Abstract:
:We have investigated the ability of long-term cultured T helper (Th) cell lines to help an in vivo cytotoxic T lymphocyte (CTL) response to non-H-2 alloantigens (minor antigens). Th cell lines specific for various single or undefined minor antigens were selected by regular restimulation with antigen in vitro. They were antigen specific and H-2 restricted in proliferation assays and were found to be able to help primary CTL responses to multiple minor antigens and secondary CTL responses to single minor antigens. Although the Th were antigen specific they did not determine the specificity of the CTL. Th cells were both necessary and limiting for an effective CTL response indicating that "helper-independent" CTL are not in themselves sufficient to generate a strong in vivo response. Under conditions where a CTL response was clearly H-2 restricted, Th cells were not. Thus, the Th cells appeared to be activated by reprocessed antigen rather than antigen on the surface of the injected antigenic cells even though the CTL themselves reacted directly to the injected antigen.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Gascoigne NR,Lai PKdoi
10.1016/0008-8749(84)90309-5subject
Has Abstractpub_date
1984-02-01 00:00:00pages
302-12issue
2eissn
0008-8749issn
1090-2163pii
0008-8749(84)90309-5journal_volume
83pub_type
杂志文章abstract::The immediate effects and mechanisms of desensitization of contact sensitivity to 2,4-dinitro-1-fluorobenzene (DNFB) were investigated. Mice were sensitized with DNFB, desensitized with antigen 2 weeks later, and challenged 1 day after desensitization. Significant inhibition (approximately 50%) of contact sensitivity ...
journal_title:Cellular immunology
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doi:10.1016/0008-8749(84)90200-4
更新日期:1984-11-01 00:00:00
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journal_title:Cellular immunology
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更新日期:2002-07-01 00:00:00
abstract::As fascinating a molecule as it can potentially get, nuclear factor-κB (NF-κB), a regulatory transcription factor, is as intriguing. NF-κB is a dimeric complex that controls the transcription of essential genes. NF-κB is involved in a variety of responses that play a pivotal role in regulating the immune response to i...
journal_title:Cellular immunology
pub_type: 杂志文章,评审
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更新日期:2011-01-01 00:00:00
abstract::With DNA vaccines, it is important to monitor the movement of transfectants and to overcome immune deviations. We used a pCMV-LacZ plasmid (expressing β-galactosidase) and a pcDNA-hNIS plasmid (expressing the human sodium/iodide symporter [hNIS] gene) as non-secreted visual-imaging markers. Transfectants carrying the ...
journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2018-07-01 00:00:00
abstract::The mechanism of suppression of experimental allergic encephalomyelitis (EAE) induced in Lewis rats by pretreatment with myelin basic protein (MBP) coupled to syngeneic spleen leukocytes (SL) was examined. Studies on the kinetics of the tolerance induction showed that pretreatment with MBP-SL suppressed EAE if given 7...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(84)90159-x
更新日期:1984-10-15 00:00:00
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journal_title:Cellular immunology
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更新日期:2001-07-10 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1993.1133
更新日期:1993-06-01 00:00:00
abstract::Interleukin-4 (IL-4) acts directly on purified human peripheral blood B cells cultured in the presence of Epstein-Barr virus (EBV) to induce IgE secretion and to enhance the secretion of IgG and IgM. Interferon-gamma (IFN-gamma) inhibits IgE secretion in this system, without affecting the secretion of the other Ig iso...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(91)90114-q
更新日期:1991-04-01 00:00:00
abstract::Imiquimod, a toll-like receptor 7 (TLR7) agonist, is an active pharmaceutical ingredient (API) established for the topical treatment of several dermal cancerous and precancerous skin lesions. Within this work, the immunostimulatory effect of imiquimod is further exploited in a transcutaneous immunization (TCI) approac...
journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2016-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2007-08-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1006/cimm.1996.1049
更新日期:1997-01-10 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1986-04-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/j.cellimm.2016.01.006
更新日期:2016-04-01 00:00:00
abstract::The role of class II antigens for B-cell activation was analyzed using purified human B cells and anti-class II monoclonal antibodies. The stimulation of purified B cells with Staphylococcus aureus Cowan I induced proliferation and differentiation into immunoglobulin-producing cells in the presence of interleukin-1 an...
journal_title:Cellular immunology
pub_type: 杂志文章
doi:10.1016/0008-8749(88)90295-x
更新日期:1988-04-01 00:00:00
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更新日期:1988-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1998-12-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1986-12-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2019-03-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1986-10-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2005-07-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1994-09-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1989-10-15 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:2010-01-01 00:00:00
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journal_title:Cellular immunology
pub_type: 杂志文章
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更新日期:1988-12-01 00:00:00