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Regulation of immune function by calorie restriction and cyclophosphamide treatment in lupus-prone NZB/NZW F1 mice.

Abstract：

:We compared the effects of calorie restriction (CR) and cyclophosphamide (CTX) on the progression of lupus nephritis and immunological changes in NZB/NZW F1 mice. Ad libitum (AL)/CTX and CR delayed onset of proteinuria and significantly decreased serum levels of anti-dsDNA, anti-histone, and circulating immune complex antibodies. CTX and CR prevented the increase in and activation of B cells, the decline in CD8(+) T cells, and maintained a higher proportion of naïve CD4(+) and CD8(+) cells. MHC class I antigen and LFA-1 expression on CD8(+) T cells and MHC class II antigen on B cells were also decreased. AL/CTX and CR prevented the increase in production of IL-10 and up-regulated IL-2 production in T cells ex vivo. We concluded that both CR and CTX can delay the onset of autoimmune disease, in part by maintaining higher numbers of naïve T cells and the immune responsiveness of T cells and decreasing the proportion of B cells.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Sun D,Krishnan A,Su J,Lawrence R,Zaman K,Fernandes G

doi

10.1016/j.cellimm.2004.04.001

subject

Has Abstract

pub_date

2004-03-01 00:00:00

pages

54-65

issue

1

eissn

0008-8749

issn

1090-2163

pii

S000887490400053X

journal_volume

228

pub_type

杂志文章

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