Abstract:
:CD40--CD40L interactions between resting B cells and activated T cells are essential for germinal center formation. It has been shown that CD40L can induce both Fas expression and susceptibility to Fas-mediated killing in B cells, while anti-Ig can partially rescue B cells from Fas-mediated killing. However, the intracellular mechanism for this phenomenon is not known. We examined the expression of Fas and bcl-2 family gene products, such as Bcl-2, Bcl-x, Bax, and Mcl-1, in human tonsillar B cells. The activation of naive B cells by CD40L induced transient expression of Bcl-xL. As the Bcl-xL level decreased in CD40-activated B cells, the cells became susceptible to apoptosis by anti-Fas antibodies. Though anti-Ig did not change the Fas expression, it protected CD40-activated B cells from Fas-mediated killing by up-regulating Bcl-xL expression. The addition of anti-Ig did not significantly change Bcl-2, Bax, and Mcl-1 levels compared to those of B cells activated by CD40L alone.
journal_name
Cell Immunoljournal_title
Cellular immunologyauthors
Zhang X,Li L,Choe J,Krajewski S,Reed JC,Thompson C,Choi YSdoi
10.1006/cimm.1996.0260subject
Has Abstractpub_date
1996-10-10 00:00:00pages
149-54issue
1eissn
0008-8749issn
1090-2163pii
S0008-8749(96)90260-9journal_volume
173pub_type
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pub_type: 杂志文章,评审
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