Vaccine-mediated immunity to experimental Mycobacterium tuberculosis is not impaired in the absence of Toll-like receptor 9.

abstract：:We have studied the antibody-induced effect of cross-linking the major histocompatibility complex class I (MHC-I) in human T leukemic cells (Jurkat) and human B lymphoma cells (Solubo, Burkitts lymphoma) on intracellular [Ca2+]i levels. The increase in [Ca2+]i after MHC-I cross-linking in Jurkat cells and Solubo cells...

journal_title：Cellular immunology

authors： Pedersen AE,Jacoby BF,Skov S,Claesson MH

更新日期：1996-11-01 00:00:00

abstract：:Mycobacterium bovis BCG, a live attenuated tuberculosis vaccine offers protection against disseminated TB in children. BCG exhibits heterologous protective effects against unrelated infections and reduces infant mortality due to non-mycobacterial infections. Recent reports have suggested that BCG vaccination might hav...

journal_title：Cellular immunology

authors： Gupta PK

更新日期：2020-10-01 00:00:00

abstract：:The objective of the present investigation was to evaluate the requirement for increased ornithine decarboxylase (ODC) activity and polyamine biosynthesis in the induction of cytolytic T lymphocytes (CTL). In this regard, we have utilized alpha-difluoromethylornithine (DFMO), an irreversible inhibitor of ODC. DFMO tre...

journal_title：Cellular immunology

authors： Bowlin TL,McKown BJ,Sunkara PS

更新日期：1987-03-01 00:00:00

abstract：:In view of the eminently important role of interleukin-2 (IL-2) in T-cell responses, and in view of reports about immune stimulatory effects of PGE2, we reinvestigated the question whether PGE2 inhibits IL-2 production. It was found that PGE2 does not inhibit IL-2 production in murine spleen cell cultures after optima...

journal_title：Cellular immunology

authors： Wolf M,Falk W,Männel D,Dröge W

更新日期：1985-01-01 00:00:00

abstract：:B-cell clonal expansions (BCE) in young mice are transient, detectable for less than 4 weeks. In contrast, BCE in old mice persist more than 2 months. The greater persistence of BCE in old mice does not appear to be due to the age of the host as the survival of phenyloxazolone chicken serum albumin-induced BCE in most...

journal_title：Cellular immunology

authors： Szabo P,Li F,Mathew J,Lillvis J,Weksler ME

更新日期：2004-09-01 00:00:00

abstract：:The role of surface aminopeptidases (APs), enzymes that cleave amino-terminal residues from polypeptide chains, in the development of fetal thymocytes was studied using a murine fetal thymic organ culture (FTOC) model. FTOC AP activity was demonstrable for various amino acid-p-nitroanilide substrates, and specific inh...

journal_title：Cellular immunology

authors： Appasamy PM,Kenniston TW Jr,Amoscato AA

更新日期：1997-04-10 00:00:00

abstract：:Human peripheral blood cells enriched for B lymphocytes were stimulated to focal proliferation in semisolid cultures with lymphocyte-conditioned media, Protein A (Prot A), lipopolysaccharide (LPS) and 2-mercaptoethanol (2-ME). After 6-8 days of incubation, two morphologically distinct colony types were observed. Type ...

journal_title：Cellular immunology

authors： Peschel C,Gattringer C,Konwalinka G,Geissler D,Boyd J,Huber H,Braunsteiner H

更新日期：1984-10-01 00:00:00

abstract：:We analyzed the effect of adherent cells on the induction of lymphokine-activated killer (LAK) cell activity by depleting adherent cells from peripheral blood lymphocytes (PBL) or by adding adherent cells to PBL before culture with interleukin-2. We found that adherent cells clearly down-regulate LAK cell induction. T...

journal_title：Cellular immunology

authors： Ibayashi Y,Hoon DS,Golub SH

更新日期：1987-12-01 00:00:00

abstract：:A mouse IgG1 monoclonal antibody ED12F8C10 (C10) binds a constant percentage of peripheral blood neutrophils in the same individual when studied over time, defining a distinct subset of neutrophils in all normal individuals studied to date. Bone marrow studies confirm that the heterogeneity is present to the same degr...

journal_title：Cellular immunology

authors： Brown CC,Malech HL,Jacobson RJ,Shrimpton CF,Beverly PC,Segal AW,Gallin JI

更新日期：1991-01-01 00:00:00

abstract：:The pathogenic antibody response to acetylcholine receptor (AChR) in experimental autoimmune myasthenia gravis (EAMG) is T cell dependent. Therefore, it should be possible to design specific immunotherapeutic approaches to treat EAMG (and human MG) by interfering with AChR-specific helper T cells. Productive T cell ac...

journal_title：Cellular immunology

authors： McIntosh KR,Linsley PS,Drachman DB

更新日期：1995-11-01 00:00:00

abstract：:To investigate a role for T lymphocytes in primary demyelination of central nervous system (CNS) tissue, antigen-specific T cell lines sensitized to myelin-associated and myelin-unrelated antigens were developed from SJL mice and tested on myelinated organotypic cultures of syngeneic spinal cord. Demyelination was ass...

journal_title：Cellular immunology

authors： Lyman WD,Roth GA,Chiu FC,Brosnan CF,Bornstein MB,Raine CS

更新日期：1986-10-01 00:00:00

abstract：:Six OKT4+ human T-cell lines that require continuing PHA stimulation and TCGF for continuous growth were established. The cells from all six of these T-cell lines became smaller in size and lost the cell surface Ia antigen when they were grown in phytohemagglutinin (PHA)-depleted growth factor. These cells were unable...

journal_title：Cellular immunology

authors： Tsui F,Underdown BJ,Klein M,Zimmerman B

更新日期：1984-04-15 00:00:00

abstract：:This study examined the characteristics of functional anergy of natural killer cells (NK) following their interaction with target cells. Purified NK cells were cocultured with K562 for 15 min or 4 hr to allow for binding of targets to NK cells. The resulting NK-target conjugates were then dissociated by EDTA, and the ...

journal_title：Cellular immunology

authors： Jewett A,Bonavida B

更新日期：1995-01-01 00:00:00

abstract：:Thymocytes develop in close apposition to the stromal cells of the thymus. The ontogeny of thymocytes is dependent on intimate interactions between these cells and the stromal cells. The molecular mechanisms involved in regulating thymocyte-stromal cell interactions remain to be clearly defined. In this study, we util...

journal_title：Cellular immunology

authors： Munro SB,Duclos AJ,Jackson AR,Baines MG,Blaschuk OW

更新日期：1996-05-01 00:00:00

abstract：:CD40--CD40L interactions between resting B cells and activated T cells are essential for germinal center formation. It has been shown that CD40L can induce both Fas expression and susceptibility to Fas-mediated killing in B cells, while anti-Ig can partially rescue B cells from Fas-mediated killing. However, the intra...

journal_title：Cellular immunology

authors： Zhang X,Li L,Choe J,Krajewski S,Reed JC,Thompson C,Choi YS

更新日期：1996-10-10 00:00:00

abstract：:There are still questions about whether macrophage differentiation is predetermined or is induced in response to tissue microenvironments. C2D macrophage cells reside early in the macrophage lineage in vitro, but differentiate to a more mature phenotype after adoptive transfer to the peritoneal cavity (PEC-C2D). Since...

journal_title：Cellular immunology

authors： Ortega MT,Xie L,Mora S,Chapes SK

更新日期：2011-01-01 00:00:00

abstract：:T-Cell subsets identified by polyclonal and monoclonal antibodies to dipeptidyl peptidase IV (DP IV) were investigated. Analysis in a cytofluorograf revealed 63 +/- 7% positive scatter-gated T lymphocytes. DP IV-positive cells were found to be T11+, 74-81% OKT4+, and 12-19% OKT8+. DP IV-negative cells were T11+ and co...

journal_title：Cellular immunology

authors： Scholz W,Mentlein R,Heymann E,Feller AC,Ulmer AJ,Flad HD

更新日期：1985-06-01 00:00:00

abstract：:Arriving at an understanding of the role of suppressor T-cells (regulatory T-cells, CD4(+)CD25+) depends on whether their functional repertoire is somatically selected to be anti-Self or anti-Nonself. Immunologists are ambivalent; often publications espousing opposite views share an author. Here the arguments are deta...

journal_title：Cellular immunology

authors： Cohn M

更新日期：2004-02-01 00:00:00

abstract：:Psychological stress evokes rapid changes to the cardiovascular and neuroendocrine systems, responses that can become habituated following repeated exposure. This study, comprising of two phases, suggests that the immune system follows a similar trend. Phase 1: 15 healthy subjects (aged between 26 and 56years) provide...

journal_title：Cellular immunology

authors： Shelton-Rayner GK,Macdonald DW,Chandler S,Robertson D,Mian R

更新日期：2010-01-01 00:00:00

abstract：:Gene products coded for within the HLA complex play an important role in the control of immune responses. Class I antigens, coded for by the HLA-A, B, and C loci, are expressed by virtually all mononuclear blood cells. Class II antigens, coded for by the DR, DQ, and DP loci, have a more limited tissue distribution. Th...

journal_title：Cellular immunology

authors： Zier KS

更新日期：1986-07-01 00:00:00

abstract：:Recently, it has been reported that IL-4 production by murine Th2 cell lines is insensitive to inhibition by E-type prostaglandins. In the present study, IL-4 production in vitro by freshly isolated concanavalin A (Con A)-stimulated murine spleen cells was readily suppressed by PGE2 with an I50 of 2 nM. Comparable sup...

journal_title：Cellular immunology

authors： Parker CW,Huber MG,Godt SM

更新日期：1995-02-01 00:00:00

abstract：:An important subset in regulating antitumor immunity is the maturation and accumulation of intratumor dendritic cells (DCs), inducing potent T cell cytotoxicity. In this study, we explored how the soluble abundant high-mobility group box 1 protein (HMGB1) affected DC activation and retention within lung cancers, and i...

journal_title：Cellular immunology

authors： Gao Q,Li F,Wang S,Shen Z,Cheng S,Ping Y,Qin G,Chen X,Yang L,Cao L,Liu S,Zhang B,Wang L,Sun Y,Zhang Y

更新日期：2019-09-01 00:00:00

abstract：:Unique dysregulated expression patterns of microRNAs (miRNAs) have been reported in many disease conditions including autoimmune diseases such as systemic lupus erythematosus (SLE). We have recently reported that miRNAs are differentially expressed not only between autoimmune and control mice, but also between male an...

journal_title：Cellular immunology

authors： Khan D,Dai R,Ansar Ahmed S

更新日期：2015-04-01 00:00:00

abstract：:The aly, alymphoplasia, is an autosomal recessive mutation in mice of an unknown etiology, which induces total aplasia of lymph nodes and Peyer's patches. We hypothesized that the lack of lymphoid tissue may be due to abnormalities of lymphocyte traffic into these tissues. Therefore, we analyzed the expression of vari...

journal_title：Cellular immunology

authors： Koike R,Watanabe T,Satoh H,Hee CS,Kitada K,Kuramoto T,Serikawa T,Miyawaki S,Miyasaka M

更新日期：1997-08-25 00:00:00

abstract：:Psoriasis is a common dermatosis mediated by T cells. This study investigated the correlation of Th22 cells and Tc22 cells with psoriasis. A total of 30 psoriasis patients and 11 age- and sex-matched healthy controls were recruited for this study. The proportions of circulating Th22 and Tc22 cells, expression of aryl ...

journal_title：Cellular immunology

authors： Luan L,Ding Y,Han S,Zhang Z,Liu X

更新日期：2014-08-01 00:00:00

abstract：:The activation by concanavalin A (Con A) of murine lymphocytes derived from aged animals is impaired, as demonstrated by lower IL-2 synthesis, display of fewer IL-2 receptors, and less [3H]thymidine incorporation relative to similarly treated cells from young animals. The ability of the phorbol ester, phorbol 12-myris...

journal_title：Cellular immunology

authors： Thoman ML,Weigle WO

更新日期：1988-06-01 00:00:00

abstract：:The role of macrophages (M phi) in the in vitro primary antibody response of murine lymphocytes to sheep erythrocytes was investigated. Peritoneal M phi were activated to express Ia antigens either in vitro or in vivo. Nonactivated Ia- M phi were also examined. We observed that only Ia- M phi but also Ia+ M phi failed...

journal_title：Cellular immunology

authors： Komatsubara S,Hirayama Y,Inaba K,Naito K,Yoshida K,Kawai J,Muramatsu S

更新日期：1985-10-15 00:00:00

abstract：:Recently we reported on a novel H2E transgenic, IA-negative model of experimental autoimmune thyroiditis (EAT) that excludes reactivity to self in its susceptibility pattern to heterologous thyroglobulin (Tg). In conventional, susceptible mouse strains, EAT is inducible with both homologous and heterologous Tg; e.g., ...

journal_title：Cellular immunology

authors： Yan Y,Panos JC,McCormick DJ,Wan Q,Giraldo AA,Brusic V,David CS,Kong YC

更新日期：2001-08-25 00:00:00

abstract：:TE44, an H-2b-restricted, self-reactive T-cell line, did not produce autocrine-acting growth factors, neither after antigenic nor after mitogenic activation; they remained for their proliferation completely dependent on exogenously added IL-2. Administration of IL-4, which poorly promotes growth by itself, resulted in...

journal_title：Cellular immunology

authors： Vandenabeele P,Grooten J,Fiers W

更新日期：1990-10-01 00:00:00

abstract：:Peroxynitrite (ONOO(-)) has been vastly implicated in mutagenesis and cancer development. Present study probes the antigenicity of peroxynitrite damaged DNA (ONOO(-)-DNA) in cancer patients. Purified human placental DNA was damaged by the synergistic action of sodium nitroprusside (SNP) and Pyrogallol for 3h at 37 deg...

journal_title：Cellular immunology

authors： Habib S,Moinuddin,Ali A,Ali R

更新日期：2009-01-01 00:00:00