Macrophage binding of cells resistant and sensitive to contact-dependent cytotoxicity.

abstract：:Murine 4-1BB is an approximately 30-kDa glycoprotein expressed on activated T cells and plays a role in T-cell-mediated proliferative response. To date the majority of work on 4-1BB has been conducted in the mouse. To assess the role of 4-1BB in humans, mAbs were made against the recombinant human (rh) 4-1BB protein. ...

journal_title：Cellular immunology

authors： Garni-Wagner BA,Lee ZH,Kim YJ,Wilde C,Kang CY,Kwon BS

更新日期：1996-04-10 00:00:00

abstract：:Overexpression of TNF-alpha in the body is critically involved in many diseases. A strategy to construct TNF-alpha autovaccine by introducing a T cell helper epitope to the protein has been developed and may be an alternative because it is cheaper and highly efficient. However, the induction of high level anti-TNF-alp...

journal_title：Cellular immunology

authors： Wan Y,Xue X,Li M,Zhang X,Qin X,Zhang C,You Y,Wang W,Jiang C,Wu S,Liu Y,Zhu W,Ran Y,Zhang Z,Han W,Zhang Y

更新日期：2007-04-01 00:00:00

abstract：:We have previously shown that whole cell preparations of Candida albicans are capable of inducing immunosuppressive B-cell activity both in vivo and in vitro. In an effort to characterize the components of the yeast which manifest this immunomodulatory activity, we have successfully generated a soluble extract with di...

journal_title：Cellular immunology

authors： Cuff CF,Taub DD,Rogers TJ

更新日期：1989-08-01 00:00:00

abstract：:The antimicrobial peptide LL-37 is known to have a potent LPS-neutralizing activity in monocytes and macrophages. Recently, LL-37 in gingival crevicular fluids is suggested to be the major protective factor preventing infection of periodontogenic pathogens. In this study, we tried to address the effect of LL-37 on pro...

journal_title：Cellular immunology

authors： Into T,Inomata M,Shibata K,Murakami Y

更新日期：2010-01-01 00:00:00

abstract：:Older humans and experimental animals have been repeatedly found to have higher titers of autoantibodies than do younger individuals despite the impaired responses of older individuals to foreign antigens. The studies reported here were designed to examine the relationship between these two age-related changes in anti...

journal_title：Cellular immunology

authors： Bovbjerg DH,Kim YT,Schwab R,Schmitt K,DeBlasio T,Weksler ME

更新日期：1991-07-01 00:00:00

abstract：:Cytokines are soluble proteins that mediate immune reactions and are responsible for communication among immune cells. CD4(+) T cells are the principle sources of cytokines of adaptive immunity. Cytokines play critical roles in the differentiation and effector function of CD4(+) T cells. They also play key roles in di...

journal_title：Cellular immunology

authors： Guo X,Zhang Y,Wang P,Li T,Fu W,Mo X,Shi T,Zhang Z,Chen Y,Ma D,Han W

更新日期：2012-07-01 00:00:00

abstract：:With old age (∼2y old), mice show substantial differences in B cell composition within the lymphoid tissues. In particular, a novel subset of IgM+ CD21/35lo/- CD23- mature B cells, the age-associated B cells or ABC, increases numerically and proportionately. This occurs at the expense of other B cell subsets, includin...

journal_title：Cellular immunology

authors： Riley RL,Khomtchouk K,Blomberg BB

更新日期：2017-11-01 00:00:00

abstract：:The concentration of cytosolic-free calcium (Ca2+i) was determined with aequorin in RAW-264 macrophage-like cells activated in vitro for tumor cell killing with lymphokine (LK) and lipopolysaccharide (LPS). Treatments of these cells with optimal doses of stimulants, which evoked the development of cytolytic activity, ...

journal_title：Cellular immunology

authors： Gorecka-Tisera AM,Snowdowne KW,Borle AB

更新日期：1986-07-01 00:00:00

abstract：:Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline ...

journal_title：Cellular immunology

authors： Leng SX,Margolick JB

更新日期：2020-02-01 00:00:00

abstract：:Osteopontin (OPN) expression in tumors is associated with more aggressive tumor growth; however, several studies have suggested that OPN as a host protein can regulate tumor growth as well. OPN is produced by macrophages and T cells, and reportedly modifies macrophage function. Here, we have investigated the effect of...

journal_title：Cellular immunology

authors： Bourassa B,Monaghan S,Rittling SR

更新日期：2004-01-01 00:00:00

abstract：:The Lyt phenotype of cytotoxic T cells generated in the primary H-2 response was investigated kinetically. The cytotoxicity generated in the early stage of culture was abolished by treatment with alpha Lyt-1,2,3, and complement (C), whereas that generated in the late stage was only partially eliminated by alpha Lyt-1,...

journal_title：Cellular immunology

authors： Nakayama E,Uenaka A

更新日期：1984-08-01 00:00:00

abstract：:Fc gamma-receptor (Fc gamma R)-bearing cells from normal rabbit bone marrow suppressed the constitutive proliferation rates of the remaining, Fc gamma R-, cells. In the absence of the suppressive influences of Fc gamma R+ cells, cells in the Fc gamma R- population spontaneously elaborated a soluble growth factor (GF) ...

journal_title：Cellular immunology

authors： Soderberg LS

更新日期：1985-05-01 00:00:00

abstract：:Macrophages are key cell types of innate immunity and play a central role in inflammation and host defense. Leukocyte-associated Ig-like receptor-1 (LAIR-1) is highly expressed on macrophages and regulates macrophage functions in several conditions. However, whether LAIR-1 is involved in governing macrophage polarizat...

journal_title：Cellular immunology

authors： Jin J,Wang Y,Ma Q,Wang N,Guo W,Jin B,Fang L,Chen L

更新日期：2018-09-01 00:00:00

abstract：:The ability of calcium ionophore and phorbol ester to stimulate entry into S phase was assessed during short-term cultures of murine B cells extensively depleted of T cells. Neither ionomycin alone nor PMA alone stimulated DNA synthesis. However, the combination of ionomycin plus PMA acted in synergy to induce initiat...

journal_title：Cellular immunology

authors： Rothstein TL,Baeker TR,Miller RA,Kolber DL

更新日期：1986-10-15 00:00:00

abstract：:OVA-specific T cells were immortalized by infection with radiation leukemia virus (RadLV). Some clones derived from such population were shown to exhibit helper activity. We then tested clones without such function and found among them some that secreted macrophage migration inhibition factor (MIF) and leukocyte migra...

journal_title：Cellular immunology

authors： Szigeti R,Kagan-Haion K,Klein E,Ben-Sasson SZ

更新日期：1986-10-01 00:00:00

abstract：:Peripheral blood lymphocytes (PBL) isolated from BALB/c mice bearing a B-cell leukemia (BCL1) showed a marked proliferative response upon two days culturing with poly(L-lysine) (PLL) of various molecular weights. An inverse relationship was noted between the molecular weight of the PLL and the dose required for optima...

journal_title：Cellular immunology

authors： Morecki S,Flechner Y,Slavin S

更新日期：1985-02-01 00:00:00

abstract：:Neutrophils exhibit intrinsic sinusoidal metabolite concentration oscillations of 3 min in resting cells and an additional approximately 10- or 20-s oscillation in migrating/adhering cells. To better understand immune complex (IC)-mediated leukocyte activation, we have studied neutrophil metabolic oscillations in the ...

journal_title：Cellular immunology

authors： Amit A,Kindzelskii AL,Zanoni J,Jarvis JN,Petty HR

更新日期：1999-05-25 00:00:00

abstract：:The in vitro effect of single or combined doses of zidovudine (AZT) and dideoxycytidine (ddC) on the production and utilization of interleukin-2 (IL-2) by normal human peripheral blood mononuclear cells (PBMC) was evaluated by measuring IL-2 concentrations in supernatants from PHA-stimulated PBMC cultures. Drugs were ...

journal_title：Cellular immunology

authors： Viora M,Camponeschi B

更新日期：1995-07-01 00:00:00

abstract：:Differences in gender immune response have resulted in differences in immune protection and susceptibility to inflammatory diseases. Cultured peripheral blood mononuclear cells (PBMC) are widely used in immunomodulation studies, yet the influence of gender is usually not considered. We examined the effect of in vitro ...

journal_title：Cellular immunology

authors： Abdullah M,Chai PS,Chong MY,Tohit ER,Ramasamy R,Pei CP,Vidyadaran S

更新日期：2012-01-01 00:00:00

abstract：:Investigation into the mechanism of action of vaccine adjuvants provides opportunities to define basic immune principles underlying the induction of strong immune responses and insights useful for the rational development of subunit vaccines. A novel HIV vaccine composed of plasmid DNA-encoding p55 gag formulated with...

journal_title：Cellular immunology

authors： Denis-Mize KS,Dupuis M,Singh M,Woo C,Ugozzoli M,O'Hagan DT,Donnelly JJ 3rd,Ott G,McDonald DM

更新日期：2003-09-01 00:00:00

abstract：:Plasmacytoid dendritic cells (PDCs) from human umbilical cord blood (UCB) produce lower amounts of IFN-α upon TLR stimulation compared with adult counterparts. This difference may play a role in the low graft-versus-host disease rate after UCB transplantation and in the impaired immune response of the neonate to patho...

journal_title：Cellular immunology

authors： Charrier E,Cordeiro P,Cordeau M,Dardari R,Michaud A,Harnois M,Merindol N,Herblot S,Duval M

更新日期：2012-03-01 00:00:00

abstract：:We have characterized in vivo and in vitro responses of mice to the BALB/c-derived carcinoma, C26. BALB/c mice were highly susceptible, in a dose-dependent fashion, to local tumor development following subcutaneous injection of C26. Other strains of mice, including allogeneic strains and major histocompatibility compl...

journal_title：Cellular immunology

authors： Mosley RL,Styre D,Klein JR

更新日期：1989-08-01 00:00:00

abstract：:Murine histocompatibility antigens were solubilized from the spleens and lungs of C57BL/6 (H-2b) animals with hypertonic salt (3 M KC1). Aggregate-free soluble antigens were incubated with nonadherent lymph node cells from BALB/c (H-2d) mice for 18 hr prior to their use as responder cells in the mixed-lymphocyte react...

journal_title：Cellular immunology

authors： Long PM,Sommer CV,Kong YM

更新日期：1983-06-01 00:00:00

abstract：:During ultrastructural studies of the early kinetics of anaphylactic degranulation and early and late recovery intervals from these release reactions induced in isolated, partially purified, cultured human lung mast cells stimulated to release histamine and granules by exposure to anti-IgE, we noted the ability of mas...

journal_title：Cellular immunology

authors： Dvorak AM,Schleimer RP,Lichtenstein LM

更新日期：1987-03-01 00:00:00

abstract：:Transforming growth factor beta1 (TGFbeta1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1-/- mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells is sufficient ...

journal_title：Cellular immunology

authors： Bommireddy R,Engle SJ,Ormsby I,Boivin GP,Babcock GF,Doetschman T

更新日期：2004-11-01 00:00:00

abstract：:Spontaneous rosette formation in humans is restricted to a subpopulation of the circulating T cells. We have previously shown that the interaction between lymphocytes and autologous red blood cells (auto-RBC) is not mediated by a self-recognition mechanism, since allogeneic (allo-) RBC bind to T cells through the same...

journal_title：Cellular immunology

authors： Nalet V,Fournier C

更新日期：1985-11-01 00:00:00

abstract：:Spontaneously cytotoxic cells possessing specificity and having a complex pattern of reactivity directed at least partly against self-determinants develop by the age of 10 weeks in the autoimmune mouse strain MRL/Mp-lpr/lpr (MRL-lpr) and by the age of 6 months in C57BL/6-lprl/lpr. Similar effector cells do not develop...

journal_title：Cellular immunology

authors： Muraoka S,Miller RG

更新日期：1988-04-15 00:00:00

abstract：:We previously reported that T cell proliferation in response to a primary signal through the T cell receptor (TCR) and a costimulatory signal via the CD28 molecule is impaired in healthy, aged mice. Here we extend these studies to examine factors which may be involved in this defect in T cells from aged mice. To deter...

journal_title：Cellular immunology

authors： Engwerda CR,Handwerger BS,Fox BS

更新日期：1996-05-25 00:00:00

abstract：:A mouse IgG1 monoclonal antibody ED12F8C10 (C10) binds a constant percentage of peripheral blood neutrophils in the same individual when studied over time, defining a distinct subset of neutrophils in all normal individuals studied to date. Bone marrow studies confirm that the heterogeneity is present to the same degr...

journal_title：Cellular immunology

authors： Brown CC,Malech HL,Jacobson RJ,Shrimpton CF,Beverly PC,Segal AW,Gallin JI

更新日期：1991-01-01 00:00:00

abstract：:The aim of this study was to analyze in vivo the L3T4+ T-cell-subset-independent reactivity of Lyt2+ T cells toward transplantation alloantigens. To this end, we depleted normal mice of L3T4+ T cells by injection of monoclonal antibodies to the L3T4 antigen. This procedure not only led phenotypically to a disappearanc...

journal_title：Cellular immunology

authors： Heeg K,Steeg C,Wagner H

更新日期：1988-01-01 00:00:00