Abstract:
:Lung cancer cells harboring multiple mutations as a consequence of long-term damage by different etiologic factors are responsible for high immunogenicity. Immune checkpoint inhibitors significantly improve treatment results in non-small cell lung cancer (NSCLC). Unfortunately, the role of T-lymphocytes in early NSCLC has not been sufficiently elucidated. The aim of this study was to characterize peripheral blood T cells expressing several selected surface antigens (CD4, CD8, CD25, CD28, PD-1, CTLA-4) and transcription factors (T-bet, ROR-yt, Fox-P3, GATA-3) in this patient population. The study group (LC) consisted of 80 treatment-naïve patients with T1/2aN0M0 NSCLC and was compared with 40 cancer-free patients matched for non-oncological diseases and demographic parameters (CG). Significantly higher counts of CTLA-4+cells (in both CD4+and CD8+subtypes), a lower proportion of PD-1 expressing cells and a significantly higher percentage of Fox-P3+CD4+cells were found in the LC group. The high proportion of CD4+PD-1+cells significantly correlated with poor outcomes in LC group, while low CD4/CD8 ratio predicted a better prognosis. Based on our results it seems that NSCLC even at early stages of development initiate changes in the proportions of T cells that may have a significant impact on the clinical outcome.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Rutkowski J,Cyman M,Ślebioda T,Bemben K,Rutkowska A,Gruchała M,Kmieć Z,Pliszka A,Zaucha Rdoi
10.1016/j.cellimm.2017.09.007subject
Has Abstractpub_date
2017-12-01 00:00:00pages
26-33eissn
0008-8749issn
1090-2163pii
S0008-8749(17)30143-0journal_volume
322pub_type
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1994-05-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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journal_title:Cellular immunology
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