Generation of a soluble IFN-gamma inducer by oxidation of galactose residues on macrophages.

abstract：:The quantitative organ distribution and tissue microenvironment positioning of radioisotopically labeled cloned T cells were characterized. Intravenous (iv) injection of 51chromium (51Cr)-labeled, long-term cultured cloned T-helper cells and cells from several cloned cytolytic T-lymphocyte lines (CTLL) resulted in poo...

journal_title：Cellular immunology

authors： Carroll AM,Palladino MA,Oettgen H,De Sousa M

更新日期：1983-02-15 00:00:00

abstract：:Antigen-specific T-helper factor (ThF) of CBA (H-2k) origin in the picryl (TNP) contact sensitivity system (Mr 60-70 kDa) was reduced with dithiothreitol under mild conditions. Affinity chromatography on antigen yielded an antigen-binding chain (Mr 20-30 kDa) and an antigen-nonbinding chain (Mr 40-50 kDa). Both chains...

journal_title：Cellular immunology

authors： Little JA,Asherson GL,Colizzi V,Zembala M

更新日期：1988-05-01 00:00:00

abstract：:Human leucocytes from peripheral blood and tonsil were examined for the presence of the IL-3 receptor using monoclonal antibodies directed to epitopes of the alpha and beta chains of the receptor. We found that the beta chain, common to IL-3, IL-5, and GM-CSF, was either present at low levels or not detected on the ma...

journal_title：Cellular immunology

authors： Macardle PJ,Chen Z,Shih CY,Huang CM,Weedon H,Sun Q,Lopez AF,Zola H

更新日期：1996-02-25 00:00:00

abstract：:Over the last three decades it has become increasingly clear that monocytes, originally thought to have fixed, stereotypic responses to foreign stimuli, mediate exquisitely balanced protective and pathogenic roles in disease and immunity. This balance is crucial in core functional organs, such as the central nervous s...

journal_title：Cellular immunology

authors： Ashhurst TM,van Vreden C,Niewold P,King NJ

更新日期：2014-09-01 00:00:00

abstract：:The voltage gated potassium channel (Kv1.3) has been shown to play a role in immune responsiveness. Blockade of the channel led to diminution of T cell activation and delayed type hypersensitivity. Previous in vitro studies of the blockade were focused on T cell activation and proliferation. In this study we examined ...

journal_title：Cellular immunology

authors： Shah K,Tom Blake J,Huang C,Fischer P,Koo GC

更新日期：2003-02-01 00:00:00

abstract：:Cells from the draining lymph nodes of DBA/2 mice bearing syngeneic intradermal P-815 tumors represent an excellent responding cell population for secondary stimulation in vitro, despite the virtual absence of response by spleen cells of the same animals. Cytotoxicity is a result of stimulation with intact mitomycin-t...

journal_title：Cellular immunology

authors： Bertschmann M,Lüscher EF

更新日期：1983-05-01 00:00:00

abstract：:Males exhibit stronger sympathetic nervous system (SNS) activity, but weaker primary CD4+ T-cell (auto)immune responses. To test the role of catecholamines, major end-point SNS mediators, in this dimorphism, influence of propranolol (β-adrenoceptor blocker) on mitogen/neuroantigen-stimulated CD4+ T cells from female a...

journal_title：Cellular immunology

authors： Vujnović I,Pilipović I,Jasnić N,Petrović R,Blagojević V,Arsenović-Ranin N,Stojić-Vukanić Z,Djordjević J,Leposavić G

更新日期：2019-02-01 00:00:00

abstract：:Burn injury induces immune dysfunction and alters numerous physiological parameters. While clinical studies indicate that burn injury size profoundly impacts patient immune status, only limited experimental studies have systematically addressed its impact on immune functional parameters. In the present study, mice wer...

journal_title：Cellular immunology

authors： Alexander M,Chaudry IH,Schwacha MG

更新日期：2002-11-01 00:00:00

abstract：:It is suggested that autologous mixed lymphocyte reaction (AMLR) may play an important role in generating suppressor inducer signals and in down-regulating the immune response following self-major histocompatibility recognition. In the present study, monoclonal antibodies directed at cell surface structures on T4+ cel...

journal_title：Cellular immunology

authors： Takeuchi T,Schlossman SF,Morimoto C

更新日期：1987-06-01 00:00:00

abstract：:Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), a model for multiple sclerosis, is a chronic T cell-mediated disease. Development of clinical symptoms in susceptible mouse strains generally correlates with TMEV-specific delayed-type hypersensitivity (DTH) responses. These responses, ...

journal_title：Cellular immunology

authors： Pelka A,Olsberg C,Miller S,Waltenbaugh C,Creighton TM,dal Canto MC,Melvold R

更新日期：1993-12-01 00:00:00

abstract：:Autoimmune regulator (Aire) is a transcriptional activator that regulates the ectopic expression of many tissue-restricted antigens in medullary thymic epithelial cells, and that has an important role in the negative selection of autoreactive T cells. However, the roles of Aire expression in peripheral lymphoid tissue...

journal_title：Cellular immunology

authors： Zhu W,Yang W,He Z,Liao X,Wu J,Sun J,Yang Y,Li Y

更新日期：2011-01-01 00:00:00

abstract：:Interleukins play a role in the process of T-cell development and, like other cytokines, seem able to modulate apoptosis. Interleukin-2 has been reported to inhibit apoptotic cell death of thymocytes induced in vitro by either activation of CD3/TCR complex or treatment with glucocorticoid hormone. We demonstrate here ...

journal_title：Cellular immunology

authors： Migliorati G,Nicoletti I,Pagliacci MC,D'Adamio L,Riccardi C

更新日期：1993-01-01 00:00:00

abstract：:The hematopoietically restricted member of the NF-kappaB/Rel family, c-Rel, is essential for B cell survival and proliferation. Here we demonstrate that the production of the interleukins 6, 10, and 15 (IL-6, IL-10, and IL-15) are diminished in c-Rel(-/-) B lymphocytes. In a manner similar to that seen in IL-6(-/-) B ...

journal_title：Cellular immunology

authors： Tumang JR,Hsia CY,Tian W,Bromberg JF,Liou HC

更新日期：2002-05-01 00:00:00

abstract：:Dendritic cells initiate the immune response by presenting antigen in the context of varying levels of costimulation. The maturation state of the dendritic cell determines the quantity and quality (Th1, Th2) of the subsequent T cell response. Members of the NF-kappaB family of transcription factors have previously bee...

journal_title：Cellular immunology

authors： Boffa DJ,Feng B,Sharma V,Dematteo R,Miller G,Suthanthiran M,Nunez R,Liou HC

更新日期：2003-04-01 00:00:00

abstract：:Infection of certain strains of mice, such as C57BL/6 and C57BL/10 [B10], with LP-BM5 murine leukemia virus (MuLV) rapidly causes a profound and lethal immune suppression. The H2d congenic strain of B10, B10.D2, is resistant to disease, but B10 x B10.D2 F1 mice are susceptible, indicating that disease sensitivity is d...

journal_title：Cellular immunology

authors： Gilmore GL

更新日期：1996-04-10 00:00:00

abstract：:The utility of multiple antigenic peptides (MAPs) for the induction of antibody and cellular immune responses in animal models has been demonstrated for a variety of peptide epitopes involved in human disease. However, little is known about immune responses to MAPs constructed with antigenic tumor epitopes, nor has pe...

journal_title：Cellular immunology

authors： Schott ME,Wells DT,Schlom J,Abrams SI

更新日期：1996-12-15 00:00:00

abstract：:In this report, a subset of CD4(+) cells which kills autologous HLA class I positive and HLA class II negative non-small-cell lung cancer (NSCLC) cells is described. Killing was performed both by direct cytolytic mechanisms and by apoptosis. The peculiar characteristic of these effectors was their capability of lysing...

journal_title：Cellular immunology

authors： Semino C,Ferlazzo G,Ratto GB,Melioli G

更新日期：1999-09-15 00:00:00

abstract：:Intravital imaging of cutaneous immune responses has revealed intricate links between the skin's structural properties, the immune cells that reside therein, and the carefully orchestrated migratory dynamics that enable rapid sensing and subsequent elimination of skin pathogens. In particular, the development of 2-pho...

journal_title：Cellular immunology

authors： Zaid A

更新日期：2020-04-01 00:00:00

abstract：:Bispecific antibodies have been successfully introduced into clinical application. γδ T cells are of special interest for tumor immunotherapy, due to their recognition of pyrophosphates that are overproduced by many tumor cells resulting in HLA-nonrestricted tumor cell killing. Here we describe in detail a [(Her2)2 × ...

journal_title：Cellular immunology

authors： Oberg HH,Kellner C,Gonnermann D,Peipp M,Peters C,Sebens S,Kabelitz D,Wesch D

更新日期：2015-07-01 00:00:00

abstract：:We systematically investigated the impact of the relative maturation levels of dendritic cells (DCs) on their cell surface phenotype, expression of cytokines and chemokines/chemokine receptors (by DNA array and RNase protection analyses), biological activities, and abilities to induce tumor immunity. Mature DCs expres...

journal_title：Cellular immunology

authors： Chen Z,Dehm S,Bonham K,Kamencic H,Juurlink B,Zhang X,Gordon JR,Xiang J

更新日期：2001-11-25 00:00:00

abstract：:Veto cells suppress generation of CD8(+) T cell immune responses in an antigen-specific manner, with specificity dictated by antigens on the veto cell surface. Activated bone marrow (ABM) veto cells belong to the NK cell type lineage and veto by clonally deleting antigen-specific precursor cytotoxic T cell lymphocyte ...

journal_title：Cellular immunology

authors： Chrobak P,Gress RE

更新日期：2001-03-15 00:00:00

abstract：:CD48, the murine homolog of human CD58, binds to CD2 in rats and mice. Whereas inhibition of CD2 signaling leads to profound immunosuppression, no information is available on CD48-targeted therapy in the rat. We could show that anti-CD2 treatment (OX34) efficiently inhibited TCR-driven as well as CD2-mediated prolifer...

journal_title：Cellular immunology

authors： Sido B,Otto G,Zimmermann R,Müller P,Meuer SC,Dengler TJ

更新日期：1997-11-25 00:00:00

abstract：:Idiotypic immunoglobulin, which can be considered to bear tumour-associated antigens in the context of B-cell lymphoma, has been obtained from the splenic A31 tumour, purified, and used to immunise syngeneic mice. On subsequent exposure to a lethal challenge of lymphoma cells, the mice showed no overt tumour developme...

journal_title：Cellular immunology

authors： Dyke RJ,McBride H,George AJ,Hamblin TJ,Stevenson FK

更新日期：1991-01-01 00:00:00

abstract：:To improve the engraftment of human peripheral blood lymphocytes (PBL) to severe combined immunodeficient (SCID) mice, and to elucidate the factors which prevent the PBL's survival, we treated SCID mice with mAb, which neutralizes murine IFN-gamma's ability to activate cell-mediated immunity. Compared with untreated m...

journal_title：Cellular immunology

authors： Shibata S,Asano T,Noguchi A,Kimura H,Ogura A,Naiki M,Doi K

更新日期：1998-01-10 00:00:00

abstract：:Extracellular adenine nucleotides are inhibitors of the human natural killer cell line NK3.3 natural cytotoxicity activity. Natural cytotoxicity was inhibited approximately 26% by 1 mM ATP and 21% by 1 mM ADP. 5'-Adenylyl imidodiphosphate, a nonhydrolyzable ATP analog, inhibited natural cytotoxicity by 41% at a concen...

journal_title：Cellular immunology

authors： Dombrowski KE,Cone JC,Bjorndahl JM,Phillips CA

更新日期：1995-02-01 00:00:00

abstract：:The many signals that control the progress of various immune responses to both foreign and self antigens can be divided into no less than three major groups. The first group is the initial positive stimulus, associated with activation events through antigen receptors and their associated proteins. These signals launch...

journal_title：Cellular immunology

authors： Sinclair NR

更新日期：1990-10-01 00:00:00

abstract：:Thirty-two cord blood samples taken after caesarean section or vaginal delivery and concurrent venous blood samples obtained from normal adult controls were evaluated using monoclonal antibodies. The percentage of circulating pan-T-cell+ lymphocytes was significantly lower in cord blood (46%) compared with adult contr...

journal_title：Cellular immunology

authors： Solinger AM

更新日期：1985-04-15 00:00:00

abstract：:A decapeptide (1182-1191) derived from the bovine interphotoreceptor retinoid-binding protein (IRBP) was found to contain two completely distinct antigenic sites when tested in Lewis rats. One site, localized in sequence 1182-1191, is the core of the immunodominant and highly uveitogenic determinant of IRBP. The secon...

journal_title：Cellular immunology

authors： Kotake S,Sasamoto Y,Kawano Y,Sanui H,Wiggert B,Chader GJ,Gery I

更新日期：1992-03-01 00:00:00

abstract：:We have analyzed the effect of cyclosporin-A (CsA) on the proliferative and cytotoxic responses induced by mixed-lymphocyte cultures (MLC-s) on low and high density T lymphocytes. Allogeneic stimulation had a different impact on the two subsets. Proliferative and cytotoxic responses were inversely correlated; i.e., hi...

journal_title：Cellular immunology

authors： Bejarano MT,Masucci MG,Klein E

更新日期：1986-12-01 00:00:00

abstract：:Recent evidence has shown that dietary phytosterols (PS) possess anti-inflammatory properties both in vivo and in vitro. Our previous work shows that PS β-Sitosterol (SIT), may function by down-regulating pro-inflammatory transcription factors NF-kB and STAT1 in response to LPS stimulation, possibly through modulation...

journal_title：Cellular immunology

authors： Valerio MS,Minderman H,Mace T,Awad AB

更新日期：2013-09-01 00:00:00