:00:00
abstract：:Study of primary immune responses in leprosy has been limited, since disease becomes manifest long after infection or is not detectable. To study primary immune responses, we immunized in vitro human peripheral blood mononuclear cells from unexposed individuals using phenolic glycolipid 1 (PGL-1), an important water-i...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90058-j
更新日期：1991-10-01 00:00:00
abstract：:This study aimed to describe the vascular and cellular histopathological changes that occurred in post-mastectomy seroma in an animal model. Unilateral mastectomies were conducted on 45 female albino rabbits. On day seven, the skin flap and the underlying tissues of the mastectomy regions were dissected and processed ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2011.10.021
更新日期：2012-01-01 00:00:00
abstract：BACKGROUND:Interleukin (IL)-23, composed of p19 and p40 subunits, has diverse functions in regulating immune systems, enhancing cell-mediated immunity. In the present study, we investigated whether forced expression of the p19-linked p40 gene in murine mammary cancer cells (MA891) produced antitumor effects in vivo. Tu...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2009.05.002
更新日期：2009-01-01 00:00:00
abstract：:In view of the critical role played by bacillus Calmette-Guérin (BCG) in the development and functional activation of protective T cells against tuberculosis, it has become important to understand the mechanisms by which cytokines regulate BCG-mediated immune responses. There is evidence that cytokine-mediated suppres...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.2000.1662
更新日期：2000-06-15 00:00:00
abstract：:Peripheral blood large granular lymphocytes (LGL) expressing Leu 11 (CD16) antigen with potent natural killer cytotoxicity inhibited soluble antigen-induced T-cell production of interleukin 2 (IL-2). Depletion of Leu 11-reactive cells from T-cells doubled IL-2 activity (P less than 0.05). Leu 11-enriched cells did not...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90389-4
更新日期：1989-02-01 00:00:00
abstract：:A mouse IgG1 monoclonal antibody ED12F8C10 (C10) binds a constant percentage of peripheral blood neutrophils in the same individual when studied over time, defining a distinct subset of neutrophils in all normal individuals studied to date. Bone marrow studies confirm that the heterogeneity is present to the same degr...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(91)90010-9
更新日期：1991-01-01 00:00:00
abstract：:We have systematically studied uncloned human cell lines derived from anti-influenza A virus or anti-Epstein-Barr virus (EBV) bulk cultures, or from cultures highly enriched for CD4+ or CD8+ lymphocytes. The most noteworthy results are the following: (1) Anti-viral bulk cultures consisted of more than 90% of CD8+ cell...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90380-8
更新日期：1989-02-01 00:00:00
abstract：:Macrophages generated with macrophage-colony stimulating factor (M-CSF) are defective in antigen presenting cell (APC) function, although they do express major histocompatibility (MHC) class II molecules, numerous accessory molecules, and intercellular adhesion molecules. In the present study, we show evidence that th...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/j.cellimm.2005.04.017
更新日期：2005-03-01 00:00:00
abstract：:AK-5 is a spontaneously regressing rat histiocytoma and the tumor regression is mediated by CD8+ NK cells. We have investigated the functional status of effector cells mediating complete remission of the tumor. The effector-target interaction takes place with the help of antibody to AK-5 and the mechanism of lysis inv...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1056
更新日期：1994-03-01 00:00:00
abstract：:The cytokine interleukin 6 (IL-6) has been shown to have multiple biological activities against many cellular targets. The present studies were designed to determine whether these activities extended to the neutrophil (PMN). Initially, we investigated the ability of IL-6 to modulate PMN-mediated antibody-dependent cel...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(89)90026-9
更新日期：1989-07-01 00:00:00
abstract：:The anti-spirochete T cell immune response to immunization with Borrelia burgdorferi was investigated. The cellular immune response to vaccination of immunocompetent BALB/c mice was characterized initially in vitro by assay of the proliferative response of primary lymph node cells to B. burgdorferi sonicate. Subsequen...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1995.1073
更新日期：1995-05-01 00:00:00
abstract：:The role of macrophages (M phi) and that of splenic dendritic cells (DC) in the allogeneic mixed leukocyte reaction (MLR) in the mouse have been investigated. In contrast with the high stimulatory capacity of DC, we obtained no evidence in favor of the competence of M phi, whether Ia + or Ia-, as an autonomous stimula...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90169-2
更新日期：1984-10-15 00:00:00
abstract：:Anti-CD3 mAb can activate T cells to help in B cell activation as detected by late events, such as maturation of B cells into Ig-secreting cells (IgSC), or by early events, such as B cell surface expression of the activation marker CD23. Two different anti-CD2 mAb each inhibited anti-CD3-induced T cell-dependent B cel...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(90)90269-w
更新日期：1990-10-15 00:00:00
abstract：:This study was conducted on human K562 lymphocytes to investigate the mechanisms implicated in the regulation of the serotonin transport process. The uptake of serotonin in these cells was saturable (Km, 3.37 microM; Vmax, 2.03 nmol/10(6) cells) and Na+ dependent; isoosmotic replacement of Na+ with choline chloride in...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1996.0242
更新日期：1996-09-15 00:00:00
abstract：:Experimental autoimmune neuritis (EAN) is a T-cell-mediated autoimmune disease characterized by demyelination and mononuclear cell infiltration of the peripheral nervous system. It is induced in Lewis rats by administration of myelin P2 protein or a synthetic peptide (SP-26) corresponding to amino acid residues 53-78 ...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1006/cimm.1994.1156
更新日期：1994-06-01 00:00:00
abstract：:Seeking common abnormalities in mice genetically predisposed to lupus-like autoimmune disease, we investigated (1) the ontogeny of Ia antigens (I-A/I-E) on the surfaces of resident peritoneal macrophages (rpM phi) of lupus and normal mice, (2) spontaneous and lectin-induced in vitro production of M phi-stimulating fac...
journal_title：Cellular immunology
pub_type： 杂志文章
doi：10.1016/0008-8749(84)90133-3
更新日期：1984-08-01 00:00:00
