Peripheral CD4+CD8+cells are the activated T cells expressed granzyme B (GrB), Foxp3, interleukin 17 (IL-17), at higher levels in Th1/Th2 cytokines.

abstract：:To investigate a role for T lymphocytes in primary demyelination of central nervous system (CNS) tissue, antigen-specific T cell lines sensitized to myelin-associated and myelin-unrelated antigens were developed from SJL mice and tested on myelinated organotypic cultures of syngeneic spinal cord. Demyelination was ass...

journal_title：Cellular immunology

authors： Lyman WD,Roth GA,Chiu FC,Brosnan CF,Bornstein MB,Raine CS

更新日期：1986-10-01 00:00:00

abstract：:Neoplastic thymocytes from rat thymic lymphoma-leukemias induced by the rat-adapted Gross leukemia virus (RAGV) were analyzed for a variety of differentiation markers. The neoplasms from individual rats all expressed the antigenic phenotype MP+, W3/13+, Thy-1+, RT-1+, RT-7+, W3/25-. However, approximately two-thirds o...

journal_title：Cellular immunology

authors： Barton RW,Greiner DL,Medlock ES,Goldschneider I

更新日期：1985-08-01 00:00:00

abstract：:We investigated the time course of the 17 beta-estradiol effect on mouse natural killer (NK) activity and the number of splenic large granular lymphocytes (LGL), a cell population recently associated with natural cytotoxicity and enriched in low density fractions of Percoll discontinuous density gradients. After 7 day...

journal_title：Cellular immunology

authors： Screpanti I,Santoni A,Gulino A,Herberman RB,Frati L

更新日期：1987-05-01 00:00:00

abstract：:The actions of interleukin-4 (IL-4) in vivo are likely to be positively influenced by the expression of membrane IL-4 receptors (mIL-4R) on target cells and negatively by the concentration of soluble IL-4 receptors (sIL-4R) in the extracellular environment. Inasmuch as the two forms of the mouse IL-4R are differential...

journal_title：Cellular immunology

authors： Chilton PM,Fernandez-Botran R

更新日期：1997-09-15 00:00:00

abstract：:Treatment with bacterial lipopolysaccharide elicits the appearance of greater numbers of background antigen-specific plaque-forming cells (PFC) in the spleens of mice previously exposed or primed to subimmunogenic amounts of various non-cross-reacting antigens so as to generate detectable immunological memory. These f...

journal_title：Cellular immunology

authors： Fauntleroy MB,Rudbach JA,Prescott B,Baker PJ

更新日期：1987-07-01 00:00:00

abstract：:Toll-like receptor (TLR) 2/1 signalling is linked to autophagy through transcriptional actions of the 1,25-dihydroxyvitamin D3 (1,25(OH)2D3)-vitamin D receptor (VDR) complex. Population-specific effects have been reported for TLR2/1-VDR signalling. We hypothesized that population effects extend to autophagy and are in...

journal_title：Cellular immunology

authors： Abhimanyu,Meyer V,Jones BR,Bornman L

更新日期：2020-06-01 00:00:00

abstract：:Modification of cytokine production by gender hormones has been postulated to affect disease susceptibility and outcome. Here we investigate the effect of gender and the menstrual cycle on production of cytokines. Mononuclear cells were isolated every week for 10 consecutive weeks from healthy pre-menopausal women and...

journal_title：Cellular immunology

authors： Temple SE,Pham K,Glendenning P,Phillips M,Waterer GW

更新日期：2008-02-01 00:00:00

abstract：:Human leucocytes from peripheral blood and tonsil were examined for the presence of the IL-3 receptor using monoclonal antibodies directed to epitopes of the alpha and beta chains of the receptor. We found that the beta chain, common to IL-3, IL-5, and GM-CSF, was either present at low levels or not detected on the ma...

journal_title：Cellular immunology

authors： Macardle PJ,Chen Z,Shih CY,Huang CM,Weedon H,Sun Q,Lopez AF,Zola H

更新日期：1996-02-25 00:00:00

abstract：:Idiotope-specific immunoenhancement or suppression was induced in C57BL/6 mice by the injection of physiological amounts (100 ng-10 micrograms) of monoclonal anti-idiotope antibody. As previously described, nanogram doses enhanced idiotope expression while a 10-micrograms dose of anti-idiotope antibody induced the act...

journal_title：Cellular immunology

authors： Kelsoe G

更新日期：1986-03-01 00:00:00

abstract：:Mice that differ at Igh loci and the reagents that permit resolution of such distinctions are powerful genetic tools for studying B cell heterogeneity. In this report, IgM-allotype-specific ELISA revealed that two of three sources of mice designated as BALB.nude express the Igh-6b (IgMb) allotype characteristic of C57...

journal_title：Cellular immunology

authors： Riggs JE

更新日期：1993-05-01 00:00:00

abstract：:A variant nonkiller (K-) T-cell clone derived from the MHC nonrestricted killer (K+) cell line TALL-103/2 (CD3/TCR gamma delta +) was studied to determine whether its lytic defects were at the tumor-binding or post-binding level. The two TALL-103/2 clones were found to display similar mRNA expression of TCR/CD3 comple...

journal_title：Cellular immunology

authors： Visonneau S,Cesano A,Santoli D

更新日期：1995-10-15 00:00:00

abstract：:Due to their immunomodulatory properties, adipose tissue (AT) and Wharton's Jelly (WJ) constitute valuable alternatives to BM as sources of MSCs for managing graft-versus-host disease. To ensure the efficiency of AT- and WJ-MSCs implies the characterization of their immunomodulatory functions in comparison to those of...

journal_title：Cellular immunology

authors： Najar M,Raicevic G,Boufker HI,Fayyad Kazan H,De Bruyn C,Meuleman N,Bron D,Toungouz M,Lagneaux L

更新日期：2010-01-01 00:00:00

abstract：:Plasmacytoid dendritic cells (PDCs) from human umbilical cord blood (UCB) produce lower amounts of IFN-α upon TLR stimulation compared with adult counterparts. This difference may play a role in the low graft-versus-host disease rate after UCB transplantation and in the impaired immune response of the neonate to patho...

journal_title：Cellular immunology

authors： Charrier E,Cordeiro P,Cordeau M,Dardari R,Michaud A,Harnois M,Merindol N,Herblot S,Duval M

更新日期：2012-03-01 00:00:00

abstract：:Estrogen displays potent immunoregulatory properties. In the present study we investigated the in vivo effect of estrogen on natural killer (NK) cell cytotoxic activity in several mouse strains. After castration, 17 beta-estradiol was administered in low or high doses. After 3-6 weeks of hormone administration an in v...

journal_title：Cellular immunology

authors： Nilsson N,Carlsten H

更新日期：1994-10-01 00:00:00

abstract：:We have performed immunoperoxidase staining on cryostat tissue sections and immunofluorescence analysis on cell suspensions to identify cells expressing the alpha/beta T cell antigen receptor during ontogeny and adult life in chickens. We used the mouse monoclonal antibody, TCR2, which was previously shown to recogniz...

journal_title：Cellular immunology

authors： Vainio O,Lassila O,Cihak J,Lösch U,Houssaint E

更新日期：1990-01-01 00:00:00

abstract：:In view of the eminently important role of interleukin-2 (IL-2) in T-cell responses, and in view of reports about immune stimulatory effects of PGE2, we reinvestigated the question whether PGE2 inhibits IL-2 production. It was found that PGE2 does not inhibit IL-2 production in murine spleen cell cultures after optima...

journal_title：Cellular immunology

authors： Wolf M,Falk W,Männel D,Dröge W

更新日期：1985-01-01 00:00:00

abstract：:Recent evidence has shown that dietary phytosterols (PS) possess anti-inflammatory properties both in vivo and in vitro. Our previous work shows that PS β-Sitosterol (SIT), may function by down-regulating pro-inflammatory transcription factors NF-kB and STAT1 in response to LPS stimulation, possibly through modulation...

journal_title：Cellular immunology

authors： Valerio MS,Minderman H,Mace T,Awad AB

更新日期：2013-09-01 00:00:00

abstract：:Interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) are major proinflammatory cytokines inducing the synthesis and release of many inflammatory mediators. They are involved in immune regulation, autoimmune diseases, and inflammation. Acanthoic acid, (-)-pimara-9(11),15-dien-19-oic acid, is a pimaradiene d...

journal_title：Cellular immunology

authors： Kang HS,Kim YH,Lee CS,Lee JJ,Choi I,Pyun KH

更新日期：1996-06-15 00:00:00

abstract：:Transforming growth factor beta1 (TGFbeta1) is a potent negative immunoregulatory molecule. We have previously shown that the autoimmune-mediated weaning-age lethality of Tgfb1-/- mice is reversed upon genetic combination with Scid or Rag null alleles. Here, we show that elimination of T but not B cells is sufficient ...

journal_title：Cellular immunology

authors： Bommireddy R,Engle SJ,Ormsby I,Boivin GP,Babcock GF,Doetschman T

更新日期：2004-11-01 00:00:00

abstract：:PHA stimulation of both freshly isolated and IL-2-dependent cultured T cells induced a rapid rise in intracytoplasmic calcium concentration. Chelation of extracellular calcium with EGTA resulted in a failure of PHA to induce a rise in intracytoplasmic calcium, resulting in the fresh T cells in an inhibition of IL-2 pr...

journal_title：Cellular immunology

authors： Watman NP,Crespo L,Davis B,Poiesz BJ,Zamkoff KW

更新日期：1988-01-01 00:00:00

abstract：:We previously reported that T cell proliferation in response to a primary signal through the T cell receptor (TCR) and a costimulatory signal via the CD28 molecule is impaired in healthy, aged mice. Here we extend these studies to examine factors which may be involved in this defect in T cells from aged mice. To deter...

journal_title：Cellular immunology

authors： Engwerda CR,Handwerger BS,Fox BS

更新日期：1996-05-25 00:00:00

abstract：:Spontaneously occurring lymphomas in SJL mice have many pathological features similar to Hodgkin's lymphoma in humans. The malignant growth of the tumor cells is dependent on the support of host FoxP3(+)CD4(+) regulatory T cells (Tregs). In this study, we report that the ablation of golli protein, a negative regulator...

journal_title：Cellular immunology

authors： Ouyang S,Han G,Wu X,Jiang Z,Feng JM

更新日期：2016-04-01 00:00:00

abstract：:The poor immunogenicity of many tumors can be partly explained by the inefficiency of the MHC class I peptide presentation pathway. MHC-I-based single-chain trimers (SCT) represent a new class of molecules with the potential to overcome this limitation. We here evaluated the ability of SCT presenting a melanoma antige...

journal_title：Cellular immunology

authors： Ordaz ML,Larmonier N,Lybarger L

更新日期：2010-01-01 00:00:00

abstract：:The loss of thymic function with age may be due to diminished numbers of T-cell progenitors and the loss of critical mediators within the thymic microenvironment. To assess the molecular changes associated with this loss, we examined transcriptomes of progressively aging mouse thymi, of different sexes and on caloric-...

journal_title：Cellular immunology

authors： Lustig A,Weeraratna AT,Wood WW 3rd,Teichberg D,Bertak D,Carter A,Poosala S,Firman J,Becker KG,Zonderman AB,Longo DL,Taub DD

更新日期：2007-01-01 00:00:00

abstract：:Stimulated macrophages are known to inhibit the growth of certain tumor cells. Using mouse peritoneal exudates as a source of macrophages and the mastocytoma cell line P815 as the target, the inhibition was found to depend on direct contact between the macrophages and the growing cells. Cytostatic activities were dete...

journal_title：Cellular immunology

authors： Ritter K,Härtl R,Bandlow G,Thomssen R

更新日期：1986-02-01 00:00:00

abstract：:Positive selection of T lymphocytes expressing self. MHC-restricted T cell receptors is mediated by MHC molecules expressed on thymic stroma. Among the more controversial aspects of this process is the relative role of MHC molecules on epithelial versus bone marrow-derived stromal elements (BM-APC). For CD4+ T cells, ...

journal_title：Cellular immunology

authors： Fort MM,Pardoll DM

更新日期：1996-07-10 00:00:00

abstract：:Previously, we reported that human B lymphocytes can be stimulated by trinitrophenylated Brucella abortus (TNP-Ba) in vitro to generate T-independent (TI) hapten specific plaque-forming cells (PFC). Furthermore we showed that addition of Con A on Day 3 of culture enhanced the anti-TNP response. In this report the char...

journal_title：Cellular immunology

authors： Golding B,Rittenberg MB

更新日期：1984-05-01 00:00:00

abstract：:We investigated the role of HLA-DR molecules in T cell stimulation by staphylococcal enterotoxin A (SEA). Previous results with immobilized purified HLA-DR preincubated with peptide showed that peptide-specific T cell clones were able to bind to and proliferate in response to purified HLA-DR/peptide complexes in the a...

journal_title：Cellular immunology

authors： Rust CJ,Koning F,van Schooten WC

更新日期：1993-10-15 00:00:00

abstract：BACKGROUND:Piper nigrum L. (Piperaceae) is commonly used as a spice and traditional medicine in many countries. It has been reported to have anti-oxidant, anti-bacterial, anti-tumor, anti-mutagenic, anti-diabetic, and anti-inflammatory properties. However, the protective role of P. nigrum on epithelial function of uppe...

journal_title：Cellular immunology

authors： Bui TT,Fan Y,Piao CH,Nguyen TV,Shin DU,Jung SY,Hyeon E,Song CH,Lee SY,Shin HS,Chai OH

更新日期：2020-05-01 00:00:00

abstract：:Mice were infected with Plasmodium (P.) yoelii blood-stage parasites. Both the liver and spleen were the sites of inflammation during malarial infection at the beginning of day 7. The major expanding cells were found to be NK1.1(-) intermediate alphabetaTCR (alphabetaTCR(int)) in the liver and spleen, although the pop...

journal_title：Cellular immunology

authors： Weerasinghe A,Sekikawa H,Watanabe H,Mannoor K,Morshed SR,Halder RC,Kawamura T,Kosaka T,Miyaji C,Kawamura H,Seki S,Abo T

更新日期：2001-01-10 00:00:00