Piper nigrum extract ameliorated allergic inflammation through inhibiting Th2/Th17 responses and mast cells activation.

abstract：:A series of Lyt 2+, trinitrophenyl (TNP)-specific T-cell lines are shown to lyse 51Cr-labeled target cells in an antigen-specific, H-2-restricted fashion in a 4-hr assay. These cells also produce lymphotoxin, in addition to other factors, upon stimulation with TNP-haptenated syngeneic splenocytes. A technique for intr...

journal_title：Cellular immunology

authors： Schmid DS,Powell MB,Mahoney KA,Ruddle NH

更新日期：1985-06-01 00:00:00

abstract：:We analyzed the effect of adherent cells on the induction of lymphokine-activated killer (LAK) cell activity by depleting adherent cells from peripheral blood lymphocytes (PBL) or by adding adherent cells to PBL before culture with interleukin-2. We found that adherent cells clearly down-regulate LAK cell induction. T...

journal_title：Cellular immunology

authors： Ibayashi Y,Hoon DS,Golub SH

更新日期：1987-12-01 00:00:00

abstract：:The effect of prior maternal immunization on the murine offspring response to subsequent immunization with hen egg-white lysozyme was examined. Adult female A/J mice were immunized with 100 micrograms HEL-CFA intraperitoneally 10-27 weeks before conception. The offspring of these experimental female mice were then imm...

journal_title：Cellular immunology

authors： Jelonek MT,Brust JL,Song CH,Calandra GB,Miller A,Sercarz EE,Keller MA

更新日期：1993-05-01 00:00:00

abstract：:The role of the cytokines IL-1 alpha, IL-1 beta, and IL-6 and the cell adhesion molecules ICAM-1, LFA-1 (alpha and beta), and Mac-1 as accessory molecules for stimulation of T cells by the superantigen staphylococcal enterotoxin B (SEB) was examined. Both blood monocytes and alveolar macrophages were used as accessory...

journal_title：Cellular immunology

authors： Salamon FT,Fayen JD,Leonard ML,Finegan CK,Rich EA

更新日期：1992-05-01 00:00:00

abstract：:Some further aspects of B-lymphocyte-promotor factor (B-LPF) activity have been studied. This activity was present in the supernatants of certain helper-T-cell lines, and it induced polyclonal activation of Ig+ B cells into Ig-secreting cells. It was found that B-LPF induced polyclonal, terminal B-cell differentiation...

journal_title：Cellular immunology

authors： Reininger L,Fueri J,Boned A,Prat M,Landolfo S,Rubin B

更新日期：1985-04-15 00:00:00

abstract：:We have previously reported that antibody secretion by B.22 hybridoma cells can be suppressed in an MHC-restricted manner, by idiotype-specific T cells. It was shown that T cells of both helper and suppressor phenotypes are involved, and that the suppression is mediated by soluble factors. In the present paper, we hav...

journal_title：Cellular immunology

authors： Gulati P,Falck-Pedersen E,Siskind GW

更新日期：1989-10-15 00:00:00

abstract：:Exogenous nonreplicating antigens (Ag) incorporated into immunostimulating complexes (iscoms) induce CTL responses under MHC class I restriction. A requirement for inducing CTL responses is that the Ag is delivered to the cytosol of antigen-presenting cells (APC), a route restricted to endogenously produced Ag. To inv...

journal_title：Cellular immunology

authors： Villacres MC,Behboudi S,Nikkila T,Lovgren-Bengtsson K,Morein B

更新日期：1998-04-10 00:00:00

abstract：:The primary and secondary responses to Tnp-Ficoll, a class 2 thymus-independent antigen, were assessed in various inbred strains of mice. The eventual implication of H-2 or IgH linked genes was searched for. Contrasting with our previous reports using Tnp-LPS, a class 1 thymus-independent antigen, no homologous memory...

journal_title：Cellular immunology

authors： Le Moal MA,Colle JH,Truffa-Bachi P

更新日期：1984-08-01 00:00:00

abstract：:Although it is well known that the CD3/T-cell receptor (TCR) complex modulates from the surface of T cells upon exposure to monoclonal antibodies (mAb) directed against it, the fate of bound mAb has not been yet elucidated. We therefore perform direct binding experiments of 125I-labeled mAb against CD3 or TCR to inves...

journal_title：Cellular immunology

authors： Schaffar L,Dallanegra A,Breittmayer JP,Carrel S,Fehlmann M

更新日期：1988-10-01 00:00:00

abstract：:Antigen processing in B cells is initiated by antigen binding to the surface B cell antigen receptor (BCR). The BCR is a signaling receptor which also functions to endocytose bound antigen for subsequent intracellular processing and presentation with class II molecules. Previously, using subcellular fractionation, we ...

journal_title：Cellular immunology

authors： Wagle NM,Kim JH,Pierce SK

更新日期：1998-02-25 00:00:00

abstract：:We investigated the cellular induction mechanism of antigen-nonspecific CD8+ T suppressor cells which suppressed delayed-type hypersensitivity to sheep red blood cells, by treating BALB/c mice with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, and 12-O-tetradecanoylphorbol 13-acetate (TPA), a tumor promote...

journal_title：Cellular immunology

authors： Negoro T,Iinuma F,Watanabe M

更新日期：1996-02-01 00:00:00

abstract：:To understand the role of cAMP during macrophage activation, we investigated the effects of various cAMP analogues in the induction of nitric oxide (NO) synthesis in murine peritoneal macrophages. Intracellular cAMP modulators such as N6,O2'-dibutyryl cyclic AMP (DB-cAMP), 8-bromo-cAMP, or 8-chloro-cAMP had no effect ...

journal_title：Cellular immunology

authors： Park YC,Park SJ,Jun CD,Kim GE,Park KI,Kim HD,Park RK,Chung HT

更新日期：1997-07-10 00:00:00

abstract：:Mice that differ at Igh loci and the reagents that permit resolution of such distinctions are powerful genetic tools for studying B cell heterogeneity. In this report, IgM-allotype-specific ELISA revealed that two of three sources of mice designated as BALB.nude express the Igh-6b (IgMb) allotype characteristic of C57...

journal_title：Cellular immunology

authors： Riggs JE

更新日期：1993-05-01 00:00:00

abstract：:Antigen-independent adhesion of CD4+ T lymphocytes to Epstein-Barr virus transformed B cells is mainly mediated by LFA-1 (CD11a/CD18) and CD2 molecules. Low-affinity binding of resting T cells can be transiently upregulated by cross-linking of CD3-TCR (T cell receptor) complexes. This inside-out signaling influences i...

journal_title：Cellular immunology

authors： Hauss P,Mazerolles F,Hivroz C,Lecomte O,Barbat C,Fischer A

更新日期：1993-09-01 00:00:00

abstract：:Using analogues of arginine to inhibit nitric oxide (NO.) production, investigators have demonstrated the intermediary role of NO. in a variety of physiological events including the antimicrobial activity exhibited by macrophages in vitro. In an effort to establish the effector function of NO. in the antimicrobial act...

journal_title：Cellular immunology

authors： Gregory SH,Sagnimeni AJ,Wing EJ

更新日期：1994-02-01 00:00:00

abstract：:The complement receptor 2 (CR2; CD21), a 145,000 MW glycoprotein, has been useful as a marker of B lymphocyte maturation. It is expressed on the 1:13 monoclonal, EBV-transformed, B cell line which produces TNP-specific IgM-kappa and displays an in vitro capacity for differentiation. The line expresses the CD20+CD21+ p...

journal_title：Cellular immunology

authors： Pillemer SR,Tsokos GC,Barbieri SA,Balow JE,Golding B

更新日期：1990-02-01 00:00:00

abstract：:BST2 is a type II transmembrane protein that had been initially identified as a surface molecule expressed on terminally differentiated B cells. Here, we characterize the expression of BST2 in human endothelial cells, HUVECs. IFN-γ, among various inflammatory stimuli, dramatically upregulates BST2 expression in HUVECs...

journal_title：Cellular immunology

authors： Yoo H,Park SH,Ye SK,Kim M

更新日期：2011-01-01 00:00:00

abstract：:We investigated the role of HLA-DR molecules in T cell stimulation by staphylococcal enterotoxin A (SEA). Previous results with immobilized purified HLA-DR preincubated with peptide showed that peptide-specific T cell clones were able to bind to and proliferate in response to purified HLA-DR/peptide complexes in the a...

journal_title：Cellular immunology

authors： Rust CJ,Koning F,van Schooten WC

更新日期：1993-10-15 00:00:00

abstract：:Activated macrophages synthesize and release numerous tumoricidal soluble factors that can be divided into receptor- or nonreceptor-dependent agents. Tumor necrosis factor (TNF) would be an example of the former. In our experimental model the killing of EL4 thymoma cells by syngeneic activated macrophages involves, bu...

journal_title：Cellular immunology

authors： Fishman M,Essani N,Costlow M

更新日期：1990-04-15 00:00:00

abstract：:T lymphocytes respond to mitogenic stimulation by expressing the receptor for interleukin 2 (Il-2) and secreting Il-2; once the receptor is expressed, Il-2 induces these cells to proliferation. In the present report using mouse T lymphocytes, thymocytes, and the lymphoma cell line EL4, we studied receptor expression a...

journal_title：Cellular immunology

authors： Truneh A,Simon P,Schmitt-Verhulst AM

更新日期：1986-12-01 00:00:00

abstract：:To determine whether human antibody responses to T cell-independent pneumococcal polysaccharide antigens are derived from CD5+ or CD5- B cells, we utilized an ELISPOT assay to detect individual anti-polysaccharide antibody-secreting cells. Human anti-type IV pneumococcal polysaccharide antibody-secreting cells were fo...

journal_title：Cellular immunology

authors： Barrett DJ,Sleasman JW,Schatz DA,Steinitz M

更新日期：1992-08-01 00:00:00

abstract：:We have observed that the CD28 molecule was present on the cell surface of a large fraction of resting CD3- thymocytes (40 to 100%). Interestingly, the majority (greater than 90%) of surface CD3-CD28-cells reacted in the cytoplasm with anti-CD28 (CK248, 9.3) and anti-CD3 epsilon chain mAbs (Leu4, OKT3). Along this lin...

journal_title：Cellular immunology

authors： Zocchi MR,Poggi A

更新日期：1991-08-01 00:00:00

abstract：:Mice that received a sublethal, intraperitoneal dose of viable Listeria monocytogenes, virulent strain 10403, exhibited a systemic increase in natural killer (NK) activity. The kinetics of the response differed with respect to the various effector cell populations analyzed. Resident peritoneal cells and peripheral blo...

journal_title：Cellular immunology

authors： Kearns RJ,Leu RW

更新日期：1984-04-01 00:00:00

abstract：:We have analyzed the effect of cyclosporin-A (CsA) on the proliferative and cytotoxic responses induced by mixed-lymphocyte cultures (MLC-s) on low and high density T lymphocytes. Allogeneic stimulation had a different impact on the two subsets. Proliferative and cytotoxic responses were inversely correlated; i.e., hi...

journal_title：Cellular immunology

authors： Bejarano MT,Masucci MG,Klein E

更新日期：1986-12-01 00:00:00

abstract：:Systemic sclerosis (SSc) is an autoimmune disease characterized by fibrosis in the skin and internal organs. The pathogenesis of SSc is not completely understood until now. Recently, many studies have focused on the role of E3 ubiquitin ligases in organ fibrosis. However, the possible regulatory mechanisms of E3 ubiqu...

journal_title：Cellular immunology

authors： Huang XL,Zhang L,Duan Y,Wang YJ,Zhao JH,Wang J

更新日期：2016-08-01 00:00:00

abstract：:In an attempt to better relate specific membrane characteristics of human adult and cord blood lymphocytes to specific functional activities, the phenotypic differences that exist in these two populations have been examined. Cord blood cells have considerably more spontaneous suppressor cell activity than adult cells....

journal_title：Cellular immunology

authors： Johnson C,Dwyer JM

更新日期：1983-10-01 00:00:00

abstract：:Murine 4-1BB is an approximately 30-kDa glycoprotein expressed on activated T cells and plays a role in T-cell-mediated proliferative response. To date the majority of work on 4-1BB has been conducted in the mouse. To assess the role of 4-1BB in humans, mAbs were made against the recombinant human (rh) 4-1BB protein. ...

journal_title：Cellular immunology

authors： Garni-Wagner BA,Lee ZH,Kim YJ,Wilde C,Kang CY,Kwon BS

更新日期：1996-04-10 00:00:00

abstract：:The glycobiology of the immune response is a topic that has garnered increased attention due to a number of key discoveries surrounding IgG function, the specificity of some broadly neutralizing anti-HIV antibodies, cancer immunoregulation by galectin molecules and others. This review is the opening article in a Speci...

journal_title：Cellular immunology

authors： Oswald DM,Cobb BA

更新日期：2018-11-01 00:00:00

abstract：:Stimulation via the CD3/TCR molecular complex induces proliferation of resting T cells, but triggers programmed cell death (apoptosis) in immature thymocytes and preactivated mature T cells. Activation-induced cell death (AICD) triggered by anti-CD3/TCR mAb or by staphylococcus enterotoxin superantigen is associated w...

journal_title：Cellular immunology

authors： Pohl T,Pechhold K,Oberg HH,Wilbert OM,Kabelitz D

更新日期：1995-12-01 00:00:00

abstract：:Interleukin (IL)-1 differs from most other cytokines by the lack of a signal sequence, which results in the retention of the immature proform intracellularly (i.c.). Several cell types have the capacity to produce IL-1, but release has been shown to be restricted predominantly to monocytes/macrophages and associated w...

journal_title：Cellular immunology

authors： Wingren AG,Björkdahl O,Labuda T,Björk L,Andersson U,Gullberg U,Hedlund G,Sjögren HO,Kalland T,Widegren B,Dohlsten M

更新日期：1996-05-01 00:00:00