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Characterization of endogenous Chinese hamster ovary cell surface molecules that mediate T cell costimulation.

Abstract：

:Chinese hamster ovary (CHO) cells are commonly used in the generation of transfectants for use in in vitro costimulation assays. However, we have noted that nontransfected CHO cells can themselves provide a low-level B7/CD28 independent costimulatory signal for CD3-mediated murine T cell activation and IL-2 production. This study set out to identify those molecules that contribute to this CHO-dependent costimulatory activity. We describe a CHO subline capable of delivering potent CD28-independent costimulation to murine T cells and the generation of monoclonal antibodies against these CHO cells that inhibited this costimulatory activity. These blocking antibodies do not affect CHO cell-independent costimulation or bind mouse cells, suggesting an effect mediated by their target molecules on the costimulatory competent CHO cells. Immunoprecipitation and expression cloning revealed that these antibodies bound the hamster homologues of Crry (CD21/35), CD44, CD54 (ICAM-1), CD63, CD87, CD147, and an 80- to 90-kDa protein which could not be cloned. Expression of these hamster genes on COS cells demonstrated that hamster CD54 was able to costimulate both CD3-mediated IL-2 secretion and T cell proliferation by naive murine T cells independent of the other molecules identified.

journal_name

Cell Immunol

journal_title

Cellular immunology

authors

Gaglia JL,Mattoo A,Greenfield EA,Freeman GJ,Kuchroo VK

doi

10.1006/cimm.2001.1867

subject

Has Abstract

pub_date

2001-11-01 00:00:00

pages

83-93

issue

2

eissn

0008-8749

issn

1090-2163

pii

S0008-8749(01)91867-2

journal_volume

213

pub_type

杂志文章

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