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A role for L3T4+ T cells and their lymphokines in the generation of suppressor effector (TS3) cells.

Abstract：

:The cellular requirements for the in vitro induction of antigen-specific suppressor T cells were examined. Previous reports indicated that Ia-bearing macrophages and anti-idiotypic B cells are required as accessory cells to facilitate the generation of suppressor effector (TS3) cells which regulate the response to the 4-hydroxy-3-nitrophenyl acetyl (NP) hapten. The present study describes two distinct T cell populations which interact to generate antigen-specific TS3. Fractionation of the T cell populations with monoclonal antibody to the L3T4 determinant led to the identification of an NP-specific L3T4- TS3 progenitor population and an L3T4+ helper/inducer subset. In the presence of NP-coupled antigen, the L3T4+ subset could induce progenitor TS3 to differentiate into mature TS3 cells. The activity of the L3T4+ inducer population could be replaced with specifically activated cloned helper cells which were not NP-reactive since an I-Ab-restricted, insulin-reactive, L3T4+ clone was capable of supporting the generation of NP-specific TS3. Inducer activity appeared to be confined to the Th1 but not the Th2 subset. In addition, 18-hr supernatants from antigen-activated clones were capable of substituting for L3T4+ cells or T cell clones in TS3 induction cultures. The TS maturation/differentiation factor(s) active in these supernatants does not appear to be IL-1, IL-2, IL-3, or interferon-gamma alone since purified sources of these lymphokines failed to induce TS3 activity.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

O'Hara RM Jr,Hausman PB,Sherr DH,Abromson-Leeman SR,Dorf ME

doi

10.1016/0008-8749(88)90242-0

subject

Has Abstract

pub_date

1988-10-15 00:00:00

pages

423-38

issue

2

eissn

0008-8749

issn

1090-2163

pii

0008-8749(88)90242-0

journal_volume

116

pub_type

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