Delayed-type hypersensitivity to Babesia microti-infected erythrocytes in mice.

abstract：:A series of Lyt 2+, trinitrophenyl (TNP)-specific T-cell lines are shown to lyse 51Cr-labeled target cells in an antigen-specific, H-2-restricted fashion in a 4-hr assay. These cells also produce lymphotoxin, in addition to other factors, upon stimulation with TNP-haptenated syngeneic splenocytes. A technique for intr...

journal_title：Cellular immunology

authors： Schmid DS,Powell MB,Mahoney KA,Ruddle NH

更新日期：1985-06-01 00:00:00

abstract：:Observational studies in multiple sclerosis (MS) demonstrated altered expression of chemokine receptors (CkRs) on comparable populations of mononuclear cells (e.g. CD4(+)/CD45RO(+) T-cells) in brain sections compared with blood. These findings raised questions about the regulation of CkRs on trafficking cells. Regulat...

journal_title：Cellular immunology

authors： Ubogu EE,Callahan MK,Tucky BH,Ransohoff RM

更新日期：2006-09-01 00:00:00

abstract：:We have established a long-lasting heart allograft tolerance in H-2-incompatible combinations by intravenous injection of 10(8) allogeneic spleen cells followed by the administration of 200 mg/kg of cyclophosphamide (CP). When C57BL/10 mice (B10, H-2b) were primed iv with 1 x 10(8) viable spleen cells from naive BALB/...

journal_title：Cellular immunology

authors： Matsuura A,Katsuno M,Suzuki Y,Ito T,Yasuura K,Abe T,Yoshikai Y

更新日期：1994-05-01 00:00:00

abstract：:We have investigated the ability of interleukin-10 (IL-10) to modulate murine intrathymic T cell differentiation using a fetal thymic organ culture (FTOC) model. Addition of as little as 11 ng of recombinant murine IL-10 (mIL-10) per day produced a significant increase in the proportion and number of gamma delta-TCR+ ...

journal_title：Cellular immunology

authors： Fine JS,Macosko HD,Grace MJ,Narula SK

更新日期：1994-04-15 00:00:00

abstract：:The aly, alymphoplasia, is an autosomal recessive mutation in mice of an unknown etiology, which induces total aplasia of lymph nodes and Peyer's patches. We hypothesized that the lack of lymphoid tissue may be due to abnormalities of lymphocyte traffic into these tissues. Therefore, we analyzed the expression of vari...

journal_title：Cellular immunology

authors： Koike R,Watanabe T,Satoh H,Hee CS,Kitada K,Kuramoto T,Serikawa T,Miyawaki S,Miyasaka M

更新日期：1997-08-25 00:00:00

abstract：:Antigen-independent adhesion of CD4+ T lymphocytes to Epstein-Barr virus transformed B cells is mainly mediated by LFA-1 (CD11a/CD18) and CD2 molecules. Low-affinity binding of resting T cells can be transiently upregulated by cross-linking of CD3-TCR (T cell receptor) complexes. This inside-out signaling influences i...

journal_title：Cellular immunology

authors： Hauss P,Mazerolles F,Hivroz C,Lecomte O,Barbat C,Fischer A

更新日期：1993-09-01 00:00:00

abstract：:During the course of differentiation in the thymus, precursor T cells are negatively selected by a self-tolerance mechanism or positively selected to acquire restriction specificity to self major histocompatibility complexes. We investigated the process of T cell differentiation and those selections using a fetal thym...

journal_title：Cellular immunology

authors： Matsuhashi N,Kawase Y,Suzuki G

更新日期：1989-10-15 00:00:00

abstract：:B-cell clonal expansions (BCE) in young mice are transient, detectable for less than 4 weeks. In contrast, BCE in old mice persist more than 2 months. The greater persistence of BCE in old mice does not appear to be due to the age of the host as the survival of phenyloxazolone chicken serum albumin-induced BCE in most...

journal_title：Cellular immunology

authors： Szabo P,Li F,Mathew J,Lillvis J,Weksler ME

更新日期：2004-09-01 00:00:00

abstract：:Coxsackievirus group B type 3 (CVB3) induces myocarditis in male Balb/c mice but produces little cardiac injury in females. Males develop cytolytic T lymphocytes (CTL) reactive to heart antigens which primarily cause the inflammation and cardiac injury observed in the disease. Infected female mice lack this CTL respon...

journal_title：Cellular immunology

authors： Job LP,Lyden DC,Huber SA

更新日期：1986-03-01 00:00:00

abstract：:The nuclear receptor Small Heterodimer Partner (SHP) is a transcriptional target and inhibitor of Liver Receptor Homolog 1 (LRH-1), the transcriptional regulator of intestinal glucocorticoid (GC) synthesis. The role of SHP in the regulation of intestinal GC synthesis and its impact on T cell-mediated anti-viral immune...

journal_title：Cellular immunology

authors： Huang J,Jia R,Brunner T

更新日期：2018-12-01 00:00:00

abstract：:The CD2 (T11) molecule belongs to a family of cell-surface glycoproteins that function as adhesion molecules in the immune system. Human CD2 is found exclusively on cells of the T lineage: peripheral T lymphocytes, NK cells, and thymocytes. CD2 binds specifically to the surface glycoprotein LFA-3. CD2/LFA-3 adhesion i...

journal_title：Cellular immunology

authors： Rabin EM,Gordon K,Knoppers MH,Luther MA,Neidhardt EA,Flynn JF,Sardonini CA,Sampo TM,Concino MF,Recny MA

更新日期：1993-06-01 00:00:00

abstract：:Here, we established CD4(+)αβTh1 clones specific for rat vascular smooth muscle antigen (VSMAg) that induced vasculitis lesions in the lungs of MRL/Mp-Fas(+/+) mice following adoptive transfer. Six different T cell clones, MV1b1 (Vβ1), MV1b4 (Vβ4), MV1b8.3 (Vβ8.3), MV1b61 (Vβ6), MV1b62 (Vβ6), and MV1b63 (Vβ6), were is...

journal_title：Cellular immunology

authors： Fujita Y,Fujii T,Shimizu H,Sato T,Nakamura T,Iwao H,Nakajima A,Miki M,Sakai T,Kawanami T,Tanaka M,Masaki Y,Fukushima T,Okazaki T,Umehara H,Mimori T

更新日期：2016-05-01 00:00:00

abstract：:We compared macrophage binding and killing of F5b cells to the binding and killing of P815 mastocytoma cells and to several other nontransformed and transformed cell lines. Formalin fixation of elicited or activated macrophages did not affect binding of F5b or 3T3 cells but did abrogate binding of P815 cells. However,...

journal_title：Cellular immunology

authors： Rosenkrans CF Jr,Chapes SK

更新日期：1991-03-01 00:00:00

abstract：:To clarify the role of B cells in the establishment of T cell response against intracellular bacteria, B-cell-deficient (muMT-/-) mice were infected with an intracellular bacteria, Listeria monocytogenes, and T cell response against the bacteria was analyzed. On day 6 of primary Listeria infection, spleen T cells of t...

journal_title：Cellular immunology

authors： Matsuzaki G,Vordermeier HM,Hashimoto A,Nomoto K,Ivanyi J

更新日期：1999-06-15 00:00:00

abstract：:Unconventional T cells are gaining center stage as important effector and regulatory cells that orchestrate innate and adaptive immune responses. Human Vγ9/Vδ2 T cells are amongst the best understood unconventional T cells, as they are easily accessible in peripheral blood, can readily be expanded and manipulated in v...

journal_title：Cellular immunology

authors： Tyler CJ,Doherty DG,Moser B,Eberl M

更新日期：2015-07-01 00:00:00

abstract：:Interleukin (IL)-1 differs from most other cytokines by the lack of a signal sequence, which results in the retention of the immature proform intracellularly (i.c.). Several cell types have the capacity to produce IL-1, but release has been shown to be restricted predominantly to monocytes/macrophages and associated w...

journal_title：Cellular immunology

authors： Wingren AG,Björkdahl O,Labuda T,Björk L,Andersson U,Gullberg U,Hedlund G,Sjögren HO,Kalland T,Widegren B,Dohlsten M

更新日期：1996-05-01 00:00:00

abstract：:Several studies have demonstrated that addition of soluble anti-CD6 mAbs to 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated naive T cells can induce cell proliferation. We showed in the present study that cell proliferation in TPA-treated T cell cultures can be enhanced several fold when the anti-CD6 mAbs are eithe...

journal_title：Cellular immunology

authors： Osorio LM,Ordonez C,Garcia CA,Jondal M,Chow SC

更新日期：1995-11-01 00:00:00

abstract：:The murine B-cell differentiation antigen Lyb-2 has been shown to be involved in B-lymphocyte activation and has been postulated by some to be related to a receptor for B-cell stimulatory factor I (BSF-1) (H. Yakura et al., J. Immunol. 137, 1475, 1986). Here we have demonstrated that monoclonal antibody (mAB) to Lyb-2...

journal_title：Cellular immunology

authors： Subbarao B,Morris J,Baluyut AR

更新日期：1988-04-01 00:00:00

abstract：:The mechanism of how superantigens function to activate cells has been linked to their ability to bind and cross-link the major histocompatibility complex class II (MHCII) molecule. Cells that lack the MHCII molecule also respond to superantigens, however, with much less efficiency. Therefore, the purpose of this stud...

journal_title：Cellular immunology

authors： Wright AD,Chapes SK

更新日期：1999-11-01 00:00:00

abstract：:Injection of the 708-amino-acid (aa) viral protein "large tumor antigen" (T-Ag) of simian virus 40 (SV40) or its N-terminal 272-aa fragment into C57BL/6 (B6) mice (H-2b) primed CD8+ cytotoxic T lymphocytes (CTL) in vivo. Surprisingly, injection of this nonstructural viral protein (or its N-terminal fragment) in solubl...

journal_title：Cellular immunology

authors： Schirmbeck R,Deppert W,Kury E,Reimann J

更新日期：1993-07-01 00:00:00

abstract：:A variant nonkiller (K-) T-cell clone derived from the MHC nonrestricted killer (K+) cell line TALL-103/2 (CD3/TCR gamma delta +) was studied to determine whether its lytic defects were at the tumor-binding or post-binding level. The two TALL-103/2 clones were found to display similar mRNA expression of TCR/CD3 comple...

journal_title：Cellular immunology

authors： Visonneau S,Cesano A,Santoli D

更新日期：1995-10-15 00:00:00

abstract：:The delayed-type hypersensitivity (DTH) reaction, a peripheral expression of cell-mediated immunity is still a crucial in vivo immunological test. Nevertheless, the biological significance of its time course remains unclear. Thus, an exhaustive study of DTH was undertaken in mice immunized with increasing doses of she...

journal_title：Cellular immunology

authors： Hurtrel B,Maire MA,Hurtrel M,Lagrange PH

更新日期：1992-07-01 00:00:00

abstract：:We have studied the effects of prostaglandin E2 (PGE2) and cholera toxin, two modulators of adenylyl cyclase, and 8-bromo cAMP (8-BrcAMP) on various parameters of lymphocyte activation using the human T cell line Jurkat. Our results show that PGE2 and cholera toxin inhibit, in a dose-related manner, the phytohemagglut...

journal_title：Cellular immunology

authors： Bastin B,Payet MD,Dupuis G

更新日期：1990-07-01 00:00:00

abstract：:We previously showed that DT-5461a, a lipid A analog, has antitumor activity and relatively low toxicity in animals. To clarify its immunostimulatory effect we have studied the cytokine inducibility of DT-5461a and the mechanism involved in the cytokine expression in macrophages. While the activity is lower than that ...

journal_title：Cellular immunology

authors： Akahane K,Someya K,Tsutomi Y,Akimoto T,Tohgo A

更新日期：1994-04-15 00:00:00

abstract：:Patients treated with monoclonal antibodies and cytokines for cancer receive often co-medication, which may influence treatment efficacy. Therefore, we investigated with a flowcytometric cytotoxicity assay the effect of several immunomodulatory drugs on antibody dependent cellular cytotoxicity (ADCC), interleukin-2 (I...

journal_title：Cellular immunology

authors： Flieger D,Varvenne M,Kleinschmidt R,Schmidt-Wolf IG

更新日期：2007-03-01 00:00:00

abstract：:It is becoming increasingly clear that regulatory T cells (Treg cells) in specific tissues are important parts of immune system. Tissue-resident Treg cells, which are largely Foxp3-expressing CD4(+) Treg cells, are distinct from one another and conventional Treg cells, and have tissue-specific phenotype and function. ...

journal_title：Cellular immunology

authors： Lu J,Meng H,Zhang A,Yang J,Zhang X

更新日期：2015-09-01 00:00:00

abstract：:Patients with head and neck cancer often have decreased local or regional immunocompetence. Lymphocytes obtained from tumor-involved or -uninvolved lymph nodes (LNL) of these patients showed low or undetectable levels of antitumor cytotoxicity and low proliferative responses in vitro to interleukin 2 (IL2) or mitogens...

journal_title：Cellular immunology

authors： Letessier EM,Sacchi M,Johnson JT,Herberman RB,Whiteside TL

更新日期：1990-10-15 00:00:00

abstract：:Aging is characterized by significant immune remodeling at both cellular and molecular levels, also known as immunosenescence. Older adults often manifest a chronic low-grade inflammatory phenotype. These age-related immune system changes have increasingly been recognized not only to lead to immune functional decline ...

journal_title：Cellular immunology

authors： Leng SX,Margolick JB

更新日期：2020-02-01 00:00:00

abstract：:We investigated the cellular induction mechanism of antigen-nonspecific CD8+ T suppressor cells which suppressed delayed-type hypersensitivity to sheep red blood cells, by treating BALB/c mice with 7,12-dimethylbenz[a]anthracene (DMBA), a tumor initiator, and 12-O-tetradecanoylphorbol 13-acetate (TPA), a tumor promote...

journal_title：Cellular immunology

authors： Negoro T,Iinuma F,Watanabe M

更新日期：1996-02-01 00:00:00

abstract：:CD40 and its ligand (CD40L) regulate several cellular functions, including T and B-cell activation. The soluble form of CD40 (sCD40) antagonizes CD40/CD40L interaction. Patients undergoing hemodialysis (HD) present elevated sCD40 serum levels, which underlying molecular mechanisms are unknown. We studied sCD40 serum a...

journal_title：Cellular immunology

authors： Esposito P,Rampino T,Gregorini M,Gabanti E,Bianzina S,Dal Canton A

更新日期：2012-07-01 00:00:00