Activation in vivo of a major antisuppressor T-cell pathway immediately after immunization. I. Its regulation by I-A gene products.

abstract：:NK activity is regulated by arachidonic acid metabolites. More precisely PGE2 and LTB4 decreases and increases respectively non-MHC-restricted cytotoxicity in humans. We have observed similar data in mice since NK activity was inhibited by PGE2 (10(-6) to 10(-8) M) and enhanced by LTB4 (10(-8) to 10(-12) M). On the ot...

journal_title：Cellular immunology

authors： Vaillier D,Daculsi R,Gualde N,Bezian JH

更新日期：1992-01-01 00:00:00

abstract：:The kinetics and quality of the alloimmune reaction were studied in CBA (H-2k) mice treated for passive enhancement of tumor allografts (Sa 1 indigenous of A/J (H-2a or H-2k/d) mice). Serum samples of treated animals were tested for their biological properties relevant to different antibody isotypes in vitro (hemagglu...

journal_title：Cellular immunology

authors： Duc HT,Kinsky RG,Monnot P,Voisin GA

更新日期：1985-10-01 00:00:00

abstract：:Controversies remain about NK cells direct responsiveness to Toll-like receptor (TLR) agonists or dependence on macrophages. In a melanoma lung metastasis model, aerosolized TLR9 and TLR3 agonists have been reported to induce antitumor immunity through NK cells activation. In the current study, we demonstrated that in...

journal_title：Cellular immunology

authors： Sommariva M,Le Noci V,Storti C,Bianchi F,Tagliabue E,Balsari A,Sfondrini L

更新日期：2017-03-01 00:00:00

abstract：:Mygalin is an antibacterial molecule isolated from the hemocytes of the spider Acanthoscurria gomesiana. It was identified as bis-acylpolyamine spermidine. We evaluated the modulator effects of synthetic Mygalin in the innate immune response. We demonstrate that Mygalin induces IFN-γ synthesis by splenocytes increasin...

journal_title：Cellular immunology

authors： Mafra DG,da Silva PI Jr,Galhardo CS,Nassar R,Daffre S,Sato MN,Borges MM

更新日期：2012-01-01 00:00:00

abstract：:The purpose of this project was to characterize changes in murine T lymphocyte subpopulations during thymic atrophy induced by protein malnutrition and to determine the role of elevated serum corticosterone in this process. A suitable animal model was generated by placing mice on protein-sufficient (PS) and protein-de...

journal_title：Cellular immunology

authors： Barone KS,O'Brien PC,Stevenson JR

更新日期：1993-04-15 00:00:00

abstract：:This investigation shows that Epstein-Barr virus (EBV)-activated human B cells from marrow transplant recipients can produce in vitro IgG anti-tetanus toxoid antibody (anti-TT) without booster immunizations with tetanus toxoid (TT). Purified B cells (E-rosette negative) from 8 normal subjects, 6 healthy long-term marr...

journal_title：Cellular immunology

authors： Jin NR,Lum LG

更新日期：1986-08-01 00:00:00

abstract：:In view of the critical role played by bacillus Calmette-Guérin (BCG) in the development and functional activation of protective T cells against tuberculosis, it has become important to understand the mechanisms by which cytokines regulate BCG-mediated immune responses. There is evidence that cytokine-mediated suppres...

journal_title：Cellular immunology

authors： Méndez-Samperio P,Hernández-Garay M,García-Martínez E

更新日期：2000-06-15 00:00:00

abstract：:Macrophages are key cell types of innate immunity and play a central role in inflammation and host defense. Leukocyte-associated Ig-like receptor-1 (LAIR-1) is highly expressed on macrophages and regulates macrophage functions in several conditions. However, whether LAIR-1 is involved in governing macrophage polarizat...

journal_title：Cellular immunology

authors： Jin J,Wang Y,Ma Q,Wang N,Guo W,Jin B,Fang L,Chen L

更新日期：2018-09-01 00:00:00

abstract：:Ca(2+) and Sr(2+) entry pathways activated by pro-inflammatory agonists FMLP, LTB(4) and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10microM) increased Ca(2+) influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca(2+) beca...

journal_title：Cellular immunology

authors： Salmon MD,Ahluwalia J

更新日期：2010-01-01 00:00:00

abstract：:Spleen cells from normal, nonautoimmune mice (C3H/HeN) spontaneously produce hemolytic plaques against autologous bromelain-treated red blood cells (BrMRBC). The number of anti-BrMRBC plaques detectable can be increased by including either a 3 M KCl extracted antigen from BrMRBCs or the hapten phosphorylcholine chlori...

journal_title：Cellular immunology

authors： Wieties KM,Moticka EJ

更新日期：1986-03-01 00:00:00

abstract：:T lymphocytes respond to mitogenic stimulation by expressing the receptor for interleukin 2 (Il-2) and secreting Il-2; once the receptor is expressed, Il-2 induces these cells to proliferation. In the present report using mouse T lymphocytes, thymocytes, and the lymphoma cell line EL4, we studied receptor expression a...

journal_title：Cellular immunology

authors： Truneh A,Simon P,Schmitt-Verhulst AM

更新日期：1986-12-01 00:00:00

abstract：:A majority (42/62) of TCR2+ interleukin 2-dependent human T lymphocyte clones was found concordantly to express not only the CD28 co-receptor structure at the cell surface but also its ligand B7. Interactions between CD28 and B7 can have important consequences for T cell activation, particularly in providing "signal 2...

journal_title：Cellular immunology

authors： Friccius H,Siegels-Hübenthal P,Rehbein A,Schlotz E,Pawelec G

更新日期：1993-10-15 00:00:00

abstract：:We have investigated the ability of interleukin-10 (IL-10) to modulate murine intrathymic T cell differentiation using a fetal thymic organ culture (FTOC) model. Addition of as little as 11 ng of recombinant murine IL-10 (mIL-10) per day produced a significant increase in the proportion and number of gamma delta-TCR+ ...

journal_title：Cellular immunology

authors： Fine JS,Macosko HD,Grace MJ,Narula SK

更新日期：1994-04-15 00:00:00

abstract：:The murine B-cell differentiation antigen Lyb-2 has been shown to be involved in B-lymphocyte activation and has been postulated by some to be related to a receptor for B-cell stimulatory factor I (BSF-1) (H. Yakura et al., J. Immunol. 137, 1475, 1986). Here we have demonstrated that monoclonal antibody (mAB) to Lyb-2...

journal_title：Cellular immunology

authors： Subbarao B,Morris J,Baluyut AR

更新日期：1988-04-01 00:00:00

abstract：:Conditioned medium (CM) from 24-hr culture of guinea pig L2C B lymphoblastic leukemia cells contained an inhibitor(s) of mitogen- and antigen-stimulated proliferation of syngeneic (strain 2 guinea pigs), allogeneic (Hartley guinea pigs), and xenogeneic (Balb/c mouse, NZW rabbit) lymphocytes. The proliferation of sever...

journal_title：Cellular immunology

authors： Collins DP,Cook DJ,Ricardo MJ Jr

更新日期：1987-04-01 00:00:00

abstract：:Hybrid human-murine major histocompatibility antigens have been constructed and expressed on the surface of both human RD and murine L cell lines after DNA mediated gene transfer. These antigens linked the polymorphic domains (alpha 1 and alpha 2) of H-2Kb and the carboxy-terminal domains (alpha 3, transmembrane, and ...

journal_title：Cellular immunology

authors： Maziarz RT,Burakoff SJ,Reiss CS

更新日期：1986-04-15 00:00:00

abstract：:Numerous reports in the literature describe the effects of beta-adrenergic agonists and/or their second messenger cyclic AMP on in vitro and in vivo immune responses. The fact that the murine spleen receives rich adrenergic innervation and that the pharmacologic disruption of this innervation leads to altered immune r...

journal_title：Cellular immunology

authors： Fuchs BA,Campbell KS,Munson AE

更新日期：1988-12-01 00:00:00

abstract：:In Jurkat cells, the three Ca(2+)-ATPase blockers, thapsigargin, cyclopiazonic acid, and di-tert-butylhydroquinone (DtBuHQ) induced both a release of Ca2+ from intracellular stores and a Ca2+ influx. In contrast to CD3 mAb, the Ca(2+)-ATPase inhibitors did not induce the formation of inositol trisphosphate from the hy...

journal_title：Cellular immunology

authors： Breittmayer JP,Ticchioni M,Ferrua B,Bernard A,Aussel C

更新日期：1993-07-01 00:00:00

abstract：:The lymphokine IL-4 is a potent enhancer of anti-IgM-induced B cell proliferation. Although the mechanism of this enhancement is not known, a commonly held view suggests that IL-4 acts together with anti-IgM as a costimulating factor for the activation of a subpopulation of B cells. To evaluate this hypothesis we exam...

journal_title：Cellular immunology

authors： Hodgkin PD,Go NF,Cupp JE,Howard M

更新日期：1991-04-15 00:00:00

abstract：:Neutrophils exhibit intrinsic sinusoidal metabolite concentration oscillations of 3 min in resting cells and an additional approximately 10- or 20-s oscillation in migrating/adhering cells. To better understand immune complex (IC)-mediated leukocyte activation, we have studied neutrophil metabolic oscillations in the ...

journal_title：Cellular immunology

authors： Amit A,Kindzelskii AL,Zanoni J,Jarvis JN,Petty HR

更新日期：1999-05-25 00:00:00

abstract：:Infection of certain strains of mice, such as C57BL/6 and C57BL/10 [B10], with LP-BM5 murine leukemia virus (MuLV) rapidly causes a profound and lethal immune suppression. The H2d congenic strain of B10, B10.D2, is resistant to disease, but B10 x B10.D2 F1 mice are susceptible, indicating that disease sensitivity is d...

journal_title：Cellular immunology

authors： Gilmore GL

更新日期：1996-04-10 00:00:00

abstract：:Six OKT4+ human T-cell lines that require continuing PHA stimulation and TCGF for continuous growth were established. The cells from all six of these T-cell lines became smaller in size and lost the cell surface Ia antigen when they were grown in phytohemagglutinin (PHA)-depleted growth factor. These cells were unable...

journal_title：Cellular immunology

authors： Tsui F,Underdown BJ,Klein M,Zimmerman B

更新日期：1984-04-15 00:00:00

abstract：:The impact of BCR:CD21 co-engagement on B cell expression of molecules critical for T cell activation was investigated with receptor-specific mAbs conjugated to high MW dextran as stimulatory ligands. In the absence of IL-4, BCR:CD21 co-ligation augmented BCR-triggered CD86 only under conditions of very low BCR ligand...

journal_title：Cellular immunology

authors： Mongini PK,Tolani S,Fattah RJ,Inman JK

更新日期：2002-03-01 00:00:00

abstract：:Enriched human B lymphocytes cocultivated with mouse L cells produced human leukocyte interferon (IFN-alpha) and shortly thereafter transferred antiviral activity to the recipient cells (99% inhibition of expected virus yield). In contrast, cocultivation of enriched T-cell populations with mouse L cells resulted in no...

journal_title：Cellular immunology

authors： Weigent DA,Langford MP,Stanton GJ,Blalock JE

更新日期：1984-09-01 00:00:00

abstract：:Previous results have shown that in addition to their ability to kill tumor cell lines, peripheral blood leukocytes (PBL) expanded in interleukin 2 (IL-2) can also destroy normal PBL targets. Cold target competition results show that PBL and tumor cells can be destroyed by the same population of IL-2-expanded leukocyt...

journal_title：Cellular immunology

authors： Chen BP,Malkovsky M,Hank JA,Sondel PM

更新日期：1987-12-01 00:00:00

abstract：:Nickel (Ni) can cause delayed-type hypersensitivity reactions, which are thought to be mediated by the accumulation of T cells into inflamed skin. Accumulated T cells at the developmental stages in metal allergy are poorly characterized because a suitable animal model has not been established. To investigate the accum...

journal_title：Cellular immunology

authors： Eguchi T,Kumagai K,Kobayashi H,Shigematsu H,Kitaura K,Suzuki S,Horikawa T,Hamada Y,Ogasawara K,Suzuki R

更新日期：2013-07-01 00:00:00

abstract：:The role of surface aminopeptidases (APs), enzymes that cleave amino-terminal residues from polypeptide chains, in the development of fetal thymocytes was studied using a murine fetal thymic organ culture (FTOC) model. FTOC AP activity was demonstrable for various amino acid-p-nitroanilide substrates, and specific inh...

journal_title：Cellular immunology

authors： Appasamy PM,Kenniston TW Jr,Amoscato AA

更新日期：1997-04-10 00:00:00

abstract：:We showed previously that the expressions of various src family protein tyrosine kinases (PTKs) were induced independently during the monocytic differentiation of HL-60 cells. The role of PTKs was further assessed in the present study by investigating the effects of PTK inhibitors on the differentiation. It was demons...

journal_title：Cellular immunology

authors： Katagiri K,Katagiri T,Kajiyama K,Uehara Y,Yamamoto T,Yoshida T

更新日期：1992-04-01 00:00:00

abstract：:Semaphorins are important regulators of peripheral T and B-cell mediated immune responses in mice and humans. Modulatory roles of semaphorins in T cell development are also being characterized. We carefully analyzed the gene expression and protein levels of semaphorins 4A, 4D, and 7A at various developmental stages of...

journal_title：Cellular immunology

authors： Linder GE,Chuntova PD,McLelland BT,Añó L,Obodo UC,Crider NJ,Matthes DJ,García-Ojeda ME,Manilay JO,Chatterjea D

更新日期：2013-02-01 00:00:00

abstract：:The aim of our work was to study apoptosis as a possible mechanism of CD4+ lymphocyte depletion in AIDS patients and to test whether IL-12 could limit this phenomenon. As an in vitro model, we used a human IL-2-dependent Th1 clone from an uninfected individual. We found that CD4 cross-linking, obtained either by mouse...

journal_title：Cellular immunology

authors： Radrizzani M,Accornero P,Amidei A,Aiello A,Delia D,Kurrle R,Colombo MP

更新日期：1995-03-01 00:00:00